Motif ID: EVI1.p2

Z-value: 0.975


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MECOMchr3_-_168864325-0.183.5e-01Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_135782246 2.740 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr17_+_53344966 2.109 HLF
hepatic leukemia factor
chr12_-_8219001 1.945 C3AR1
complement component 3a receptor 1
chr12_-_8218930 1.646 NM_004054
C3AR1
complement component 3a receptor 1
chr11_-_64727608 1.553 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr6_-_22297729 1.510 NM_000948
PRL
prolactin
chr5_-_41213513 1.435 NM_000065
C6
complement component 6
chrX_+_15525430 1.418 NM_001721
BMX
BMX non-receptor tyrosine kinase
chrX_-_101694848 1.406 NM_022053
NM_001099686
NXF2
NXF2B
nuclear RNA export factor 2
nuclear RNA export factor 2B
chr14_-_76447323 1.406 TGFB3
transforming growth factor, beta 3
chrX_+_101502093 1.400 NM_022053
NM_001099686
NXF2
NXF2B
nuclear RNA export factor 2
nuclear RNA export factor 2B
chr5_+_121465214 1.247 NM_207317
ZNF474
zinc finger protein 474
chr19_+_6135650 1.227 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr5_-_137475076 1.188 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr1_+_179575361 1.170 NM_001199092
TDRD5
tudor domain containing 5
chr3_-_145968819 1.166 PLSCR4
phospholipid scramblase 4
chr3_+_97158453 1.160 NM_173655
EPHA6
EPH receptor A6
chr7_-_16921596 1.113 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr19_-_41388656 1.096 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr10_+_7745325 1.085 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_27115935 1.077 STMN4
stathmin-like 4
chr8_-_27115897 1.074 NM_030795
STMN4
stathmin-like 4
chr11_+_60989820 1.031 NM_001079808
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr6_+_52529157 1.016 LOC730101
uncharacterized LOC730101
chr10_+_7745341 0.974 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_26724748 0.940 ADRA1A
adrenergic, alpha-1A-, receptor
chr1_-_146697155 0.939 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr1_+_212738675 0.925 NM_001030287
ATF3
activating transcription factor 3
chr3_-_145968958 0.900 NM_001128306
NM_001177304
NM_020353
PLSCR4


phospholipid scramblase 4


chr1_+_244515936 0.889 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr8_+_17396285 0.884 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr19_+_41281081 0.883 NM_001202553
MIA
melanoma inhibitory activity
chr11_+_65266980 0.879


chr20_+_9198036 0.876 NM_182797
PLCB4
phospholipase C, beta 4
chr10_+_7745354 0.873 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr18_-_24722757 0.862 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr12_-_95945226 0.859 NM_032147
USP44
ubiquitin specific peptidase 44
chr5_-_158526698 0.849 NM_024007
EBF1
early B-cell factor 1
chr18_+_61582744 0.846 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_-_5323174 0.829 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr19_+_41281281 0.813 NM_006533
MIA
melanoma inhibitory activity
chr12_+_13349716 0.807 EMP1
epithelial membrane protein 1
chr10_-_50122279 0.807 NM_001006939
LRRC18
leucine rich repeat containing 18
chr19_+_51760963 0.796 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr15_+_34261088 0.790 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr6_+_32407618 0.789 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr19_-_52133589 0.784 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chrX_-_65259839 0.776 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr3_-_167371288 0.775 NM_178824
WDR49
WD repeat domain 49
chr1_-_157811491 0.758 NM_005894
CD5L
CD5 molecule-like
chr13_+_43355685 0.747 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr4_-_156787377 0.746 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr3_-_167371701 0.740 WDR49
WD repeat domain 49
chr1_+_162602198 0.740 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr2_+_98330030 0.736 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr9_+_74920329 0.731


chr4_+_189060597 0.709 NM_178556
TRIML1
tripartite motif family-like 1
chr3_+_132316080 0.703 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr5_+_140602914 0.694 NM_018934
PCDHB14
protocadherin beta 14
chr11_+_65266642 0.684


chr12_+_12223872 0.673 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr14_-_76447445 0.660 TGFB3
transforming growth factor, beta 3
chr14_+_75988838 0.660 BATF
basic leucine zipper transcription factor, ATF-like
chr12_-_371994 0.656 NM_001190997
NM_001243392
NM_016615
SLC6A13


solute carrier family 6 (neurotransmitter transporter, GABA), member 13


chr7_+_123249076 0.654 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr4_+_8951476 0.651 NM_001040071
LOC650293
seven transmembrane helix receptor
chr12_-_10151689 0.642 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr5_+_156820161 0.635 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr19_+_15121538 0.629 NM_173482
CCDC105
coiled-coil domain containing 105
chr5_-_35938736 0.628 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr1_+_162602308 0.626 DDR2
discoidin domain receptor tyrosine kinase 2
chr14_+_75988765 0.626 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr11_+_60146022 0.625 MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr13_+_50589389 0.602 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr12_+_20848288 0.600 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr20_+_207898 0.592 NM_080831
DEFB129
defensin, beta 129
chr12_+_1738411 0.574 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr5_-_114515733 0.573 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr7_+_142829169 0.572 NM_002652
PIP
prolactin-induced protein
chr10_+_7745229 0.571 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_-_32784727 0.555 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr11_+_60970983 0.534 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr21_+_43710190 0.525 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr20_+_15177503 0.524 NM_001033087
MACROD2
MACRO domain containing 2
chr5_+_140165875 0.524 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr11_+_112047088 0.523 NM_001037290
BCO2
beta-carotene oxygenase 2
chr3_-_57326709 0.515 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr8_+_17354562 0.505 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr1_+_104292439 0.504 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chrX_-_115594136 0.494 NM_001017978
CXorf61
chromosome X open reading frame 61
chr11_-_84634219 0.491 DLG2
discs, large homolog 2 (Drosophila)
chr6_-_22303014 0.490 NM_001163558
PRL
prolactin
chr15_-_90222572 0.488 NM_001145311
NM_002666
PLIN1

perilipin 1

chr10_+_7745284 0.480 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_-_17171789 0.479 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr17_+_11786218 0.474 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr19_-_11564568 0.471 ELAVL3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr12_-_10251520 0.469 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr9_+_12693385 0.464 NM_000550
TYRP1
tyrosinase-related protein 1
chr5_-_158526428 0.458 EBF1
early B-cell factor 1
chr6_-_88854989 0.457 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr10_+_43867089 0.448 NM_001184963
NM_173160
FXYD4

FXYD domain containing ion transport regulator 4

chr9_-_43630729 0.444 NM_001145196
FAM75A6
family with sequence similarity 75, member A6
chr13_+_24144402 0.436 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr19_+_44084758 0.435 LOC390940
uncharacterized protein ENSP00000244321
chr3_-_45883562 0.432 NM_020347
LZTFL1
leucine zipper transcription factor-like 1
chr6_-_87804773 0.429 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr6_-_52774460 0.428 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr4_+_70894129 0.417 NM_000200
HTN3
histatin 3
chr8_+_134203281 0.414 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chr12_-_131002409 0.411 NM_015347
RIMBP2
RIMS binding protein 2
chr3_+_44916097 0.408 NM_003241
TGM4
transglutaminase 4 (prostate)
chr16_-_90096308 0.404 NM_001214
C16orf3
chromosome 16 open reading frame 3
chr8_+_133879202 0.404 NM_003235
TG
thyroglobulin
chr5_+_140588267 0.402 NM_018932
PCDHB12
protocadherin beta 12
chr13_+_27844463 0.399 NM_206827
RASL11A
RAS-like, family 11, member A
chr18_-_44561967 0.399 NM_016427
TCEB3B
transcription elongation factor B polypeptide 3B (elongin A2)
chr5_+_139876504 0.395 ANKHD1
ankyrin repeat and KH domain containing 1
chr4_+_36285643 0.395 NM_001170700
DTHD1
death domain containing 1
chr6_+_123100860 0.389 FABP7
fatty acid binding protein 7, brain
chr19_-_35981345 0.388 NM_001244847
NM_207392
KRTDAP

keratinocyte differentiation-associated protein

chr1_-_117753476 0.384 NM_001253850
NM_024626
VTCN1

V-set domain containing T cell activation inhibitor 1

chr5_+_161112657 0.382 NM_000811
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr1_+_174417211 0.380 NM_005684
GPR52
G protein-coupled receptor 52
chr8_+_21900389 0.380 NM_003867
FGF17
fibroblast growth factor 17
chr1_-_20445991 0.380 NM_012400
PLA2G2D
phospholipase A2, group IID
chr6_-_165723074 0.378 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr1_-_197036350 0.376 NM_001994
F13B
coagulation factor XIII, B polypeptide
chrX_-_43741593 0.376 NM_000898
MAOB
monoamine oxidase B
chr22_-_31688329 0.374 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr19_+_13134782 0.373 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_+_153019029 0.372 NM_025107
MYCT1
myc target 1
chr1_-_177939347 0.370 SEC16B
SEC16 homolog B (S. cerevisiae)
chr17_-_39306053 0.370 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr12_-_54758228 0.370 NM_020370
GPR84
G protein-coupled receptor 84
chr1_+_210501595 0.363 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr9_+_120466607 0.363 TLR4
toll-like receptor 4
chr10_-_69455926 0.359 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_104198301 0.357 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr7_-_130418859 0.357 NM_138693
KLF14
Kruppel-like factor 14
chr17_-_56621682 0.354 NM_001038704
C17orf47
chromosome 17 open reading frame 47
chr21_-_42557165 0.354 NM_182832
PLAC4
placenta-specific 4
chr20_-_44006876 0.348 NM_014477
TP53TG5
TP53 target 5
chr17_+_56414563 0.344 LOC100506779
uncharacterized LOC100506779
chr12_-_7818467 0.344 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr2_+_115822246 0.341 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr17_-_54893249 0.340 NM_001085430
C17orf67
chromosome 17 open reading frame 67
chr2_-_158300517 0.340 NM_004288
CYTIP
cytohesin 1 interacting protein
chr17_+_55333843 0.338 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr11_-_33891361 0.337 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_+_88896868 0.335 SPP1
secreted phosphoprotein 1
chr12_-_55042135 0.333 NM_053283
DCD
dermcidin
chr21_-_39956823 0.330 NM_001243429
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr9_+_40700290 0.330 NM_001083124
FAM75A3
family with sequence similarity 75, member A3
chr1_+_154293568 0.329 NM_080429
AQP10
aquaporin 10
chrX_+_50653734 0.327 NM_005448
BMP15
bone morphogenetic protein 15
chr16_-_21289571 0.325 CRYM
crystallin, mu
chr6_-_130544098 0.325 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chrX_+_119292466 0.324 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr11_-_33891485 0.323 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_-_56296965 0.322 NM_001165927
MKS1
Meckel syndrome, type 1
chr17_-_39334439 0.321 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr1_+_47901688 0.318 NM_004474
FOXD2
forkhead box D2
chrX_-_78623006 0.317 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr6_-_117086812 0.316 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr4_-_7436614 0.315 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chrX_+_72667089 0.312 NM_005193
CDX4
caudal type homeobox 4
chr15_+_42052574 0.311 MGA
MAX gene associated
chrX_+_41548225 0.310 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr14_-_94844881 0.309 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr11_+_49053151 0.308 NM_001206626
LOC283116
tripartite motif-containing protein LOC642612-like
chr19_-_14260728 0.306 LPHN1
latrophilin 1
chr17_-_29641068 0.305 EVI2B
ecotropic viral integration site 2B
chr20_-_35407693 0.303 KIAA0889
KIAA0889
chr11_-_59952138 0.302 NM_001247999
NM_152852
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr3_-_119379269 0.301 NM_022135
POPDC2
popeye domain containing 2
chr2_-_113810439 0.301 NM_014438
NM_173178
IL36B

interleukin 36, beta

chr1_-_93399531 0.299


chr9_+_108424737 0.298 NM_005421
TAL2
T-cell acute lymphocytic leukemia 2
chr7_-_76038894 0.297 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr4_+_41614911 0.294 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr11_+_60145954 0.294 NM_021201
NM_206938
NM_206939
NM_206940
MS4A7



membrane-spanning 4-domains, subfamily A, member 7



chr20_+_44258384 0.294 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr15_-_40401041 0.293 NM_001003940
BMF
Bcl2 modifying factor
chr5_+_53751430 0.293 NM_006308
HSPB3
heat shock 27kDa protein 3
chr17_-_19651586 0.292 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr19_-_35085489 0.292 NM_001025591
SCGBL
secretoglobin-like
chr11_-_124190092 0.291 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr22_-_30960875 0.290 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr9_+_134378324 0.290 POMT1
protein-O-mannosyltransferase 1
chr16_-_21289637 0.288 CRYM
crystallin, mu
chr5_+_72469022 0.288 NM_153217
TMEM174
transmembrane protein 174
chr9_+_1050333 0.286 NM_006557
NM_001130865
DMRT2

doublesex and mab-3 related transcription factor 2

chr6_-_110736748 0.286 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr2_-_231989755 0.285 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chrX_-_119211516 0.285 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr9_+_120466625 0.284 TLR4
toll-like receptor 4
chr17_+_56414660 0.284 LOC100506779
uncharacterized LOC100506779
chr9_+_123850573 0.282 NM_007018
CNTRL
centriolin
chr5_-_147162264 0.281 JAKMIP2
janus kinase and microtubule interacting protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.74 2.59e-05 GO:0050865 regulation of cell activation
2.78 2.90e-05 GO:0002694 regulation of leukocyte activation
1.88 5.24e-05 GO:0006952 defense response
2.96 9.41e-05 GO:0050867 positive regulation of cell activation
2.92 2.23e-04 GO:0002696 positive regulation of leukocyte activation
2.16 2.49e-04 GO:0050776 regulation of immune response
2.73 2.71e-04 GO:0051249 regulation of lymphocyte activation
2.45 5.84e-04 GO:0006954 inflammatory response
1.87 6.54e-04 GO:0002682 regulation of immune system process
1.72 1.58e-03 GO:0009611 response to wounding
2.78 2.50e-03 GO:0050863 regulation of T cell activation
2.65 2.79e-03 GO:0010817 regulation of hormone levels
2.87 5.53e-03 GO:0042445 hormone metabolic process
2.01 5.87e-03 GO:0002684 positive regulation of immune system process
2.71 6.44e-03 GO:0051251 positive regulation of lymphocyte activation
2.27 6.86e-03 GO:0050778 positive regulation of immune response
3.06 1.43e-02 GO:0051606 detection of stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.52 6.39e-07 GO:0044459 plasma membrane part
1.33 2.52e-06 GO:0005886 plasma membrane
1.70 2.55e-06 GO:0005887 integral to plasma membrane
1.68 3.87e-06 GO:0031226 intrinsic to plasma membrane
1.32 4.96e-06 GO:0071944 cell periphery
1.47 3.98e-05 GO:0005576 extracellular region
1.22 6.99e-04 GO:0031224 intrinsic to membrane
1.22 9.66e-04 GO:0016021 integral to membrane
1.15 4.61e-03 GO:0016020 membrane
1.17 6.64e-03 GO:0044425 membrane part
1.63 8.94e-03 GO:0005615 extracellular space
1.88 2.97e-02 GO:0009986 cell surface

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.39 3.14e-02 GO:0004872 receptor activity