Motif ID: AGUGGUU

Z-value: 1.247


Mature miRNA associated with seed AGUGGUU:

NamemiRBase Accession
hsa-miR-140-5p MIMAT0000431



Activity profile for motif AGUGGUU.

activity profile for motif AGUGGUU


Sorted Z-values histogram for motif AGUGGUU

Sorted Z-values for motif AGUGGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGUGGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_61584451 4.247 NM_013402
FADS1
fatty acid desaturase 1
chr6_-_131291480 3.604 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr9_+_131182690 3.408 NM_016174
CERCAM
cerebral endothelial cell adhesion molecule
chr12_-_25102281 3.282 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr6_-_131384387 3.277 NM_001135554
NM_001135555
NM_001199388
NM_001431
EPB41L2



erythrocyte membrane protein band 4.1-like 2



chr14_+_85996454 3.217 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_-_25055966 3.133 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_25055228 3.075 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr15_+_81071708 3.045 NM_018689
KIAA1199
KIAA1199
chr8_+_26371461 3.031 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr2_+_10262694 2.740 NM_001165931
RRM2
ribonucleotide reductase M2
chr2_+_10262853 2.513 NM_001034
RRM2
ribonucleotide reductase M2
chr19_+_11200037 2.486 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr8_+_26435339 2.455 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr16_+_50321822 2.289 NM_001114
ADCY7
adenylate cyclase 7
chr20_+_6748744 2.242 NM_001200
BMP2
bone morphogenetic protein 2
chr5_+_38845962 2.238 NM_003999
OSMR
oncostatin M receptor
chr14_+_65171149 2.229 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr9_-_107690526 2.166 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr6_+_80714321 2.092 NM_001166691
NM_003318
TTK

TTK protein kinase

chr9_+_112887780 2.090 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr10_-_3827418 2.074 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr1_-_109825767 2.061 NM_001005290
NM_001032291
NM_032636
PSRC1


proline/serine-rich coiled-coil 1


chr5_-_77944341 2.023 NM_005779
LHFPL2
lipoma HMGIC fusion partner-like 2
chr7_-_98741681 1.944 NM_001199847
NM_020429
NM_181349
SMURF1


SMAD specific E3 ubiquitin protein ligase 1


chr1_+_178694273 1.927 NM_152663
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr9_+_112810877 1.827 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr3_-_172428773 1.813 NM_001146276
NM_001146277
NM_001146278
NM_020792
NCEH1



neutral cholesterol ester hydrolase 1



chr1_+_182992329 1.812 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr10_+_102106771 1.801 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr2_+_48541767 1.796 NM_002158
FOXN2
forkhead box N2
chr3_+_150126705 1.614 NM_014779
TSC22D2
TSC22 domain family, member 2
chr1_-_168105620 1.592 NM_153832
GPR161
G protein-coupled receptor 161
chr19_+_54926604 1.588 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr19_-_2096263 1.570 NM_130807
MOB3A
MOB kinase activator 3A
chr6_+_43737937 1.535 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr9_-_99801924 1.521 NM_001201575
CTSL2
cathepsin L2
chr5_-_172756505 1.506 NM_003714
STC2
stanniocalcin 2
chr5_-_127873734 1.422 NM_001999
FBN2
fibrillin 2
chr17_+_61086897 1.412 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr9_-_99801365 1.401 NM_001333
CTSL2
cathepsin L2
chr5_-_136834887 1.391 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr2_+_208576239 1.373 NM_001142300
NM_152523
CCNYL1

cyclin Y-like 1

chr5_+_149887673 1.358 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr1_-_117210301 1.350 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr17_+_57232859 1.349 NM_018304
PRR11
proline rich 11
chr2_-_172291227 1.322 NM_024770
METTL8
methyltransferase like 8
chr19_-_49496566 1.276 NM_001161587
NM_002103
GYS1

glycogen synthase 1 (muscle)

chr15_+_38544966 1.272 NM_152594
SPRED1
sprouty-related, EVH1 domain containing 1
chr10_+_11206928 1.250 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr7_+_2671582 1.248 NM_025250
TTYH3
tweety homolog 3 (Drosophila)
chr6_+_106534188 1.235 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr9_+_112542496 1.232 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr6_-_108395939 1.229 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr5_+_126112314 1.215 NM_005573
LMNB1
lamin B1
chr5_+_126112819 1.205 NM_001198557
LMNB1
lamin B1
chr16_+_2479387 1.204 NM_001761
CCNF
cyclin F
chr21_-_16437125 1.193 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr10_+_11047253 1.159 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr5_-_141704575 1.152 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr21_-_15755439 1.146 NM_006948
HSPA13
heat shock protein 70kDa family, member 13
chr10_-_99052429 1.128 NM_001204300
NM_032900
ARHGAP19

Rho GTPase activating protein 19

chr1_+_11994710 1.124 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr7_-_100860991 1.120 NM_001084
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr14_+_37126772 1.099 NM_006194
PAX9
paired box 9
chr17_-_33390676 1.099 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr6_-_88411984 1.091 NM_018064
AKIRIN2
akirin 2
chr1_-_43424834 1.091 NM_006516
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr20_-_48729664 1.065 NM_001032288
UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr3_-_124774735 1.052 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr2_+_202316391 1.046 NM_001206864
NM_018571
STRADB

STE20-related kinase adaptor beta

chr10_+_11059854 1.035 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr5_-_16936371 1.024 NM_012334
MYO10
myosin X
chr3_+_135741576 1.016 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr1_-_20812727 1.016 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_51522953 1.013 NM_145888
KLK10
kallikrein-related peptidase 10
chr10_-_90611675 0.999 NM_144590
ANKRD22
ankyrin repeat domain 22
chr20_-_10654429 0.978 NM_000214
JAG1
jagged 1
chr12_-_27167332 0.974 NM_016551
TM7SF3
transmembrane 7 superfamily member 3
chr3_-_195808958 0.954 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr21_+_30671736 0.944 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr6_+_106546736 0.933 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr9_+_132815984 0.928 NM_001136557
NM_001136558
NM_020960
GPR107


G protein-coupled receptor 107


chr4_+_55095263 0.924 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr15_+_90544608 0.920 NM_198526
ZNF710
zinc finger protein 710
chr15_-_59041933 0.913 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chr22_-_36784055 0.907 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr20_-_48732479 0.883 NM_022442
NM_021988
NM_199144
UBE2V1


ubiquitin-conjugating enzyme E2 variant 1


chr3_-_195808997 0.880 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr5_+_72251753 0.875 NM_001146032
NM_138782
FCHO2

FCH domain only 2

chr14_-_100070442 0.873 NM_001144995
CCDC85C
coiled-coil domain containing 85C
chr7_-_42276617 0.867 NM_000168
GLI3
GLI family zinc finger 3
chr9_-_22009270 0.865 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr12_-_80307690 0.859 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr2_-_9771101 0.858 NM_006826
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr8_+_70405027 0.852 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr20_-_46415277 0.827 NM_001161841
NM_198596
SULF2

sulfatase 2

chr1_+_82266081 0.826 NM_012302
LPHN2
latrophilin 2
chr19_-_51523272 0.820 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr9_+_5629110 0.814 NM_001135920
NM_001206557
NM_020829
KIAA1432


KIAA1432


chr1_-_29450406 0.808 NM_001003682
TMEM200B
transmembrane protein 200B
chr1_-_68299047 0.803 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr12_+_41086189 0.803 NM_001843
NM_175038
CNTN1

contactin 1

chr6_-_35656677 0.796 NM_001145776
NM_001145777
NM_004117
FKBP5


FK506 binding protein 5


chr20_-_46414636 0.788 NM_018837
SULF2
sulfatase 2
chr2_-_37193609 0.779 NM_003162
STRN
striatin, calmodulin binding protein
chr17_-_53499055 0.775 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr11_-_46939908 0.772 NM_002334
LRP4
low density lipoprotein receptor-related protein 4
chr22_-_50913270 0.767 NM_002972
SBF1
SET binding factor 1
chr9_-_73029539 0.740 NM_001206
KLF9
Kruppel-like factor 9
chr19_-_41196419 0.732 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr7_+_39663140 0.723 NM_005402
RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr6_-_53213747 0.719 NM_001242828
NM_001242830
NM_001242831
NM_021814
ELOVL5



ELOVL fatty acid elongase 5



chr17_-_63052884 0.718 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr12_-_80329234 0.702 NM_001143885
NM_001244990
PPP1R12A

protein phosphatase 1, regulatory subunit 12A

chr6_-_110501164 0.701 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chrX_+_37208527 0.693 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr5_+_32710742 0.686 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr1_-_29449012 0.684 NM_001171868
TMEM200B
transmembrane protein 200B
chr1_+_15736387 0.678 NM_024329
EFHD2
EF-hand domain family, member D2
chr7_-_121784236 0.654 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr21_+_30671217 0.653 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr15_-_30114536 0.653 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr4_+_155665150 0.645 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr12_-_80328926 0.641 NM_002480
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr5_-_39219578 0.632 NM_001465
NM_199335
FYB

FYN binding protein

chr17_-_35766762 0.624 NM_198834
NM_198839
ACACA

acetyl-CoA carboxylase alpha

chr12_-_12715244 0.606 NM_030640
DUSP16
dual specificity phosphatase 16
chr5_+_89770680 0.596 NM_006467
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr1_+_53192021 0.585 NM_024646
ZYG11B
zyg-11 homolog B (C. elegans)
chr17_-_35656691 0.583 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr18_-_24442534 0.568 NM_004028
AQP4
aquaporin 4
chrX_-_72299224 0.568 NM_001012977
PABPC1L2A
PABPC1L2B
poly(A) binding protein, cytoplasmic 1-like 2A
poly(A) binding protein, cytoplasmic 1-like 2B
chr12_-_49177876 0.566 NM_015270
ADCY6
adenylate cyclase 6
chr8_+_70378858 0.564 NM_001128204
NM_015170
SULF1

sulfatase 1

chrX_+_72223351 0.558 NM_001042506
PABPC1L2B
poly(A) binding protein, cytoplasmic 1-like 2B
chr9_-_115095933 0.549 NM_001163788
NM_001163790
NM_001244896
NM_001244897
NM_005156
PTBP3




polypyrimidine tract binding protein 3




chr12_+_113659216 0.546 NM_001143819
NM_017901
TPCN1

two pore segment channel 1

chr7_-_32931409 0.545 NM_015483
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr13_-_25745778 0.543 NM_152704
NM_199138
FAM123A

family with sequence similarity 123A

chr12_-_117747214 0.541 NM_001204214
NOS1
nitric oxide synthase 1 (neuronal)
chr1_+_10270680 0.538 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr20_-_54967221 0.534 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr12_+_45686465 0.525 NM_001142678
ANO6
anoctamin 6
chr7_+_86974928 0.524 NM_001143935
NM_001243745
NM_021151
CROT


carnitine O-octanoyltransferase


chr19_+_10736167 0.499 NM_020428
SLC44A2
solute carrier family 44, member 2
chr18_-_812268 0.495 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr7_+_128379345 0.495 NM_001130674
NM_001199671
NM_001199672
NM_001199673
NM_001199674
NM_001219
CALU





calumenin





chr15_-_56535475 0.487 NM_022841
RFX7
regulatory factor X, 7
chr19_+_10713055 0.474 NM_001145056
SLC44A2
solute carrier family 44, member 2
chr5_-_83016850 0.473 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr22_-_18507151 0.471 NM_001122731
NM_001136004
NM_015241
MICAL3


microtubule associated monoxygenase, calponin and LIM domain containing 3


chr17_+_33914278 0.466 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr11_+_61560108 0.462 NM_004111
FEN1
flap structure-specific endonuclease 1
chr15_+_79724857 0.456 NM_015206
KIAA1024
KIAA1024
chr8_-_95907423 0.454 NM_057749
CCNE2
cyclin E2
chr15_-_45406345 0.452 NM_014080
DUOX2
dual oxidase 2
chr3_+_111451326 0.450 NM_001134437
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_+_111578026 0.447 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr18_-_24445652 0.444 NM_001650
AQP4
aquaporin 4
chr22_+_19118320 0.440 NM_053006
TSSK2
testis-specific serine kinase 2
chr12_-_117742856 0.440 NM_001204213
NOS1
nitric oxide synthase 1 (neuronal)
chr4_-_153601085 0.439 NM_152680
TMEM154
transmembrane protein 154
chr6_-_42185603 0.436 NM_018141
MRPS10
mitochondrial ribosomal protein S10
chr9_+_101867401 0.435 NM_001130916
NM_004612
TGFBR1

transforming growth factor, beta receptor 1

chr16_-_20911560 0.435 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr18_+_9708187 0.432 NM_006868
RAB31
RAB31, member RAS oncogene family
chr11_-_64646053 0.432 NM_006795
EHD1
EH-domain containing 1
chr12_-_95044205 0.423 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr9_+_112403067 0.416 NM_001037293
PALM2
paralemmin 2
chr3_+_135684463 0.400 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr12_-_53207843 0.385 NM_002272
KRT4
keratin 4
chr20_-_48770302 0.382 NM_001162505
NM_199129
NM_199203
TMEM189

TMEM189-UBE2V1
transmembrane protein 189

TMEM189-UBE2V1 readthrough
chr2_-_183903225 0.373 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr11_-_47516072 0.373 NM_198700
CELF1
CUGBP, Elav-like family member 1
chr7_-_66460403 0.369 NM_016038
SBDS
Shwachman-Bodian-Diamond syndrome
chr3_-_15140652 0.367 NM_022340
ZFYVE20
zinc finger, FYVE domain containing 20
chr12_+_45609767 0.367 NM_001025356
NM_001142679
NM_001204803
ANO6


anoctamin 6


chr4_-_80329354 0.366 NM_033214
GK2
glycerol kinase 2
chr5_+_14581890 0.366 NM_019018
FAM105A
family with sequence similarity 105, member A
chr6_+_41040687 0.362 NM_002505
NM_021705
NFYA

nuclear transcription factor Y, alpha

chr20_+_19998438 0.362 NM_181527
NAA20
N(alpha)-acetyltransferase 20, NatB catalytic subunit
chr10_-_104262404 0.361 NM_005736
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr7_-_132766697 0.358 NM_017812
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr1_-_79472360 0.357 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr2_+_26256728 0.356 NM_016131
RAB10
RAB10, member RAS oncogene family
chr15_-_23086842 0.355 NM_001142275
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chrX_-_30907408 0.355 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr4_+_40198526 0.354 NM_004310
RHOH
ras homolog gene family, member H
chr10_+_101419169 0.353 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr5_+_14143287 0.351 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr1_-_44497132 0.351 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr20_+_19997930 0.349 NM_016100
NM_181528
NAA20

N(alpha)-acetyltransferase 20, NatB catalytic subunit

chrX_+_107288199 0.349 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr6_+_53883713 0.347 NM_138569
MLIP
muscular LMNA-interacting protein
chrX_+_47077426 0.346 NM_033018
CDK16
cyclin-dependent kinase 16
chr7_-_106301329 0.335 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr9_-_23826062 0.332 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr8_+_38854431 0.330 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr12_-_117799410 0.328 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 4.33e-04 GO:0032502 developmental process
1.55 1.61e-03 GO:0007275 multicellular organismal development
1.59 1.77e-03 GO:0048856 anatomical structure development
1.60 4.23e-03 GO:0048731 system development
1.87 9.27e-03 GO:0007399 nervous system development
1.29 1.78e-02 GO:0050794 regulation of cellular process
1.26 2.47e-02 GO:0065007 biological regulation
1.27 3.71e-02 GO:0050789 regulation of biological process
2.07 3.80e-02 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 4.15e-03 GO:0005737 cytoplasm
3.84 1.82e-02 GO:0005769 early endosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.27 4.72e-03 GO:0005515 protein binding