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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for HOXB13

Z-value: 0.52

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.7 homeobox B13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_468065580.087.1e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_84630645 2.88 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_84630053 1.79 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_-_14180778 1.73 ENST00000380924.1
ENST00000543693.1
NFIB
nuclear factor I/B
chr7_-_11871815 1.43 ENST00000423059.4
THSD7A
thrombospondin, type I, domain containing 7A
chr15_+_66994561 0.97 ENST00000288840.5
SMAD6
SMAD family member 6
chr8_+_97597148 0.95 ENST00000521590.1
SDC2
syndecan 2
chr18_-_52989217 0.80 ENST00000570287.2
TCF4
transcription factor 4
chr1_+_66458072 0.68 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr18_-_52989525 0.52 ENST00000457482.3
TCF4
transcription factor 4
chr21_-_35899113 0.50 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr16_-_24942411 0.44 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr1_+_84630367 0.43 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr16_-_2205352 0.42 ENST00000563192.1
RP11-304L19.5
RP11-304L19.5
chr16_-_24942273 0.41 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr16_+_2205755 0.40 ENST00000326181.6
TRAF7
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
chr16_-_71610985 0.35 ENST00000355962.4
TAT
tyrosine aminotransferase
chr22_+_35462129 0.33 ENST00000404699.2
ENST00000308700.6
ISX
intestine-specific homeobox
chr11_-_102714534 0.30 ENST00000299855.5
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr17_-_73663168 0.29 ENST00000578201.1
ENST00000423245.2
RECQL5
RecQ protein-like 5
chr3_-_114790179 0.28 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_210501589 0.28 ENST00000413764.2
ENST00000541565.1
HHAT
hedgehog acyltransferase
chr1_-_36863481 0.27 ENST00000315732.2
LSM10
LSM10, U7 small nuclear RNA associated
chr11_+_118401706 0.25 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
TMEM25
transmembrane protein 25
chr3_-_123710199 0.25 ENST00000184183.4
ROPN1
rhophilin associated tail protein 1
chr1_+_52682052 0.24 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr2_-_175629135 0.23 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr17_-_73663245 0.23 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
RECQL5
RecQ protein-like 5
chr1_-_45956822 0.22 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr7_+_132937820 0.21 ENST00000393161.2
ENST00000253861.4
EXOC4
exocyst complex component 4
chr16_-_80926457 0.21 ENST00000563626.1
ENST00000562231.1
RP11-314O13.1
RP11-314O13.1
chr8_+_86376081 0.20 ENST00000285379.5
CA2
carbonic anhydrase II
chr13_+_28813645 0.19 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr9_+_125132803 0.19 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_69111401 0.19 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr6_-_43021612 0.18 ENST00000535468.1
CUL7
cullin 7
chr1_-_151148492 0.18 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr1_-_45956800 0.16 ENST00000538496.1
TESK2
testis-specific kinase 2
chrM_-_14670 0.15 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr9_+_125133315 0.15 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr18_+_3252265 0.13 ENST00000580887.1
ENST00000536605.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr19_-_5903714 0.12 ENST00000586349.1
ENST00000585661.1
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000252675.5
AC024592.12
NDUFA11
FUT5
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr17_+_18086392 0.12 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr1_+_110993795 0.12 ENST00000271331.3
PROK1
prokineticin 1
chr2_-_175629164 0.12 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr1_-_149783914 0.12 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
HIST2H2BF
histone cluster 2, H2bf
chr5_-_145214893 0.11 ENST00000394450.2
PRELID2
PRELI domain containing 2
chr2_-_51259292 0.11 ENST00000401669.2
NRXN1
neurexin 1
chr6_-_27782548 0.10 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr7_+_128784712 0.09 ENST00000289407.4
TSPAN33
tetraspanin 33
chr2_-_51259229 0.09 ENST00000405472.3
NRXN1
neurexin 1
chr17_-_10560619 0.09 ENST00000583535.1
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr6_-_116833500 0.08 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr12_+_8309630 0.07 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr14_+_76776957 0.07 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr17_-_39646116 0.07 ENST00000328119.6
KRT36
keratin 36
chr3_+_89156674 0.07 ENST00000336596.2
EPHA3
EPH receptor A3
chr1_-_155880672 0.06 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chr6_+_122793058 0.06 ENST00000392491.2
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr11_+_63606373 0.05 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
MARK2
MAP/microtubule affinity-regulating kinase 2
chr3_-_150690786 0.05 ENST00000327047.1
CLRN1
clarin 1
chr2_-_69180083 0.04 ENST00000328895.4
GKN2
gastrokine 2
chr9_+_103947311 0.04 ENST00000395056.2
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr2_-_176046391 0.04 ENST00000392541.3
ENST00000409194.1
ATP5G3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr11_-_102826434 0.03 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr5_-_145214848 0.03 ENST00000505416.1
ENST00000334744.4
ENST00000358004.2
ENST00000511435.1
PRELID2
PRELI domain containing 2
chr12_-_81992111 0.03 ENST00000443686.3
ENST00000407050.4
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr18_+_3252206 0.01 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr4_+_110749143 0.01 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr5_-_140053152 0.00 ENST00000542735.1
DND1
DND microRNA-mediated repression inhibitor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.1 GO:0097338 response to clozapine(GO:0097338)
0.2 1.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 0.5 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.2 1.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.0 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:1904479 regulation of isoprenoid metabolic process(GO:0019747) negative regulation of intestinal absorption(GO:1904479)
0.1 0.2 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.4 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.1 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.3 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.5 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0070698 type I activin receptor binding(GO:0070698)
0.3 5.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 1.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.5 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.3 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.2 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.7 GO:0043015 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.0 PID FGF PATHWAY FGF signaling pathway
0.0 1.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide