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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HOXA10_HOXB9

Z-value: 0.59

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Transcription factors associated with HOXA10_HOXB9

Gene Symbol Gene ID Gene Info
HOXA10
ENSG00000253293.3 homeobox A10
HOXB9
ENSG00000170689.8 homeobox B9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA10hg19_v2_chr7_-_27213893_27213954-0.386.2e-02Click!
HOXB9hg19_v2_chr17_-_46703826_467038450.115.9e-01Click!

Activity profile of HOXA10_HOXB9 motif

Sorted Z-values of HOXA10_HOXB9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_67418047 1.85 ENST00000540846.2
SMAD3
SMAD family member 3
chr15_-_55541227 1.53 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr14_-_72458326 1.22 ENST00000542853.1
AC005477.1
AC005477.1
chr15_-_58571445 0.73 ENST00000558231.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr6_+_28249299 0.72 ENST00000405948.2
PGBD1
piggyBac transposable element derived 1
chr6_+_28249332 0.71 ENST00000259883.3
PGBD1
piggyBac transposable element derived 1
chr21_-_35899113 0.63 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr2_+_161993465 0.63 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr3_-_150690471 0.60 ENST00000468836.1
ENST00000328863.4
CLRN1
clarin 1
chr18_-_5396271 0.60 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr1_-_160231451 0.58 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr5_-_16738451 0.55 ENST00000274203.9
ENST00000515803.1
MYO10
myosin X
chr2_+_208423840 0.53 ENST00000539789.1
CREB1
cAMP responsive element binding protein 1
chr2_-_216878305 0.52 ENST00000263268.6
MREG
melanoregulin
chr4_+_70916119 0.48 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr22_-_32651326 0.46 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr2_+_173686303 0.45 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr5_+_135496675 0.45 ENST00000507637.1
SMAD5
SMAD family member 5
chr2_+_208423891 0.45 ENST00000448277.1
ENST00000457101.1
CREB1
cAMP responsive element binding protein 1
chr16_-_75498553 0.42 ENST00000569276.1
ENST00000357613.4
ENST00000561878.1
ENST00000566980.1
ENST00000567194.1
TMEM170A
RP11-77K12.1
transmembrane protein 170A
Uncharacterized protein
chrX_-_117119243 0.40 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr6_-_137539651 0.40 ENST00000543628.1
IFNGR1
interferon gamma receptor 1
chr15_+_63414760 0.39 ENST00000557972.1
LACTB
lactamase, beta
chr9_+_82187630 0.37 ENST00000265284.6
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr9_+_82187487 0.37 ENST00000435650.1
ENST00000414465.1
ENST00000376537.4
ENST00000376534.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr9_+_82188077 0.36 ENST00000425506.1
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr14_+_31046959 0.36 ENST00000547532.1
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr10_+_102106829 0.36 ENST00000370355.2
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr2_+_161993412 0.34 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr3_-_172241250 0.32 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr10_+_78078088 0.32 ENST00000496424.2
C10orf11
chromosome 10 open reading frame 11
chr18_-_52989217 0.31 ENST00000570287.2
TCF4
transcription factor 4
chr10_-_129691195 0.31 ENST00000368671.3
CLRN3
clarin 3
chr8_-_81083890 0.31 ENST00000518937.1
TPD52
tumor protein D52
chr9_+_34652164 0.30 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr7_+_108210012 0.30 ENST00000249356.3
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr16_-_15180257 0.29 ENST00000540462.1
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr3_+_138340067 0.28 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr12_+_1800179 0.28 ENST00000357103.4
ADIPOR2
adiponectin receptor 2
chr1_+_151735431 0.27 ENST00000321531.5
ENST00000315067.8
OAZ3
ornithine decarboxylase antizyme 3
chr14_-_51027838 0.27 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr8_-_6420930 0.26 ENST00000325203.5
ANGPT2
angiopoietin 2
chr1_-_161207875 0.26 ENST00000512372.1
ENST00000437437.2
ENST00000442691.2
ENST00000412844.2
ENST00000428574.2
ENST00000505005.1
ENST00000508740.1
ENST00000508387.1
ENST00000504010.1
ENST00000511676.1
ENST00000502985.1
ENST00000367981.3
ENST00000515621.1
ENST00000511944.1
ENST00000511748.1
ENST00000367984.4
ENST00000367985.3
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr18_-_52989525 0.26 ENST00000457482.3
TCF4
transcription factor 4
chr12_-_71551868 0.26 ENST00000247829.3
TSPAN8
tetraspanin 8
chr18_-_12656715 0.25 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
SPIRE1
spire-type actin nucleation factor 1
chr1_-_161207953 0.25 ENST00000367982.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr2_+_102928009 0.25 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr1_-_161208013 0.24 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr15_-_98417780 0.24 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr1_-_161207986 0.23 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr2_-_209010874 0.23 ENST00000260988.4
CRYGB
crystallin, gamma B
chr14_-_60952739 0.23 ENST00000555476.1
ENST00000321731.3
C14orf39
chromosome 14 open reading frame 39
chr11_-_13517565 0.23 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr21_+_35736302 0.22 ENST00000290310.3
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr3_-_50375657 0.22 ENST00000395126.3
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr12_-_71551652 0.21 ENST00000546561.1
TSPAN8
tetraspanin 8
chr3_+_138340049 0.21 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr12_+_54892550 0.20 ENST00000545638.2
NCKAP1L
NCK-associated protein 1-like
chr14_+_56584414 0.20 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr1_+_192127578 0.20 ENST00000367460.3
RGS18
regulator of G-protein signaling 18
chr18_-_53069419 0.19 ENST00000570177.2
TCF4
transcription factor 4
chr18_-_74839891 0.19 ENST00000581878.1
MBP
myelin basic protein
chr7_-_140482926 0.19 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr3_+_57875711 0.18 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr13_-_103719196 0.18 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr6_+_12717892 0.18 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr10_-_24770632 0.18 ENST00000596413.1
AL353583.1
AL353583.1
chr12_-_81992111 0.17 ENST00000443686.3
ENST00000407050.4
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chrX_+_55744228 0.17 ENST00000262850.7
RRAGB
Ras-related GTP binding B
chr2_+_220144052 0.17 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chrX_-_45060135 0.17 ENST00000398000.2
ENST00000377934.4
CXorf36
chromosome X open reading frame 36
chrX_+_55744166 0.17 ENST00000374941.4
ENST00000414239.1
RRAGB
Ras-related GTP binding B
chr16_-_80603558 0.17 ENST00000567317.1
RP11-18F14.1
RP11-18F14.1
chr6_+_88054530 0.16 ENST00000388923.4
C6orf163
chromosome 6 open reading frame 163
chr17_-_67264947 0.16 ENST00000586811.1
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr2_+_220143989 0.16 ENST00000336576.5
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr18_+_42260861 0.16 ENST00000282030.5
SETBP1
SET binding protein 1
chr7_+_35756186 0.16 ENST00000430518.1
AC018647.3
AC018647.3
chr7_+_35756092 0.16 ENST00000458087.3
AC018647.3
AC018647.3
chrX_+_105937068 0.16 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr4_-_69536346 0.15 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr4_-_72649763 0.15 ENST00000513476.1
GC
group-specific component (vitamin D binding protein)
chr15_+_66797627 0.15 ENST00000565627.1
ENST00000564179.1
ZWILCH
zwilch kinetochore protein
chrX_+_144908928 0.15 ENST00000408967.2
TMEM257
transmembrane protein 257
chr11_-_7961141 0.15 ENST00000360759.3
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr1_+_84630645 0.15 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_91933726 0.15 ENST00000534113.2
SECISBP2
SECIS binding protein 2
chr4_+_56815102 0.15 ENST00000257287.4
CEP135
centrosomal protein 135kDa
chr5_+_67586465 0.14 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_38821373 0.14 ENST00000394052.3
KRT222
keratin 222
chr9_+_105757590 0.14 ENST00000374798.3
ENST00000487798.1
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr19_-_3500635 0.14 ENST00000250937.3
DOHH
deoxyhypusine hydroxylase/monooxygenase
chr19_+_21106028 0.14 ENST00000597314.1
ENST00000601924.1
ZNF85
zinc finger protein 85
chr4_-_90759440 0.14 ENST00000336904.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr5_-_111312622 0.14 ENST00000395634.3
NREP
neuronal regeneration related protein
chr20_-_25320367 0.14 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chr4_-_110723194 0.14 ENST00000394635.3
CFI
complement factor I
chr2_-_231989808 0.13 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chrX_+_36254051 0.13 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr1_-_226926864 0.13 ENST00000429204.1
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr6_-_83903600 0.13 ENST00000506587.1
ENST00000507554.1
PGM3
phosphoglucomutase 3
chr7_+_56131917 0.12 ENST00000434526.2
ENST00000275607.9
ENST00000395435.2
ENST00000413952.2
ENST00000342190.6
ENST00000437307.2
ENST00000413756.1
ENST00000451338.1
SUMF2
sulfatase modifying factor 2
chr15_+_93447675 0.12 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2
chr3_-_112329110 0.12 ENST00000479368.1
CCDC80
coiled-coil domain containing 80
chr3_+_157828152 0.12 ENST00000476899.1
RSRC1
arginine/serine-rich coiled-coil 1
chr14_+_73706308 0.12 ENST00000554301.1
ENST00000555445.1
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr6_-_52859046 0.12 ENST00000457564.1
ENST00000541324.1
ENST00000370960.1
GSTA4
glutathione S-transferase alpha 4
chr3_-_196911002 0.12 ENST00000452595.1
DLG1
discs, large homolog 1 (Drosophila)
chr16_+_70380825 0.12 ENST00000417604.2
DDX19A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
chr15_-_56209306 0.12 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr6_+_32812568 0.12 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr20_-_8000426 0.12 ENST00000527925.1
ENST00000246024.2
TMX4
thioredoxin-related transmembrane protein 4
chrX_+_36246735 0.11 ENST00000378653.3
CXorf30
chromosome X open reading frame 30
chr6_+_80816342 0.11 ENST00000369760.4
ENST00000356489.5
ENST00000320393.6
BCKDHB
branched chain keto acid dehydrogenase E1, beta polypeptide
chr3_+_149191723 0.11 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chrX_-_80457385 0.11 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr1_+_110993795 0.11 ENST00000271331.3
PROK1
prokineticin 1
chr15_+_52155001 0.11 ENST00000544199.1
TMOD3
tropomodulin 3 (ubiquitous)
chr17_+_61086917 0.11 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr20_-_7921090 0.11 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr3_-_100712352 0.11 ENST00000471714.1
ENST00000284322.5
ABI3BP
ABI family, member 3 (NESH) binding protein
chr6_+_83903061 0.11 ENST00000369724.4
ENST00000539997.1
RWDD2A
RWD domain containing 2A
chr11_-_114430570 0.11 ENST00000251921.2
NXPE1
neurexophilin and PC-esterase domain family, member 1
chr20_-_50384864 0.10 ENST00000311637.5
ENST00000402822.1
ATP9A
ATPase, class II, type 9A
chr16_-_21663919 0.10 ENST00000569602.1
IGSF6
immunoglobulin superfamily, member 6
chr5_+_141346385 0.10 ENST00000513019.1
ENST00000356143.1
RNF14
ring finger protein 14
chr2_+_109237717 0.10 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_90198535 0.10 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr5_-_87516448 0.10 ENST00000511218.1
TMEM161B
transmembrane protein 161B
chr1_+_151739131 0.10 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chr9_+_21967137 0.10 ENST00000441769.2
C9orf53
chromosome 9 open reading frame 53
chr2_+_109204743 0.10 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_+_138915102 0.09 ENST00000486663.1
UBN2
ubinuclein 2
chr19_+_50016610 0.09 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr22_-_23922448 0.09 ENST00000438703.1
ENST00000330377.2
IGLL1
immunoglobulin lambda-like polypeptide 1
chr17_-_39324424 0.09 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr4_-_104021009 0.09 ENST00000509245.1
ENST00000296424.4
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr14_+_57671888 0.09 ENST00000391612.1
AL391152.1
AL391152.1
chr5_+_72143988 0.09 ENST00000506351.2
TNPO1
transportin 1
chr11_-_3400330 0.09 ENST00000427810.2
ENST00000005082.9
ENST00000534569.1
ENST00000438262.2
ENST00000528796.1
ENST00000528410.1
ENST00000529678.1
ENST00000354599.6
ENST00000526601.1
ENST00000525502.1
ENST00000533036.1
ENST00000399602.4
ZNF195
zinc finger protein 195
chr4_+_186317133 0.09 ENST00000507753.1
ANKRD37
ankyrin repeat domain 37
chr10_-_103599591 0.09 ENST00000348850.5
KCNIP2
Kv channel interacting protein 2
chr6_-_27782548 0.08 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr15_+_66797455 0.08 ENST00000446801.2
ZWILCH
zwilch kinetochore protein
chr2_-_71062938 0.08 ENST00000410009.3
CD207
CD207 molecule, langerin
chr11_+_120973375 0.08 ENST00000264037.2
TECTA
tectorin alpha
chr1_+_248201474 0.08 ENST00000366479.2
OR2L2
olfactory receptor, family 2, subfamily L, member 2
chr12_-_18243075 0.08 ENST00000536890.1
RERGL
RERG/RAS-like
chr1_-_17766198 0.08 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr4_+_88896819 0.08 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr5_-_86534822 0.08 ENST00000445770.2
AC008394.1
Uncharacterized protein
chr3_-_9921934 0.08 ENST00000423850.1
CIDEC
cell death-inducing DFFA-like effector c
chr1_-_186430222 0.08 ENST00000391997.2
PDC
phosducin
chr8_-_59412717 0.08 ENST00000301645.3
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr11_-_3400442 0.08 ENST00000429541.2
ENST00000532539.1
ZNF195
zinc finger protein 195
chr10_+_24755416 0.08 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr17_-_39150385 0.08 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr12_-_8765446 0.08 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr4_+_155484103 0.07 ENST00000302068.4
FGB
fibrinogen beta chain
chr1_+_229440129 0.07 ENST00000366688.3
SPHAR
S-phase response (cyclin related)
chr21_+_34398153 0.07 ENST00000382357.3
ENST00000430860.1
ENST00000333337.3
OLIG2
oligodendrocyte lineage transcription factor 2
chrX_-_100604184 0.07 ENST00000372902.3
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr20_-_29994007 0.07 ENST00000376314.2
DEFB121
defensin, beta 121
chr2_+_101591314 0.07 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr6_+_44215603 0.07 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr15_+_40886439 0.07 ENST00000532056.1
ENST00000399668.2
CASC5
cancer susceptibility candidate 5
chr5_-_176433693 0.07 ENST00000507513.1
ENST00000511320.1
UIMC1
ubiquitin interaction motif containing 1
chrX_-_15619076 0.06 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr3_+_15045419 0.06 ENST00000406272.2
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr6_-_87804815 0.06 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr4_+_70894130 0.06 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr9_+_124413873 0.06 ENST00000408936.3
DAB2IP
DAB2 interacting protein
chr16_-_21663950 0.06 ENST00000268389.4
IGSF6
immunoglobulin superfamily, member 6
chr12_-_12491608 0.06 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr5_+_140767452 0.06 ENST00000519479.1
PCDHGB4
protocadherin gamma subfamily B, 4
chr4_-_186317034 0.06 ENST00000505916.1
LRP2BP
LRP2 binding protein
chr6_-_109804412 0.06 ENST00000230122.3
ZBTB24
zinc finger and BTB domain containing 24
chr13_+_24144509 0.06 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_-_155880672 0.06 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chr5_-_125930929 0.06 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr10_-_73848531 0.05 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr11_-_104916034 0.05 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
CARD16
caspase recruitment domain family, member 16
chr8_-_81083731 0.05 ENST00000379096.5
TPD52
tumor protein D52
chr20_+_42984330 0.05 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A
hepatocyte nuclear factor 4, alpha
chr1_+_52682052 0.05 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr16_+_70380732 0.05 ENST00000302243.7
DDX19A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
chr22_-_43010928 0.05 ENST00000348657.2
ENST00000252115.5
POLDIP3
polymerase (DNA-directed), delta interacting protein 3
chr10_-_73848086 0.05 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr18_+_19192228 0.05 ENST00000300413.5
ENST00000579618.1
ENST00000582475.1
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr14_+_22433675 0.05 ENST00000390442.3
TRAV12-3
T cell receptor alpha variable 12-3
chrX_+_70503433 0.05 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr2_-_51259229 0.05 ENST00000405472.3
NRXN1
neurexin 1
chr6_-_31830655 0.05 ENST00000375631.4
NEU1
sialidase 1 (lysosomal sialidase)
chr8_+_107738343 0.05 ENST00000521592.1
OXR1
oxidation resistance 1
chr2_-_51259292 0.05 ENST00000401669.2
NRXN1
neurexin 1
chr9_+_130026756 0.05 ENST00000314904.5
ENST00000373387.4
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr11_-_40315640 0.05 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr19_+_21265028 0.05 ENST00000291770.7
ZNF714
zinc finger protein 714
chr1_+_154401791 0.05 ENST00000476006.1
IL6R
interleukin 6 receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA10_HOXB9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.3 1.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 1.0 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.2 1.0 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.4 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.3 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.7 GO:0035799 ureter maturation(GO:0035799)
0.1 0.2 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.4 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 0.6 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.4 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.3 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.2 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.1 0.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.5 GO:0050957 equilibrioception(GO:0050957)
0.0 0.3 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.3 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.2 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.1 GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.1 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:1903598 positive regulation of gap junction assembly(GO:1903598)
0.0 0.4 GO:0071786 nuclear pore complex assembly(GO:0051292) endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.1 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 1.1 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.2 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.0 0.3 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.1 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.1 GO:0035726 regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.0 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.1 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.6 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.5 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.5 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.0 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.2 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0 0.0 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.0 GO:0003099 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.4 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.5 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.0 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 1.0 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.2 GO:1990423 RZZ complex(GO:1990423)
0.1 0.3 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.6 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.1 GO:0043219 lateral loop(GO:0043219)
0.0 0.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 1.0 GO:0004882 androgen receptor activity(GO:0004882)
0.2 1.0 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.0 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 0.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.3 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.1 0.4 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.1 0.2 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.4 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1 0.6 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.7 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.5 GO:0031489 myosin V binding(GO:0031489)
0.1 0.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.0 0.1 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0001884 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.2 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 1.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.0 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815) phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.0 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.4 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 1.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.2 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway