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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NFKB1

Z-value: 2.94

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Transcription factors associated with NFKB1

Gene Symbol Gene ID Gene Info
ENSG00000109320.7 nuclear factor kappa B subunit 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFKB1hg19_v2_chr4_+_103423055_1034231120.871.7e-08Click!

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_29527702 32.34 ENST00000377050.4
ubiquitin D
chr4_-_76944621 30.23 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr6_-_31550192 28.45 ENST00000429299.2
ENST00000446745.2
lymphotoxin beta (TNF superfamily, member 3)
chr19_+_45504688 25.90 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr2_+_228678550 22.48 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr10_+_104154229 22.34 ENST00000428099.1
ENST00000369966.3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr4_-_76957214 19.76 ENST00000306621.3
chemokine (C-X-C motif) ligand 11
chr5_-_150466692 18.41 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNFAIP3 interacting protein 1
chr11_+_102188224 17.78 ENST00000263464.3
baculoviral IAP repeat containing 3
chr11_+_102188272 16.38 ENST00000532808.1
baculoviral IAP repeat containing 3
chr5_-_150460914 16.28 ENST00000389378.2
TNFAIP3 interacting protein 1
chr1_+_110453109 16.15 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr1_-_8000872 15.94 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr12_-_49259643 15.89 ENST00000309739.5
Rho family GTPase 1
chr4_+_103422471 15.60 ENST00000226574.4
ENST00000394820.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr6_+_14117872 15.59 ENST00000379153.3
CD83 molecule
chr1_+_110453203 14.50 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
colony stimulating factor 1 (macrophage)
chr9_-_123691047 14.40 ENST00000373887.3
TNF receptor-associated factor 1
chr5_-_150460539 14.14 ENST00000520931.1
ENST00000520695.1
ENST00000521591.1
ENST00000518977.1
TNFAIP3 interacting protein 1
chr6_+_138188551 13.77 ENST00000237289.4
ENST00000433680.1
tumor necrosis factor, alpha-induced protein 3
chr17_+_40440481 13.75 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
signal transducer and activator of transcription 5A
chr6_-_32821599 13.34 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_32821924 13.28 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr4_+_74735102 13.24 ENST00000395761.3
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr16_+_50776021 13.11 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
cylindromatosis (turban tumor syndrome)
chr4_-_74904398 12.92 ENST00000296026.4
chemokine (C-X-C motif) ligand 3
chr4_-_120550146 12.76 ENST00000354960.3
phosphodiesterase 5A, cGMP-specific
chr4_-_74864386 12.73 ENST00000296027.4
chemokine (C-X-C motif) ligand 5
chr11_+_19798964 11.74 ENST00000527559.2
neuron navigator 2
chr4_-_74964904 11.57 ENST00000508487.2
chemokine (C-X-C motif) ligand 2
chr1_+_110453462 11.15 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr3_+_53195136 10.94 ENST00000394729.2
ENST00000330452.3
protein kinase C, delta
chr11_+_19799327 10.88 ENST00000540292.1
neuron navigator 2
chr4_+_142557717 10.69 ENST00000320650.4
ENST00000296545.7
interleukin 15
chr4_-_120549163 10.48 ENST00000394439.1
ENST00000420633.1
phosphodiesterase 5A, cGMP-specific
chr16_+_50775971 10.38 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
cylindromatosis (turban tumor syndrome)
chr16_+_50775948 10.37 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
cylindromatosis (turban tumor syndrome)
chr4_+_142558078 10.05 ENST00000529613.1
interleukin 15
chr14_-_24616426 9.83 ENST00000216802.5
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr4_+_142557771 9.68 ENST00000514653.1
interleukin 15
chr9_-_136344197 9.24 ENST00000414172.1
ENST00000371897.4
solute carrier family 2 (facilitated glucose transporter), member 6
chr12_-_57504069 8.66 ENST00000543873.2
ENST00000554663.1
ENST00000557635.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr8_+_86157699 8.50 ENST00000321764.3
carbonic anhydrase XIII
chr20_+_6748311 8.24 ENST00000378827.4
bone morphogenetic protein 2
chr19_-_47734448 6.94 ENST00000439096.2
BCL2 binding component 3
chr16_+_50730910 6.81 ENST00000300589.2
nucleotide-binding oligomerization domain containing 2
chr6_-_44233361 6.63 ENST00000275015.5
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr21_+_34775698 6.52 ENST00000381995.1
interferon gamma receptor 2 (interferon gamma transducer 1)
chr4_-_122085469 6.40 ENST00000057513.3
TNFAIP3 interacting protein 3
chr6_+_29691198 6.40 ENST00000440587.2
ENST00000434407.2
major histocompatibility complex, class I, F
chr20_+_35090150 6.39 ENST00000340491.4
discs, large (Drosophila) homolog-associated protein 4
chr21_+_34775772 6.32 ENST00000405436.1
interferon gamma receptor 2 (interferon gamma transducer 1)
chr12_-_9913489 6.29 ENST00000228434.3
ENST00000536709.1
CD69 molecule
chr20_+_44746939 6.28 ENST00000372276.3
CD40 molecule, TNF receptor superfamily member 5
chr2_-_163175133 6.27 ENST00000421365.2
ENST00000263642.2
interferon induced with helicase C domain 1
chr1_+_169077172 6.24 ENST00000499679.3
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr21_+_34775181 6.23 ENST00000290219.6
interferon gamma receptor 2 (interferon gamma transducer 1)
chr4_-_146859623 6.09 ENST00000379448.4
ENST00000513320.1
zinc finger protein 827
chr17_-_61777090 6.09 ENST00000578061.1
LIM domain containing 2
chr20_+_44746885 6.07 ENST00000372285.3
CD40 molecule, TNF receptor superfamily member 5
chr14_+_73704201 5.92 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
papilin, proteoglycan-like sulfated glycoprotein
chr17_+_74381343 5.80 ENST00000392496.3
sphingosine kinase 1
chr2_+_32853093 5.73 ENST00000448773.1
ENST00000317907.4
tetratricopeptide repeat domain 27
chr19_-_4338783 5.73 ENST00000601482.1
ENST00000600324.1
signal transducing adaptor family member 2
chr19_-_4338838 5.71 ENST00000594605.1
signal transducing adaptor family member 2
chr6_+_29691056 5.70 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
major histocompatibility complex, class I, F
chr19_+_45251804 5.68 ENST00000164227.5
B-cell CLL/lymphoma 3
chr17_+_21191341 5.61 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
mitogen-activated protein kinase kinase 3
chr19_-_17958832 5.59 ENST00000458235.1
Janus kinase 3
chr10_+_13142075 5.56 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
optineurin
chr4_-_185395672 5.40 ENST00000393593.3
interferon regulatory factor 2
chr10_+_13142225 5.38 ENST00000378747.3
optineurin
chr2_+_97202480 5.30 ENST00000357485.3
AT rich interactive domain 5A (MRF1-like)
chr6_+_80341000 5.23 ENST00000369838.4
SH3 domain binding glutamic acid-rich protein like 2
chr2_+_97203082 5.16 ENST00000454558.2
AT rich interactive domain 5A (MRF1-like)
chr10_+_13141585 5.15 ENST00000378764.2
optineurin
chr14_-_35873856 5.13 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr6_+_18155632 4.99 ENST00000297792.5
lysine (K)-specific demethylase 1B
chr1_+_6845384 4.97 ENST00000303635.7
calmodulin binding transcription activator 1
chr10_+_12391481 4.70 ENST00000378847.3
calcium/calmodulin-dependent protein kinase ID
chr3_-_4793274 4.42 ENST00000414938.1
eosinophil granule ontogeny transcript (non-protein coding)
chr3_+_101546827 4.37 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_+_183441600 4.36 ENST00000367537.3
SMG7 nonsense mediated mRNA decay factor
chr5_-_95297534 4.35 ENST00000513343.1
ENST00000431061.2
elongation factor, RNA polymerase II, 2
chr3_+_9691117 4.27 ENST00000353332.5
ENST00000420925.1
ENST00000296003.4
ENST00000351233.5
myotubularin related protein 14
chr11_-_3862206 4.20 ENST00000351018.4
ras homolog family member G
chr14_-_24615805 4.19 ENST00000560410.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr5_-_95297678 4.10 ENST00000237853.4
elongation factor, RNA polymerase II, 2
chr15_+_89346699 4.08 ENST00000558207.1
aggrecan
chr11_-_75062829 4.05 ENST00000393505.4
arrestin, beta 1
chr2_+_68694678 3.89 ENST00000303795.4
aprataxin and PNKP like factor
chr11_+_118307179 3.85 ENST00000534358.1
ENST00000531904.2
ENST00000389506.5
ENST00000354520.4
lysine (K)-specific methyltransferase 2A
chr9_-_117568365 3.84 ENST00000374045.4
tumor necrosis factor (ligand) superfamily, member 15
chr19_+_39390320 3.77 ENST00000576510.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr5_+_170846640 3.73 ENST00000274625.5
fibroblast growth factor 18
chr8_-_145582118 3.70 ENST00000455319.2
ENST00000331890.5
F-box and leucine-rich repeat protein 6
chr1_+_183441500 3.59 ENST00000456731.2
SMG7 nonsense mediated mRNA decay factor
chr14_-_51297197 3.59 ENST00000382043.4
ninein (GSK3B interacting protein)
chr1_+_100818156 3.58 ENST00000336454.3
cell division cycle 14A
chr11_+_35639735 3.56 ENST00000317811.4
four jointed box 1 (Drosophila)
chr5_+_159895275 3.54 ENST00000517927.1
microRNA 146a
chr13_+_97874574 3.50 ENST00000343600.4
ENST00000345429.6
ENST00000376673.3
muscleblind-like splicing regulator 2
chr11_-_75062730 3.47 ENST00000420843.2
ENST00000360025.3
arrestin, beta 1
chr19_+_39390587 3.29 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr14_-_51297837 3.22 ENST00000245441.5
ENST00000389868.3
ENST00000382041.3
ENST00000324330.9
ENST00000453196.1
ENST00000453401.2
ninein (GSK3B interacting protein)
chr1_-_65432171 3.16 ENST00000342505.4
Janus kinase 1
chr1_+_183441618 3.09 ENST00000507691.2
ENST00000508461.1
ENST00000419169.1
ENST00000347615.2
ENST00000507469.1
ENST00000515829.2
SMG7 nonsense mediated mRNA decay factor
chr1_+_110453514 3.06 ENST00000369802.3
ENST00000420111.2
colony stimulating factor 1 (macrophage)
chr2_-_136743169 3.05 ENST00000264161.4
aspartyl-tRNA synthetase
chr1_+_18434240 3.04 ENST00000251296.1
immunoglobin superfamily, member 21
chr6_+_135502466 2.98 ENST00000367814.4
v-myb avian myeloblastosis viral oncogene homolog
chr15_+_85923797 2.98 ENST00000559362.1
A kinase (PRKA) anchor protein 13
chr6_+_29910301 2.90 ENST00000376809.5
ENST00000376802.2
major histocompatibility complex, class I, A
chr2_-_100721923 2.88 ENST00000356421.2
AF4/FMR2 family, member 3
chr16_-_66959429 2.84 ENST00000420652.1
ENST00000299759.6
Ras-related associated with diabetes
chr8_+_145582217 2.83 ENST00000530047.1
ENST00000527078.1
solute carrier family 52 (riboflavin transporter), member 2
chr20_+_18488528 2.82 ENST00000377465.1
Sec23 homolog B (S. cerevisiae)
chr16_+_53738053 2.78 ENST00000394647.3
fat mass and obesity associated
chr22_-_38380543 2.77 ENST00000396884.2
SRY (sex determining region Y)-box 10
chr14_+_24616588 2.72 ENST00000324103.6
ENST00000559260.1
ring finger protein 31
chr2_+_64681641 2.72 ENST00000409537.2
lectin, galactoside-binding-like
chr6_+_106534192 2.63 ENST00000369091.2
ENST00000369096.4
PR domain containing 1, with ZNF domain
chr4_-_146859787 2.60 ENST00000508784.1
zinc finger protein 827
chr20_+_18488137 2.59 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
Sec23 homolog B (S. cerevisiae)
chr6_+_144471643 2.57 ENST00000367568.4
syntaxin 11
chr20_-_50159198 2.52 ENST00000371564.3
ENST00000396009.3
ENST00000610033.1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr4_-_76928641 2.51 ENST00000264888.5
chemokine (C-X-C motif) ligand 9
chr15_-_77712477 2.50 ENST00000560626.2
pseudopodium-enriched atypical kinase 1
chr17_-_1389419 2.47 ENST00000575158.1
myosin IC
chr2_-_100721178 2.47 ENST00000409236.2
AF4/FMR2 family, member 3
chr4_-_76598544 2.41 ENST00000515457.1
ENST00000357854.3
GTPase activating protein (SH3 domain) binding protein 2
chr9_+_132934835 2.41 ENST00000372398.3
neuronal calcium sensor 1
chr8_+_145582231 2.39 ENST00000526338.1
ENST00000402965.1
ENST00000534725.1
ENST00000532887.1
ENST00000329994.2
solute carrier family 52 (riboflavin transporter), member 2
chr1_+_100818009 2.39 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
cell division cycle 14A
chr1_-_205904950 2.33 ENST00000340781.4
solute carrier family 26 (anion exchanger), member 9
chr22_-_37640456 2.27 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr19_-_41222775 2.20 ENST00000324464.3
ENST00000450541.1
ENST00000594720.1
aarF domain containing kinase 4
chr17_-_1389228 2.19 ENST00000438665.2
myosin IC
chr12_-_54982300 2.19 ENST00000547431.1
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr11_-_46142505 2.18 ENST00000524497.1
ENST00000418153.2
PHD finger protein 21A
chr17_-_7590745 2.17 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
tumor protein p53
chr4_-_103748696 2.12 ENST00000321805.7
ubiquitin-conjugating enzyme E2D 3
chr2_+_208394794 2.06 ENST00000536726.1
ENST00000374397.4
ENST00000452474.1
cAMP responsive element binding protein 1
chr1_-_151299842 2.03 ENST00000438243.2
ENST00000489223.2
ENST00000368873.1
ENST00000430800.1
ENST00000368872.1
phosphatidylinositol 4-kinase, catalytic, beta
chr1_+_37940153 2.02 ENST00000373087.6
zinc finger CCCH-type containing 12A
chr11_-_46142615 2.00 ENST00000529734.1
ENST00000323180.6
PHD finger protein 21A
chr14_+_103243813 1.99 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TNF receptor-associated factor 3
chr11_+_118478313 1.98 ENST00000356063.5
pleckstrin homology-like domain, family B, member 1
chr4_-_5890145 1.94 ENST00000397890.2
collapsin response mediator protein 1
chr17_+_8924837 1.93 ENST00000173229.2
netrin 1
chr4_-_76598296 1.92 ENST00000395719.3
GTPase activating protein (SH3 domain) binding protein 2
chr20_-_62462566 1.90 ENST00000245663.4
ENST00000302995.2
zinc finger and BTB domain containing 46
chr1_+_107683436 1.89 ENST00000370068.1
netrin G1
chr11_+_65292884 1.86 ENST00000527009.1
SCY1-like 1 (S. cerevisiae)
chr12_+_100661156 1.83 ENST00000360820.2
SCY1-like 2 (S. cerevisiae)
chr10_-_97050777 1.81 ENST00000329399.6
PDZ and LIM domain 1
chr3_+_9773409 1.80 ENST00000433861.2
ENST00000424362.1
ENST00000383829.2
ENST00000302054.3
ENST00000420291.1
bromodomain and PHD finger containing, 1
chr5_+_72861560 1.80 ENST00000296792.4
ENST00000509005.1
ENST00000543251.1
ENST00000508686.1
ENST00000508491.1
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
chr1_+_27561104 1.79 ENST00000361771.3
WD and tetratricopeptide repeats 1
chr1_+_107683644 1.78 ENST00000370067.1
netrin G1
chr2_+_208394455 1.75 ENST00000430624.1
cAMP responsive element binding protein 1
chr2_+_124782857 1.68 ENST00000431078.1
contactin associated protein-like 5
chr12_+_49761147 1.64 ENST00000549298.1
spermatogenesis associated, serine-rich 2
chr11_+_128562372 1.63 ENST00000344954.6
Fli-1 proto-oncogene, ETS transcription factor
chr1_-_161279749 1.62 ENST00000533357.1
ENST00000360451.6
ENST00000336559.4
myelin protein zero
chr19_+_496454 1.61 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
mucosal vascular addressin cell adhesion molecule 1
chr16_+_67571351 1.60 ENST00000428437.2
ENST00000569253.1
family with sequence similarity 65, member A
chr6_+_33168637 1.59 ENST00000374677.3
solute carrier family 39 (zinc transporter), member 7
chr6_+_33168597 1.55 ENST00000374675.3
solute carrier family 39 (zinc transporter), member 7
chr12_-_48499591 1.53 ENST00000551330.1
ENST00000004980.5
ENST00000339976.6
ENST00000448372.1
SUMO1/sentrin specific peptidase 1
chr15_+_22892663 1.52 ENST00000313077.7
ENST00000561274.1
ENST00000560848.1
cytoplasmic FMR1 interacting protein 1
chr10_+_89419370 1.50 ENST00000361175.4
ENST00000456849.1
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr5_-_78365437 1.48 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
dimethylglycine dehydrogenase
chr19_+_51728316 1.48 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33 molecule
chr11_-_46142948 1.47 ENST00000257821.4
PHD finger protein 21A
chr7_-_96654133 1.47 ENST00000486603.2
ENST00000222598.4
distal-less homeobox 5
chr22_-_37640277 1.45 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr17_+_17685422 1.42 ENST00000395774.1
retinoic acid induced 1
chr11_+_65292538 1.38 ENST00000270176.5
ENST00000525364.1
ENST00000420247.2
ENST00000533862.1
ENST00000279270.6
ENST00000524944.1
SCY1-like 1 (S. cerevisiae)
chr20_+_1115821 1.36 ENST00000435720.1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr20_+_57430162 1.32 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
GNAS complex locus
chr4_-_103749205 1.32 ENST00000508249.1
ubiquitin-conjugating enzyme E2D 3
chr1_+_27561007 1.31 ENST00000319394.3
WD and tetratricopeptide repeats 1
chr1_+_100818484 1.31 ENST00000544534.1
cell division cycle 14A
chr1_-_16302565 1.30 ENST00000537142.1
ENST00000448462.2
zinc finger and BTB domain containing 17
chr4_-_103748880 1.29 ENST00000453744.2
ENST00000349311.8
ubiquitin-conjugating enzyme E2D 3
chr1_-_16302608 1.29 ENST00000375743.4
ENST00000375733.2
zinc finger and BTB domain containing 17
chr6_+_149068464 1.27 ENST00000367463.4
uronyl-2-sulfotransferase
chr14_+_32798462 1.25 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr2_+_54951679 1.25 ENST00000356458.6
echinoderm microtubule associated protein like 6
chr20_-_2451395 1.24 ENST00000339610.6
ENST00000381342.2
ENST00000438552.2
small nuclear ribonucleoprotein polypeptides B and B1
chr15_-_44010458 1.23 ENST00000541030.1
stereocilin
chr17_-_7197881 1.20 ENST00000007699.5
Y box binding protein 2
chr12_+_49761224 1.19 ENST00000553127.1
ENST00000321898.6
spermatogenesis associated, serine-rich 2
chr14_+_75536280 1.17 ENST00000238686.8
zinc finger, C2HC-type containing 1C
chr6_+_31540056 1.16 ENST00000418386.2
lymphotoxin alpha
chr12_+_57624119 1.15 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_56732658 1.15 ENST00000228534.4
interleukin 23, alpha subunit p19
chr5_+_152870106 1.14 ENST00000285900.5
glutamate receptor, ionotropic, AMPA 1
chr16_-_4303767 1.13 ENST00000573268.1
ENST00000573042.1
RP11-95P2.1

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 48.8 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
11.3 33.9 GO:1990108 protein linear deubiquitination(GO:1990108)
10.1 30.4 GO:0045062 extrathymic T cell selection(GO:0045062)
9.0 44.9 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
7.5 22.5 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
7.0 28.0 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
6.8 6.8 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
6.5 32.3 GO:0070842 aggresome assembly(GO:0070842)
5.2 52.5 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
4.9 44.0 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
4.6 13.8 GO:0001922 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
3.8 34.2 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
3.4 13.8 GO:0000255 allantoin metabolic process(GO:0000255)
3.3 13.3 GO:0046967 cytosol to ER transport(GO:0046967)
3.1 21.6 GO:0060282 positive regulation of oocyte development(GO:0060282)
2.8 22.6 GO:0021564 vagus nerve development(GO:0021564)
2.7 8.2 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
2.7 10.9 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
2.7 15.9 GO:2001183 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
2.5 12.3 GO:0033590 response to cobalamin(GO:0033590)
2.2 8.7 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
2.0 58.7 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
1.9 5.8 GO:0046521 sphingoid catabolic process(GO:0046521)
1.8 16.1 GO:0001920 negative regulation of receptor recycling(GO:0001920) parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
1.7 15.6 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
1.7 5.2 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
1.7 5.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
1.6 6.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.5 19.0 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
1.4 4.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
1.3 13.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
1.3 2.6 GO:0033078 extrathymic T cell differentiation(GO:0033078)
1.2 6.2 GO:1903281 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288)
1.1 2.2 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
1.0 5.2 GO:0032218 riboflavin transport(GO:0032218)
1.0 3.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
1.0 3.0 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.0 15.9 GO:0016322 neuron remodeling(GO:0016322)
0.9 2.8 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.9 2.8 GO:1904616 regulation of actin filament binding(GO:1904529) negative regulation of actin filament binding(GO:1904530) regulation of actin binding(GO:1904616) negative regulation of actin binding(GO:1904617)
0.8 4.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.8 7.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.7 4.3 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.7 2.8 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.7 5.6 GO:0035897 proteolysis in other organism(GO:0035897)
0.7 2.8 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.7 2.0 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
0.7 6.6 GO:0042940 D-amino acid transport(GO:0042940)
0.6 3.8 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674) regulation of cellular response to drug(GO:2001038)
0.6 5.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.5 2.7 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.5 3.7 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.5 1.0 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.5 1.5 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.5 1.5 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.5 1.5 GO:0060166 olfactory pit development(GO:0060166)
0.5 6.8 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.5 3.9 GO:0051106 positive regulation of DNA ligation(GO:0051106)
0.5 7.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.4 16.9 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.4 1.2 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.4 1.5 GO:0000103 sulfate assimilation(GO:0000103)
0.3 1.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.3 4.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.3 2.0 GO:0008063 Toll signaling pathway(GO:0008063)
0.3 2.3 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.3 1.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 1.2 GO:0009386 translational attenuation(GO:0009386)
0.3 1.8 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.3 0.9 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.3 28.7 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.3 9.2 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.3 1.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.3 1.9 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.3 1.8 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.3 4.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.3 14.4 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.2 13.9 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.2 1.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 0.4 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.2 0.6 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.2 1.6 GO:0072553 terminal button organization(GO:0072553)
0.2 0.6 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.2 0.6 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.2 3.8 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.2 1.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 1.3 GO:2000828 post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.2 1.7 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 0.9 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.2 8.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 2.3 GO:0019532 oxalate transport(GO:0019532)
0.2 1.0 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.2 5.2 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.2 3.8 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.2 1.0 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 6.9 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.2 2.3 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.2 10.6 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 1.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 2.6 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 1.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.9 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 1.3 GO:0006477 protein sulfation(GO:0006477)
0.1 4.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 1.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 5.0 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.1 2.5 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 8.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 0.3 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 2.0 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.1 0.6 GO:0007296 vitellogenesis(GO:0007296)
0.1 1.5 GO:0034063 stress granule assembly(GO:0034063)
0.1 8.5 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 1.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 2.6 GO:0007398 ectoderm development(GO:0007398)
0.1 2.6 GO:0010842 retina layer formation(GO:0010842)
0.1 0.9 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.1 1.6 GO:0098743 cell aggregation(GO:0098743)
0.1 0.9 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 1.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 6.8 GO:0007004 telomere maintenance via telomerase(GO:0007004)
0.1 0.6 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 1.6 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 3.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.6 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.4 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 1.2 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 4.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.0 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 3.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 2.0 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 4.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 2.4 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.0 0.7 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 1.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.7 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.9 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 2.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.0 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.2 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.2 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 44.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
7.0 28.0 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
5.0 39.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
2.3 14.0 GO:0008537 proteasome activator complex(GO:0008537)
1.9 13.3 GO:0042825 TAP complex(GO:0042825)
1.5 12.3 GO:0043196 varicosity(GO:0043196)
1.5 13.3 GO:1990111 spermatoproteasome complex(GO:1990111)
1.2 13.3 GO:0042612 MHC class I protein complex(GO:0042612)
1.2 4.7 GO:0045160 myosin I complex(GO:0045160)
0.9 22.6 GO:0005614 interstitial matrix(GO:0005614)
0.9 7.8 GO:0036449 microtubule minus-end(GO:0036449)
0.8 9.6 GO:0060091 kinocilium(GO:0060091)
0.6 4.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.6 33.9 GO:0097542 ciliary tip(GO:0097542)
0.5 2.7 GO:0071797 LUBAC complex(GO:0071797)
0.5 32.3 GO:0016235 aggresome(GO:0016235)
0.3 2.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.3 2.3 GO:0070552 BRISC complex(GO:0070552)
0.3 6.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 0.8 GO:0016938 kinesin I complex(GO:0016938)
0.2 3.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 9.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 7.0 GO:0031143 pseudopodium(GO:0031143)
0.2 5.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 1.1 GO:0044308 axonal spine(GO:0044308)
0.2 16.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 0.6 GO:0031933 telomeric heterochromatin(GO:0031933)
0.2 1.5 GO:0044294 dendritic growth cone(GO:0044294)
0.2 2.0 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 1.7 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 10.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 2.0 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.2 2.4 GO:0031045 dense core granule(GO:0031045)
0.1 3.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 55.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.8 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 2.0 GO:0045180 basal cortex(GO:0045180)
0.1 10.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 0.9 GO:0005638 lamin filament(GO:0005638)
0.1 16.1 GO:0016363 nuclear matrix(GO:0016363)
0.1 3.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 5.7 GO:1990391 DNA repair complex(GO:1990391)
0.1 2.8 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.1 36.1 GO:0045121 membrane raft(GO:0045121)
0.1 4.9 GO:0005796 Golgi lumen(GO:0005796)
0.1 4.2 GO:0008180 COP9 signalosome(GO:0008180)
0.1 5.0 GO:0000786 nucleosome(GO:0000786)
0.1 3.0 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 129.3 GO:0005615 extracellular space(GO:0005615)
0.1 8.8 GO:0005884 actin filament(GO:0005884)
0.1 1.4 GO:0005839 proteasome core complex(GO:0005839)
0.1 10.1 GO:0001650 fibrillar center(GO:0001650)
0.0 0.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.0 2.6 GO:0031201 SNARE complex(GO:0031201)
0.0 7.5 GO:0043209 myelin sheath(GO:0043209)
0.0 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 24.1 GO:0005912 adherens junction(GO:0005912)
0.0 1.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 10.2 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 3.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 4.4 GO:0010008 endosome membrane(GO:0010008)
0.0 2.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.8 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.8 GO:0030496 midbody(GO:0030496)
0.0 2.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 7.6 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 0.7 GO:0042383 sarcolemma(GO:0042383)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 52.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
7.5 22.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
5.6 44.9 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
4.6 50.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
3.8 19.1 GO:0004906 interferon-gamma receptor activity(GO:0004906)
3.6 25.4 GO:0046979 TAP2 binding(GO:0046979)
3.0 47.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
2.5 7.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
1.8 14.0 GO:0061133 endopeptidase activator activity(GO:0061133)
1.7 33.7 GO:0070628 proteasome binding(GO:0070628)
1.4 4.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
1.3 70.4 GO:0031593 polyubiquitin binding(GO:0031593)
1.3 3.8 GO:0045322 unmethylated CpG binding(GO:0045322)
1.0 5.2 GO:0032217 riboflavin transporter activity(GO:0032217)
1.0 16.4 GO:0031996 thioesterase binding(GO:0031996)
1.0 5.8 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.9 2.8 GO:0035514 DNA demethylase activity(GO:0035514)
0.8 5.0 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.8 8.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.8 23.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.7 28.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.7 34.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.6 9.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.6 3.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.5 4.3 GO:1990763 arrestin family protein binding(GO:1990763)
0.5 1.6 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.5 2.7 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.5 1.5 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.5 20.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.5 8.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.5 1.9 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.4 13.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 6.8 GO:0042834 peptidoglycan binding(GO:0042834)
0.4 1.5 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.4 1.8 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.3 6.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3 4.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 2.3 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 3.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 0.9 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 2.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 3.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 1.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.3 11.4 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.3 1.5 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2 3.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 0.7 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.2 0.9 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 10.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.2 1.2 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.2 4.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 10.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 5.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 2.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 3.9 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2 1.8 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 0.9 GO:0032810 sterol response element binding(GO:0032810)
0.2 2.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 2.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 1.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.2 5.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 4.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 5.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 5.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 4.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.7 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 26.7 GO:0004386 helicase activity(GO:0004386)
0.1 1.3 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 6.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.6 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.1 2.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 2.8 GO:0031005 filamin binding(GO:0031005)
0.1 25.6 GO:0001047 core promoter binding(GO:0001047)
0.1 1.2 GO:0071837 HMG box domain binding(GO:0071837)
0.1 6.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 1.0 GO:0046790 virion binding(GO:0046790)
0.1 21.3 GO:0005125 cytokine activity(GO:0005125)
0.1 7.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 3.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 25.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 1.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.4 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 1.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 22.8 GO:0003924 GTPase activity(GO:0003924)
0.1 0.4 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.1 5.2 GO:0051117 ATPase binding(GO:0051117)
0.1 2.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 7.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 4.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 6.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 5.7 GO:0042393 histone binding(GO:0042393)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 4.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 2.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.3 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.9 GO:0005525 GTP binding(GO:0005525)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 5.7 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
2.2 116.3 PID CD40 PATHWAY CD40/CD40L signaling
1.5 44.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.4 47.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
1.0 36.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
1.0 64.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.5 15.9 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.4 5.8 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.4 11.8 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.3 18.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.3 15.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.3 2.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 127.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 1.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 0.9 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 3.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 3.0 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 3.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 5.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 19.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.1 0.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 4.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.6 PID MYC PATHWAY C-MYC pathway
0.1 3.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.0 ST ADRENERGIC Adrenergic Pathway
0.1 3.5 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 1.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 0.8 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.1 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 1.5 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 2.0 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.9 123.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.6 88.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
1.6 34.5 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
1.3 13.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.1 22.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.9 5.6 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.8 15.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.7 6.3 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.6 13.7 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.5 15.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.5 8.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.5 23.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.4 9.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.4 30.8 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.4 15.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.3 4.1 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.3 2.9 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.3 15.3 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.3 4.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.3 6.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 9.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 7.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 7.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 4.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 2.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 5.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 5.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 6.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 12.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.6 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.1 2.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 3.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.0 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 0.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 1.9 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.1 2.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 4.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.1 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 7.2 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.9 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 1.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 3.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.2 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 1.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions