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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for EBF1
Z-value: 1.33
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Transcription factors associated with EBF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF1 | hg19_v2_chr5_-_158526693_158526706 | 0.24 | 2.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_31550192 Show fit | 7.34 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr14_+_103592636 Show fit | 4.99 |
ENST00000333007.1
|
tumor necrosis factor, alpha-induced protein 2 |
|
| chr14_+_24630465 Show fit | 3.87 |
ENST00000557894.1
ENST00000559284.1 ENST00000560275.1 |
interferon regulatory factor 9 |
|
| chr19_+_4229495 Show fit | 3.71 |
ENST00000221847.5
|
Epstein-Barr virus induced 3 |
|
| chr8_+_23386557 Show fit | 3.38 |
ENST00000523930.1
|
solute carrier family 25 (mitochondrial iron transporter), member 37 |
|
| chr11_+_19798964 Show fit | 2.92 |
ENST00000527559.2
|
neuron navigator 2 |
|
| chr12_-_49259643 Show fit | 2.91 |
ENST00000309739.5
|
Rho family GTPase 1 |
|
| chr2_+_150187020 Show fit | 2.70 |
ENST00000334166.4
|
LY6/PLAUR domain containing 6 |
|
| chr8_+_23386305 Show fit | 2.63 |
ENST00000519973.1
|
solute carrier family 25 (mitochondrial iron transporter), member 37 |
|
| chr1_-_184943610 Show fit | 2.61 |
ENST00000367511.3
|
family with sequence similarity 129, member A |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 9.6 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) |
| 0.9 | 7.3 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 6.3 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 2.0 | 6.0 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.3 | 5.2 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.2 | 5.2 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 4.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.8 | 4.0 | GO:1903971 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.3 | 3.9 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.1 | 3.7 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.7 | 6.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 5.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 5.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 4.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 4.2 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.7 | 4.0 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.1 | 3.6 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.1 | 3.5 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 3.5 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 10.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.2 | 10.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 6.0 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.2 | 6.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 5.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 4.9 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.3 | 4.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 4.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.7 | 4.1 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 6.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 6.1 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 4.4 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.3 | 4.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 4.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 3.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 3.3 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 3.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 5.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 5.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 4.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 4.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 4.0 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 3.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 3.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.9 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |