Motif ID: GTF2I.p2

Z-value: 1.531


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_74072038-0.469.7e-03Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51487070 11.366 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr19_-_51472003 7.801 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr19_-_51472816 6.602 NM_002774
KLK6
kallikrein-related peptidase 6
chr1_-_20812271 4.904 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_128509616 4.091 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr19_+_35646006 3.665 FXYD5
FXYD domain containing ion transport regulator 5
chr19_-_41859519 3.430 TGFB1
transforming growth factor, beta 1
chr19_-_41859830 3.399 NM_000660
TGFB1
transforming growth factor, beta 1
chr11_-_123065836 3.371 CLMP
CXADR-like membrane protein
chr1_-_20812727 3.197 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr11_-_2160199 3.030 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_-_51504799 2.948 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr6_-_30655078 2.806 NM_001134870
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr19_-_41859332 2.738 TGFB1
transforming growth factor, beta 1
chr2_-_72374919 2.727 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr6_-_30654978 2.720 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr21_-_28217692 2.515 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_-_2159472 2.500 IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_-_123065988 2.471 NM_024769
CLMP
CXADR-like membrane protein
chr19_-_41933255 2.426


chr19_+_35645640 2.423 NM_144779
NM_001164605
FXYD5

FXYD domain containing ion transport regulator 5

chr19_-_49339913 2.194 NM_016246
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr21_-_28217272 2.173 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr19_-_44285012 2.172 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr8_+_22022677 2.160 BMP1
bone morphogenetic protein 1
chr5_+_92918924 2.158 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr19_+_54926604 2.120 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr1_+_167599329 2.071 NM_052862
RCSD1
RCSD domain containing 1
chr2_+_79740059 2.069 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr2_+_239756672 2.061 NM_057179
TWIST2
twist homolog 2 (Drosophila)
chr19_-_41859253 2.036 TGFB1
transforming growth factor, beta 1
chr19_-_11689765 2.013 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr1_+_150480584 1.999 ECM1
extracellular matrix protein 1
chr17_+_1959512 1.984 NM_001098202
HIC1
hypermethylated in cancer 1
chr19_+_54369610 1.974 NM_001020820
MYADM
myeloid-associated differentiation marker
chr12_+_4382882 1.957 NM_001759
CCND2
cyclin D2
chr12_+_93964801 1.943 SOCS2
suppressor of cytokine signaling 2
chr19_-_55658310 1.916 TNNT1
troponin T type 1 (skeletal, slow)
chr19_+_41725098 1.912 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr15_-_74500394 1.872 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr12_+_56915587 1.867 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr3_-_50349811 1.839 NM_153281
HYAL1
hyaluronoglucosaminidase 1
chr17_+_70117177 1.788 SOX9
SRY (sex determining region Y)-box 9
chr8_+_22022872 1.778 BMP1
bone morphogenetic protein 1
chr9_+_35673852 1.769 NM_001216
CA9
carbonic anhydrase IX
chr6_+_37137882 1.748 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr2_+_23608297 1.736 NM_052920
KLHL29
kelch-like 29 (Drosophila)
chr7_+_18126543 1.733 NM_001204144
HDAC9
histone deacetylase 9
chr7_-_23509972 1.710 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr5_-_127873734 1.704 NM_001999
FBN2
fibrillin 2
chr19_-_11689591 1.699 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr16_+_31483066 1.688 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr6_-_42419782 1.652 NM_033502
TRERF1
transcriptional regulating factor 1
chr2_-_26205437 1.649 NM_002254
KIF3C
kinesin family member 3C
chr22_-_37584254 1.638 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr11_-_2159925 1.631 IGF2
insulin-like growth factor 2 (somatomedin A)
chr9_+_125137600 1.629 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_+_45169036 1.590 NM_005413
SIX3
SIX homeobox 3
chr12_-_54813002 1.587 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_2159784 1.562 IGF2
insulin-like growth factor 2 (somatomedin A)
chr21_-_16437125 1.556 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr6_-_10412606 1.555 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr7_+_86273867 1.550 GRM3
glutamate receptor, metabotropic 3
chr6_-_32157511 1.521 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr19_-_49865638 1.505 NM_003598
TEAD2
TEA domain family member 2
chr1_-_113498828 1.501 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr5_+_135364583 1.497 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr22_-_36236264 1.496 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_13921617 1.466 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chrX_+_198060 1.462 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr14_+_68086633 1.458 ARG2
arginase, type II
chr12_+_57853917 1.451 NM_001160045
NM_001167609
NM_005269
GLI1


GLI family zinc finger 1


chr11_+_130318457 1.446 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr1_+_150480486 1.443 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr14_-_24047993 1.439 NM_001146028
NM_032452
JPH4

junctophilin 4

chr1_-_155948206 1.439 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr2_-_26205327 1.437 KIF3C
kinesin family member 3C
chr9_-_72287097 1.434 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr16_+_725679 1.417 RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr1_+_205473768 1.415 CDK18
cyclin-dependent kinase 18
chr19_+_45281125 1.376 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr10_-_5541401 1.368 NM_017422
CALML5
calmodulin-like 5
chr8_+_22022644 1.362 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr19_-_41858948 1.353 TGFB1
transforming growth factor, beta 1
chr11_+_61595633 1.344 NM_004265
FADS2
fatty acid desaturase 2
chrY_+_148060 1.333 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr14_-_94595925 1.323 NM_032036
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr10_+_102505337 1.314 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr7_-_143059696 1.313 NM_001031690
FAM131B
family with sequence similarity 131, member B
chr4_-_177713664 1.310 NM_005429
VEGFC
vascular endothelial growth factor C
chr19_+_54926721 1.309 TTYH1
tweety homolog 1 (Drosophila)
chrX_+_56258785 1.295 NM_007250
NM_001159296
KLF8

Kruppel-like factor 8

chr4_-_114682594 1.290 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr2_+_79740171 1.273 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr22_-_36236330 1.270 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr7_-_28220146 1.262 JAZF1
JAZF zinc finger 1
chr14_+_24837225 1.262 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr12_+_49209300 1.260 NM_001206916
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr9_+_33817168 1.257 NM_017811
UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr20_-_22564893 1.245 FOXA2
forkhead box A2
chr1_+_205473683 1.222 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr2_+_39664544 1.207 LOC728730
uncharacterized LOC728730
chr17_+_60705042 1.202 MRC2
mannose receptor, C type 2
chr5_+_92920592 1.183 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr1_-_27930101 1.170 NM_001029882
AHDC1
AT hook, DNA binding motif, containing 1
chr19_+_39687600 1.169 NM_001001414
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chrX_-_54522318 1.168 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr1_-_150849062 1.160 ARNT
aryl hydrocarbon receptor nuclear translocator
chr16_+_726074 1.156 NM_003961
RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr5_+_31193761 1.151 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr19_-_51512803 1.133 NM_012315
KLK9
kallikrein-related peptidase 9
chr7_-_94285477 1.130 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr15_-_80216004 1.125 ST20
suppressor of tumorigenicity 20
chr19_-_54984341 1.118 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr17_+_4736612 1.118 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr17_+_60705051 1.113 MRC2
mannose receptor, C type 2
chr6_+_34204647 1.090 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr22_-_36424397 1.088 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr12_-_25055966 1.085 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr19_-_2015628 1.084 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr2_+_62932786 1.080 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr20_+_33759773 1.078 NM_006404
PROCR
protein C receptor, endothelial
chr7_-_143059144 1.077 NM_014690
FAM131B
family with sequence similarity 131, member B
chr22_+_38071612 1.075 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr12_-_53625834 1.075 NM_000966
NM_001243730
NM_001243731
RARG


retinoic acid receptor, gamma


chr7_-_94285426 1.062 SGCE
sarcoglycan, epsilon
chr14_+_23305816 1.054 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_-_150849043 1.054 ARNT
aryl hydrocarbon receptor nuclear translocator
chr18_+_42260774 1.052 NM_015559
SETBP1
SET binding protein 1
chr22_+_31487315 1.051 SMTN
smoothelin
chr10_-_121355978 1.037 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr10_+_94833646 1.031 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr1_+_155147051 1.031 TRIM46
tripartite motif containing 46
chr11_-_72385411 1.024 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr19_+_48828627 1.023 NM_001425
EMP3
epithelial membrane protein 3
chr2_+_148778573 1.019 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr1_+_6673744 1.008 NM_153812
PHF13
PHD finger protein 13
chrX_-_54521866 1.008 FGD1
FYVE, RhoGEF and PH domain containing 1
chr11_-_64410785 1.004 NM_138734
NRXN2
neurexin 2
chr15_+_93443559 1.003 CHD2
chromodomain helicase DNA binding protein 2
chr3_-_98620452 1.002 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr17_-_58469446 0.994 USP32
ubiquitin specific peptidase 32
chr3_+_6902797 0.994 NM_000844
NM_181874
GRM7

glutamate receptor, metabotropic 7

chr10_+_17271341 0.993 VIM
vimentin
chr10_+_17271302 0.989 VIM
vimentin
chr10_+_17271276 0.986 VIM
vimentin
chr14_-_24047428 0.980 JPH4
junctophilin 4
chr5_-_149535309 0.980 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr17_+_60704747 0.978 NM_006039
MRC2
mannose receptor, C type 2
chr15_-_74495093 0.976 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr2_-_165478357 0.970 NM_004490
GRB14
growth factor receptor-bound protein 14
chr6_+_34204928 0.968 HMGA1
high mobility group AT-hook 1
chr14_+_75745480 0.967 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr19_-_47975074 0.963 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr19_+_35782988 0.959 NM_001199216
NM_002361
NM_080600
MAG


myelin associated glycoprotein


chr19_+_54371125 0.954 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr1_-_214724844 0.952 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr10_+_17271277 0.952 VIM
vimentin
chr6_+_151561094 0.951 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_11714396 0.949 FBXO2
F-box protein 2
chr12_+_49208214 0.943 NM_001206917
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr17_-_40828441 0.939 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr14_+_24838301 0.939 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr5_-_146833150 0.939 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr11_+_124735281 0.938 NM_022370
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr2_-_165477986 0.935 GRB14
growth factor receptor-bound protein 14
chr22_-_36236421 0.933 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr14_+_23305792 0.930 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_-_29450406 0.930 NM_001003682
TMEM200B
transmembrane protein 200B
chr5_+_68462836 0.925 NM_031966
CCNB1
cyclin B1
chr11_-_71752099 0.923 NUMA1
nuclear mitotic apparatus protein 1
chr22_-_37823503 0.916 NM_052906
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr16_-_84651639 0.916 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr19_+_48828820 0.914 EMP3
epithelial membrane protein 3
chr17_-_43209681 0.913 NM_133373
PLCD3
phospholipase C, delta 3
chr15_+_63335086 0.913 TPM1
tropomyosin 1 (alpha)
chr19_-_51523272 0.901 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr2_-_55646946 0.900 NM_001135597
NM_018084
CCDC88A

coiled-coil domain containing 88A

chr1_-_154155594 0.900 TPM3
tropomyosin 3
chr17_-_36904545 0.894 NM_007144
PCGF2
polycomb group ring finger 2
chr2_+_220492286 0.892 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr14_+_23305907 0.891 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr12_-_117799410 0.889 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)

chr15_-_59041777 0.889 ADAM10
ADAM metallopeptidase domain 10
chr6_-_30652434 0.886 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr10_+_88718287 0.880 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr2_+_54683276 0.876 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr14_+_23305913 0.870 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_-_150849211 0.868 NM_001197325
NM_001668
NM_178427
ARNT


aryl hydrocarbon receptor nuclear translocator


chr5_-_10308167 0.868 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr18_+_657461 0.868 NM_001071
TYMS
thymidylate synthetase
chr8_+_54793516 0.867 RGS20
regulator of G-protein signaling 20
chrX_+_135229536 0.866 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr2_-_165477818 0.865 GRB14
growth factor receptor-bound protein 14
chr5_+_31193852 0.861 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr5_+_169064238 0.861 NM_004946
DOCK2
dedicator of cytokinesis 2
chr19_-_36019194 0.859 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr7_+_143412938 0.859 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr7_+_100770378 0.854 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr8_-_9008138 0.846 NM_024607
PPP1R3B
protein phosphatase 1, regulatory subunit 3B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 2.92e-34 GO:0065007 biological regulation
1.20 8.60e-34 GO:0050794 regulation of cellular process
1.18 1.85e-32 GO:0050789 regulation of biological process
1.29 6.51e-29 GO:0023052 signaling
1.10 1.22e-24 GO:0009987 cellular process
1.31 4.59e-22 GO:0048518 positive regulation of biological process
1.27 9.74e-22 GO:0007165 signal transduction
1.31 3.21e-20 GO:0048522 positive regulation of cellular process
1.28 1.36e-19 GO:0048731 system development
1.25 3.75e-19 GO:0007275 multicellular organismal development
1.23 4.12e-19 GO:0032502 developmental process
1.22 1.71e-18 GO:0051716 cellular response to stimulus
1.39 2.50e-17 GO:0007399 nervous system development
1.25 8.24e-17 GO:0048856 anatomical structure development
1.37 2.69e-15 GO:0009653 anatomical structure morphogenesis
1.48 2.64e-14 GO:0048699 generation of neurons
1.34 2.73e-14 GO:0023051 regulation of signaling
1.46 3.10e-14 GO:0022008 neurogenesis
1.44 5.28e-14 GO:0032879 regulation of localization
1.31 1.59e-13 GO:0048583 regulation of response to stimulus
1.27 1.93e-13 GO:0048519 negative regulation of biological process
1.27 1.26e-12 GO:0048523 negative regulation of cellular process
1.34 3.95e-12 GO:0009966 regulation of signal transduction
1.47 7.23e-12 GO:0007267 cell-cell signaling
1.48 4.01e-11 GO:0030182 neuron differentiation
1.26 6.79e-11 GO:0030154 cell differentiation
1.28 8.41e-11 GO:0048513 organ development
1.60 1.39e-10 GO:0007268 synaptic transmission
1.28 1.45e-10 GO:0007166 cell surface receptor linked signaling pathway
1.19 1.61e-10 GO:0031323 regulation of cellular metabolic process
1.17 2.59e-10 GO:0019222 regulation of metabolic process
1.19 3.02e-10 GO:0016043 cellular component organization
1.35 3.13e-10 GO:0010604 positive regulation of macromolecule metabolic process
1.38 3.57e-10 GO:0007154 cell communication
1.25 7.41e-10 GO:0048869 cellular developmental process
1.42 9.31e-10 GO:0051128 regulation of cellular component organization
1.54 1.09e-09 GO:0031175 neuron projection development
1.33 1.61e-09 GO:0009893 positive regulation of metabolic process
1.50 1.67e-09 GO:0048666 neuron development
1.53 2.06e-09 GO:0000904 cell morphogenesis involved in differentiation
1.45 2.20e-09 GO:0009719 response to endogenous stimulus
1.56 2.36e-09 GO:0048812 neuron projection morphogenesis
1.18 2.51e-09 GO:0080090 regulation of primary metabolic process
1.56 3.02e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.42 3.03e-09 GO:0051173 positive regulation of nitrogen compound metabolic process
1.18 3.71e-09 GO:0071840 cellular component organization or biogenesis
1.32 3.97e-09 GO:0051239 regulation of multicellular organismal process
1.23 3.99e-09 GO:0042221 response to chemical stimulus
1.35 4.32e-09 GO:0010646 regulation of cell communication
1.53 4.54e-09 GO:0019226 transmission of nerve impulse
1.53 4.54e-09 GO:0035637 multicellular organismal signaling
1.42 5.74e-09 GO:0010557 positive regulation of macromolecule biosynthetic process
1.42 6.93e-09 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.37 1.11e-08 GO:0050793 regulation of developmental process
1.32 1.14e-08 GO:0031325 positive regulation of cellular metabolic process
1.44 1.16e-08 GO:0010628 positive regulation of gene expression
1.42 1.62e-08 GO:0051049 regulation of transport
1.39 1.85e-08 GO:0031328 positive regulation of cellular biosynthetic process
1.45 1.98e-08 GO:0045893 positive regulation of transcription, DNA-dependent
1.55 2.18e-08 GO:0007409 axonogenesis
1.38 2.57e-08 GO:0009891 positive regulation of biosynthetic process
1.35 2.76e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.43 3.44e-08 GO:0051254 positive regulation of RNA metabolic process
1.18 3.56e-08 GO:0060255 regulation of macromolecule metabolic process
1.45 5.61e-08 GO:0009887 organ morphogenesis
1.37 9.40e-08 GO:0040011 locomotion
1.44 1.04e-07 GO:0009725 response to hormone stimulus
1.39 1.81e-07 GO:2000026 regulation of multicellular organismal development
1.22 1.85e-07 GO:0065008 regulation of biological quality
1.43 3.25e-07 GO:0000902 cell morphogenesis
1.47 4.88e-07 GO:0048858 cell projection morphogenesis
1.62 6.45e-07 GO:0051270 regulation of cellular component movement
1.41 7.19e-07 GO:0030030 cell projection organization
1.41 7.70e-07 GO:0032989 cellular component morphogenesis
1.57 1.09e-06 GO:0007411 axon guidance
1.40 1.22e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.46 1.23e-06 GO:0032990 cell part morphogenesis
1.28 1.40e-06 GO:0010033 response to organic substance
1.27 1.68e-06 GO:0035556 intracellular signal transduction
1.33 1.99e-06 GO:0048468 cell development
1.32 2.17e-06 GO:0042127 regulation of cell proliferation
1.11 3.26e-06 GO:0050896 response to stimulus
1.44 5.78e-06 GO:0006935 chemotaxis
1.44 5.78e-06 GO:0042330 taxis
1.15 5.97e-06 GO:0051179 localization
1.55 6.57e-06 GO:0001501 skeletal system development
1.37 7.07e-06 GO:0045595 regulation of cell differentiation
1.70 1.00e-05 GO:0048732 gland development
1.18 1.01e-05 GO:0031326 regulation of cellular biosynthetic process
1.43 1.04e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.57 1.10e-05 GO:0040012 regulation of locomotion
1.18 1.26e-05 GO:0071842 cellular component organization at cellular level
1.55 1.58e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.44 1.80e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.11 1.85e-05 GO:0032501 multicellular organismal process
1.17 2.16e-05 GO:0009889 regulation of biosynthetic process
1.49 4.17e-05 GO:0007420 brain development
1.28 4.51e-05 GO:0051246 regulation of protein metabolic process
1.29 4.54e-05 GO:0009605 response to external stimulus
1.58 5.10e-05 GO:0030334 regulation of cell migration
1.31 5.61e-05 GO:0009888 tissue development
1.33 5.76e-05 GO:0016192 vesicle-mediated transport
1.38 6.75e-05 GO:0042060 wound healing
1.51 8.59e-05 GO:0060284 regulation of cell development
1.40 9.26e-05 GO:0007417 central nervous system development
1.17 9.40e-05 GO:0010468 regulation of gene expression
1.69 1.03e-04 GO:0030900 forebrain development
1.52 1.11e-04 GO:0051130 positive regulation of cellular component organization
1.56 1.21e-04 GO:2000145 regulation of cell motility
1.33 1.32e-04 GO:0006468 protein phosphorylation
1.59 1.47e-04 GO:0051129 negative regulation of cellular component organization
1.27 1.67e-04 GO:0032268 regulation of cellular protein metabolic process
1.16 1.79e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.17 1.91e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.75 2.78e-04 GO:0060627 regulation of vesicle-mediated transport
1.48 3.72e-04 GO:0071495 cellular response to endogenous stimulus
1.16 4.36e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.38 4.48e-04 GO:0008284 positive regulation of cell proliferation
1.40 5.86e-04 GO:0051094 positive regulation of developmental process
1.32 6.27e-04 GO:0009790 embryo development
1.16 6.68e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.60 8.09e-04 GO:0044087 regulation of cellular component biogenesis
1.15 1.02e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.68 1.06e-03 GO:0031344 regulation of cell projection organization
1.23 1.30e-03 GO:0051641 cellular localization
1.53 1.33e-03 GO:0050767 regulation of neurogenesis
1.29 1.38e-03 GO:0048584 positive regulation of response to stimulus
1.65 1.46e-03 GO:0051272 positive regulation of cellular component movement
1.45 1.54e-03 GO:0032535 regulation of cellular component size
1.39 1.81e-03 GO:0032583 regulation of gene-specific transcription
1.91 1.87e-03 GO:0030100 regulation of endocytosis
1.39 2.03e-03 GO:0060341 regulation of cellular localization
1.57 2.36e-03 GO:0045664 regulation of neuron differentiation
1.49 2.36e-03 GO:0051960 regulation of nervous system development
1.25 2.37e-03 GO:0006793 phosphorus metabolic process
1.25 2.37e-03 GO:0006796 phosphate metabolic process
1.39 2.55e-03 GO:0007243 intracellular protein kinase cascade
1.39 2.55e-03 GO:0023014 signal transduction via phosphorylation event
1.35 2.60e-03 GO:0010647 positive regulation of cell communication
1.35 2.66e-03 GO:0023056 positive regulation of signaling
1.34 2.68e-03 GO:0006928 cellular component movement
1.31 2.94e-03 GO:0071310 cellular response to organic substance
1.42 2.94e-03 GO:0090066 regulation of anatomical structure size
1.45 2.97e-03 GO:0051050 positive regulation of transport
1.66 3.05e-03 GO:0045165 cell fate commitment
1.63 3.37e-03 GO:0070482 response to oxygen levels
1.71 3.67e-03 GO:0010975 regulation of neuron projection development
1.39 4.20e-03 GO:0016477 cell migration
1.40 4.50e-03 GO:0007264 small GTPase mediated signal transduction
1.35 4.82e-03 GO:0009967 positive regulation of signal transduction
1.65 5.12e-03 GO:0034330 cell junction organization
1.10 5.29e-03 GO:0044260 cellular macromolecule metabolic process
1.54 5.67e-03 GO:0043193 positive regulation of gene-specific transcription
1.70 6.37e-03 GO:0010959 regulation of metal ion transport
1.17 6.80e-03 GO:0006464 protein modification process
1.23 7.89e-03 GO:0043067 regulation of programmed cell death
1.61 7.93e-03 GO:0040017 positive regulation of locomotion
1.62 8.25e-03 GO:0001666 response to hypoxia
1.26 8.67e-03 GO:0008219 cell death
1.26 8.76e-03 GO:0006351 transcription, DNA-dependent
1.23 8.82e-03 GO:0042981 regulation of apoptosis
1.36 9.01e-03 GO:0048870 cell motility
1.36 9.01e-03 GO:0051674 localization of cell
1.25 9.88e-03 GO:0016265 death
1.32 1.02e-02 GO:0050878 regulation of body fluid levels
1.31 1.04e-02 GO:0010629 negative regulation of gene expression
1.26 1.06e-02 GO:0016310 phosphorylation
1.23 1.11e-02 GO:0010941 regulation of cell death
1.89 1.13e-02 GO:0022612 gland morphogenesis
1.46 1.18e-02 GO:0048545 response to steroid hormone stimulus
1.22 1.53e-02 GO:0051649 establishment of localization in cell
1.09 1.55e-02 GO:0043170 macromolecule metabolic process
1.32 1.78e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.60 1.85e-02 GO:0030335 positive regulation of cell migration
1.60 1.85e-02 GO:2000147 positive regulation of cell motility
1.12 2.02e-02 GO:0051234 establishment of localization
1.47 2.09e-02 GO:0030036 actin cytoskeleton organization
1.35 2.10e-02 GO:0046903 secretion
1.87 2.15e-02 GO:2000027 regulation of organ morphogenesis
1.13 2.16e-02 GO:0006810 transport
1.33 2.21e-02 GO:0007596 blood coagulation
1.33 2.21e-02 GO:0050817 coagulation
1.33 2.26e-02 GO:0007599 hemostasis
1.33 2.30e-02 GO:0048585 negative regulation of response to stimulus
1.16 2.37e-02 GO:0043412 macromolecule modification
1.24 2.40e-02 GO:0070887 cellular response to chemical stimulus
1.28 2.41e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.28 2.50e-02 GO:0019220 regulation of phosphate metabolic process
1.28 2.50e-02 GO:0051174 regulation of phosphorus metabolic process
1.65 2.59e-02 GO:0022604 regulation of cell morphogenesis
1.15 2.70e-02 GO:0051252 regulation of RNA metabolic process
1.27 2.86e-02 GO:0009890 negative regulation of biosynthetic process
1.29 3.03e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.39 3.07e-02 GO:0043434 response to peptide hormone stimulus
1.36 3.10e-02 GO:0009968 negative regulation of signal transduction
1.41 3.11e-02 GO:0032870 cellular response to hormone stimulus
1.42 3.36e-02 GO:0001944 vasculature development
1.34 3.41e-02 GO:0023057 negative regulation of signaling
1.44 3.55e-02 GO:0001568 blood vessel development
1.45 3.73e-02 GO:0008361 regulation of cell size
1.24 3.74e-02 GO:0009611 response to wounding
1.15 3.95e-02 GO:0006355 regulation of transcription, DNA-dependent
1.40 3.97e-02 GO:0032940 secretion by cell
1.07 4.15e-02 GO:0044237 cellular metabolic process
2.37 4.27e-02 GO:0043588 skin development
1.63 4.32e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.64 4.45e-02 GO:0007050 cell cycle arrest
1.18 4.54e-02 GO:0065009 regulation of molecular function

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 2.35e-10 GO:0005737 cytoplasm
1.06 1.25e-09 GO:0044424 intracellular part
1.06 6.30e-09 GO:0005622 intracellular
1.22 1.02e-08 GO:0005829 cytosol
1.49 4.68e-07 GO:0043005 neuron projection
1.31 3.39e-06 GO:0042995 cell projection
1.45 5.42e-06 GO:0045202 synapse
1.09 2.54e-05 GO:0044444 cytoplasmic part
1.35 4.83e-05 GO:0030054 cell junction
1.17 5.85e-05 GO:0044459 plasma membrane part
1.03 7.25e-05 GO:0044464 cell part
1.49 7.50e-05 GO:0044456 synapse part
1.03 7.83e-05 GO:0005623 cell
1.30 8.20e-05 GO:0031988 membrane-bounded vesicle
1.29 1.03e-04 GO:0031982 vesicle
1.26 1.58e-04 GO:0005794 Golgi apparatus
1.29 2.16e-04 GO:0031410 cytoplasmic vesicle
1.30 2.41e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
1.44 3.49e-04 GO:0044433 cytoplasmic vesicle part
1.22 1.08e-03 GO:0000267 cell fraction
1.56 1.12e-03 GO:0030424 axon
1.45 1.12e-03 GO:0012506 vesicle membrane
1.56 1.24e-03 GO:0031252 cell leading edge
1.82 1.69e-03 GO:0030027 lamellipodium
1.56 1.89e-03 GO:0043025 neuronal cell body
1.44 3.16e-03 GO:0030659 cytoplasmic vesicle membrane
1.42 3.47e-03 GO:0015629 actin cytoskeleton
1.06 4.45e-03 GO:0043227 membrane-bounded organelle
1.05 4.55e-03 GO:0043226 organelle
1.24 6.28e-03 GO:0005624 membrane fraction
1.35 6.40e-03 GO:0009986 cell surface
1.64 7.31e-03 GO:0030662 coated vesicle membrane
1.05 7.32e-03 GO:0043231 intracellular membrane-bounded organelle
1.52 7.41e-03 GO:0044297 cell body
1.05 8.62e-03 GO:0043229 intracellular organelle
2.15 9.91e-03 GO:0042734 presynaptic membrane
1.23 1.00e-02 GO:0005626 insoluble fraction
1.76 1.22e-02 GO:0014069 postsynaptic density
1.48 1.31e-02 GO:0030425 dendrite
1.32 3.54e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 7.31e-29 GO:0005515 protein binding
1.08 1.62e-16 GO:0005488 binding
1.43 2.11e-09 GO:0043565 sequence-specific DNA binding
1.33 2.10e-08 GO:0030528 transcription regulator activity
1.33 3.38e-08 GO:0001071 nucleic acid binding transcription factor activity
1.33 3.38e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.26 1.37e-04 GO:0005102 receptor binding
1.30 1.48e-04 GO:0019899 enzyme binding
1.33 2.34e-04 GO:0004672 protein kinase activity
1.39 2.75e-04 GO:0019904 protein domain specific binding
1.29 5.63e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.31 5.72e-03 GO:0008092 cytoskeletal protein binding
1.25 6.66e-03 GO:0016301 kinase activity
1.34 7.63e-03 GO:0004674 protein serine/threonine kinase activity
1.39 1.13e-02 GO:0016563 transcription activator activity
1.56 2.34e-02 GO:0003714 transcription corepressor activity
1.38 2.51e-02 GO:0022836 gated channel activity
1.36 3.43e-02 GO:0003779 actin binding
1.23 4.27e-02 GO:0042802 identical protein binding