Motif ID: GAGGUAG

Z-value: 1.210


Mature miRNA associated with seed GAGGUAG:

NamemiRBase Accession
hsa-let-7a MIMAT0000062
hsa-let-7b MIMAT0000063
hsa-let-7c MIMAT0000064
hsa-let-7d MIMAT0000065
hsa-let-7e MIMAT0000066
hsa-let-7f MIMAT0000067
hsa-let-7g MIMAT0000414
hsa-let-7i MIMAT0000415
hsa-miR-4458 MIMAT0018980
hsa-miR-4500 MIMAT0019036
hsa-miR-98 MIMAT0000096



Activity profile for motif GAGGUAG.

activity profile for motif GAGGUAG


Sorted Z-values histogram for motif GAGGUAG

Sorted Z-values for motif GAGGUAG



Network of associatons between targets according to the STRING database.



First level regulatory network of GAGGUAG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_1748285 2.259 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr5_-_139726173 1.722 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr12_-_25102281 1.623 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr12_-_25055966 1.503 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_25055228 1.409 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr8_-_29206321 1.286 NM_057158
DUSP4
dual specificity phosphatase 4
chr13_+_110959592 1.235 NM_001846
COL4A2
collagen, type IV, alpha 2
chr19_+_6531009 1.220 NM_003811
TNFSF9
tumor necrosis factor (ligand) superfamily, member 9
chr19_+_4910339 1.152 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr5_+_156887026 1.130 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr8_-_29207795 1.101 NM_001394
DUSP4
dual specificity phosphatase 4
chr1_-_204121144 1.087 NM_018208
ETNK2
ethanolamine kinase 2
chr20_-_5591487 1.084 NM_019593
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr5_-_159739482 1.077 NM_024565
CCNJL
cyclin J-like
chr9_+_131182690 1.066 NM_016174
CERCAM
cerebral endothelial cell adhesion molecule
chr7_-_148580600 1.047 NM_001203249
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr1_-_165325474 1.016 NM_001174069
LMX1A
LIM homeobox transcription factor 1, alpha
chr1_-_165325951 1.011 NM_177398
LMX1A
LIM homeobox transcription factor 1, alpha
chr2_-_230933618 1.005 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr10_+_102732285 0.978 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr16_+_2479387 0.964 NM_001761
CCNF
cyclin F
chr12_-_69357019 0.960 NM_001874
CPM
carboxypeptidase M
chr17_+_41476351 0.951 NM_001661
ARL4D
ADP-ribosylation factor-like 4D
chr21_-_28217692 0.943 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr6_+_36646455 0.935 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr12_-_69326946 0.912 NM_001005502
NM_198320
CPM

carboxypeptidase M

chr13_-_61989654 0.909 NM_022843
PCDH20
protocadherin 20
chr7_-_148581403 0.898 NM_001203247
NM_001203248
NM_004456
NM_152998
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr5_+_38845962 0.894 NM_003999
OSMR
oncostatin M receptor
chr1_+_152486977 0.862 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr6_+_36644236 0.855 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr3_-_16306283 0.819 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr6_+_138188352 0.809 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr20_-_46414636 0.804 NM_018837
SULF2
sulfatase 2
chr22_+_26825220 0.802 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr17_-_42907606 0.796 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr9_+_101705710 0.786 NM_001855
COL15A1
collagen, type XV, alpha 1
chr1_+_41444968 0.782 NM_001905
CTPS
CTP synthase
chr19_+_4909447 0.778 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr7_+_76090971 0.760 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr4_+_74606222 0.759 NM_000584
IL8
interleukin 8
chr12_+_111843743 0.757 NM_005475
SH2B3
SH2B adaptor protein 3
chr7_+_76109826 0.756 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr12_-_95611023 0.748 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr20_-_46415277 0.734 NM_001161841
NM_198596
SULF2

sulfatase 2

chr8_+_86099909 0.734 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr9_-_27529434 0.718 NM_024761
MOB3B
MOB kinase activator 3B
chr7_+_100797685 0.708 NM_001283
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr17_+_40169592 0.708 NM_001001349
NKIRAS2
NFKB inhibitor interacting Ras-like 2
chr17_-_42908178 0.694 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr1_+_15736387 0.693 NM_024329
EFHD2
EF-hand domain family, member D2
chr8_-_124544376 0.692 NM_148177
FBXO32
F-box protein 32
chr18_-_12656730 0.691 NM_001128627
SPIRE1
spire homolog 1 (Drosophila)
chr11_+_130318457 0.684 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr13_-_33859835 0.684 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr7_+_130131921 0.676 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr18_-_12657911 0.672 NM_001128626
NM_020148
SPIRE1

spire homolog 1 (Drosophila)

chr8_-_124553448 0.664 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr11_+_66624875 0.659 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr2_+_10262694 0.654 NM_001165931
RRM2
ribonucleotide reductase M2
chr21_-_46131461 0.649 NM_144991
TSPEAR
thrombospondin-type laminin G domain and EAR repeats
chr2_-_99347588 0.648 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr18_+_57567191 0.642 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr6_+_12290528 0.639 NM_001168319
NM_001955
EDN1

endothelin 1

chr11_-_102668892 0.635 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr3_+_171757413 0.635 NM_022763
FNDC3B
fibronectin type III domain containing 3B
chr1_+_38158129 0.634 NM_018101
CDCA8
cell division cycle associated 8
chr17_-_3819959 0.630 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr12_+_1800188 0.626 NM_024551
ADIPOR2
adiponectin receptor 2
chr8_-_144623611 0.623 NM_015117
ZC3H3
zinc finger CCCH-type containing 3
chr8_+_86089618 0.623 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr3_-_27498244 0.622 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr6_+_34204647 0.611 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr20_-_32700082 0.610 NM_003908
EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr7_+_108210188 0.606 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr6_+_34204576 0.604 NM_002131
NM_145899
NM_145903
HMGA1


high mobility group AT-hook 1


chr7_+_120628722 0.603 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr7_+_107221203 0.598 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chr17_+_40172086 0.597 NM_001144927
NM_001144928
NM_001144929
NM_017595
NKIRAS2



NFKB inhibitor interacting Ras-like 2



chr3_+_49591897 0.596 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chr6_+_34206567 0.591 NM_145905
HMGA1
high mobility group AT-hook 1
chr2_+_10262853 0.590 NM_001034
RRM2
ribonucleotide reductase M2
chr7_-_112579726 0.588 NM_152556
C7orf60
chromosome 7 open reading frame 60
chr4_+_95128994 0.587 NM_001128429
NM_020159
SMARCAD1

SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1

chr16_-_2908105 0.583 NM_022119
PRSS22
protease, serine, 22
chr19_+_531688 0.582 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr17_+_39968961 0.580 NM_021939
FKBP10
FK506 binding protein 10, 65 kDa
chr12_-_95942570 0.580 NM_001042403
USP44
ubiquitin specific peptidase 44
chr6_+_106534188 0.580 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr2_-_11606276 0.579 NM_198256
E2F6
E2F transcription factor 6
chr17_-_48278987 0.576 NM_000088
COL1A1
collagen, type I, alpha 1
chr1_-_153363544 0.575 NM_002964
S100A8
S100 calcium binding protein A8
chr1_+_150122095 0.569 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr13_-_33780142 0.567 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chrX_-_54071568 0.565 NM_001184896
PHF8
PHD finger protein 8
chr7_-_23509972 0.559 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr9_-_77502635 0.556 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr5_-_55008125 0.556 NM_173514
SLC38A9
solute carrier family 38, member 9
chr9_+_128509616 0.555 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr13_-_33760215 0.553 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr5_+_148206155 0.551 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr3_-_87040246 0.551 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr9_+_128510477 0.551 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr15_+_90544608 0.550 NM_198526
ZNF710
zinc finger protein 710
chr1_-_160492982 0.548 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr1_+_206643585 0.543 NM_001193321
NM_001193322
NM_014002
IKBKE


inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon


chr4_+_95128750 0.542 NM_001128430
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr14_+_24867926 0.540 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr12_-_95945226 0.536 NM_032147
USP44
ubiquitin specific peptidase 44
chr2_+_102314162 0.536 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr7_+_130131172 0.533 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr7_+_130126035 0.533 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr7_-_106301329 0.533 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr13_+_39261172 0.531 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr6_+_43399488 0.524 NM_033450
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr17_-_8113862 0.523 NM_004217
AURKB
aurora kinase B
chr6_+_43395285 0.521 NM_001198934
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr9_+_118916069 0.517 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr16_+_68279206 0.517 NM_012320
PLA2G15
phospholipase A2, group XV
chr6_+_11094265 0.514 NM_001135575
C6orf228
chromosome 6 open reading frame 228
chr3_+_196594708 0.513 NM_152699
SENP5
SUMO1/sentrin specific peptidase 5
chr19_-_47975244 0.508 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr15_+_89164522 0.502 NM_022767
AEN
apoptosis enhancing nuclease
chr9_+_102668904 0.498 NM_017919
STX17
syntaxin 17
chr2_+_198570027 0.498 NM_138395
MARS2
methionyl-tRNA synthetase 2, mitochondrial
chr21_-_42879908 0.498 NM_001135099
TMPRSS2
transmembrane protease, serine 2
chr2_+_75059781 0.496 NM_000189
HK2
hexokinase 2
chr3_+_171758289 0.495 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr22_+_50609159 0.495 NM_001160300
NM_052839
PANX2

pannexin 2

chr12_-_85306579 0.495 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr12_+_49372235 0.493 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr2_+_30454396 0.493 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr1_-_120190389 0.493 NM_001080470
ZNF697
zinc finger protein 697
chr3_-_185216545 0.492 NM_080652
TMEM41A
transmembrane protein 41A
chr5_+_143550395 0.491 NM_020768
KCTD16
potassium channel tetramerisation domain containing 16
chr2_+_113239733 0.490 NM_153712
TTL
tubulin tyrosine ligase
chr9_-_35115844 0.489 NM_025182
FAM214B
family with sequence similarity 214, member B
chr3_-_69062744 0.485 NM_173654
C3orf64
chromosome 3 open reading frame 64
chr15_+_63481713 0.483 NM_016530
RAB8B
RAB8B, member RAS oncogene family
chr9_-_72287097 0.478 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr9_+_4662285 0.473 NM_203453
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr20_-_54967221 0.471 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr12_+_13197284 0.465 NM_020853
KIAA1467
KIAA1467
chr11_+_63580922 0.465 NM_138471
C11orf84
chromosome 11 open reading frame 84
chr22_+_46546498 0.463 NM_001001928
NM_005036
PPARA

peroxisome proliferator-activated receptor alpha

chr22_-_22863504 0.463 NM_080764
ZNF280B
zinc finger protein 280B
chr4_-_128887092 0.462 NM_152778
MFSD8
major facilitator superfamily domain containing 8
chr2_+_74881353 0.460 NM_004263
SEMA4F
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
chr11_+_119076974 0.453 NM_005188
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr9_-_77502262 0.451 NM_001177311
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr3_-_48229800 0.447 NM_001789
NM_201567
CDC25A

cell division cycle 25 homolog A (S. pombe)

chr9_-_77567735 0.445 NM_017998
C9orf40
chromosome 9 open reading frame 40
chrX_-_54070606 0.442 NM_001184897
NM_015107
PHF8

PHD finger protein 8

chrX_+_152907892 0.441 NM_001395
DUSP9
dual specificity phosphatase 9
chr8_-_48650703 0.438 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr2_-_190044330 0.437 NM_000393
COL5A2
collagen, type V, alpha 2
chr14_+_55518313 0.433 NM_144578
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr3_+_49208979 0.430 NM_173546
KLHDC8B
kelch domain containing 8B
chr2_-_74667553 0.429 NM_001015056
NM_033046
RTKN

rhotekin

chr14_+_100150596 0.424 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr17_+_1958354 0.424 NM_006497
HIC1
hypermethylated in cancer 1
chr21_+_30671736 0.422 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr2_+_65215577 0.422 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr15_-_29862926 0.421 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr5_+_150157507 0.420 NM_032947
C5orf62
chromosome 5 open reading frame 62
chr15_+_83654954 0.416 NM_031452
FAM103A1
family with sequence similarity 103, member A1
chrX_+_107683015 0.412 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr19_+_925984 0.412 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr16_+_18995508 0.411 NM_001160364
TMC7
transmembrane channel-like 7
chr16_+_18995255 0.410 NM_024847
TMC7
transmembrane channel-like 7
chr7_+_94285620 0.410 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr21_-_42880080 0.409 NM_005656
TMPRSS2
transmembrane protease, serine 2
chr4_+_144106052 0.408 NM_032557
USP38
ubiquitin specific peptidase 38
chr17_+_3539761 0.407 NM_001031681
NM_004937
CTNS

cystinosin, lysosomal cystine transporter

chr18_+_55816546 0.405 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr9_-_77503009 0.405 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chrX_-_15353675 0.401 NM_002641
NM_020473
PIGA

phosphatidylinositol glycan anchor biosynthesis, class A

chr21_+_30671217 0.401 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr10_+_101419169 0.400 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr1_-_28503454 0.400 NM_000952
NM_001164723
PTAFR

platelet-activating factor receptor

chr2_+_74710193 0.399 NM_022492
TTC31
tetratricopeptide repeat domain 31
chr12_+_53894704 0.399 NM_004178
NM_134323
TARBP2

TAR (HIV-1) RNA binding protein 2

chr2_+_65216482 0.399 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr3_+_111805174 0.398 NM_001171747
NM_024616
C3orf52

chromosome 3 open reading frame 52

chr2_+_170590241 0.397 NM_144711
KLHL23
kelch-like 23 (Drosophila)
chr3_-_122233781 0.395 NM_002264
KPNA1
karyopherin alpha 1 (importin alpha 5)
chrX_+_152599544 0.395 NM_001080485
ZNF275
zinc finger protein 275
chr5_+_176237435 0.394 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr7_+_90032647 0.394 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr4_+_699529 0.391 NM_006315
PCGF3
polycomb group ring finger 3
chr10_+_125425870 0.390 NM_153442
GPR26
G protein-coupled receptor 26
chr1_+_204042191 0.388 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chr12_-_12715244 0.386 NM_030640
DUSP16
dual specificity phosphatase 16
chr3_-_36986535 0.385 NM_014831
TRANK1
tetratricopeptide repeat and ankyrin repeat containing 1
chr2_-_220094354 0.385 NM_001077198
NM_024085
ATG9A

ATG9 autophagy related 9 homolog A (S. cerevisiae)

chr12_+_53895376 0.378 NM_134324
TARBP2
TAR (HIV-1) RNA binding protein 2
chr18_+_55714457 0.376 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_28520379 0.373 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr7_+_94285676 0.373 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr2_+_191002485 0.371 NM_001042521
C2orf88
chromosome 2 open reading frame 88

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.62 3.30e-02 GO:0033673 negative regulation of kinase activity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.37 7.77e-03 GO:0005581 collagen
1.92 3.93e-02 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

enrichment   p-value GO term description
11.03 2.12e-02 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
10.24 3.20e-02 GO:0033549 MAP kinase phosphatase activity
3.94 4.18e-02 GO:0005201 extracellular matrix structural constituent