Motif ID: AGCUGCC

Z-value: 0.548


Mature miRNA associated with seed AGCUGCC:

NamemiRBase Accession
hsa-miR-22 MIMAT0000077



Activity profile for motif AGCUGCC.

activity profile for motif AGCUGCC


Sorted Z-values histogram for motif AGCUGCC

Sorted Z-values for motif AGCUGCC



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCUGCC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_17354562 0.968 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr9_+_36136710 0.933 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr15_-_45670955 0.840 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr8_+_17396285 0.785 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr6_-_43478423 0.756 NM_001012974
LRRC73
leucine rich repeat containing 73
chrX_-_112066353 0.737 NM_001113490
AMOT
angiomotin
chr2_+_121103670 0.604 NM_002193
INHBB
inhibin, beta B
chr13_+_43355685 0.582 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr16_+_57406398 0.558 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr10_-_99094427 0.556 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr6_+_24495166 0.508 NM_001080
NM_170740
ALDH5A1

aldehyde dehydrogenase 5 family, member A1

chr20_+_37434294 0.484 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr5_-_159739482 0.471 NM_024565
CCNJL
cyclin J-like
chr7_-_131241321 0.470 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr16_-_75590107 0.448 NM_001077416
NM_001077418
NM_001077419
TMEM231


transmembrane protein 231


chr2_-_99552677 0.443 NM_207362
C2orf55
chromosome 2 open reading frame 55
chrX_-_112084006 0.435 NM_133265
AMOT
angiomotin
chr5_+_149109814 0.435 NM_001172698
NM_133263
PPARGC1B

peroxisome proliferator-activated receptor gamma, coactivator 1 beta

chr2_-_240322620 0.426 NM_006037
HDAC4
histone deacetylase 4
chr2_-_213403280 0.423 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr14_-_23285011 0.416 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_+_149151502 0.404 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr2_-_71454200 0.402 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr11_-_75062650 0.401 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr22_-_39268230 0.396 NM_014292
CBX6
chromobox homolog 6
chr12_+_6930689 0.377 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr14_-_23288912 0.357 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_204329043 0.352 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr17_+_40439564 0.344 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chrX_-_54070606 0.323 NM_001184897
NM_015107
PHF8

PHD finger protein 8

chr14_-_90085325 0.320 NM_001085471
FOXN3
forkhead box N3
chr19_+_18118921 0.317 NM_015683
ARRDC2
arrestin domain containing 2
chr14_-_89883306 0.311 NM_005197
FOXN3
forkhead box N3
chr2_-_219432955 0.300 NM_020935
USP37
ubiquitin specific peptidase 37
chr19_+_18111923 0.299 NM_001025604
ARRDC2
arrestin domain containing 2
chr18_-_74729049 0.298 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr14_-_67982020 0.297 NM_182526
TMEM229B
transmembrane protein 229B
chr7_+_138482696 0.295 NM_001085429
TMEM213
transmembrane protein 213
chr3_-_135914654 0.293 NM_018133
MSL2
male-specific lethal 2 homolog (Drosophila)
chr11_-_57479510 0.288 NM_153450
MED19
mediator complex subunit 19
chr5_-_100238870 0.287 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chrX_-_108868250 0.282 NM_012282
KCNE1L
KCNE1-like
chr13_+_100258886 0.280 NM_206808
CLYBL
citrate lyase beta like
chr5_+_139927182 0.279 NM_003732
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr16_+_67282774 0.279 NM_004594
SLC9A5
solute carrier family 9 (sodium/hydrogen exchanger), member 5
chr15_-_37392358 0.277 NM_170674
NM_170675
NM_170676
NM_170677
MEIS2



Meis homeobox 2



chr8_+_103563847 0.275 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr2_+_115919512 0.273 NM_001178034
NM_001004360
DPP10

dipeptidyl-peptidase 10 (non-functional)

chr10_+_69644938 0.272 NM_001142498
SIRT1
sirtuin 1
chr17_+_73780842 0.265 NM_001080419
UNK
unkempt homolog (Drosophila)
chr3_+_160473995 0.264 NM_139245
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr1_-_212873306 0.261 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr1_+_27561006 0.261 NM_015023
WDTC1
WD and tetratricopeptide repeats 1
chr11_+_118978087 0.259 NM_014807
C2CD2L
C2CD2-like
chr10_+_69644341 0.259 NM_012238
SIRT1
sirtuin 1
chr12_+_49372235 0.252 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr15_-_37393364 0.249 NM_001220482
NM_002399
MEIS2

Meis homeobox 2

chr1_+_52870214 0.244 NM_032864
PRPF38A
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr15_-_37391596 0.240 NM_172316
MEIS2
Meis homeobox 2
chr2_+_115219153 0.235 NM_001178036
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr1_-_213189087 0.235 NM_144567
ANGEL2
angel homolog 2 (Drosophila)
chr12_+_56414688 0.234 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr15_-_37390372 0.233 NM_172315
MEIS2
Meis homeobox 2
chr6_-_152957985 0.233 NM_033071
SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_-_152958533 0.229 NM_182961
SYNE1
spectrin repeat containing, nuclear envelope 1
chr16_+_24266873 0.228 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr12_+_93771607 0.223 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr11_-_6502563 0.220 NM_001242854
NM_001242855
NM_001242856
NM_012402
ARFIP2



ADP-ribosylation factor interacting protein 2



chrX_-_54071568 0.220 NM_001184896
PHF8
PHD finger protein 8
chr11_+_8102691 0.219 NM_177972
TUB
tubby homolog (mouse)
chr1_-_169863048 0.219 NM_020423
NM_181093
SCYL3

SCY1-like 3 (S. cerevisiae)

chr2_+_115199898 0.210 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr17_+_40118696 0.209 NM_033133
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr1_+_26438267 0.209 NM_001243533
NM_152835
PDIK1L

PDLIM1 interacting kinase 1 like

chr3_+_185000714 0.204 NM_001242314
NM_001242317
MAP3K13

mitogen-activated protein kinase kinase kinase 13

chr20_-_31071187 0.203 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr5_-_175964223 0.201 NM_014901
RNF44
ring finger protein 44
chr2_+_115822246 0.199 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr1_-_40367539 0.198 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr16_+_28303622 0.197 NM_001024401
SBK1
SH3-binding domain kinase 1
chr21_-_34852282 0.195 NM_006134
TMEM50B
transmembrane protein 50B
chr10_+_76586299 0.193 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr7_+_94536926 0.192 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr3_-_135913276 0.188 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr12_-_53893195 0.185 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr22_+_41488607 0.183 NM_001429
EP300
E1A binding protein p300
chr11_+_65479472 0.182 NM_001206833
NM_006388
NM_182709
NM_182710
KAT5



K(lysine) acetyltransferase 5



chr5_+_56469655 0.180 NM_001203246
NM_022913
GPBP1

GC-rich promoter binding protein 1

chr2_+_98703594 0.179 NM_144992
VWA3B
von Willebrand factor A domain containing 3B
chr1_-_38412725 0.179 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr8_-_102217907 0.178 NM_001042510
NM_016096
ZNF706

zinc finger protein 706

chr22_+_31031672 0.177 NM_001001479
SLC35E4
solute carrier family 35, member E4
chr4_-_87374282 0.176 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr22_-_39190146 0.175 NM_005740
DNAL4
dynein, axonemal, light chain 4
chr5_+_57878901 0.175 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr15_-_83316621 0.174 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr15_-_40398286 0.172 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr9_+_129089092 0.172 NM_001011703
NM_033446
FAM125B

family with sequence similarity 125, member B

chr17_+_47865980 0.171 NM_001199155
NM_001199156
NM_001199157
NM_001199158
NM_007067
KAT7




K(lysine) acetyltransferase 7




chr22_-_39548448 0.171 NM_175709
CBX7
chromobox homolog 7
chr1_-_114354906 0.170 NM_018364
RSBN1
round spermatid basic protein 1
chr8_-_102217868 0.170 NM_001042511
ZNF706
zinc finger protein 706
chr15_-_40398573 0.170 NM_033503
BMF
Bcl2 modifying factor
chr18_+_48556483 0.170 NM_005359
SMAD4
SMAD family member 4
chr12_+_48166929 0.170 NM_017842
SLC48A1
solute carrier family 48 (heme transporter), member 1
chr3_+_185080835 0.168 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr15_-_40401041 0.168 NM_001003940
BMF
Bcl2 modifying factor
chr17_+_7761063 0.168 NM_144607
CYB5D1
cytochrome b5 domain containing 1
chr10_+_72163860 0.167 NM_004096
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr17_-_47439326 0.165 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr19_+_49468557 0.165 NM_000146
FTL
ferritin, light polypeptide
chr17_-_73775822 0.163 NM_005324
H3F3B
H3 histone, family 3B (H3.3B)
chr10_-_116418056 0.162 NM_002313
ABLIM1
actin binding LIM protein 1
chr2_-_162931051 0.160 NM_001935
DPP4
dipeptidyl-peptidase 4
chr16_-_1429612 0.159 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr10_-_116444374 0.159 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr12_-_122985471 0.157 NM_017612
ZCCHC8
zinc finger, CCHC domain containing 8
chr1_+_78956727 0.156 NM_000959
NM_001039585
PTGFR

prostaglandin F receptor (FP)

chr17_-_7590731 0.155 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr2_+_86668270 0.155 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr4_-_87028805 0.155 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr10_+_92980322 0.155 NM_032373
PCGF5
polycomb group ring finger 5
chr21_-_35831856 0.154 NM_001127668
NM_001127669
KCNE1

potassium voltage-gated channel, Isk-related family, member 1

chr3_-_169381417 0.152 NM_001205194
NM_004991
MECOM

MDS1 and EVI1 complex locus

chr22_+_39853316 0.151 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr12_-_89918531 0.151 NM_003774
GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
chr20_-_43438881 0.151 NM_001205317
NM_182970
RIMS4

regulating synaptic membrane exocytosis 4

chr7_+_90338711 0.151 NM_012395
CDK14
cyclin-dependent kinase 14
chr21_-_35883570 0.150 NM_000219
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr1_-_8931634 0.150 NM_001201483
ENO1
enolase 1, (alpha)
chr19_+_34745452 0.149 NM_014686
KIAA0355
KIAA0355
chr10_-_116286661 0.148 NM_006720
ABLIM1
actin binding LIM protein 1
chr16_-_87525317 0.148 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr12_+_56473808 0.148 NM_001982
NM_001005915
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chr22_-_30783301 0.148 NM_001017981
RNF215
ring finger protein 215
chr12_+_53574506 0.146 NM_001004304
ZNF740
zinc finger protein 740
chr12_-_6809965 0.145 NM_001244014
NM_153685
C12orf53

chromosome 12 open reading frame 53

chr5_+_36608430 0.145 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr16_+_27561441 0.144 NM_015202
KIAA0556
KIAA0556
chr20_-_3219835 0.143 NM_001174089
SLC4A11
solute carrier family 4, sodium borate transporter, member 11
chr1_-_153895450 0.142 NM_020699
GATAD2B
GATA zinc finger domain containing 2B
chr8_+_61591239 0.142 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr10_+_102295572 0.141 NM_017902
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr10_-_118031542 0.139 NM_145793
GFRA1
GDNF family receptor alpha 1
chr21_-_35828038 0.139 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr4_-_87281374 0.139 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr15_+_57668702 0.138 NM_001252335
NM_032866
CGNL1

cingulin-like 1

chr11_-_62559423 0.138 NM_001080501
TMEM223
transmembrane protein 223
chr17_+_29718641 0.138 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr11_+_93063782 0.137 NM_181645
CCDC67
coiled-coil domain containing 67
chr12_+_52301201 0.137 NM_000020
ACVRL1
activin A receptor type II-like 1
chr11_+_1411089 0.136 NM_003957
BRSK2
BR serine/threonine kinase 2
chr14_-_78083109 0.136 NM_004863
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr1_+_45965855 0.135 NM_015506
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr3_+_43328001 0.135 NM_001100594
NM_017719
SNRK

SNF related kinase

chr17_+_61699786 0.134 NM_002401
NM_203351
MAP3K3

mitogen-activated protein kinase kinase kinase 3

chr10_-_118032975 0.134 NM_005264
GFRA1
GDNF family receptor alpha 1
chrX_-_153363174 0.134 NM_001110792
NM_004992
MECP2

methyl CpG binding protein 2 (Rett syndrome)

chr3_-_168864325 0.133 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr12_-_49182718 0.133 NM_020983
ADCY6
adenylate cyclase 6
chr1_+_231298673 0.132 NM_001004342
TRIM67
tripartite motif containing 67
chr17_+_6926366 0.131 NM_181844
BCL6B
B-cell CLL/lymphoma 6, member B
chr20_-_3218834 0.131 NM_001174090
SLC4A11
solute carrier family 4, sodium borate transporter, member 11
chr10_-_7453412 0.130 NM_001029880
SFMBT2
Scm-like with four mbt domains 2
chr15_+_51633712 0.129 NM_181789
GLDN
gliomedin
chr20_-_3218345 0.129 NM_032034
SLC4A11
solute carrier family 4, sodium borate transporter, member 11
chr1_-_156051788 0.128 NM_001093725
MEX3A
mex-3 homolog A (C. elegans)
chr2_-_127864505 0.128 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr4_+_106067754 0.128 NM_001127208
TET2
tet methylcytosine dioxygenase 2
chr12_+_52345437 0.128 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr6_-_32821743 0.127 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_198650008 0.126 NM_033030
BOLL
bol, boule-like (Drosophila)
chr9_-_14314036 0.125 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr4_+_106816593 0.125 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr19_+_14142261 0.123 NM_004843
IL27RA
interleukin 27 receptor, alpha
chr22_+_39883228 0.123 NM_001098270
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr10_-_32636084 0.122 NM_025209
EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr4_-_2263706 0.121 NM_006454
MXD4
MAX dimerization protein 4
chr16_+_66400524 0.121 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr7_+_94539209 0.121 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr11_-_126870685 0.121 NM_001161707
NM_032531
KIRREL3

kin of IRRE like 3 (Drosophila)

chr9_-_14398981 0.120 NM_001190738
NFIB
nuclear factor I/B
chr22_+_41777932 0.120 NM_003216
TEF
thyrotrophic embryonic factor
chr10_-_118032717 0.120 NM_001145453
GFRA1
GDNF family receptor alpha 1
chr1_+_38261079 0.120 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr1_+_38259458 0.120 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr5_+_56509900 0.118 NM_001127236
GPBP1
GC-rich promoter binding protein 1
chr12_-_57400199 0.117 NM_014830
ZBTB39
zinc finger and BTB domain containing 39
chr12_+_52306112 0.117 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr7_-_44924946 0.117 NM_033224
PURB
purine-rich element binding protein B
chr5_+_142150291 0.117 NM_001135608
NM_015071
ARHGAP26

Rho GTPase activating protein 26

chr19_-_35264091 0.116 NM_001007248
ZNF599
zinc finger protein 599
chr1_-_17765052 0.116 NM_001136204
RCC2
regulator of chromosome condensation 2
chr12_+_107168336 0.113 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr3_+_124303505 0.113 NM_007064
KALRN
kalirin, RhoGEF kinase
chr1_-_25256767 0.112 NM_004350
RUNX3
runt-related transcription factor 3
chr12_-_108733075 0.112 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr3_-_168865521 0.112 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr17_-_47841517 0.111 NM_030802
FAM117A
family with sequence similarity 117, member A
chr1_-_39338976 0.111 NM_012333
MYCBP
c-myc binding protein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.83 4.35e-04 GO:0006464 protein modification process
1.74 3.15e-03 GO:0043412 macromolecule modification
2.95 3.91e-03 GO:0016568 chromatin modification
3.69 2.28e-02 GO:0016570 histone modification
3.62 2.82e-02 GO:0016569 covalent chromatin modification
2.50 2.89e-02 GO:0006325 chromatin organization
2.01 3.47e-02 GO:0010605 negative regulation of macromolecule metabolic process
4.59 4.18e-02 GO:0021700 developmental maturation
4.98 4.76e-02 GO:0030879 mammary gland development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.09 2.21e-05 GO:0045202 synapse
1.30 1.17e-02 GO:0005634 nucleus
2.73 2.07e-02 GO:0044456 synapse part

Gene overrepresentation in function category:

enrichment   p-value GO term description
11.26 3.48e-03 GO:0045182 translation regulator activity
20.65 7.27e-03 GO:0030371 translation repressor activity
2.89 8.03e-03 GO:0008134 transcription factor binding
30.97 1.82e-02 GO:0000900 translation repressor activity, nucleic acid binding
2.13 3.00e-02 GO:0004672 protein kinase activity
2.37 3.23e-02 GO:0004674 protein serine/threonine kinase activity
15.02 3.23e-02 GO:0090079 translation regulator activity, nucleic acid binding