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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.65

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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol Gene ID Gene Info
BHLHE22
ENSG00000180828.1 basic helix-loop-helix family member e22
BHLHA15
ENSG00000180535.3 basic helix-loop-helix family member a15
BHLHE23
ENSG00000125533.4 basic helix-loop-helix family member e23

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE22hg19_v2_chr8_+_65492756_654928140.116.0e-01Click!
BHLHE23hg19_v2_chr20_-_61638313_616383870.106.4e-01Click!

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_111312622 2.72 ENST00000395634.3
NREP
neuronal regeneration related protein
chr10_+_5135981 2.02 ENST00000380554.3
AKR1C3
aldo-keto reductase family 1, member C3
chr3_-_18480260 1.83 ENST00000454909.2
SATB1
SATB homeobox 1
chr7_-_27205136 1.82 ENST00000396345.1
ENST00000343483.6
HOXA9
homeobox A9
chr1_+_47489240 1.72 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr19_-_11450249 1.64 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr2_-_165424973 1.64 ENST00000543549.1
GRB14
growth factor receptor-bound protein 14
chr1_+_61330931 1.60 ENST00000371191.1
NFIA
nuclear factor I/A
chr1_+_244214577 1.29 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr20_+_57226841 1.19 ENST00000358029.4
ENST00000361830.3
STX16
syntaxin 16
chr2_-_183387430 1.11 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_-_114477962 1.09 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr2_-_188378368 1.04 ENST00000392365.1
ENST00000435414.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr3_-_114477787 1.02 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_116502605 0.94 ENST00000458284.2
ENST00000490693.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr2_-_183387064 0.86 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr15_+_65843130 0.81 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr9_+_2158485 0.72 ENST00000417599.1
ENST00000382185.1
ENST00000382183.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_-_197300194 0.72 ENST00000358186.2
ENST00000431056.1
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr9_+_2158443 0.69 ENST00000302401.3
ENST00000324954.5
ENST00000423555.1
ENST00000382186.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_-_55700216 0.69 ENST00000569205.1
CCPG1
cell cycle progression 1
chr5_+_175299743 0.68 ENST00000502265.1
CPLX2
complexin 2
chr13_+_28813645 0.66 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr8_-_38239732 0.63 ENST00000534155.1
ENST00000433384.2
ENST00000317025.8
ENST00000316985.3
WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr4_+_144354644 0.62 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr3_-_178984759 0.61 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr15_+_40650408 0.61 ENST00000267889.3
DISP2
dispatched homolog 2 (Drosophila)
chr14_+_22675388 0.60 ENST00000390461.2
TRAV34
T cell receptor alpha variable 34
chr7_+_116502527 0.57 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr4_-_159094194 0.52 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr7_-_38403077 0.52 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr15_-_55700522 0.51 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr19_+_18208603 0.51 ENST00000262811.6
MAST3
microtubule associated serine/threonine kinase 3
chr15_-_65503801 0.48 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr4_-_141075330 0.47 ENST00000509479.2
MAML3
mastermind-like 3 (Drosophila)
chr5_-_114632307 0.47 ENST00000506442.1
ENST00000379611.5
CCDC112
coiled-coil domain containing 112
chr19_-_37019562 0.41 ENST00000523638.1
ZNF260
zinc finger protein 260
chrX_+_70798261 0.39 ENST00000373696.3
ACRC
acidic repeat containing
chr13_+_49551020 0.38 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr2_-_183387283 0.37 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chrX_-_19817869 0.37 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chr4_-_74088800 0.37 ENST00000509867.2
ANKRD17
ankyrin repeat domain 17
chr12_-_102872317 0.35 ENST00000424202.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_+_25915896 0.35 ENST00000514384.1
SMIM20
small integral membrane protein 20
chr1_+_159272111 0.34 ENST00000368114.1
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr2_-_166930131 0.33 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr10_-_48416849 0.32 ENST00000249598.1
GDF2
growth differentiation factor 2
chr12_-_30887948 0.32 ENST00000433722.2
CAPRIN2
caprin family member 2
chr6_+_97010424 0.31 ENST00000541107.1
ENST00000450218.1
ENST00000326771.2
FHL5
four and a half LIM domains 5
chr8_-_135522425 0.31 ENST00000521673.1
ZFAT
zinc finger and AT hook domain containing
chr15_-_55700457 0.30 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr17_+_7211656 0.29 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr6_-_119031228 0.28 ENST00000392500.3
ENST00000368488.5
ENST00000434604.1
CEP85L
centrosomal protein 85kDa-like
chr1_-_186344802 0.26 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr17_+_60758814 0.25 ENST00000579432.1
ENST00000446119.2
MRC2
mannose receptor, C type 2
chr10_-_94257512 0.24 ENST00000371581.5
IDE
insulin-degrading enzyme
chr8_+_21823726 0.23 ENST00000433566.4
XPO7
exportin 7
chr9_+_18474163 0.21 ENST00000380566.4
ADAMTSL1
ADAMTS-like 1
chr20_-_34117447 0.20 ENST00000246199.2
ENST00000424444.1
ENST00000374345.4
ENST00000444723.1
C20orf173
chromosome 20 open reading frame 173
chr4_+_2813946 0.19 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr3_+_46924829 0.19 ENST00000313049.5
PTH1R
parathyroid hormone 1 receptor
chr6_-_169364429 0.19 ENST00000444586.1
RP3-495K2.3
RP3-495K2.3
chr19_-_54876558 0.19 ENST00000391742.2
ENST00000434277.2
LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chrX_+_107334895 0.18 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
ATG4A
autophagy related 4A, cysteine peptidase
chr4_-_147043058 0.18 ENST00000512063.1
ENST00000507726.1
RP11-6L6.3
long intergenic non-protein coding RNA 1095
chr17_-_39597173 0.17 ENST00000246646.3
KRT38
keratin 38
chr18_-_52989525 0.17 ENST00000457482.3
TCF4
transcription factor 4
chr3_+_97868170 0.16 ENST00000437310.1
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr2_+_234637754 0.16 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr1_+_95975672 0.16 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
RP11-286B14.1
chr6_-_112115074 0.16 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr15_-_63448973 0.16 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr2_+_181845843 0.15 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr7_+_148287657 0.15 ENST00000307003.2
C7orf33
chromosome 7 open reading frame 33
chr14_-_69864993 0.14 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chr6_-_29324054 0.14 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr3_-_108672609 0.13 ENST00000393963.3
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr14_+_77292715 0.13 ENST00000393774.3
ENST00000555189.1
ENST00000450042.2
C14orf166B
chromosome 14 open reading frame 166B
chr8_+_67782984 0.13 ENST00000396592.3
ENST00000422365.2
ENST00000492775.1
MCMDC2
minichromosome maintenance domain containing 2
chr2_+_210444748 0.13 ENST00000392194.1
MAP2
microtubule-associated protein 2
chr6_+_73076432 0.13 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr7_-_112758665 0.12 ENST00000397764.3
LINC00998
long intergenic non-protein coding RNA 998
chr14_+_27342334 0.11 ENST00000548170.1
ENST00000552926.1
RP11-384J4.1
RP11-384J4.1
chr13_+_111766897 0.11 ENST00000317133.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chrX_+_105855160 0.11 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr3_-_33700933 0.11 ENST00000480013.1
CLASP2
cytoplasmic linker associated protein 2
chr17_-_47286729 0.11 ENST00000300406.2
ENST00000511277.1
ENST00000511673.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr15_+_85144217 0.10 ENST00000540936.1
ENST00000448803.2
ENST00000546275.1
ENST00000546148.1
ENST00000442073.3
ENST00000334141.3
ENST00000358472.3
ENST00000502939.2
ENST00000379358.3
ENST00000327179.6
ZSCAN2
zinc finger and SCAN domain containing 2
chr1_-_44818599 0.10 ENST00000537474.1
ERI3
ERI1 exoribonuclease family member 3
chr10_-_15902449 0.10 ENST00000277632.3
FAM188A
family with sequence similarity 188, member A
chr3_-_33700589 0.09 ENST00000461133.3
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr3_-_108672742 0.09 ENST00000261047.3
GUCA1C
guanylate cyclase activator 1C
chr8_+_67976593 0.09 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr7_+_114562909 0.09 ENST00000423503.1
ENST00000427207.1
MDFIC
MyoD family inhibitor domain containing
chr3_+_97887544 0.09 ENST00000356526.2
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr6_-_117150198 0.09 ENST00000310357.3
ENST00000368549.3
ENST00000530250.1
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr16_+_14726672 0.08 ENST00000261658.2
ENST00000563971.1
BFAR
bifunctional apoptosis regulator
chr7_-_41742697 0.08 ENST00000242208.4
INHBA
inhibin, beta A
chr11_-_62359027 0.08 ENST00000494385.1
ENST00000308436.7
TUT1
terminal uridylyl transferase 1, U6 snRNA-specific
chr3_+_137717571 0.08 ENST00000343735.4
CLDN18
claudin 18
chr7_-_97881429 0.07 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr12_+_50794730 0.07 ENST00000523389.1
ENST00000518561.1
ENST00000347328.5
ENST00000550260.1
LARP4
La ribonucleoprotein domain family, member 4
chr5_+_156607829 0.06 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr2_-_227050079 0.06 ENST00000423838.1
AC068138.1
AC068138.1
chr14_+_24540046 0.06 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chr21_-_36421401 0.06 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr4_+_2814011 0.06 ENST00000502260.1
ENST00000435136.2
SH3BP2
SH3-domain binding protein 2
chr16_-_52640834 0.05 ENST00000510238.3
CASC16
cancer susceptibility candidate 16 (non-protein coding)
chr12_-_91573316 0.05 ENST00000393155.1
DCN
decorin
chr1_+_12524965 0.05 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr7_-_101212244 0.04 ENST00000451953.1
ENST00000434537.1
ENST00000437900.1
LINC01007
long intergenic non-protein coding RNA 1007
chrX_+_120181457 0.04 ENST00000328078.1
GLUD2
glutamate dehydrogenase 2
chrX_+_107288239 0.03 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr3_+_113251143 0.03 ENST00000264852.4
ENST00000393830.3
SIDT1
SID1 transmembrane family, member 1
chr3_-_53164423 0.03 ENST00000467048.1
ENST00000394738.3
ENST00000296292.3
RFT1
RFT1 homolog (S. cerevisiae)
chr3_+_112930306 0.03 ENST00000495514.1
BOC
BOC cell adhesion associated, oncogene regulated
chr19_-_52227221 0.03 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr7_-_99573677 0.03 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr3_+_137728842 0.03 ENST00000183605.5
CLDN18
claudin 18
chr4_+_69313145 0.03 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr3_+_119298429 0.02 ENST00000478927.1
ADPRH
ADP-ribosylarginine hydrolase
chr11_+_66008698 0.02 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr8_+_62747349 0.02 ENST00000517953.1
ENST00000520097.1
ENST00000519766.1
RP11-705O24.1
RP11-705O24.1
chr9_+_12775011 0.02 ENST00000319264.3
LURAP1L
leucine rich adaptor protein 1-like
chr6_+_37400974 0.02 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr1_-_157670647 0.02 ENST00000368184.3
FCRL3
Fc receptor-like 3
chr11_-_44972476 0.02 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr12_-_95397442 0.02 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chrX_-_15402498 0.01 ENST00000297904.3
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr8_-_67976509 0.01 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr4_+_154178520 0.00 ENST00000433687.1
TRIM2
tripartite motif containing 2
chr2_-_32490859 0.00 ENST00000404025.2
NLRC4
NLR family, CARD domain containing 4
chr12_-_108714412 0.00 ENST00000412676.1
ENST00000550573.1
CMKLR1
chemokine-like receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0016095 polyprenol catabolic process(GO:0016095)
0.3 1.6 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.3 1.5 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.7 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 1.0 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 2.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.3 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.1 1.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.8 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.4 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.3 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.2 GO:1901143 insulin catabolic process(GO:1901143)
0.1 0.4 GO:1904073 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 1.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 0.7 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 1.2 GO:0072189 ureter development(GO:0072189)
0.0 0.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 1.5 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 2.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.5 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.2 GO:0051697 protein delipidation(GO:0051697)
0.0 0.2 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.6 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.6 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.5 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.1 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0 0.4 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.3 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.6 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.1 GO:1903895 negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
0.0 0.1 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0031251 PAN complex(GO:0031251)
0.1 1.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.7 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.6 GO:0042588 zymogen granule(GO:0042588)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 0.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 1.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 1.2 GO:0031201 SNARE complex(GO:0031201)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.7 GO:0098576 lumenal side of membrane(GO:0098576)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.2 GO:0031597 cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0047718 androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.3 2.3 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 0.7 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.1 1.7 GO:0070330 aromatase activity(GO:0070330)
0.1 0.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE binding(GO:0019863)
0.0 0.2 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.2 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0043559 insulin binding(GO:0043559)
0.0 0.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.4 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.6 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID INSULIN PATHWAY Insulin Pathway
0.0 1.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.6 PID EPO PATHWAY EPO signaling pathway
0.0 1.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.4 PID IGF1 PATHWAY IGF1 pathway
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.5 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.0 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 1.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation