Motif ID: EN1,2.p2

Z-value: 0.760


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_155250705-0.086.8e-01Click!
EN1chr2_-_1196057580.048.3e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_171154387 1.980 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr8_+_7738725 1.425 NM_001081551
DEFB103A
DEFB103B
defensin, beta 103A
defensin, beta 103B
chr19_-_51472816 1.274 NM_002774
KLK6
kallikrein-related peptidase 6
chr11_-_121986800 1.124 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr7_+_80267922 1.079 CD36
CD36 molecule (thrombospondin receptor)
chr2_-_216259197 1.040 FN1
fibronectin 1
chr2_-_216241321 0.906 FN1
fibronectin 1
chr7_+_80267972 0.857 CD36
CD36 molecule (thrombospondin receptor)
chr6_-_76782204 0.850 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr4_+_70916158 0.813 NM_002159
HTN1
histatin 1
chr17_+_56232493 0.797 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr1_-_205391180 0.795 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr20_-_23967431 0.767 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr17_+_39411635 0.739 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr8_+_7738908 0.732 NM_018661
DEFB103B
defensin, beta 103B
chr4_-_46996423 0.718 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr5_-_77844975 0.697 LHFPL2
lipoma HMGIC fusion partner-like 2
chr1_+_86934525 0.650 NM_001285
CLCA1
chloride channel accessory 1
chr1_+_32050510 0.636 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr5_-_22853730 0.631 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr6_-_30652434 0.604 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr15_-_80263460 0.603 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr15_+_97326629 0.600 NM_173499
SPATA8
spermatogenesis associated 8
chr1_+_32043745 0.577 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr7_+_117864711 0.570 NM_019644
ANKRD7
ankyrin repeat domain 7
chr7_+_80267782 0.553 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr10_-_13276327 0.544 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr12_+_100041527 0.543 NM_153364
FAM71C
family with sequence similarity 71, member C
chr8_-_27115935 0.509 STMN4
stathmin-like 4
chr5_+_173472692 0.508 NM_015980
HMP19
HMP19 protein
chr11_+_5009420 0.504 NM_021801
MMP26
matrix metallopeptidase 26
chr17_-_32483550 0.503 NM_001094
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr3_-_38835500 0.501 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chrX_+_49593905 0.490 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr4_+_74281884 0.479 ALB
albumin
chr6_-_114384008 0.476 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr1_-_28520379 0.452 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr16_+_57050985 0.442 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr13_-_114526166 0.440 GAS6
growth arrest-specific 6
chr1_+_145413190 0.438 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr11_+_124095343 0.435 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr10_+_75673346 0.433 PLAU
plasminogen activator, urokinase
chr12_-_49999259 0.419 NM_032130
FAM186B
family with sequence similarity 186, member B
chr2_-_158300517 0.412 NM_004288
CYTIP
cytohesin 1 interacting protein
chr7_+_107110501 0.394 NM_005295
GPR22
G protein-coupled receptor 22
chr4_-_39033981 0.392 NM_024943
TMEM156
transmembrane protein 156
chr14_+_88471467 0.390 NM_003608
GPR65
G protein-coupled receptor 65
chr12_+_10460416 0.387 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr16_-_20416032 0.382 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr4_-_159092509 0.381 FAM198B
family with sequence similarity 198, member B
chr9_-_19786886 0.381 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr4_-_76928601 0.378 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr14_+_95027760 0.373 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chrX_-_48327739 0.370 SLC38A5
solute carrier family 38, member 5
chr4_+_78432905 0.369 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chrX_+_50653734 0.366 NM_005448
BMP15
bone morphogenetic protein 15
chr17_-_29624249 0.364 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr2_-_192015706 0.362 STAT4
signal transducer and activator of transcription 4
chr1_-_27701302 0.362 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr5_+_40909558 0.359 NM_000587
C7
complement component 7
chr7_+_80275967 0.355 CD36
CD36 molecule (thrombospondin receptor)
chr4_+_71200670 0.354 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr10_+_118187381 0.354 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chrX_-_65259839 0.353 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr5_-_22853435 0.353 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_-_93342706 0.346 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr9_+_116207010 0.345 NM_144488
RGS3
regulator of G-protein signaling 3
chr2_-_161056573 0.340 NM_000888
ITGB6
integrin, beta 6
chr7_-_132192837 0.330 PLXNA4
plexin A4
chr14_+_23305792 0.328 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr7_+_80231503 0.322 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr1_-_11188800 0.321


chr4_-_156787377 0.321 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr17_-_72357957 0.315 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr15_-_74659926 0.315 NM_000781
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr14_-_94984180 0.314 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr10_-_92680784 0.313 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr11_-_57004674 0.313 NM_005161
APLNR
apelin receptor
chr9_+_105757592 0.313 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr2_-_192711651 0.311 SDPR
serum deprivation response
chr12_-_91398744 0.310 EPYC
epiphycan
chr11_-_51412447 0.308 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr10_-_105845556 0.307 COL17A1
collagen, type XVII, alpha 1
chr6_+_31583766 0.303 NM_032955
AIF1
allograft inflammatory factor 1
chr1_+_171217632 0.299 NM_002021
FMO1
flavin containing monooxygenase 1
chr5_+_40909617 0.298 C7
complement component 7
chr10_+_17270257 0.293 NM_003380
VIM
vimentin
chr10_-_105845619 0.293 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr13_-_34250899 0.292 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_35547144 0.292 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr14_+_78870092 0.288 NM_004796
NRXN3
neurexin 3
chr12_-_71148331 0.286 PTPRR
protein tyrosine phosphatase, receptor type, R
chr6_-_32013806 0.284 NM_032470
TNXB
tenascin XB
chr9_-_104145800 0.283 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr7_+_28452143 0.283 NM_182898
CREB5
cAMP responsive element binding protein 5
chr12_-_71148383 0.282 NM_130846
NM_001207016
PTPRR

protein tyrosine phosphatase, receptor type, R

chr17_+_43922255 0.280 NM_175882
IMP5
intramembrane protease 5
chr1_-_12908141 0.280 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr16_+_31085751 0.280 ZNF646
zinc finger protein 646
chr5_+_147582338 0.279 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr1_-_161039703 0.275 ARHGAP30
Rho GTPase activating protein 30
chr8_-_7287869 0.255 NM_001081551
DEFB103A
DEFB103B
defensin, beta 103A
defensin, beta 103B
chr19_-_49567123 0.254 NM_006179
NTF4
neurotrophin 4
chrX_+_41548225 0.251 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr8_+_11141983 0.251 NM_015458
MTMR9
myotubularin related protein 9
chr7_-_50800018 0.251 NM_001001549
NM_005311
GRB10

growth factor receptor-bound protein 10

chrX_-_47489703 0.248 NM_002621
CFP
complement factor properdin
chr15_-_50558161 0.246 NM_002112
HDC
histidine decarboxylase
chr12_-_91505215 0.243 LUM
lumican
chr4_+_110749149 0.241 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr3_+_138066489 0.241 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr11_-_102826433 0.238 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr3_-_186262114 0.237 NM_017541
CRYGS
crystallin, gamma S
chr11_+_60223281 0.235 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr7_-_76038894 0.234 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr2_-_163008913 0.234 NM_002054
GCG
glucagon
chr6_-_51952368 0.233 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr1_-_13184325 0.232 NM_001136561
LOC440563
heterogeneous nuclear ribonucleoprotein C-like
chr1_-_154943001 0.229 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr22_-_37545944 0.226 NM_000878
IL2RB
interleukin 2 receptor, beta
chr17_+_34538464 0.226 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr6_+_42123143 0.225 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr8_+_11142314 0.224 MTMR9
myotubularin related protein 9
chr6_-_32977351 0.223 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr11_-_49003246 0.222 NM_001206625
LOC120824
tripartite motif-containing protein ENSP00000309378-like
chr6_-_152702450 0.221 SYNE1
spectrin repeat containing, nuclear envelope 1
chr14_-_65409445 0.220 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr19_-_51512803 0.220 NM_012315
KLK9
kallikrein-related peptidase 9
chr18_-_13915534 0.220 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr11_-_31832784 0.218 PAX6
paired box 6
chr1_-_197036350 0.218 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr8_-_7287651 0.215 NM_018661
DEFB103B
defensin, beta 103B
chr5_+_60933635 0.215 NM_173667
C5orf64
chromosome 5 open reading frame 64
chr12_-_123201319 0.214 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr9_+_35041101 0.214 NM_001040411
NM_001040412
C9orf131

chromosome 9 open reading frame 131

chr17_-_10600823 0.213 NM_004589
SCO1
SCO cytochrome oxidase deficient homolog 1 (yeast)
chr6_+_30104509 0.213 NM_138700
TRIM40
tripartite motif containing 40
chrX_+_110366304 0.213 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr11_-_31832758 0.213 PAX6
paired box 6
chr12_-_71148063 0.213 PTPRR
protein tyrosine phosphatase, receptor type, R
chr11_-_71781091 0.212 NUMA1
nuclear mitotic apparatus protein 1
chr21_+_43823970 0.211 NM_001001895
NM_001243467
NM_018961
UBASH3A


ubiquitin associated and SH3 domain containing A


chr22_+_23054862 0.210 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr1_-_161039649 0.210 ARHGAP30
Rho GTPase activating protein 30
chr14_+_21525980 0.209 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr17_+_45810609 0.209 NM_013351
TBX21
T-box 21
chr6_-_32977312 0.208 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr1_-_161039413 0.206 ARHGAP30
Rho GTPase activating protein 30
chr20_+_20037289 0.206 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr15_+_71433787 0.205 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr17_+_60447578 0.205 NM_001144933
EFCAB3
EF-hand calcium binding domain 3
chr21_+_31768294 0.204 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr15_+_72102893 0.201 NM_014249
NM_016346
NR2E3

nuclear receptor subfamily 2, group E, member 3

chr11_+_49053151 0.200 NM_001206626
LOC283116
tripartite motif-containing protein LOC642612-like
chr9_-_95298251 0.198 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr1_+_16348365 0.196 NM_001042704
NM_004070
CLCNKA

CLCNKB
chloride channel Ka

chloride channel Kb
chr12_+_21679190 0.195 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr8_-_42065193 0.195 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr11_-_10590078 0.194 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr9_-_71155729 0.192 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr16_-_28518131 0.192 NM_145659
IL27
interleukin 27
chr16_+_31085722 0.192 NM_014699
ZNF646
zinc finger protein 646
chr6_-_127780534 0.191 NM_014702
KIAA0408
KIAA0408
chr1_-_158301211 0.189 NM_001764
CD1B
CD1b molecule
chr17_-_39211462 0.188 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr2_-_49381555 0.188 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr5_-_176836535 0.188 NM_000505
F12
coagulation factor XII (Hageman factor)
chr7_+_141463896 0.187 NM_016943
TAS2R3
taste receptor, type 2, member 3
chr2_+_69201704 0.185 NM_019617
GKN1
gastrokine 1
chr14_-_24047993 0.184 NM_001146028
NM_032452
JPH4

junctophilin 4

chr19_-_39826625 0.184 GMFG
glia maturation factor, gamma
chr4_+_71091787 0.184 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr1_+_111770280 0.184 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr2_+_234668914 0.183 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chrX_+_49325433 0.183 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chrX_+_49334991 0.183 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chr2_+_88472657 0.182 NM_018271
THNSL2
threonine synthase-like 2 (S. cerevisiae)
chr18_-_31628557 0.182 NM_001198549
NOL4
nucleolar protein 4
chr2_-_228244005 0.181 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr2_-_88427535 0.180 NM_001443
FABP1
fatty acid binding protein 1, liver
chr7_-_115670774 0.179 TFEC
transcription factor EC
chr10_+_102222797 0.179 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chrX_+_49216616 0.179 NM_012196
NM_001472
NM_001474
NM_001475
NM_021123
NM_001477
NM_001127200
NM_001127212
GAGE8
GAGE1
GAGE2C
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE2E
GAGE12B
GAGE2A
G antigen 8
G antigen 1
G antigen 2C
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 2E
G antigen 12B
G antigen 2A
chr10_-_69425356 0.178 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chrX_-_7895424 0.178 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr15_+_68908878 0.178 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr22_-_37403838 0.177 NM_001163857
NM_178552
C22orf33

chromosome 22 open reading frame 33

chrX_+_18709044 0.176 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr19_-_39826676 0.174 NM_004877
GMFG
glia maturation factor, gamma
chr21_-_32201926 0.174 NM_181606
KRTAP7-1
keratin associated protein 7-1 (gene/pseudogene)
chr15_-_76304762 0.174 NM_138573
NRG4
neuregulin 4
chr12_+_52056547 0.174 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr2_+_33738941 0.174 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_-_163099877 0.173 NM_004460
FAP
fibroblast activation protein, alpha
chr9_+_116263706 0.173 NM_130795
RGS3
regulator of G-protein signaling 3
chr12_+_6554032 0.173 NM_001242
CD27
CD27 molecule
chr2_+_115822246 0.171 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr6_-_116447225 0.171 NM_000493
COL10A1
collagen, type X, alpha 1
chr1_+_113236679 0.170 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_-_159684274 0.169 NM_000567
CRP
C-reactive protein, pentraxin-related

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.11 9.22e-09 GO:0006955 immune response
1.80 5.86e-08 GO:0002376 immune system process
1.99 1.60e-07 GO:0006952 defense response
1.25 4.47e-06 GO:0050896 response to stimulus
1.84 5.94e-06 GO:0009611 response to wounding
2.23 1.99e-04 GO:0045087 innate immune response
1.42 2.26e-04 GO:0006950 response to stress
1.25 3.06e-04 GO:0032501 multicellular organismal process
2.53 1.57e-03 GO:0071345 cellular response to cytokine stimulus
4.04 2.58e-03 GO:0060337 type I interferon-mediated signaling pathway
4.04 2.58e-03 GO:0071357 cellular response to type I interferon
2.76 2.87e-03 GO:0009615 response to virus
3.97 3.25e-03 GO:0034340 response to type I interferon
1.45 6.01e-03 GO:0003008 system process
1.98 9.26e-03 GO:0051707 response to other organism
2.16 1.00e-02 GO:0034097 response to cytokine stimulus
2.47 1.25e-02 GO:0019221 cytokine-mediated signaling pathway
3.16 1.40e-02 GO:0007586 digestion
1.26 1.48e-02 GO:0023052 signaling
1.79 2.03e-02 GO:0050878 regulation of body fluid levels
1.59 2.30e-02 GO:0070887 cellular response to chemical stimulus
1.75 3.09e-02 GO:0042060 wound healing
2.12 3.47e-02 GO:0006954 inflammatory response
1.81 4.84e-02 GO:0007596 blood coagulation
1.81 4.84e-02 GO:0050817 coagulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.81 2.35e-17 GO:0005576 extracellular region
1.96 1.13e-10 GO:0044421 extracellular region part
1.97 3.72e-08 GO:0005615 extracellular space
1.34 1.41e-07 GO:0005886 plasma membrane
1.51 1.90e-07 GO:0044459 plasma membrane part
1.33 2.14e-07 GO:0071944 cell periphery
1.20 8.30e-05 GO:0044425 membrane part
1.58 1.06e-04 GO:0005887 integral to plasma membrane
1.56 1.61e-04 GO:0031226 intrinsic to plasma membrane
1.20 1.55e-03 GO:0031224 intrinsic to membrane
7.30 5.91e-03 GO:0034706 sodium channel complex
1.19 5.92e-03 GO:0016021 integral to membrane
7.82 1.51e-02 GO:0001518 voltage-gated sodium channel complex
2.49 2.06e-02 GO:0009897 external side of plasma membrane
1.13 2.83e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.62 4.48e-04 GO:0005102 receptor binding
1.96 1.88e-03 GO:0015267 channel activity
1.96 2.02e-03 GO:0022803 passive transmembrane transporter activity
1.57 6.93e-03 GO:0022857 transmembrane transporter activity
2.34 8.43e-03 GO:0005125 cytokine activity
1.90 8.46e-03 GO:0022838 substrate-specific channel activity
1.89 1.21e-02 GO:0005216 ion channel activity
3.37 2.62e-02 GO:0005496 steroid binding
12.51 4.29e-02 GO:0032052 bile acid binding