Motif ID: GUAGUGU

Z-value: 0.600


Mature miRNA associated with seed GUAGUGU:

NamemiRBase Accession
hsa-miR-142-3p MIMAT0000434



Activity profile for motif GUAGUGU.

activity profile for motif GUAGUGU


Sorted Z-values histogram for motif GUAGUGU

Sorted Z-values for motif GUAGUGU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAGUGU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_16077740 1.038 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr4_-_16085593 0.984 NM_001145847
NM_001145848
PROM1

prominin 1

chr11_-_76381787 0.691 NM_001128922
LRRC32
leucine rich repeat containing 32
chr11_-_76380894 0.681 NM_005512
LRRC32
leucine rich repeat containing 32
chrX_+_44732402 0.559 NM_021140
KDM6A
lysine (K)-specific demethylase 6A
chr17_-_4806368 0.524 NM_000080
CHRNE
cholinergic receptor, nicotinic, epsilon
chr1_-_29450406 0.450 NM_001003682
TMEM200B
transmembrane protein 200B
chr1_-_29449012 0.422 NM_001171868
TMEM200B
transmembrane protein 200B
chr1_+_25071759 0.398 NM_013943
CLIC4
chloride intracellular channel 4
chr6_-_138820578 0.386 NM_001144060
NHSL1
NHS-like 1
chr11_+_34654010 0.367 NM_001206616
EHF
ets homologous factor
chr4_-_139163222 0.367 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr6_-_138893666 0.349 NM_020464
NHSL1
NHS-like 1
chr9_-_80646150 0.349 NM_002072
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr5_-_55290601 0.336 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr11_+_34642587 0.330 NM_001206615
NM_012153
EHF

ets homologous factor

chr4_+_113066552 0.323 NM_152400
C4orf32
chromosome 4 open reading frame 32
chr7_+_20370724 0.322 NM_002214
ITGB8
integrin, beta 8
chr1_+_218518675 0.321 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr5_+_95066628 0.306 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr14_+_65453439 0.293 NM_002028
FNTB
farnesyltransferase, CAAX box, beta
chr18_+_56338617 0.285 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr19_+_45596406 0.279 NM_019121
PPP1R37
protein phosphatase 1, regulatory subunit 37
chr10_-_11574273 0.276 NM_001080491
USP6NL
USP6 N-terminal like
chr3_-_151047309 0.270 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr5_+_166711842 0.268 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr19_+_16178170 0.264 NM_001145160
TPM4
tropomyosin 4
chr12_+_65004191 0.254 NM_178169
RASSF3
Ras association (RalGDS/AF-6) domain family member 3
chr4_-_40631846 0.251 NM_001098634
RBM47
RNA binding motif protein 47
chr1_-_155532322 0.244 NM_018489
ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr14_-_31495524 0.239 NM_001083893
NM_014574
STRN3

striatin, calmodulin binding protein 3

chr10_+_5726781 0.238 NM_017782
FAM208B
family with sequence similarity 208, member B
chr4_-_146859568 0.235 NM_178835
ZNF827
zinc finger protein 827
chr6_+_144612872 0.234 NM_007124
UTRN
utrophin
chr11_-_85780899 0.227 NM_001206947
PICALM
phosphatidylinositol binding clathrin assembly protein
chr12_-_54582588 0.223 NM_001243789
NM_001243790
NM_001243787
NM_001243788
NM_001243791
NM_014311
SMUG1





single-strand-selective monofunctional uracil-DNA glycosylase 1





chr9_-_110252045 0.218 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr19_+_16187047 0.218 NM_003290
TPM4
tropomyosin 4
chr7_-_123388711 0.216 NM_003941
WASL
Wiskott-Aldrich syndrome-like
chr3_+_187943192 0.215 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr19_-_11450254 0.214 NM_004283
RAB3D
RAB3D, member RAS oncogene family
chr5_-_90679115 0.210 NM_020801
ARRDC3
arrestin domain containing 3
chr3_+_20081523 0.199 NM_003884
KAT2B
K(lysine) acetyltransferase 2B
chr5_+_36608430 0.197 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_114866090 0.196 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr9_+_101867401 0.196 NM_001130916
NM_004612
TGFBR1

transforming growth factor, beta receptor 1

chr7_+_101460881 0.195 NM_181552
CUX1
cut-like homeobox 1
chr4_-_40517913 0.193 NM_019027
RBM47
RNA binding motif protein 47
chr17_-_48785016 0.192 NM_052855
ANKRD40
ankyrin repeat domain 40
chr16_-_87525317 0.190 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr2_+_198380294 0.188 NM_199482
MOB4
MOB family member 4, phocein
chr15_-_52821004 0.184 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr6_+_149639435 0.182 NM_015093
TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr21_+_30671736 0.182 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr14_-_31676680 0.179 NM_015382
HECTD1
HECT domain containing 1
chr3_-_50396930 0.178 NM_007024
TMEM115
transmembrane protein 115
chr5_-_101631965 0.176 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr12_-_53614121 0.173 NM_001042728
NM_001243732
RARG

retinoic acid receptor, gamma

chr18_+_57567191 0.172 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr4_-_129209983 0.172 NM_006320
PGRMC2
progesterone receptor membrane component 2
chr3_+_47422471 0.171 NM_015466
PTPN23
protein tyrosine phosphatase, non-receptor type 23
chr3_+_187930720 0.171 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr6_-_134498973 0.171 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_134639195 0.170 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr10_+_17686123 0.168 NM_003473
STAM
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr20_+_57766074 0.165 NM_178457
ZNF831
zinc finger protein 831
chr1_-_8483701 0.162 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr19_-_50380451 0.159 NM_032375
NM_001098633
NM_001098632
AKT1S1


AKT1 substrate 1 (proline-rich)


chr12_-_53625834 0.159 NM_000966
NM_001243730
NM_001243731
RARG


retinoic acid receptor, gamma


chr10_-_61666236 0.156 NM_005436
CCDC6
coiled-coil domain containing 6
chr1_-_92952429 0.156 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr20_-_30310597 0.154 NM_001191
NM_138578
BCL2L1

BCL2-like 1

chr16_+_67143783 0.154 NM_025187
C16orf70
chromosome 16 open reading frame 70
chr15_+_41245635 0.153 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr8_+_61429390 0.152 NM_001242644
NM_002865
RAB2A

RAB2A, member RAS oncogene family

chr6_-_134496006 0.152 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chrX_+_70315637 0.150 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr16_+_640172 0.147 NM_021168
RAB40C
RAB40C, member RAS oncogene family
chr2_+_187464931 0.146 NM_001144999
ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr16_+_639356 0.144 NM_001172663
RAB40C
RAB40C, member RAS oncogene family
chr11_-_85780105 0.144 NM_001008660
NM_001206946
NM_007166
PICALM


phosphatidylinositol binding clathrin assembly protein


chr1_-_8877379 0.142 NM_001042681
NM_012102
RERE

arginine-glutamic acid dipeptide (RE) repeats

chr3_+_23987514 0.139 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr14_-_35344852 0.139 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr17_+_2699731 0.138 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr1_-_92949355 0.137 NM_001127215
GFI1
growth factor independent 1 transcription repressor
chr16_-_18937722 0.137 NM_015092
SMG1
smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr11_+_57529233 0.136 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001206883
NM_001206884
NM_001206885
NM_001206886
NM_001206887
NM_001206888
NM_001206889
NM_001206890
NM_001206891
NM_001331
CTNND1





















catenin (cadherin-associated protein), delta 1





















chr9_-_36400212 0.136 NM_022781
NM_194329
RNF38

ring finger protein 38

chrX_+_9431314 0.134 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr3_-_114478117 0.133 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr8_-_28243941 0.133 NM_018660
ZNF395
zinc finger protein 395
chr6_-_31628509 0.133 NM_021184
C6orf47
chromosome 6 open reading frame 47
chr4_-_102268626 0.133 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr10_+_134351272 0.133 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr3_+_23986735 0.132 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr5_-_53606387 0.129 NM_019087
ARL15
ADP-ribosylation factor-like 15
chr10_+_11047253 0.129 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr10_-_32345337 0.128 NM_004521
KIF5B
kinesin family member 5B
chr6_-_134497069 0.127 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr5_+_53813494 0.126 NM_001145427
NM_001102575
NM_052870
SNX18


sorting nexin 18


chr10_-_65028825 0.126 NM_004241
JMJD1C
jumonji domain containing 1C
chr17_+_73521744 0.124 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr11_+_70244588 0.120 NM_001184740
NM_005231
NM_138565
CTTN


cortactin


chr19_-_15560761 0.119 NM_021241
WIZ
widely interspaced zinc finger motifs
chr9_-_36401149 0.118 NM_194330
RNF38
ring finger protein 38
chr18_+_67956136 0.118 NM_004232
SOCS6
suppressor of cytokine signaling 6
chr1_+_57110745 0.117 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr10_-_61900659 0.116 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr6_-_88411984 0.115 NM_018064
AKIRIN2
akirin 2
chr20_-_3996035 0.114 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr8_-_17579729 0.114 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr17_+_7210317 0.112 NM_001143760
EIF5A
eukaryotic translation initiation factor 5A
chr17_+_27717942 0.111 NM_020791
NM_025142
TAOK1

TAO kinase 1

chr16_-_70557430 0.111 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr9_-_36400817 0.111 NM_194328
NM_194332
RNF38

ring finger protein 38

chrX_-_24045302 0.110 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chrX_-_77914824 0.109 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr8_-_17555158 0.109 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr10_-_27529263 0.108 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chrX_+_16964730 0.107 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr10_-_27531041 0.107 NM_001042473
ACBD5
acyl-CoA binding domain containing 5
chr3_+_187871473 0.105 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_-_91487769 0.105 NM_032186
NM_201269
ZNF644

zinc finger protein 644

chr8_-_17580024 0.104 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr18_-_33647336 0.104 NM_018170
RPRD1A
regulation of nuclear pre-mRNA domain containing 1A
chr21_+_30671217 0.103 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr16_+_640056 0.103 NM_001172665
NM_001172666
RAB40C

RAB40C, member RAS oncogene family

chr2_+_198381021 0.102 NM_001204094
MOB4
MOB family member 4, phocein
chr2_+_148602569 0.101 NM_001616
ACVR2A
activin A receptor, type IIA
chr2_+_198380752 0.101 NM_001100819
NM_015387
MOB4

MOB family member 4, phocein

chr10_-_81205091 0.101 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr7_-_112726143 0.099 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr5_+_42549657 0.099 NM_001242404
GHR
growth hormone receptor
chr2_+_187454724 0.099 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chrX_-_41782230 0.097 NM_001126054
NM_001126055
NM_003688
CASK


calcium/calmodulin-dependent serine protein kinase (MAGUK family)


chr1_+_11072678 0.097 NM_007375
TARDBP
TAR DNA binding protein
chrX_+_122993536 0.097 NM_001204401
NM_001167
XIAP

X-linked inhibitor of apoptosis

chr19_+_56187990 0.097 NM_001130071
EPN1
epsin 1
chr17_+_7211693 0.096 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr16_+_28875181 0.094 NM_001145812
NM_015503
SH2B1

SH2B adaptor protein 1

chr3_-_114790221 0.094 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_42550181 0.093 NM_001242405
GHR
growth hormone receptor
chr16_+_639668 0.092 NM_001172664
RAB40C
RAB40C, member RAS oncogene family
chr15_+_38544966 0.092 NM_152594
SPRED1
sprouty-related, EVH1 domain containing 1
chr11_+_13299260 0.091 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr8_-_17658385 0.090 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr5_+_42565562 0.090 NM_001242406
GHR
growth hormone receptor
chr5_+_42548314 0.089 NM_001242403
GHR
growth hormone receptor
chr11_-_8680382 0.088 NM_014818
TRIM66
tripartite motif containing 66
chr2_-_39664129 0.088 NM_003618
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr7_-_112727832 0.088 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr14_-_35182944 0.087 NM_021914
CFL2
cofilin 2 (muscle)
chr5_+_42565963 0.087 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chrX_+_9432980 0.087 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr10_-_62149487 0.086 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_42548144 0.086 NM_001242402
GHR
growth hormone receptor
chr11_+_102188180 0.086 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr17_+_44668034 0.084 NM_006178
NSF
N-ethylmaleimide-sensitive factor
chr6_-_159466019 0.083 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr5_+_42424553 0.083 NM_001242399
NM_001242400
GHR

growth hormone receptor

chr10_-_32217762 0.082 NM_018287
ARHGAP12
Rho GTPase activating protein 12
chrX_-_109683457 0.081 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr4_+_15004297 0.081 NM_001177381
NM_001177382
NM_001177383
NM_001177384
NM_182485
NM_182646
CPEB2





cytoplasmic polyadenylation element binding protein 2





chr18_+_42260774 0.081 NM_015559
SETBP1
SET binding protein 1
chrX_-_102942968 0.081 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chr5_+_112073555 0.081 NM_000038
NM_001127510
APC

adenomatous polyposis coli

chr16_+_28875077 0.081 NM_001145795
NM_001145796
NM_001145797
SH2B1


SH2B adaptor protein 1


chr2_+_74273449 0.081 NM_144993
TET3
tet methylcytosine dioxygenase 3
chr2_-_99347588 0.081 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr5_+_42425093 0.079 NM_001242401
GHR
growth hormone receptor
chr9_-_115095933 0.079 NM_001163788
NM_001163790
NM_001244896
NM_001244897
NM_005156
PTBP3




polypyrimidine tract binding protein 3




chr6_-_132834165 0.079 NM_003569
STX7
syntaxin 7
chr3_-_114102488 0.079 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_42423811 0.078 NM_000163
GHR
growth hormone receptor
chr3_+_238274 0.077 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr22_-_36784055 0.077 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr12_-_44200047 0.076 NM_001242397
NM_002822
TWF1

twinfilin, actin-binding protein, homolog 1 (Drosophila)

chr5_-_142815076 0.076 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr6_+_34206567 0.074 NM_145905
HMGA1
high mobility group AT-hook 1
chr17_-_47439326 0.074 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr19_-_22379752 0.073 NM_001001411
ZNF676
zinc finger protein 676
chr3_-_114343791 0.071 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_7210841 0.071 NM_001970
EIF5A
eukaryotic translation initiation factor 5A
chr2_-_86948244 0.071 NM_001198954
RNF103-CHMP3
RNF103-CHMP3 readthrough
chr17_+_7211260 0.071 NM_001143761
EIF5A
eukaryotic translation initiation factor 5A
chr17_-_62340652 0.070 NM_018469
TEX2
testis expressed 2
chr14_-_35183722 0.068 NM_001243645
NM_138638
CFL2

cofilin 2 (muscle)

chr3_-_114343052 0.068 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_224301790 0.068 NM_001136115
NM_015176
FBXO28

F-box protein 28

chr5_+_31799030 0.067 NM_178140
PDZD2
PDZ domain containing 2
chr6_-_33267128 0.066 NM_001243738
NM_004761
RGL2

ral guanine nucleotide dissociation stimulator-like 2

chr15_+_66161769 0.065 NM_001206836
NM_004663
RAB11A

RAB11A, member RAS oncogene family

chr19_-_6279927 0.065 NM_005934
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr2_-_61765394 0.063 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr21_+_18885104 0.063 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr1_+_114493766 0.063 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr8_+_81398416 0.063 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr5_+_112043188 0.063 NM_001127511
APC
adenomatous polyposis coli
chr8_-_116681103 0.062 NM_014112
TRPS1
trichorhinophalangeal syndrome I

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.93 7.18e-04 GO:0007167 enzyme linked receptor protein signaling pathway
2.60 3.15e-03 GO:0046907 intracellular transport
1.60 3.81e-03 GO:0023052 signaling
1.64 4.07e-03 GO:0007165 signal transduction
3.01 5.62e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.51 2.08e-02 GO:0051716 cellular response to stimulus
2.17 2.14e-02 GO:0051649 establishment of localization in cell
2.07 2.46e-02 GO:0051641 cellular localization
1.34 2.92e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 6.60e-05 GO:0005622 intracellular
1.23 7.66e-05 GO:0044424 intracellular part
1.28 3.53e-03 GO:0005737 cytoplasm
1.21 3.52e-02 GO:0043229 intracellular organelle
1.20 3.96e-02 GO:0043226 organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.39 6.29e-05 GO:0005515 protein binding
1.90 3.47e-04 GO:0008270 zinc ion binding
1.20 3.54e-04 GO:0005488 binding
1.70 8.40e-03 GO:0046914 transition metal ion binding
1.46 2.60e-02 GO:0046872 metal ion binding
1.45 3.85e-02 GO:0043169 cation binding
1.44 4.19e-02 GO:0043167 ion binding