Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for HOXD9

Z-value: 0.88

Motif logo

Transcription factors associated with HOXD9

Gene Symbol Gene ID Gene Info
ENSG00000128709.10 homeobox D9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD9hg19_v2_chr2_+_176987088_176987088-0.442.8e-02Click!

Activity profile of HOXD9 motif

Sorted Z-values of HOXD9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_76944621 7.91 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr1_-_173020056 4.64 ENST00000239468.2
ENST00000404377.3
tumor necrosis factor (ligand) superfamily, member 18
chr6_+_32812568 4.13 ENST00000414474.1
proteasome (prosome, macropain) subunit, beta type, 9
chr1_+_101185290 3.60 ENST00000370119.4
ENST00000347652.2
ENST00000294728.2
ENST00000370115.1
vascular cell adhesion molecule 1
chr4_+_74606223 3.58 ENST00000307407.3
ENST00000401931.1
interleukin 8
chr18_+_61554932 3.34 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr2_-_231989808 2.69 ENST00000258400.3
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr2_+_143635067 2.66 ENST00000264170.4
kynureninase
chrX_+_144908928 2.49 ENST00000408967.2
transmembrane protein 257
chr18_-_5396271 2.20 ENST00000579951.1
erythrocyte membrane protein band 4.1-like 3
chr2_-_202562716 2.06 ENST00000428900.2
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr2_-_202562774 1.99 ENST00000396886.3
ENST00000409143.1
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr22_-_41682172 1.93 ENST00000356244.3
Ran GTPase activating protein 1
chr7_-_92777606 1.91 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
sterile alpha motif domain containing 9-like
chr11_-_128457446 1.73 ENST00000392668.4
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr3_-_107777208 1.57 ENST00000398258.3
CD47 molecule
chr3_-_27498235 1.40 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr12_-_88974236 1.35 ENST00000228280.5
ENST00000552044.1
ENST00000357116.4
KIT ligand
chr3_+_111393501 1.32 ENST00000393934.3
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr11_-_104905840 1.30 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
caspase 1, apoptosis-related cysteine peptidase
chr7_-_107880508 1.22 ENST00000425651.2
neuronal cell adhesion molecule
chr6_+_132891461 1.20 ENST00000275198.1
trace amine associated receptor 6
chrX_-_68385274 1.19 ENST00000374584.3
ENST00000590146.1
praja ring finger 1, E3 ubiquitin protein ligase
chr18_-_57027194 1.13 ENST00000251047.5
lectin, mannose-binding, 1
chr2_+_161993465 1.12 ENST00000457476.1
TRAF family member-associated NFKB activator
chr11_-_104972158 1.12 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr16_-_18887627 1.08 ENST00000563235.1
SMG1 phosphatidylinositol 3-kinase-related kinase
chrX_-_68385354 1.08 ENST00000361478.1
praja ring finger 1, E3 ubiquitin protein ligase
chr6_+_149539767 1.03 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr7_-_121944491 0.99 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr15_+_66797627 0.99 ENST00000565627.1
ENST00000564179.1
zwilch kinetochore protein
chr4_-_76928641 0.96 ENST00000264888.5
chemokine (C-X-C motif) ligand 9
chr22_+_23487513 0.95 ENST00000263116.2
ENST00000341989.4
RAB36, member RAS oncogene family
chr7_-_122339162 0.94 ENST00000340112.2
ring finger protein 133
chr19_+_10397648 0.86 ENST00000340992.4
ENST00000393717.2
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr15_-_55562582 0.86 ENST00000396307.2
RAB27A, member RAS oncogene family
chr1_-_95391315 0.84 ENST00000545882.1
ENST00000415017.1
calponin 3, acidic
chr4_-_68749699 0.84 ENST00000545541.1
transmembrane protease, serine 11D
chrX_-_110513703 0.81 ENST00000324068.1
calpain 6
chr2_-_175712270 0.81 ENST00000295497.7
ENST00000444394.1
chimerin 1
chr11_+_61957687 0.80 ENST00000306238.3
secretoglobin, family 1D, member 1
chr2_+_161993412 0.79 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr4_+_175839551 0.78 ENST00000404450.4
ENST00000514159.1
ADAM metallopeptidase domain 29
chr21_+_35736302 0.76 ENST00000290310.3
potassium voltage-gated channel, Isk-related family, member 2
chr6_+_123317116 0.75 ENST00000275162.5
clavesin 2
chr22_+_30477000 0.73 ENST00000403975.1
HORMA domain containing 2
chr6_-_88411911 0.73 ENST00000257787.5
akirin 2
chr8_+_86089460 0.72 ENST00000418930.2
E2F transcription factor 5, p130-binding
chr8_+_86089619 0.68 ENST00000256117.5
ENST00000416274.2
E2F transcription factor 5, p130-binding
chr3_-_157221380 0.68 ENST00000468233.1
ventricular zone expressed PH domain-containing 1
chr2_+_143635222 0.68 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
kynureninase
chr15_+_66797455 0.66 ENST00000446801.2
zwilch kinetochore protein
chr17_-_10452929 0.65 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
myosin, heavy chain 2, skeletal muscle, adult
chr2_+_114647504 0.64 ENST00000263238.2
ARP3 actin-related protein 3 homolog (yeast)
chr6_+_29274403 0.64 ENST00000377160.2
olfactory receptor, family 14, subfamily J, member 1
chr4_-_68749745 0.64 ENST00000283916.6
transmembrane protease, serine 11D
chr4_+_186990298 0.61 ENST00000296795.3
ENST00000513189.1
toll-like receptor 3
chr1_+_181057638 0.61 ENST00000367577.4
immediate early response 5
chr3_-_167191814 0.59 ENST00000466903.1
ENST00000264677.4
serpin peptidase inhibitor, clade I (pancpin), member 2
chr11_-_104827425 0.58 ENST00000393150.3
caspase 4, apoptosis-related cysteine peptidase
chr11_+_30253410 0.57 ENST00000533718.1
follicle stimulating hormone, beta polypeptide
chr6_+_45390222 0.56 ENST00000359524.5
runt-related transcription factor 2
chr3_-_182703688 0.56 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCN1, defective in cullin neddylation 1, domain containing 1
chr2_+_185463093 0.56 ENST00000302277.6
zinc finger protein 804A
chr6_+_15401075 0.55 ENST00000541660.1
jumonji, AT rich interactive domain 2
chr1_-_236046872 0.53 ENST00000536965.1
lysosomal trafficking regulator
chr6_+_13272904 0.50 ENST00000379335.3
ENST00000379329.1
phosphatase and actin regulator 1
chr21_-_19775973 0.50 ENST00000284885.3
transmembrane protease, serine 15
chr2_+_143886877 0.50 ENST00000295095.6
Rho GTPase activating protein 15
chr3_+_155838337 0.50 ENST00000490337.1
ENST00000389636.5
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chrX_+_149887090 0.49 ENST00000538506.1
myotubularin related protein 1
chr9_+_12693336 0.49 ENST00000381137.2
ENST00000388918.5
tyrosinase-related protein 1
chr19_+_55014085 0.47 ENST00000351841.2
leukocyte-associated immunoglobulin-like receptor 2
chr15_+_52155001 0.46 ENST00000544199.1
tropomodulin 3 (ubiquitous)
chr8_-_20040601 0.46 ENST00000265808.7
ENST00000522513.1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr9_+_96846740 0.45 ENST00000288976.3
protein tyrosine phosphatase domain containing 1
chrX_-_130423200 0.45 ENST00000361420.3
immunoglobulin superfamily, member 1
chr8_-_20040638 0.45 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr19_+_55014013 0.45 ENST00000301202.2
leukocyte-associated immunoglobulin-like receptor 2
chr12_-_21927736 0.44 ENST00000240662.2
potassium inwardly-rectifying channel, subfamily J, member 8
chr3_-_195310802 0.44 ENST00000421243.1
ENST00000453131.1
apolipoprotein D
chr5_+_135496675 0.44 ENST00000507637.1
SMAD family member 5
chr2_-_228497888 0.44 ENST00000264387.4
ENST00000409066.1
chromosome 2 open reading frame 83
chr4_+_71263599 0.44 ENST00000399575.2
proline rich, lacrimal 1
chr6_+_131894284 0.44 ENST00000368087.3
ENST00000356962.2
arginase 1
chr19_-_56826157 0.43 ENST00000592509.1
ENST00000592679.1
ENST00000588442.1
ENST00000593106.1
ENST00000587492.1
ENST00000254165.3
zinc finger and SCAN domain containing 5A
chr5_+_147582387 0.43 ENST00000325630.2
serine peptidase inhibitor, Kazal type 6
chr20_+_5987890 0.43 ENST00000378868.4
cardiolipin synthase 1
chr1_-_100643765 0.42 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
leucine rich repeat containing 39
chrX_-_15332665 0.41 ENST00000537676.1
ENST00000344384.4
ankyrin repeat and SOCS box containing 11
chr5_+_94727048 0.41 ENST00000283357.5
family with sequence similarity 81, member B
chr3_+_108855558 0.40 ENST00000467240.1
ENST00000477643.1
ENST00000479039.1
ENST00000593799.1
RP11-59E19.1
chr14_+_22615942 0.40 ENST00000390457.2
T cell receptor alpha variable 27
chr12_+_26348246 0.39 ENST00000422622.2
sarcospan
chr10_-_31146615 0.38 ENST00000444692.2
zinc finger protein 438
chr10_-_115614127 0.38 ENST00000369305.1
DNA cross-link repair 1A
chr22_-_36236265 0.38 ENST00000414461.2
ENST00000416721.2
ENST00000449924.2
ENST00000262829.7
ENST00000397305.3
RNA binding protein, fox-1 homolog (C. elegans) 2
chr15_-_75748115 0.37 ENST00000360439.4
SIN3 transcription regulator family member A
chr2_-_163695238 0.37 ENST00000328032.4
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr6_-_31632962 0.37 ENST00000456540.1
ENST00000445768.1
G patch domain and ankyrin repeats 1
chr5_-_177207634 0.37 ENST00000513554.1
ENST00000440605.3
family with sequence similarity 153, member A
chr1_+_146373546 0.36 ENST00000446760.2
neuroblastoma breakpoint family, member 12
chr12_+_15125954 0.36 ENST00000266395.2
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr1_-_165414414 0.35 ENST00000359842.5
retinoid X receptor, gamma
chr1_-_244006528 0.35 ENST00000336199.5
ENST00000263826.5
v-akt murine thymoma viral oncogene homolog 3
chr13_+_46039037 0.34 ENST00000349995.5
component of oligomeric golgi complex 3
chr2_+_89986318 0.34 ENST00000491977.1
immunoglobulin kappa variable 2D-29
chr3_+_63428982 0.34 ENST00000479198.1
ENST00000460711.1
ENST00000465156.1
synaptoporin
chr17_-_73389737 0.34 ENST00000392563.1
growth factor receptor-bound protein 2
chr4_-_146859787 0.34 ENST00000508784.1
zinc finger protein 827
chr2_-_163695128 0.34 ENST00000332142.5
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr7_+_5920429 0.34 ENST00000242104.5
oncomodulin
chr1_+_192127578 0.33 ENST00000367460.3
regulator of G-protein signaling 18
chr6_+_31021225 0.32 ENST00000565192.1
ENST00000562344.1
HLA complex group 22
chr6_+_131958436 0.32 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr1_-_146082633 0.31 ENST00000605317.1
ENST00000604938.1
ENST00000339388.5
neuroblastoma breakpoint family, member 11
chr6_+_10528560 0.31 ENST00000379597.3
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chrX_-_130423386 0.31 ENST00000370903.3
immunoglobulin superfamily, member 1
chr2_+_145780739 0.31 ENST00000597173.1
ENST00000602108.1
ENST00000420472.1
testis expressed 41 (non-protein coding)
chr20_-_13971255 0.31 ENST00000284951.5
ENST00000378072.5
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr11_+_49050504 0.30 ENST00000332682.7
tripartite motif containing 49B
chr2_-_179567206 0.30 ENST00000414766.1
titin
chrX_-_109590174 0.30 ENST00000372054.1
guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2
chrX_+_135388147 0.28 ENST00000394141.1
G protein-coupled receptor 112
chr8_+_7801144 0.28 ENST00000443676.1
zinc finger protein 705B
chr8_+_104892639 0.28 ENST00000436393.2
regulating synaptic membrane exocytosis 2
chr1_+_104615595 0.27 ENST00000418362.1
RP11-364B6.1
chr9_-_123812542 0.27 ENST00000223642.1
complement component 5
chr11_-_13517565 0.27 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chrX_+_48620147 0.26 ENST00000303227.6
glyoxalase domain containing 5
chr1_+_87012753 0.26 ENST00000370563.3
chloride channel accessory 4
chr11_+_12115543 0.26 ENST00000537344.1
ENST00000532179.1
ENST00000526065.1
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr11_-_16430399 0.26 ENST00000528252.1
SRY (sex determining region Y)-box 6
chr2_-_128284020 0.26 ENST00000295321.4
ENST00000455721.2
IWS1 homolog (S. cerevisiae)
chr14_+_62462541 0.26 ENST00000430451.2
synaptotagmin XVI
chr15_-_54025300 0.26 ENST00000559418.1
WD repeat domain 72
chr7_-_130353553 0.26 ENST00000330992.7
ENST00000445977.2
coatomer protein complex, subunit gamma 2
chr2_+_145780725 0.26 ENST00000451478.1
testis expressed 41 (non-protein coding)
chr3_-_112564797 0.25 ENST00000398214.1
ENST00000448932.1
CD200 receptor 1-like
chr2_+_145780767 0.25 ENST00000599358.1
ENST00000596278.1
ENST00000596747.1
ENST00000608652.1
ENST00000609705.1
ENST00000608432.1
ENST00000596970.1
ENST00000602041.1
ENST00000601578.1
ENST00000596034.1
ENST00000414195.2
ENST00000594837.1
testis expressed 41 (non-protein coding)
chr5_+_125967372 0.24 ENST00000357147.3
chromosome 5 open reading frame 48
chr4_-_168155577 0.24 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr19_+_7030589 0.24 ENST00000329753.5
methyl-CpG binding domain protein 3-like 5
chr1_+_160370344 0.23 ENST00000368061.2
VANGL planar cell polarity protein 2
chr15_-_90222610 0.23 ENST00000300055.5
perilipin 1
chr22_+_50609150 0.23 ENST00000159647.5
ENST00000395842.2
pannexin 2
chr3_+_94657086 0.23 ENST00000463200.1
long intergenic non-protein coding RNA 879
chr22_-_32651326 0.22 ENST00000266086.4
solute carrier family 5 (glucose activated ion channel), member 4
chr15_-_90222642 0.22 ENST00000430628.2
perilipin 1
chr4_-_83765613 0.22 ENST00000503937.1
SEC31 homolog A (S. cerevisiae)
chr8_+_107738343 0.22 ENST00000521592.1
oxidation resistance 1
chr4_-_168155730 0.22 ENST00000502330.1
ENST00000357154.3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr5_+_177435986 0.21 ENST00000398106.2
family with sequence similarity 153, member C
chr10_+_115614370 0.21 ENST00000369301.3
NHL repeat containing 2
chr10_+_5406935 0.21 ENST00000380433.3
urocortin 3
chr1_-_39339777 0.21 ENST00000397572.2
MYC binding protein
chr7_-_92855762 0.21 ENST00000453812.2
ENST00000394468.2
HEPACAM family member 2
chr17_+_66521936 0.21 ENST00000592800.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr3_+_63428752 0.20 ENST00000295894.5
synaptoporin
chr5_+_29143603 0.20 ENST00000602470.1
ENST00000602801.1
CTD-2118P12.1
chr6_+_53948328 0.20 ENST00000370876.2
muscular LMNA-interacting protein
chr6_+_1312675 0.20 ENST00000296839.2
forkhead box Q1
chr1_+_197237352 0.20 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
crumbs homolog 1 (Drosophila)
chr12_-_95510743 0.19 ENST00000551521.1
FYVE, RhoGEF and PH domain containing 6
chr14_+_57671888 0.19 ENST00000391612.1
AL391152.1
chr6_+_63921351 0.19 ENST00000370659.1
FK506 binding protein 1C
chr13_-_47012325 0.19 ENST00000409879.2
KIAA0226-like
chr3_+_94657118 0.19 ENST00000466089.1
ENST00000470465.1
long intergenic non-protein coding RNA 879
chr1_+_45140360 0.19 ENST00000418644.1
ENST00000458657.2
ENST00000441519.1
ENST00000535358.1
ENST00000445071.1
chromosome 1 open reading frame 228
chr12_+_9980069 0.19 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
killer cell lectin-like receptor subfamily F, member 1
chr7_+_93535866 0.19 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr1_+_44870866 0.19 ENST00000355387.2
ENST00000361799.2
ring finger protein 220
chr2_-_136594740 0.18 ENST00000264162.2
lactase
chr2_-_158345462 0.18 ENST00000439355.1
ENST00000540637.1
cytohesin 1 interacting protein
chrY_-_13524717 0.18 ENST00000331172.6
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 pseudogene 1
chr11_-_105010320 0.18 ENST00000532895.1
ENST00000530950.1
caspase recruitment domain family, member 18
chr5_+_147582348 0.18 ENST00000514389.1
serine peptidase inhibitor, Kazal type 6
chr1_-_152332480 0.17 ENST00000388718.5
filaggrin family member 2
chr1_+_240177627 0.17 ENST00000447095.1
formin 2
chr4_+_48485341 0.17 ENST00000273861.4
solute carrier family 10, member 4
chr4_-_168155700 0.16 ENST00000357545.4
ENST00000512648.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_-_39646116 0.16 ENST00000328119.6
keratin 36
chr1_+_196857144 0.16 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
complement factor H-related 4
chr8_-_66701319 0.16 ENST00000379419.4
phosphodiesterase 7A
chr14_+_23654525 0.15 ENST00000399910.1
ENST00000492621.1
chromosome 14 open reading frame 164
chr8_-_26724784 0.15 ENST00000380573.3
adrenoceptor alpha 1A
chr22_-_37213554 0.15 ENST00000443735.1
parvalbumin
chr18_-_70532906 0.15 ENST00000299430.2
ENST00000397929.1
neuropilin (NRP) and tolloid (TLL)-like 1
chr14_-_68000442 0.15 ENST00000554278.1
transmembrane protein 229B
chr9_-_138391692 0.15 ENST00000429260.2
chromosome 9 open reading frame 116
chr1_+_202385953 0.14 ENST00000466968.1
protein phosphatase 1, regulatory subunit 12B
chr12_-_10607084 0.14 ENST00000408006.3
ENST00000544822.1
ENST00000536188.1
killer cell lectin-like receptor subfamily C, member 1
chr17_+_60447579 0.14 ENST00000450662.2
EF-hand calcium binding domain 3
chr10_-_28623368 0.14 ENST00000441595.2
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr8_-_117886955 0.14 ENST00000297338.2
RAD21 homolog (S. pombe)
chr3_+_155860751 0.14 ENST00000471742.1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr15_+_58430567 0.14 ENST00000536493.1
aquaporin 9
chr3_+_102153859 0.14 ENST00000306176.1
ENST00000466937.1
zona pellucida-like domain containing 1
chr6_-_49712123 0.14 ENST00000263045.4
cysteine-rich secretory protein 3
chr7_+_93535817 0.14 ENST00000248572.5
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD9

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
1.1 3.3 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.9 8.9 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.6 2.4 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.5 2.7 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.5 3.6 GO:0022614 membrane to membrane docking(GO:0022614)
0.4 1.3 GO:0033025 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.3 1.9 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 2.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 1.7 GO:0030578 PML body organization(GO:0030578)
0.2 1.9 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.2 0.8 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.2 0.5 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.2 1.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.9 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 0.6 GO:0002282 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.1 0.4 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.8 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.1 1.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 0.3 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 1.0 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.6 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.4 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 3.3 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.7 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.1 0.3 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.4 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.1 0.3 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.6 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 0.2 GO:0061341 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.2 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.1 1.4 GO:0008228 opsonization(GO:0008228)
0.1 1.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.6 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.3 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.4 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.1 0.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.6 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.5 GO:0048023 regulation of melanin biosynthetic process(GO:0048021) positive regulation of melanin biosynthetic process(GO:0048023) regulation of secondary metabolite biosynthetic process(GO:1900376) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 1.4 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 4.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.3 GO:2000197 regulation of ribonucleoprotein complex localization(GO:2000197)
0.0 0.3 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0051685 maintenance of ER location(GO:0051685)
0.0 0.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.4 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.6 GO:0045116 protein neddylation(GO:0045116)
0.0 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.2 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.8 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.3 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 1.0 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 1.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.2 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.1 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0 0.2 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.2 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of activated T cell proliferation(GO:0046007) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.2 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.0 GO:0006788 heme oxidation(GO:0006788)
0.0 0.1 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.5 GO:0042462 eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.5 4.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 1.6 GO:1990423 RZZ complex(GO:1990423)
0.4 2.4 GO:0072558 NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179)
0.3 1.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 1.1 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 0.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.6 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 0.9 GO:0070083 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.1 2.2 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 1.3 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.2 GO:0043194 axon initial segment(GO:0043194)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 0.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 8.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.6 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.7 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0000439 core TFIIH complex(GO:0000439)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.6 3.3 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.5 3.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 1.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 1.9 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 0.9 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.2 2.7 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.2 1.6 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.2 3.2 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.4 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 0.4 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.4 GO:0030572 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.1 4.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.7 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.8 GO:0034711 inhibin binding(GO:0034711)
0.1 0.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 1.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 1.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.8 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.1 GO:0005537 mannose binding(GO:0005537)
0.1 4.6 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.1 0.2 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 1.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 1.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.4 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 1.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.2 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.0 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.6 GO:0070402 NADPH binding(GO:0070402)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.3 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.0 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.8 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 1.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 8.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 3.6 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 2.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 12.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 3.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.6 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 4.1 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 1.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 4.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 3.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane