Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for AIRE
Z-value: 0.52
Motif logo
Transcription factors associated with AIRE
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| AIRE | hg19_v2_chr21_+_45705752_45705767 | -0.40 | 4.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_225811747 Show fit | 1.52 |
ENST00000409592.3
|
dedicator of cytokinesis 10 |
|
| chr1_+_79115503 Show fit | 0.93 |
ENST00000370747.4
ENST00000438486.1 ENST00000545124.1 |
interferon-induced protein 44 |
|
| chr8_+_54764346 Show fit | 0.85 |
ENST00000297313.3
ENST00000344277.6 |
regulator of G-protein signaling 20 |
|
| chr12_+_75874984 Show fit | 0.85 |
ENST00000550491.1
|
GLI pathogenesis-related 1 |
|
| chr6_+_127898312 Show fit | 0.80 |
ENST00000329722.7
|
chromosome 6 open reading frame 58 |
|
| chr1_+_165864821 Show fit | 0.79 |
ENST00000470820.1
|
uridine-cytidine kinase 2 |
|
| chr12_+_75874580 Show fit | 0.68 |
ENST00000456650.3
|
GLI pathogenesis-related 1 |
|
| chr11_+_35211511 Show fit | 0.67 |
ENST00000524922.1
|
CD44 molecule (Indian blood group) |
|
| chr8_+_104384616 Show fit | 0.60 |
ENST00000520337.1
|
collagen triple helix repeat containing 1 |
|
| chr6_-_32806506 Show fit | 0.60 |
ENST00000374897.2
ENST00000452392.2 |
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Uncharacterized protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of AIRE
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.2 | 0.8 | GO:0046035 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.1 | 0.8 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.1 | 0.7 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 0.6 | GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) |
| 0.1 | 0.6 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.1 | 0.6 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.2 | 0.5 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.2 | 0.5 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.0 | 0.5 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 1.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.7 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 0.6 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 0.5 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.3 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 0.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.1 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 0.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 0.6 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.1 | 0.6 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.0 | 0.6 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.2 | 0.5 | GO:0070025 | cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809) |
| 0.1 | 0.5 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.1 | 0.5 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.0 | 0.5 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 0.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 0.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.4 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.8 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.4 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.2 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |