Motif ID: AACACUG

Z-value: 0.991


Mature miRNA associated with seed AACACUG:

NamemiRBase Accession
hsa-miR-141 MIMAT0000432
hsa-miR-200a MIMAT0000682



Activity profile for motif AACACUG.

activity profile for motif AACACUG


Sorted Z-values histogram for motif AACACUG

Sorted Z-values for motif AACACUG



Network of associatons between targets according to the STRING database.



First level regulatory network of AACACUG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_35696359 1.338 NM_001145775
FKBP5
FK506 binding protein 5
chr6_-_35656677 1.161 NM_001145776
NM_001145777
NM_004117
FKBP5


FK506 binding protein 5


chrX_+_37892786 1.045 NM_001163334
SYTL5
synaptotagmin-like 5
chrX_+_37865834 1.042 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chr9_-_124984018 0.862 NM_001242335
LHX6
LIM homeobox 6
chr17_+_38171613 0.808 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr9_-_124990706 0.804 NM_001242333
LHX6
LIM homeobox 6
chr12_+_4382882 0.791 NM_001759
CCND2
cyclin D2
chr3_-_195808958 0.779 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr2_-_113542970 0.765 NM_000575
IL1A
interleukin 1, alpha
chr9_-_124990949 0.752 NM_014368
NM_199160
LHX6

LIM homeobox 6

chr3_-_195808997 0.698 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr7_-_111846384 0.698 NM_014705
DOCK4
dedicator of cytokinesis 4
chr11_-_87908551 0.693 NM_022337
RAB38
RAB38, member RAS oncogene family
chr5_-_43313581 0.676 NM_001098272
NM_002130
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr9_-_124989755 0.648 NM_001242334
LHX6
LIM homeobox 6
chr10_+_102106771 0.608 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr2_-_72374919 0.590 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr10_+_11865310 0.562 NM_153256
C10orf47
chromosome 10 open reading frame 47
chr1_+_84630575 0.558 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr8_-_95907423 0.534 NM_057749
CCNE2
cyclin E2
chr22_-_38714088 0.524 NM_001894
CSNK1E
casein kinase 1, epsilon
chr13_+_98605928 0.519 NM_002271
IPO5
importin 5
chr17_-_29151724 0.512 NM_015986
CRLF3
cytokine receptor-like factor 3
chr2_+_102314162 0.505 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr22_-_38713384 0.482 NM_152221
CSNK1E
casein kinase 1, epsilon
chr12_-_54653369 0.481 NM_001127321
CBX5
chromobox homolog 5
chr1_-_6418966 0.475 NM_181866
ACOT7
acyl-CoA thioesterase 7
chr17_-_42907606 0.472 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr2_+_191745546 0.464 NM_014905
GLS
glutaminase
chr1_-_6420719 0.463 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr1_+_218458628 0.462 NM_016052
RRP15
ribosomal RNA processing 15 homolog (S. cerevisiae)
chr2_+_178257371 0.456 NM_003659
AGPS
alkylglycerone phosphate synthase
chr1_+_84630014 0.448 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr17_-_42908178 0.445 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr1_-_6445737 0.442 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr11_+_119076974 0.442 NM_005188
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr1_-_179198814 0.435 NM_001136001
NM_001168236
NM_001168237
NM_001168238
NM_007314
ABL2




v-abl Abelson murine leukemia viral oncogene homolog 2




chr3_-_33700932 0.431 NM_001207044
CLASP2
cytoplasmic linker associated protein 2
chr2_-_65593866 0.429 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr6_+_20402040 0.428 NM_001949
E2F3
E2F transcription factor 3
chr1_-_85514174 0.427 NM_001253693
NM_018298
MCOLN3

mucolipin 3

chr2_-_65659634 0.423 NM_181784
SPRED2
sprouty-related, EVH1 domain containing 2
chr1_-_6453773 0.421 NM_007274
ACOT7
acyl-CoA thioesterase 7
chr4_-_41216455 0.415 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr1_-_150207025 0.412 NM_001136479
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr18_-_13726582 0.412 NM_001098801
NM_152352
FAM210A

family with sequence similarity 210, member A

chr12_-_54653317 0.412 NM_001127322
CBX5
chromobox homolog 5
chr1_+_84609941 0.411 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_84647342 0.410 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_44173217 0.407 NM_006279
NM_174963
NM_174964
NM_174965
NM_174966
NM_174967
NM_174968
NM_174969
NM_174970
NM_174971
ST3GAL3









ST3 beta-galactoside alpha-2,3-sialyltransferase 3









chr9_+_32384560 0.392 NM_002197
ACO1
aconitase 1, soluble
chr1_-_67520028 0.385 NM_015139
SLC35D1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr4_-_40859081 0.383 NM_001166051
NM_001166052
NM_001166053
NM_001166054
APBB2



amyloid beta (A4) precursor protein-binding, family B, member 2



chr12_-_42631982 0.381 NM_001190977
YAF2
YY1 associated factor 2
chr1_+_184356128 0.378 NM_030806
C1orf21
chromosome 1 open reading frame 21
chrX_-_107681555 0.371 NM_033641
COL4A6
collagen, type IV, alpha 6
chr1_+_150480486 0.368 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr2_+_179184970 0.367 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr4_+_144257982 0.367 NM_002039
NM_207123
GAB1

GRB2-associated binding protein 1

chr11_-_115375065 0.366 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chrX_-_107682600 0.364 NM_001847
COL4A6
collagen, type IV, alpha 6
chr22_+_46546498 0.361 NM_001001928
NM_005036
PPARA

peroxisome proliferator-activated receptor alpha

chr8_-_110342107 0.361 NM_001128211
NUDCD1
NudC domain containing 1
chr14_-_57735614 0.359 NM_006544
EXOC5
exocyst complex component 5
chr16_-_20911560 0.358 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr12_-_76425375 0.355 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr18_+_19749403 0.352 NM_005257
GATA6
GATA binding protein 6
chr2_+_179059071 0.350 NM_001201480
NM_001201481
NM_001201482
NM_032523
OSBPL6



oxysterol binding protein-like 6



chr4_+_1902352 0.348 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr7_+_107221203 0.347 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chr17_-_63052884 0.346 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr12_-_25102281 0.345 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr17_-_8534008 0.344 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr10_-_81205091 0.342 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr12_-_16759531 0.342 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_-_30881141 0.339 NM_001014380
KATNAL1
katanin p60 subunit A-like 1
chr1_+_178694273 0.338 NM_152663
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr1_-_173962050 0.335 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr1_-_76076762 0.330 NM_001130058
NM_152697
SLC44A5

solute carrier family 44, member 5

chr9_+_5450455 0.329 NM_014143
CD274
CD274 molecule
chr1_-_150208462 0.329 NM_001136478
NM_030920
ANP32E

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr13_-_30881556 0.328 NM_032116
KATNAL1
katanin p60 subunit A-like 1
chr12_-_25055966 0.327 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr3_-_48229800 0.324 NM_001789
NM_201567
CDC25A

cell division cycle 25 homolog A (S. pombe)

chr20_+_35974458 0.323 NM_198291
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr12_-_25055228 0.322 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_89746244 0.318 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr10_+_101419169 0.312 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr16_+_50321822 0.307 NM_001114
ADCY7
adenylate cyclase 7
chr1_-_179112178 0.302 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr4_-_68566847 0.299 NM_018227
UBA6
ubiquitin-like modifier activating enzyme 6
chr1_+_95582827 0.299 NM_152487
TMEM56
transmembrane protein 56
chr10_+_129705299 0.298 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr10_+_119000583 0.295 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chr11_-_2170792 0.294 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr10_+_129845806 0.292 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr12_-_46663207 0.291 NM_001077484
NM_030674
SLC38A1

solute carrier family 38, member 1

chr10_+_76871345 0.288 NM_001174156
NM_144660
SAMD8

sterile alpha motif domain containing 8

chr1_+_28585959 0.287 NM_031459
SESN2
sestrin 2
chr17_+_57232859 0.282 NM_018304
PRR11
proline rich 11
chr11_-_2162340 0.280 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr8_-_110346272 0.279 NM_032869
NUDCD1
NudC domain containing 1
chr7_+_129007942 0.272 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_93811476 0.270 NM_001938
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr2_+_26568900 0.269 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr11_+_122526339 0.269 NM_032873
UBASH3B
ubiquitin associated and SH3 domain containing B
chr9_+_116638544 0.268 NM_133374
ZNF618
zinc finger protein 618
chr10_-_14372807 0.267 NM_018027
FRMD4A
FERM domain containing 4A
chr4_-_74864296 0.267 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr4_-_57547845 0.266 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr22_-_28197469 0.265 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr4_-_57522469 0.264 NM_001145459
NM_139211
HOPX

HOP homeobox

chr7_+_129015483 0.263 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr9_+_106856810 0.257 NM_001042550
SMC2
structural maintenance of chromosomes 2
chr1_+_95558072 0.257 NM_001199679
TMEM56
transmembrane protein 56
chr9_+_131644780 0.255 NM_001127244
LRRC8A
leucine rich repeat containing 8 family, member A
chr2_+_173292306 0.254 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr10_-_29923900 0.254 NM_021738
SVIL
supervillin
chr3_-_113465101 0.253 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_-_131850988 0.251 NM_001009993
FAM168B
family with sequence similarity 168, member B
chr11_-_2160199 0.250 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_24536176 0.248 NM_000461
NM_001128176
NM_001128177
NM_001252634
THRB



thyroid hormone receptor, beta



chr18_+_19321544 0.247 NM_020774
MIB1
mindbomb homolog 1 (Drosophila)
chr3_+_151985828 0.246 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr2_+_64681270 0.245 NM_014181
LGALSL
lectin, galactoside-binding-like
chr10_-_30024594 0.244 NM_003174
SVIL
supervillin
chr9_+_106856531 0.243 NM_001042551
NM_006444
SMC2

structural maintenance of chromosomes 2

chr3_-_45017600 0.239 NM_001135179
NM_016598
ZDHHC3

zinc finger, DHHC-type containing 3

chr4_+_156680125 0.239 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr6_-_18264638 0.237 NM_001134709
NM_003472
DEK

DEK oncogene

chr20_-_22566092 0.237 NM_153675
FOXA2
forkhead box A2
chr17_+_70117154 0.236 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr3_-_59035700 0.232 NM_198463
C3orf67
chromosome 3 open reading frame 67
chr2_+_10262694 0.229 NM_001165931
RRM2
ribonucleotide reductase M2
chrX_+_16804531 0.227 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr11_-_107729913 0.226 NM_017515
SLC35F2
solute carrier family 35, member F2
chr13_+_39261172 0.226 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr10_+_115614384 0.226 NM_198514
NHLRC2
NHL repeat containing 2
chr9_-_27529434 0.225 NM_024761
MOB3B
MOB kinase activator 3B
chr12_-_109125289 0.225 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr9_+_131644368 0.224 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr3_+_152017193 0.223 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr2_+_10262853 0.223 NM_001034
RRM2
ribonucleotide reductase M2
chr2_-_230933618 0.223 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr7_+_128864740 0.221 NM_001130720
NM_015328
AHCYL2

adenosylhomocysteinase-like 2

chr20_-_22565050 0.219 NM_021784
FOXA2
forkhead box A2
chr1_-_85358851 0.216 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr15_-_52821004 0.216 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr1_-_225616556 0.215 NM_194442
LBR
lamin B receptor
chr1_+_36621751 0.215 NM_018067
MAP7D1
MAP7 domain containing 1
chr6_+_64281910 0.214 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_+_27008881 0.214 NM_001809
NM_001042426
CENPA

centromere protein A

chr20_+_35973083 0.211 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr9_+_112887780 0.210 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr3_+_5021096 0.210 NM_003670
BHLHE40
basic helix-loop-helix family, member e40
chrX_-_72434667 0.209 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr4_+_146019155 0.208 NM_001040876
NM_002940
ABCE1

ATP-binding cassette, sub-family E (OABP), member 1

chr20_+_43104513 0.208 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr20_+_3776385 0.206 NM_004358
NM_021872
NM_021873
CDC25B


cell division cycle 25 homolog B (S. pombe)


chr7_-_28220342 0.206 NM_175061
JAZF1
JAZF zinc finger 1
chr3_+_158991035 0.205 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr3_-_125314367 0.201 NM_022776
OSBPL11
oxysterol binding protein-like 11
chr12_-_16760935 0.198 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr12_+_13349601 0.198 NM_001423
EMP1
epithelial membrane protein 1
chr5_-_141704575 0.197 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr20_-_30795346 0.196 NM_002657
PLAGL2
pleiomorphic adenoma gene-like 2
chr5_+_156887026 0.195 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr9_+_112810877 0.195 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr16_-_85784628 0.193 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr9_-_8733893 0.193 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr17_-_73401788 0.193 NM_002086
NM_203506
GRB2

growth factor receptor-bound protein 2

chr6_+_163835668 0.193 NM_006775
NM_206853
NM_206854
NM_206855
QKI



QKI, KH domain containing, RNA binding



chr21_-_32931289 0.192 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chrX_+_21857655 0.191 NM_015884
MBTPS2
membrane-bound transcription factor peptidase, site 2
chr12_+_60083125 0.190 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr1_+_38158129 0.188 NM_018101
CDCA8
cell division cycle associated 8
chr3_-_33759684 0.188 NM_015097
CLASP2
cytoplasmic linker associated protein 2
chr4_+_75230856 0.188 NM_001432
EREG
epiregulin
chr14_+_55518313 0.188 NM_144578
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr17_-_41856180 0.186 NM_004090
DUSP3
dual specificity phosphatase 3
chr17_+_16945766 0.186 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr12_-_52585686 0.186 NM_001081492
NM_182507
KRT80

keratin 80

chr16_+_70147528 0.184 NM_017990
PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr8_+_55370494 0.183 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr7_+_18548899 0.182 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr3_+_159557649 0.182 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr7_+_18126543 0.181 NM_001204144
HDAC9
histone deacetylase 9
chr12_-_42632150 0.181 NM_001190979
NM_001190980
NM_005748
YAF2


YY1 associated factor 2


chr4_-_71705188 0.180 NM_001098477
GRSF1
G-rich RNA sequence binding factor 1
chr6_+_11094265 0.179 NM_001135575
C6orf228
chromosome 6 open reading frame 228
chr3_+_133293256 0.178 NM_001134423
CDV3
CDV3 homolog (mouse)
chr17_+_36584692 0.177 NM_001199417
ARHGAP23
Rho GTPase activating protein 23
chr8_+_25316512 0.177 NM_152562
CDCA2
cell division cycle associated 2
chr12_+_50898744 0.176 NM_173602
DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr18_+_56338617 0.175 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr15_-_91537724 0.175 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chr14_+_54863672 0.174 NM_001130851
NM_005192
CDKN3

cyclin-dependent kinase inhibitor 3

chr6_+_72596648 0.174 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_42801529 0.173 NM_001198850
FOXJ3
forkhead box J3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 4.98e-05 GO:0009987 cellular process
1.50 1.24e-03 GO:0051641 cellular localization
1.26 3.14e-03 GO:0051179 localization
1.52 7.83e-03 GO:0032268 regulation of cellular protein metabolic process
1.28 9.01e-03 GO:0051234 establishment of localization
5.28 1.57e-02 GO:0071478 cellular response to radiation
1.27 1.85e-02 GO:0006810 transport
1.57 2.15e-02 GO:0046907 intracellular transport
1.47 2.19e-02 GO:0051246 regulation of protein metabolic process
1.71 2.44e-02 GO:0034613 cellular protein localization
1.70 3.04e-02 GO:0070727 cellular macromolecule localization
1.45 4.39e-02 GO:0051649 establishment of localization in cell

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 2.01e-07 GO:0005622 intracellular
1.17 2.63e-07 GO:0005737 cytoplasm
1.12 3.35e-07 GO:0044424 intracellular part
1.14 6.82e-05 GO:0043227 membrane-bounded organelle
1.14 7.27e-05 GO:0043231 intracellular membrane-bounded organelle
1.12 2.98e-04 GO:0043229 intracellular organelle
1.12 3.30e-04 GO:0043226 organelle
1.28 6.97e-04 GO:0043234 protein complex
1.39 2.06e-03 GO:0012505 endomembrane system
1.16 5.38e-03 GO:0044444 cytoplasmic part
1.27 4.20e-02 GO:0031090 organelle membrane
1.04 4.84e-02 GO:0044464 cell part
1.04 4.97e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.21 3.37e-08 GO:0005515 protein binding
1.09 1.76e-03 GO:0005488 binding
1.98 1.38e-02 GO:0016791 phosphatase activity
1.28 2.19e-02 GO:0000166 nucleotide binding