Motif ID: EP300.p2

Z-value: 1.215


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_41488607-0.604.2e-04Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_28681429 4.096 DSC2
desmocollin 2
chr18_-_28681885 3.354 NM_004949
NM_024422
DSC2

desmocollin 2

chr12_-_25101993 2.763 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_54813002 2.581 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr9_+_33750463 2.155 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr19_-_11689591 2.041 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr12_-_54812936 1.998 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr22_-_37640187 1.895 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr2_+_110371887 1.887 NM_023016
ANKRD57
ankyrin repeat domain 57
chr1_+_20915440 1.871 NM_001785
CDA
cytidine deaminase
chr1_-_109825683 1.823 PSRC1
proline/serine-rich coiled-coil 1
chr7_-_752083 1.817 PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr10_-_116164514 1.790 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr12_+_70759974 1.752 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr22_-_37640287 1.750 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr12_-_57634474 1.733 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chrX_+_135229536 1.665 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr7_+_48128939 1.621 UPP1
uridine phosphorylase 1
chr19_-_11689765 1.576 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr10_-_3827205 1.568 KLF6
Kruppel-like factor 6
chr10_+_99400441 1.541 NM_018425
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr3_+_111578640 1.506 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr4_+_75480628 1.467 NM_001657
AREG
amphiregulin
chr6_-_35992269 1.413 NM_138718
NM_001193476
NM_052961
SLC26A8


solute carrier family 26, member 8


chr4_+_75310852 1.410 NM_001657
AREG
amphiregulin
chr7_-_128049959 1.389 IMPDH1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr20_+_62328002 1.388 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_-_20812727 1.384 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr8_-_23261626 1.380 LOXL2
lysyl oxidase-like 2
chr6_+_43738757 1.366 VEGFA
vascular endothelial growth factor A
chr17_+_15848230 1.354 NM_000676
ADORA2B
adenosine A2b receptor
chrX_+_135251454 1.329 NM_001159704
FHL1
four and a half LIM domains 1
chr1_-_209957872 1.323 NM_152485
C1orf74
chromosome 1 open reading frame 74
chr12_-_48152180 1.319 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr15_-_74726258 1.318 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr1_+_32043745 1.315 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr8_-_23261632 1.311 LOXL2
lysyl oxidase-like 2
chr2_+_54683276 1.276 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr3_+_154797435 1.265 NM_000902
MME
membrane metallo-endopeptidase
chr10_-_3827418 1.264 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr4_+_8200918 1.254 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr7_-_128050006 1.246 NM_000883
NM_001102605
NM_001142576
NM_183243
IMPDH1



IMP (inosine 5'-monophosphate) dehydrogenase 1



chr8_-_23261591 1.226 LOXL2
lysyl oxidase-like 2
chr7_+_99156263 1.212 ZNF655
zinc finger protein 655
chr11_-_2160199 1.212 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chrX_-_153599581 1.206 FLNA
filamin A, alpha
chr5_+_95998678 1.202 CAST
calpastatin
chr13_-_40177355 1.194 NM_005780
LHFP
lipoma HMGIC fusion partner
chr15_+_69706619 1.190 NM_004856
NM_138555
KIF23

kinesin family member 23

chr14_-_69446038 1.180 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr17_+_39969205 1.173 FKBP10
FK506 binding protein 10, 65 kDa
chr14_-_69446008 1.167 ACTN1
actinin, alpha 1
chr21_-_38639593 1.165 DSCR3
Down syndrome critical region gene 3
chr3_-_179169180 1.161 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr8_+_31497267 1.157 NM_013962
NRG1
neuregulin 1
chr13_-_114567040 1.150 NM_000820
GAS6
growth arrest-specific 6
chr6_-_40555111 1.142 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr6_+_33359312 1.140 NM_002263
KIFC1
kinesin family member C1
chrX_-_153599719 1.136 FLNA
filamin A, alpha
chr11_-_65667858 1.135 FOSL1
FOS-like antigen 1
chr17_+_39969200 1.131 FKBP10
FK506 binding protein 10, 65 kDa
chr13_-_114567011 1.118 GAS6
growth arrest-specific 6
chr22_-_29137776 1.113 NM_001005735
NM_007194
NM_145862
CHEK2


checkpoint kinase 2


chr1_-_10003321 1.113 LZIC
leucine zipper and CTNNBIP1 domain containing
chr19_+_11039419 1.104 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr13_-_114566951 1.104 GAS6
growth arrest-specific 6
chr18_+_55102777 1.098 NM_004852
ONECUT2
one cut homeobox 2
chr7_-_128045995 1.094 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr3_+_111578136 1.094 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr10_-_92617417 1.092 HTR7
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
chr13_-_40177200 1.089 LHFP
lipoma HMGIC fusion partner
chr6_+_43043944 1.086 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr14_-_69445978 1.081 ACTN1
actinin, alpha 1
chr5_-_149535309 1.071 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr19_+_48828820 1.069 EMP3
epithelial membrane protein 3
chr19_-_15343767 1.060 NM_001142886
EPHX3
epoxide hydrolase 3
chr7_-_1199822 1.056 NM_182491
ZFAND2A
zinc finger, AN1-type domain 2A
chr10_+_91461333 1.053 NM_016195
KIF20B
kinesin family member 20B
chr14_-_69445772 1.050 ACTN1
actinin, alpha 1
chr2_-_190044330 1.044 NM_000393
COL5A2
collagen, type V, alpha 2
chr2_+_113816684 1.044 NM_012275
IL36RN
interleukin 36 receptor antagonist
chr14_-_69445948 1.038 ACTN1
actinin, alpha 1
chr14_-_69445974 1.034 ACTN1
actinin, alpha 1
chr6_-_110501164 1.032 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr5_-_39219578 1.026 NM_001465
NM_199335
FYB

FYN binding protein

chr14_-_69445989 1.019 ACTN1
actinin, alpha 1
chr8_+_27168953 1.017 NM_173174
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr4_-_111119752 1.014 NM_001130721
NM_024090
ELOVL6

ELOVL fatty acid elongase 6

chr4_-_39033981 1.011 NM_024943
TMEM156
transmembrane protein 156
chr12_-_99038705 1.008 IKBIP
IKBKB interacting protein
chr19_-_55658310 1.003 TNNT1
troponin T type 1 (skeletal, slow)
chr12_+_107712151 1.002 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr20_+_62328068 1.000 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr14_-_103995336 0.998


chr14_-_55658205 0.989 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr11_+_33061560 0.985 NM_001145541
TCP11L1
t-complex 11 (mouse)-like 1
chr13_-_114567034 0.981 GAS6
growth arrest-specific 6
chr7_-_1199785 0.980 ZFAND2A
zinc finger, AN1-type domain 2A
chr2_-_27718098 0.977 NM_022823
FNDC4
fibronectin type III domain containing 4
chr20_+_61340165 0.971 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr3_+_154797644 0.970 NM_007287
MME
membrane metallo-endopeptidase
chr2_-_110371404 0.969 SEPT10
septin 10
chr8_+_10530146 0.969 NM_001040032
C8orf74
chromosome 8 open reading frame 74
chr1_+_212209129 0.967 DTL
denticleless homolog (Drosophila)
chr2_-_27718059 0.959 FNDC4
fibronectin type III domain containing 4
chr16_-_86542463 0.952 LOC400550
uncharacterized LOC400550
chr8_-_23261675 0.943 NM_002318
LOXL2
lysyl oxidase-like 2
chr6_+_151561653 0.938 AKAP12
A kinase (PRKA) anchor protein 12
chrX_+_64887510 0.937 NM_002444
MSN
moesin
chr17_+_1933365 0.933 NM_001383
DPH1
DPH1 homolog (S. cerevisiae)
chr16_+_66638652 0.931 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr10_-_5541401 0.929 NM_017422
CALML5
calmodulin-like 5
chr7_+_143078395 0.926 ZYX
zyxin
chr2_-_110371669 0.926 NM_144710
NM_178584
SEPT10

septin 10

chr1_+_150521786 0.912 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr7_+_143078358 0.906 NM_001010972
NM_003461
ZYX

zyxin

chr13_-_40177304 0.903 LHFP
lipoma HMGIC fusion partner
chr19_+_16187315 0.898 TPM4
tropomyosin 4
chr12_+_27677044 0.897 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr12_-_54813010 0.896 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_3862183 0.894 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr7_-_1199813 0.890 ZFAND2A
zinc finger, AN1-type domain 2A
chr10_+_99400469 0.887 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr11_+_33060962 0.884 NM_018393
TCP11L1
t-complex 11 (mouse)-like 1
chr1_-_154946830 0.884 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr20_-_56286540 0.882 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr3_+_156392204 0.875 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr20_-_10654429 0.875 NM_000214
JAG1
jagged 1
chr1_-_175161832 0.875 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr3_+_111578026 0.874 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr12_-_48152860 0.873 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr8_+_32504250 0.872 NM_013959
NRG1
neuregulin 1
chr17_+_76210276 0.872 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr3_-_13921617 0.868 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr3_-_51996855 0.866 NM_033010
PCBP4
poly(rC) binding protein 4
chr19_+_45843997 0.862 NM_177417
KLC3
kinesin light chain 3
chr15_-_81616439 0.859 NM_181900
STARD5
StAR-related lipid transfer (START) domain containing 5
chr3_+_19189969 0.858 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr12_-_49365545 0.856 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr5_+_31193761 0.852 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr22_+_31063914 0.848


chr15_+_40453263 0.848 BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr11_+_706607 0.847 EPS8L2
EPS8-like 2
chr3_+_156392714 0.847 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr11_-_65667860 0.847 NM_005438
FOSL1
FOS-like antigen 1
chr11_+_35160385 0.845 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr1_-_113498828 0.844 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr17_-_4851797 0.844 NM_005022
PFN1
profilin 1
chrX_-_54522318 0.843 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr7_-_752132 0.835 NM_002735
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr8_-_145013628 0.833 NM_201384
PLEC
plectin
chr6_-_42162693 0.833 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr2_+_113816214 0.832 NM_173170
IL36RN
interleukin 36 receptor antagonist
chr11_-_2925174 0.830 NM_007105
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr19_-_41859253 0.829 TGFB1
transforming growth factor, beta 1
chr3_+_136537860 0.829 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr1_-_155224668 0.829 FAM189B
family with sequence similarity 189, member B
chr6_+_46655611 0.827 NM_001010870
NM_001168359
TDRD6

tudor domain containing 6

chr22_-_37915209 0.827 NM_014550
CARD10
caspase recruitment domain family, member 10
chr9_-_34590137 0.825 NM_001207011
CNTFR
ciliary neurotrophic factor receptor
chr11_-_46722139 0.825 ARHGAP1
Rho GTPase activating protein 1
chr6_+_43738394 0.823 VEGFA
vascular endothelial growth factor A
chr11_+_33061291 0.817 TCP11L1
t-complex 11 (mouse)-like 1
chr2_+_191745912 0.815 GLS
glutaminase
chr1_-_154946859 0.814 NM_001130041
NM_001202859
NM_003029
SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr22_-_39095991 0.812 NM_014876
JOSD1
Josephin domain containing 1
chr11_+_129245834 0.811 NM_003658
BARX2
BARX homeobox 2
chr1_-_109825745 0.811


chr1_+_26606621 0.804 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr15_+_67358194 0.803 NM_005902
SMAD3
SMAD family member 3
chr1_+_153651050 0.801 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr1_-_95007139 0.800 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr11_-_102962600 0.793 DCUN1D5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr1_+_1550794 0.792 NM_001170686
NM_001170687
NM_001170688
NM_080875
MIB2



mindbomb homolog 2 (Drosophila)



chr7_+_116165089 0.789 CAV1
caveolin 1, caveolae protein, 22kDa
chr2_-_9695827 0.788 ADAM17
ADAM metallopeptidase domain 17
chr8_+_22022644 0.785 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr1_+_222886655 0.785 BROX
BRO1 domain and CAAX motif containing
chr12_+_6937764 0.784 LEPREL2
leprecan-like 2
chr1_-_197115566 0.778 NM_001206846
NM_018136
ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr2_+_31456879 0.777 NM_014600
EHD3
EH-domain containing 3
chr16_-_10275743 0.773 NM_001134408
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr17_-_43209681 0.770 NM_133373
PLCD3
phospholipase C, delta 3
chr1_-_154946801 0.761 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr9_-_129884961 0.761 ANGPTL2
angiopoietin-like 2
chr1_+_206138909 0.760 NM_001123168
FAM72B
FAM72A
family with sequence similarity 72, member B
family with sequence similarity 72, member A
chrX_-_100662788 0.755 GLA
galactosidase, alpha
chr11_+_61595633 0.754 NM_004265
FADS2
fatty acid desaturase 2
chr8_-_23021447 0.754 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr5_-_60140041 0.752 NM_001104558
NM_024930
ELOVL7

ELOVL fatty acid elongase 7

chr1_+_212208918 0.752 NM_016448
DTL
denticleless homolog (Drosophila)
chr15_+_40453209 0.750 NM_001211
BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr4_-_40859081 0.750 NM_001166051
NM_001166052
NM_001166053
NM_001166054
APBB2



amyloid beta (A4) precursor protein-binding, family B, member 2



chr14_+_53019865 0.749 NM_001099652
GPR137C
G protein-coupled receptor 137C
chr1_+_26606580 0.747 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr20_+_44034632 0.746 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr7_+_143078457 0.743 ZYX
zyxin
chr15_-_75871508 0.743 NM_002833
PTPN9
protein tyrosine phosphatase, non-receptor type 9
chr19_-_19052032 0.743 NM_004838
HOMER3
homer homolog 3 (Drosophila)
chrX_-_154033729 0.743 NM_001166460
NM_001166461
NM_001166462
NM_002436
MPP1



membrane protein, palmitoylated 1, 55kDa




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 2.61e-10 GO:0009987 cellular process
1.24 3.00e-09 GO:0023052 signaling
1.14 6.31e-09 GO:0065007 biological regulation
1.13 1.17e-07 GO:0050789 regulation of biological process
1.62 4.41e-07 GO:0050878 regulation of body fluid levels
1.13 1.94e-06 GO:0050794 regulation of cellular process
1.22 3.33e-06 GO:0007165 signal transduction
1.58 4.10e-06 GO:0042060 wound healing
1.61 1.16e-05 GO:0007599 hemostasis
1.60 2.70e-05 GO:0007596 blood coagulation
1.60 2.70e-05 GO:0050817 coagulation
1.40 8.32e-04 GO:0040011 locomotion
1.20 1.25e-03 GO:0048731 system development
1.23 1.48e-03 GO:0065008 regulation of biological quality
1.16 1.49e-03 GO:0051716 cellular response to stimulus
1.18 2.72e-03 GO:0048856 anatomical structure development
1.36 3.43e-03 GO:0009611 response to wounding
2.05 3.76e-03 GO:0007265 Ras protein signal transduction
1.15 1.45e-02 GO:0032502 developmental process
1.18 1.54e-02 GO:0048518 positive regulation of biological process
1.16 1.71e-02 GO:0007275 multicellular organismal development
1.68 1.88e-02 GO:0030168 platelet activation
1.32 1.92e-02 GO:0032879 regulation of localization
1.27 2.01e-02 GO:0035556 intracellular signal transduction
1.25 2.45e-02 GO:0009653 anatomical structure morphogenesis
1.16 2.59e-02 GO:0016043 cellular component organization
1.24 3.19e-02 GO:0023051 regulation of signaling
1.15 3.46e-02 GO:0071840 cellular component organization or biogenesis
1.25 3.76e-02 GO:0007399 nervous system development
1.43 4.67e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 1.94e-08 GO:0005737 cytoplasm
1.29 1.95e-07 GO:0005829 cytosol
1.47 1.28e-04 GO:0030054 cell junction
1.66 3.01e-04 GO:0015629 actin cytoskeleton
1.12 3.93e-04 GO:0044444 cytoplasmic part
1.21 1.73e-03 GO:0044459 plasma membrane part
1.05 7.69e-03 GO:0044424 intracellular part
1.13 1.22e-02 GO:0071944 cell periphery
1.70 1.25e-02 GO:0031252 cell leading edge
1.83 1.37e-02 GO:0005938 cell cortex
1.46 1.47e-02 GO:0045202 synapse
1.05 1.88e-02 GO:0005622 intracellular
1.16 2.01e-02 GO:0043228 non-membrane-bounded organelle
1.16 2.01e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.68 4.06e-02 GO:0070161 anchoring junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 2.74e-20 GO:0005515 protein binding
1.08 1.44e-08 GO:0005488 binding
1.50 1.60e-04 GO:0008092 cytoskeletal protein binding
1.56 5.56e-03 GO:0003779 actin binding