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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TLX2

Z-value: 0.96

Motif logo

Transcription factors associated with TLX2

Gene Symbol Gene ID Gene Info
ENSG00000115297.9 T cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TLX2hg19_v2_chr2_+_74741569_74741620-0.301.5e-01Click!

Activity profile of TLX2 motif

Sorted Z-values of TLX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_57406368 5.74 ENST00000006053.6
ENST00000563383.1
chemokine (C-X3-C motif) ligand 1
chr1_-_169703203 5.37 ENST00000333360.7
ENST00000367781.4
ENST00000367782.4
ENST00000367780.4
ENST00000367779.4
selectin E
chr6_-_31550192 3.76 ENST00000429299.2
ENST00000446745.2
lymphotoxin beta (TNF superfamily, member 3)
chr6_-_143266297 3.61 ENST00000367603.2
human immunodeficiency virus type I enhancer binding protein 2
chr5_+_131409476 2.98 ENST00000296871.2
colony stimulating factor 2 (granulocyte-macrophage)
chr19_+_676385 2.39 ENST00000166139.4
follistatin-like 3 (secreted glycoprotein)
chr14_+_55034599 2.27 ENST00000392067.3
ENST00000357634.3
sterile alpha motif domain containing 4A
chr4_+_156680518 2.15 ENST00000513437.1
guanylate cyclase 1, soluble, beta 3
chr16_-_11681023 2.09 ENST00000570904.1
ENST00000574701.1
lipopolysaccharide-induced TNF factor
chr4_+_156680143 1.89 ENST00000505154.1
guanylate cyclase 1, soluble, beta 3
chr14_+_103589789 1.63 ENST00000558056.1
ENST00000560869.1
tumor necrosis factor, alpha-induced protein 2
chr7_+_155090271 1.58 ENST00000476756.1
insulin induced gene 1
chr4_+_156680153 1.51 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
guanylate cyclase 1, soluble, beta 3
chr5_-_16916624 1.45 ENST00000513882.1
myosin X
chr4_+_156588806 1.42 ENST00000513574.1
guanylate cyclase 1, soluble, alpha 3
chr2_+_111878483 1.42 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2-like 11 (apoptosis facilitator)
chr21_-_38639601 1.41 ENST00000539844.1
ENST00000476950.1
ENST00000399001.1
Down syndrome critical region gene 3
chr16_-_11680759 1.39 ENST00000571459.1
ENST00000570798.1
ENST00000572255.1
ENST00000574763.1
ENST00000574703.1
ENST00000571277.1
ENST00000381810.3
lipopolysaccharide-induced TNF factor
chr12_-_89918522 1.36 ENST00000529983.2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
chr2_+_102928009 1.36 ENST00000404917.2
ENST00000447231.1
interleukin 1 receptor-like 1
chr8_+_22423219 1.35 ENST00000523965.1
ENST00000521554.1
sorbin and SH3 domain containing 3
chr12_-_57522813 1.32 ENST00000556155.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr17_+_66509019 1.23 ENST00000585981.1
ENST00000589480.1
ENST00000585815.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr8_-_91657740 1.17 ENST00000422900.1
transmembrane protein 64
chr15_-_50411412 1.16 ENST00000284509.6
ATPase, class I, type 8B, member 4
chr10_+_35416090 1.15 ENST00000354759.3
cAMP responsive element modulator
chr10_+_35415719 1.12 ENST00000474362.1
ENST00000374721.3
cAMP responsive element modulator
chr16_-_11680791 1.10 ENST00000571976.1
ENST00000413364.2
lipopolysaccharide-induced TNF factor
chr21_+_43639211 1.06 ENST00000450121.1
ENST00000398449.3
ENST00000361802.2
ATP-binding cassette, sub-family G (WHITE), member 1
chr3_-_195997410 0.99 ENST00000419333.1
phosphate cytidylyltransferase 1, choline, alpha
chr1_+_214161272 0.98 ENST00000498508.2
ENST00000366958.4
prospero homeobox 1
chr16_-_67693846 0.94 ENST00000602850.1
adrenocortical dysplasia homolog (mouse)
chr14_-_92414055 0.94 ENST00000342058.4
fibulin 5
chr10_+_35415978 0.93 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
cAMP responsive element modulator
chr20_-_1373682 0.93 ENST00000381724.3
FK506 binding protein 1A, 12kDa
chr3_-_182880541 0.91 ENST00000470251.1
ENST00000265598.3
lysosomal-associated membrane protein 3
chr10_+_35416223 0.90 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
cAMP responsive element modulator
chr3_-_149051194 0.90 ENST00000470080.1
transmembrane 4 L six family member 18
chr3_+_30647994 0.87 ENST00000295754.5
transforming growth factor, beta receptor II (70/80kDa)
chr6_+_106546808 0.84 ENST00000369089.3
PR domain containing 1, with ZNF domain
chr6_+_37787704 0.84 ENST00000474522.1
zinc finger, AN1-type domain 3
chr3_-_107809816 0.83 ENST00000361309.5
ENST00000355354.7
CD47 molecule
chr5_-_150080472 0.81 ENST00000521464.1
ENST00000518917.1
ENST00000447771.2
ENST00000540000.1
ENST00000199814.4
RNA binding motif protein 22
chr10_-_60027642 0.80 ENST00000373935.3
inositol polyphosphate multikinase
chr4_+_1873100 0.80 ENST00000508803.1
Wolf-Hirschhorn syndrome candidate 1
chr10_-_123687431 0.80 ENST00000423243.1
arginyltransferase 1
chrX_-_45629661 0.79 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2
chr2_-_225811747 0.79 ENST00000409592.3
dedicator of cytokinesis 10
chr7_+_112063192 0.77 ENST00000005558.4
interferon-related developmental regulator 1
chr20_+_44746939 0.76 ENST00000372276.3
CD40 molecule, TNF receptor superfamily member 5
chr8_-_105601134 0.74 ENST00000276654.5
ENST00000424843.2
low density lipoprotein receptor-related protein 12
chr2_-_204400113 0.73 ENST00000319170.5
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr1_-_161279749 0.73 ENST00000533357.1
ENST00000360451.6
ENST00000336559.4
myelin protein zero
chr3_-_194373831 0.71 ENST00000437613.1
large 60S subunit nuclear export GTPase 1
chr10_-_121632266 0.71 ENST00000360003.3
ENST00000369077.3
minichromosome maintenance complex binding protein
chr11_+_128563652 0.70 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr2_+_169923577 0.70 ENST00000432060.2
dehydrogenase/reductase (SDR family) member 9
chr3_+_151986709 0.69 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr12_-_76953349 0.68 ENST00000551927.1
oxysterol binding protein-like 8
chr19_+_47104553 0.67 ENST00000598871.1
ENST00000594523.1
calmodulin 3 (phosphorylase kinase, delta)
chrX_+_70752945 0.66 ENST00000373701.3
O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_-_22263790 0.64 ENST00000374695.3
heparan sulfate proteoglycan 2
chr2_+_150187020 0.64 ENST00000334166.4
LY6/PLAUR domain containing 6
chr2_+_10184302 0.61 ENST00000440320.1
ENST00000535335.1
Kruppel-like factor 11
chr1_-_68698197 0.58 ENST00000370973.2
ENST00000370971.1
wntless Wnt ligand secretion mediator
chr4_+_169552748 0.58 ENST00000504519.1
ENST00000512127.1
palladin, cytoskeletal associated protein
chr12_+_50794730 0.57 ENST00000523389.1
ENST00000518561.1
ENST00000347328.5
ENST00000550260.1
La ribonucleoprotein domain family, member 4
chr1_+_16174280 0.56 ENST00000375759.3
spen family transcriptional repressor
chr22_-_22221658 0.56 ENST00000544786.1
mitogen-activated protein kinase 1
chr19_-_12833361 0.55 ENST00000592287.1
transportin 2
chr12_-_50677255 0.54 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIM domain and actin binding 1
chr8_-_141728760 0.54 ENST00000430260.2
protein tyrosine kinase 2
chr20_-_47894569 0.54 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
zinc finger, NFX1-type containing 1
chr12_-_51740463 0.54 ENST00000293636.1
chymotrypsin-like elastase family, member 1
chr11_-_57089671 0.54 ENST00000532437.1
tankyrase 1 binding protein 1, 182kDa
chr15_-_38856836 0.53 ENST00000450598.2
ENST00000559830.1
ENST00000558164.1
ENST00000310803.5
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr11_-_85780853 0.53 ENST00000531930.1
ENST00000528398.1
phosphatidylinositol binding clathrin assembly protein
chr1_-_224033596 0.52 ENST00000391878.2
ENST00000343537.7
tumor protein p53 binding protein, 2
chr2_+_219433588 0.52 ENST00000295701.5
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_+_169923504 0.50 ENST00000357546.2
dehydrogenase/reductase (SDR family) member 9
chr5_-_133968459 0.49 ENST00000505758.1
ENST00000439578.1
ENST00000502286.1
SAR1 homolog B (S. cerevisiae)
chr10_+_124030819 0.49 ENST00000260723.4
ENST00000368994.2
BTB (POZ) domain containing 16
chr1_+_154229547 0.49 ENST00000428595.1
ubiquitin associated protein 2-like
chr12_-_322504 0.48 ENST00000424061.2
solute carrier family 6 (neurotransmitter transporter), member 12
chr9_+_116267536 0.48 ENST00000374136.1
regulator of G-protein signaling 3
chr1_+_107683644 0.48 ENST00000370067.1
netrin G1
chr16_+_1876936 0.48 ENST00000382668.4
ENST00000382666.4
fumarylacetoacetate hydrolase domain containing 1
chr10_+_35415851 0.47 ENST00000374726.3
cAMP responsive element modulator
chr2_+_10183651 0.47 ENST00000305883.1
Kruppel-like factor 11
chr2_+_219433281 0.47 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr10_-_43892279 0.47 ENST00000443950.2
heterogeneous nuclear ribonucleoprotein F
chr10_-_50970322 0.46 ENST00000374103.4
oxoglutarate dehydrogenase-like
chr2_-_175870085 0.46 ENST00000409156.3
chimerin 1
chr20_+_2795626 0.46 ENST00000603872.1
ENST00000380589.4
chromosome 20 open reading frame 141
chr10_-_123687943 0.46 ENST00000540606.1
ENST00000455628.1
arginyltransferase 1
chr20_+_44746885 0.46 ENST00000372285.3
CD40 molecule, TNF receptor superfamily member 5
chrX_-_118826784 0.46 ENST00000394616.4
septin 6
chr18_+_55862622 0.46 ENST00000456173.2
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr22_+_42229100 0.45 ENST00000361204.4
sterol regulatory element binding transcription factor 2
chr9_+_116225999 0.44 ENST00000317613.6
regulator of G-protein signaling 3
chr15_+_89631647 0.44 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
abhydrolase domain containing 2
chr12_+_9144626 0.43 ENST00000543895.1
killer cell lectin-like receptor subfamily G, member 1
chr20_-_42839378 0.43 ENST00000255174.2
oxidative stress responsive serine-rich 1
chr12_-_76953513 0.43 ENST00000547540.1
oxysterol binding protein-like 8
chr20_-_61557821 0.43 ENST00000354665.4
ENST00000370368.1
ENST00000395343.1
ENST00000395340.1
death inducer-obliterator 1
chr10_-_50970382 0.43 ENST00000419399.1
ENST00000432695.1
oxoglutarate dehydrogenase-like
chr1_+_24286287 0.42 ENST00000334351.7
ENST00000374468.1
proline-rich nuclear receptor coactivator 2
chr10_+_76871229 0.42 ENST00000372690.3
sterile alpha motif domain containing 8
chr17_+_42925270 0.41 ENST00000253410.2
ENST00000587021.1
HIG1 hypoxia inducible domain family, member 1B
chr6_-_43496605 0.40 ENST00000455285.2
exportin 5
chr12_-_71031185 0.40 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
protein tyrosine phosphatase, receptor type, B
chr10_-_123687399 0.39 ENST00000543447.1
arginyltransferase 1
chr9_+_139847347 0.39 ENST00000371632.3
lipocalin 12
chr19_+_36236491 0.39 ENST00000591949.1
presenilin enhancer gamma secretase subunit
chr12_-_48119301 0.39 ENST00000545824.2
ENST00000422538.3
endonuclease, polyU-specific
chr16_+_31404624 0.39 ENST00000389202.2
integrin, alpha D
chr21_-_16437126 0.39 ENST00000318948.4
nuclear receptor interacting protein 1
chr19_-_4517613 0.39 ENST00000301286.3
perilipin 4
chr5_+_133984462 0.38 ENST00000398844.2
ENST00000322887.4
SEC24 family member A
chr12_+_69864129 0.38 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
fibroblast growth factor receptor substrate 2
chr21_-_16437255 0.38 ENST00000400199.1
ENST00000400202.1
nuclear receptor interacting protein 1
chr14_-_21737551 0.38 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr19_+_36236514 0.38 ENST00000222266.2
presenilin enhancer gamma secretase subunit
chr14_+_70233810 0.37 ENST00000394366.2
ENST00000553548.1
ENST00000553369.1
ENST00000557154.1
ENST00000451983.2
ENST00000553635.1
serine/arginine-rich splicing factor 5
chr17_-_76899275 0.37 ENST00000322630.2
ENST00000586713.1
Protein DDC8 homolog
chr2_-_175869936 0.36 ENST00000409900.3
chimerin 1
chrX_-_77395186 0.36 ENST00000341864.5
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr8_-_145018905 0.36 ENST00000398774.2
plectin
chr1_-_17304771 0.36 ENST00000375534.3
microfibrillar-associated protein 2
chrX_+_70752917 0.36 ENST00000373719.3
O-linked N-acetylglucosamine (GlcNAc) transferase
chr12_-_48119340 0.36 ENST00000229003.3
endonuclease, polyU-specific
chr1_+_160160283 0.35 ENST00000368079.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr20_-_1373726 0.35 ENST00000400137.4
FK506 binding protein 1A, 12kDa
chr8_+_91952750 0.34 ENST00000521366.1
N-terminal EF-hand calcium binding protein 1
chr1_-_217262969 0.34 ENST00000361525.3
estrogen-related receptor gamma
chr12_+_113229737 0.34 ENST00000551052.1
ENST00000415485.3
rabphilin 3A homolog (mouse)
chr12_-_113658892 0.34 ENST00000299732.2
ENST00000416617.2
IQ motif containing D
chr1_+_160160346 0.34 ENST00000368078.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr7_+_45197383 0.34 ENST00000242249.4
ENST00000496212.1
ENST00000481345.1
receptor (G protein-coupled) activity modifying protein 3
chr19_+_47104493 0.33 ENST00000291295.9
ENST00000597743.1
calmodulin 3 (phosphorylase kinase, delta)
chr12_+_54519842 0.33 ENST00000508564.1
RP11-834C11.4
chr5_+_133451254 0.33 ENST00000517851.1
ENST00000521639.1
ENST00000522375.1
ENST00000378560.4
ENST00000432532.2
ENST00000520958.1
ENST00000518915.1
ENST00000395023.1
transcription factor 7 (T-cell specific, HMG-box)
chr1_-_204135450 0.33 ENST00000272190.8
ENST00000367195.2
renin
chr5_-_147162078 0.33 ENST00000507386.1
janus kinase and microtubule interacting protein 2
chr8_+_62737875 0.33 ENST00000523042.1
ENST00000518593.1
ENST00000519452.1
ENST00000519967.1
RP11-705O24.1
chr15_+_89631381 0.32 ENST00000352732.5
abhydrolase domain containing 2
chrX_+_38420783 0.32 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
tetraspanin 7
chr11_-_3818688 0.32 ENST00000355260.3
ENST00000397004.4
ENST00000397007.4
ENST00000532475.1
nucleoporin 98kDa
chr1_-_31769656 0.31 ENST00000446633.2
small nuclear ribonucleoprotein 40kDa (U5)
chr12_+_65672702 0.31 ENST00000538045.1
ENST00000535239.1
methionine sulfoxide reductase B3
chr12_+_57522439 0.30 ENST00000338962.4
low density lipoprotein receptor-related protein 1
chr12_+_50478977 0.30 ENST00000381513.4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr1_-_17766198 0.30 ENST00000375436.4
regulator of chromosome condensation 2
chr17_+_66508537 0.30 ENST00000392711.1
ENST00000585427.1
ENST00000589228.1
ENST00000536854.2
ENST00000588702.1
ENST00000589309.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr20_+_61569463 0.30 ENST00000266069.3
GID complex subunit 8
chr1_-_217262933 0.30 ENST00000359162.2
estrogen-related receptor gamma
chr19_-_1876156 0.30 ENST00000565797.1
CTB-31O20.2
chr6_+_84563295 0.30 ENST00000369687.1
ripply transcriptional repressor 2
chr18_+_29077990 0.30 ENST00000261590.8
desmoglein 2
chr6_+_111303218 0.30 ENST00000441448.2
ribosome production factor 2 homolog (S. cerevisiae)
chr2_+_242255275 0.30 ENST00000391971.2
septin 2
chr6_+_74072375 0.30 ENST00000370367.3
KH domain containing 3-like, subcortical maternal complex member
chr14_-_21737610 0.29 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr2_-_204400013 0.29 ENST00000374489.2
ENST00000374488.2
ENST00000308091.4
ENST00000453034.1
ENST00000420371.1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr5_-_147162263 0.29 ENST00000333010.6
ENST00000265272.5
janus kinase and microtubule interacting protein 2
chr3_+_46412345 0.29 ENST00000292303.4
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr1_+_207627575 0.28 ENST00000367058.3
ENST00000367057.3
ENST00000367059.3
complement component (3d/Epstein Barr virus) receptor 2
chr19_+_39421556 0.28 ENST00000407800.2
ENST00000402029.3
mitochondrial ribosomal protein S12
chr11_+_64058758 0.28 ENST00000538767.1
potassium channel, subfamily K, member 4
chr16_-_70835034 0.28 ENST00000261776.5
Vac14 homolog (S. cerevisiae)
chr8_-_131455835 0.28 ENST00000518721.1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr15_-_34502197 0.27 ENST00000557877.1
katanin p80 subunit B-like 1
chr2_+_191045562 0.27 ENST00000340623.4
chromosome 2 open reading frame 88
chrX_-_73512411 0.27 ENST00000602576.1
ENST00000429124.1
FTX transcript, XIST regulator (non-protein coding)
chr10_-_27529486 0.27 ENST00000375888.1
acyl-CoA binding domain containing 5
chr1_-_153517473 0.27 ENST00000368715.1
S100 calcium binding protein A4
chr3_+_121796697 0.27 ENST00000482356.1
ENST00000393627.2
CD86 molecule
chrX_-_72095622 0.27 ENST00000290273.5
DMRT-like family C1
chr7_+_54610086 0.27 ENST00000404951.1
V-set and transmembrane domain containing 2A
chrX_+_38420623 0.27 ENST00000378482.2
tetraspanin 7
chr6_+_37787458 0.26 ENST00000373391.2
zinc finger, AN1-type domain 3
chr17_+_7211280 0.26 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
eukaryotic translation initiation factor 5A
chr2_-_228497888 0.26 ENST00000264387.4
ENST00000409066.1
chromosome 2 open reading frame 83
chrX_-_38186811 0.26 ENST00000318842.7
retinitis pigmentosa GTPase regulator
chr19_-_52150053 0.26 ENST00000599649.1
ENST00000429354.3
ENST00000360844.6
ENST00000222107.4
SIGLEC5
sialic acid binding Ig-like lectin 14
sialic acid binding Ig-like lectin 5
chr3_-_112693865 0.26 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200 receptor 1
chr12_-_76953453 0.26 ENST00000549570.1
oxysterol binding protein-like 8
chr10_-_124768300 0.26 ENST00000368886.5
IKAROS family zinc finger 5 (Pegasus)
chr19_+_10400615 0.26 ENST00000221980.4
intercellular adhesion molecule 5, telencephalin
chr16_+_81478775 0.26 ENST00000537098.3
c-Maf inducing protein
chr1_+_207627697 0.26 ENST00000458541.2
complement component (3d/Epstein Barr virus) receptor 2
chr7_+_130794846 0.26 ENST00000421797.2
muskelin 1, intracellular mediator containing kelch motifs
chr14_-_57272366 0.26 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
orthodenticle homeobox 2
chr1_-_183622442 0.26 ENST00000308641.4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr1_+_214161854 0.26 ENST00000435016.1
prospero homeobox 1
chr15_-_40401062 0.25 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
Bcl2 modifying factor
chr12_+_71833756 0.25 ENST00000536515.1
ENST00000540815.2
leucine-rich repeat containing G protein-coupled receptor 5
chr3_+_122283064 0.25 ENST00000296161.4
deltex 3-like (Drosophila)
chr1_+_205473720 0.25 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
cyclin-dependent kinase 18
chr20_-_1373606 0.25 ENST00000381715.1
ENST00000439640.2
ENST00000381719.3
FK506 binding protein 1A, 12kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.7 1.4 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.7 5.5 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.6 3.0 GO:0032747 positive regulation of interleukin-23 production(GO:0032747) negative regulation of cytolysis(GO:0045918)
0.5 3.8 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.5 1.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.4 1.7 GO:0016598 protein arginylation(GO:0016598)
0.4 1.2 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.4 0.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.3 1.3 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.3 0.9 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.3 0.9 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.3 1.1 GO:0055099 detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
0.3 0.8 GO:0007518 myoblast fate determination(GO:0007518)
0.3 1.0 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 1.2 GO:0033590 response to cobalamin(GO:0033590)
0.2 5.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.2 2.4 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 1.4 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.2 0.7 GO:0019858 cytosine metabolic process(GO:0019858)
0.2 1.1 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
0.2 1.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 1.2 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.2 0.5 GO:0045404 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.2 0.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.4 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.1 4.9 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 1.5 GO:0022417 protein maturation by protein folding(GO:0022417)
0.1 1.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.5 GO:0051541 elastin metabolic process(GO:0051541)
0.1 1.3 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.5 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.1 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.1 0.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 1.6 GO:0051601 exocyst localization(GO:0051601)
0.1 0.4 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.3 GO:0070352 positive regulation of white fat cell proliferation(GO:0070352)
0.1 0.5 GO:0032252 secretory granule localization(GO:0032252)
0.1 1.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 0.3 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 1.0 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 5.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.2 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.2 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.9 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.5 GO:1902962 positive regulation of beta-amyloid clearance(GO:1900223) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.3 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
0.1 0.3 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.1 0.2 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.3 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1 0.7 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.5 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.5 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 0.3 GO:0003164 His-Purkinje system development(GO:0003164)
0.1 0.2 GO:0021763 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.1 0.3 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.1 0.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.2 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.4 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.3 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.1 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.4 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.8 GO:0008228 opsonization(GO:0008228)
0.0 0.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 2.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 1.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.3 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.5 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.2 GO:0051142 positive regulation of activation of Janus kinase activity(GO:0010536) regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.8 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.1 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 0.3 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.9 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.2 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.0 0.4 GO:0030091 protein repair(GO:0030091)
0.0 0.3 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.1 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
0.0 0.2 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.1 GO:0031081 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.3 GO:1902570 protein localization to nucleolus(GO:1902570)
0.0 0.8 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.1 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.8 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.5 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.1 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.3 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 1.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.1 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 1.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:0036518 chemorepulsion of dopaminergic neuron axon(GO:0036518)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0006579 amino-acid betaine catabolic process(GO:0006579) carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.2 GO:0015824 proline transport(GO:0015824)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:1902534 single-organism membrane invagination(GO:1902534)
0.0 0.3 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 0.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.3 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.1 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.2 GO:0002643 regulation of tolerance induction(GO:0002643)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.0 GO:0010193 response to ozone(GO:0010193)
0.0 0.5 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 0.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.4 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.6 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.5 2.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 1.5 GO:1990425 ryanodine receptor complex(GO:1990425)
0.3 0.9 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.3 0.8 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.3 7.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 0.7 GO:0014802 terminal cisterna(GO:0014802)
0.2 0.5 GO:0032173 septin ring(GO:0005940) septin collar(GO:0032173)
0.2 1.2 GO:0043196 varicosity(GO:0043196)
0.1 0.4 GO:0042565 RNA nuclear export complex(GO:0042565)
0.1 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.0 GO:0042587 glycogen granule(GO:0042587)
0.1 0.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.9 GO:0071953 elastic fiber(GO:0071953)
0.1 1.1 GO:0070187 telosome(GO:0070187)
0.1 0.5 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.8 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 1.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.5 GO:0032433 filopodium tip(GO:0032433)
0.1 0.2 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.1 0.8 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 1.9 GO:0000145 exocyst(GO:0000145)
0.0 6.0 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:0097447 dendritic tree(GO:0097447)
0.0 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 3.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.5 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 2.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0004057 arginyltransferase activity(GO:0004057)
0.4 1.2 GO:0002113 interleukin-33 binding(GO:0002113)
0.4 1.1 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.3 5.2 GO:0033691 sialic acid binding(GO:0033691)
0.3 4.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 7.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.3 1.0 GO:0097363 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.2 0.9 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.2 3.9 GO:0048185 activin binding(GO:0048185)
0.2 0.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 0.8 GO:0051765 inositol tetrakisphosphate kinase activity(GO:0051765)
0.2 1.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 1.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 1.2 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.4 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.1 0.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 5.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.4 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 0.5 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.6 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.3 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.1 1.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.5 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 4.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 4.6 GO:0050699 WW domain binding(GO:0050699)
0.1 1.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.3 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.1 0.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 1.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.5 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.3 GO:0097643 amylin receptor activity(GO:0097643)
0.0 1.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 2.3 GO:0030371 translation repressor activity(GO:0030371)
0.0 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.5 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 1.4 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.2 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 1.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 2.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.2 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0003955 NAD(P)H dehydrogenase (quinone) activity(GO:0003955)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 3.1 GO:0008083 growth factor activity(GO:0008083)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0001848 complement binding(GO:0001848)
0.0 0.2 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.0 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 5.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 7.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.9 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.8 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.9 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.8 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 5.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling
0.0 0.5 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.2 ST GAQ PATHWAY G alpha q Pathway
0.0 0.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.8 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 5.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.2 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.1 1.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.8 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 2.1 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.0 0.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.0 1.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.0 1.2 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.1 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains