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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for DBX2_HLX
Z-value: 0.62
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Transcription factors associated with DBX2_HLX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HLX | hg19_v2_chr1_+_221051699_221051699 | 0.44 | 2.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_156587853 Show fit | 4.35 |
ENST00000506455.1
ENST00000511108.1 |
guanylate cyclase 1, soluble, alpha 3 |
|
| chr8_+_98900132 Show fit | 1.80 |
ENST00000520016.1
|
matrilin 2 |
|
| chr4_+_41540160 Show fit | 1.60 |
ENST00000503057.1
ENST00000511496.1 |
LIM and calponin homology domains 1 |
|
| chr1_+_84630645 Show fit | 1.53 |
ENST00000394839.2
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr1_+_76540386 Show fit | 1.44 |
ENST00000328299.3
|
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 |
|
| chr12_-_10978957 Show fit | 1.21 |
ENST00000240619.2
|
taste receptor, type 2, member 10 |
|
| chr4_+_156587979 Show fit | 1.19 |
ENST00000511507.1
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr11_-_63376013 Show fit | 1.08 |
ENST00000540943.1
|
phospholipase A2, group XVI |
|
| chr20_-_33735070 Show fit | 1.05 |
ENST00000374491.3
ENST00000542871.1 ENST00000374492.3 |
ER degradation enhancer, mannosidase alpha-like 2 |
|
| chr6_+_132455526 Show fit | 1.00 |
ENST00000443303.1
|
long intergenic non-protein coding RNA 1013 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DBX2_HLX
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.5 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.0 | 2.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 1.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 1.8 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.2 | 1.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.0 | 1.5 | GO:0006677 | glycosylceramide metabolic process(GO:0006677) |
| 0.0 | 1.2 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 1.1 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.1 | 1.1 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.0 | 1.1 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 1.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 1.0 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 1.0 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 1.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 1.0 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.9 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.9 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 1.7 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.2 | 1.5 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.1 | 1.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 1.3 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 1.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.2 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.2 | 1.1 | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
| 0.0 | 1.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 1.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.2 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.8 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 0.7 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 1.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.1 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 1.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.0 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 1.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |