Motif ID: HLF.p2

Z-value: 1.043


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HLFchr17_+_533423200.096.4e-01Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_55866972 4.780 CES1
carboxylesterase 1
chr16_-_55867016 4.644 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr8_-_6735438 2.338 NM_005218
DEFB1
defensin, beta 1
chr2_-_113594325 2.302 NM_000576
IL1B
interleukin 1, beta
chr2_-_216300770 2.181 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr2_+_113885137 2.170 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr12_-_91505215 2.155 LUM
lumican
chr13_-_20110884 2.006 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr2_-_31637598 1.798 NM_000379
XDH
xanthine dehydrogenase
chr2_+_113885145 1.611 IL1RN
interleukin 1 receptor antagonist
chr8_+_124194751 1.585 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr8_+_124194873 1.555 FAM83A
family with sequence similarity 83, member A
chr11_+_69061599 1.521 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr19_-_41356193 1.496 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr12_-_52845862 1.403 NM_005555
KRT6B
keratin 6B
chr20_+_16728997 1.343 NM_020157
OTOR
otoraplin
chr20_-_56285576 1.268 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr1_+_151032150 1.247 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_105757592 1.211 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr5_-_147211141 1.194 SPINK1
serine peptidase inhibitor, Kazal type 1
chrX_-_15620191 1.071 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr13_-_38172862 1.063 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr1_-_153348057 1.029 NM_005621
S100A12
S100 calcium binding protein A12
chr3_-_48130633 1.023 NM_001134364
NM_002375
NM_030885
MAP4


microtubule-associated protein 4


chr5_-_147162251 1.011 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr16_-_4588738 0.997 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr22_+_24979717 0.964 NM_013430
GGT1
gamma-glutamyltransferase 1
chr1_+_154377847 0.933 IL6R
interleukin 6 receptor
chr19_+_49259343 0.923 NM_019113
FGF21
fibroblast growth factor 21
chr19_+_35849487 0.908 NM_005304
FFAR3
free fatty acid receptor 3
chr19_+_41430123 0.880 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr5_+_150632612 0.873 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr1_-_151032036 0.842 CDC42SE1
CDC42 small effector 1
chr17_-_7155258 0.839 NM_015343
CTDNEP1
CTD nuclear envelope phosphatase 1
chr16_+_72088507 0.829 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_112016588 0.825 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr22_+_25003610 0.816 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr20_+_58296264 0.809 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr2_-_31637553 0.792 XDH
xanthine dehydrogenase
chr5_-_147286064 0.790 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr8_+_27179918 0.788 NM_004103
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr5_-_147211235 0.787 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr2_-_214015053 0.779 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr4_+_69962191 0.765 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr4_-_76928601 0.763 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr8_-_143999255 0.695 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr8_+_24151579 0.664 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr5_+_96212167 0.660 ERAP2
endoplasmic reticulum aminopeptidase 2
chr17_+_34431219 0.644 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr10_+_118305427 0.636 NM_000936
PNLIP
pancreatic lipase
chr7_+_65958643 0.631


chr17_+_41277608 0.622 NBR2
neighbor of BRCA1 gene 2 (non-protein coding)
chr17_-_39092714 0.609 KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_158300517 0.607 NM_004288
CYTIP
cytohesin 1 interacting protein
chr2_-_68694389 0.602 NM_001024680
FBXO48
F-box protein 48
chr2_-_88427535 0.601 NM_001443
FABP1
fatty acid binding protein 1, liver
chr19_-_40919270 0.598 NM_020956
NM_181882
PRX

periaxin

chr15_+_58430394 0.597 NM_020980
AQP9
aquaporin 9
chr1_-_151032082 0.592 NM_001038707
NM_020239
CDC42SE1

CDC42 small effector 1

chr2_+_70142303 0.589 MXD1
MAX dimerization protein 1
chr14_-_70263871 0.587 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr12_+_112856701 0.585 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr10_+_103911932 0.576 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr9_+_36169384 0.571 NM_005893
CCIN
calicin
chr5_+_36606456 0.571 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr9_-_118416 0.562 NM_207305
FOXD4
forkhead box D4
chr9_-_95298251 0.553 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr22_+_50925212 0.549 NM_017584
MIOX
myo-inositol oxygenase
chr5_-_147162264 0.546 JAKMIP2
janus kinase and microtubule interacting protein 2
chr7_-_129592794 0.538 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr8_+_40010986 0.537 NM_020130
C8orf4
chromosome 8 open reading frame 4
chrX_-_33229428 0.515 NM_004006
DMD
dystrophin
chr17_-_39183453 0.502 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr11_-_66675334 0.501 NM_022172
PC
pyruvate carboxylase
chr19_-_46088084 0.500 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr3_-_42843217 0.499


chr12_-_8765438 0.497 NM_020661
AICDA
activation-induced cytidine deaminase
chr7_-_129592711 0.496 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr3_-_99594915 0.493 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr9_-_91267004 0.485 NM_001100111
LOC286238
uncharacterized LOC286238
chr20_+_36011936 0.477 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr19_+_49109999 0.472 NM_133498
SPACA4
sperm acrosome associated 4
chr13_-_25745778 0.468 NM_152704
NM_199138
FAM123A

family with sequence similarity 123A

chr15_-_74495528 0.467 NM_001142618
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr9_-_19786886 0.463 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr18_+_61254533 0.462 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr12_-_53074172 0.454 NM_006121
KRT1
keratin 1
chr8_-_130799133 0.454 NM_031415
GSDMC
gasdermin C
chr19_-_51141301 0.448 NM_032298
SYT3
synaptotagmin III
chr5_+_150399980 0.447 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr10_-_52645430 0.441 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr14_-_24732344 0.441 NM_000359
TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr11_-_102714240 0.438 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr6_-_30043547 0.437 NM_170769
NM_025236
RNF39

ring finger protein 39

chr2_+_113279582 0.421 TTL
tubulin tyrosine ligase
chr7_+_45933096 0.404


chr7_+_80267922 0.400 CD36
CD36 molecule (thrombospondin receptor)
chr10_+_123923104 0.394 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr2_-_234652623 0.392 NM_001001394
DNAJB3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr5_+_36606667 0.387 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr17_-_39274587 0.385 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr15_-_63674074 0.384 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr21_+_45138973 0.383 NM_003681
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr5_+_140501399 0.380 PCDHB4
protocadherin beta 4
chr5_+_173472737 0.378 HMP19
HMP19 protein
chr3_+_121902529 0.367 NM_000388
CASR
calcium-sensing receptor
chr17_-_71308118 0.367 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr19_-_41388656 0.367 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr12_+_112856756 0.364 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr5_-_39364562 0.359 NM_001737
C9
complement component 9
chr17_+_74536114 0.357 NM_001077620
PRCD
progressive rod-cone degeneration
chr4_+_118955499 0.355 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr17_+_34538464 0.355 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr20_+_62496650 0.353 TPD52L2
tumor protein D52-like 2
chr19_-_52391095 0.352 NM_001135590
NM_032679
ZNF577

zinc finger protein 577

chr5_+_175308843 0.352 CPLX2
complexin 2
chr9_-_2844071 0.352 KIAA0020
KIAA0020
chr11_+_62104773 0.352 NM_001083926
NM_025080
ASRGL1

asparaginase like 1

chrX_+_15518899 0.349 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr15_-_80263460 0.347 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr20_+_62496634 0.346 TPD52L2
tumor protein D52-like 2
chr15_-_72598655 0.345 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr6_-_169654047 0.342 NM_003247
THBS2
thrombospondin 2
chr4_-_159092509 0.340 FAM198B
family with sequence similarity 198, member B
chr13_-_25745620 0.338 FAM123A
family with sequence similarity 123A
chr1_+_84864214 0.336 NM_021233
DNASE2B
deoxyribonuclease II beta
chr7_+_134464161 0.333 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr20_+_62496678 0.333 TPD52L2
tumor protein D52-like 2
chr7_+_128349111 0.331 FAM71F1
family with sequence similarity 71, member F1
chr17_-_41623246 0.326 NM_001986
ETV4
ets variant 4
chr2_+_30454396 0.325 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr6_-_137494719 0.324 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr5_-_140012730 0.324 CD14
CD14 molecule
chr20_+_4666796 0.323 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr5_+_167956545 0.323


chr6_-_133035180 0.315 NM_004666
VNN1
vanin 1
chr5_-_140013034 0.314 NM_000591
CD14
CD14 molecule
chr1_-_62784971 0.313 KANK4
KN motif and ankyrin repeat domains 4
chr3_-_58200397 0.307 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr3_-_128186090 0.306 NM_153330
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr6_+_121756744 0.306 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr13_-_46679143 0.306 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr10_+_70980058 0.304 NM_025130
HKDC1
hexokinase domain containing 1
chr3_-_154042204 0.303 NM_001114397
NM_020865
DHX36

DEAH (Asp-Glu-Ala-His) box polypeptide 36

chr7_+_129847699 0.301 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr19_-_460995 0.299 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr6_+_31940098 0.297 STK19
serine/threonine kinase 19
chr1_+_11249344 0.295 NM_021146
ANGPTL7
angiopoietin-like 7
chr2_+_113825546 0.294 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr20_-_1600589 0.293 NM_001083910
NM_001135844
NM_006065
SIRPB1


signal-regulatory protein beta 1


chr20_+_33759773 0.292 NM_006404
PROCR
protein C receptor, endothelial
chr3_+_124303505 0.287 NM_007064
KALRN
kalirin, RhoGEF kinase
chr17_-_39324423 0.287 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr14_+_24540742 0.286 NM_006032
CPNE6
copine VI (neuronal)
chr19_+_1450208 0.286 APC2
adenomatosis polyposis coli 2
chr6_-_169653922 0.284 THBS2
thrombospondin 2
chr1_+_241815579 0.283 NM_144625
WDR64
WD repeat domain 64
chr17_+_41322413 0.282 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr9_+_70917782 0.281 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr14_+_103388992 0.280 NM_030943
AMN
amnionless homolog (mouse)
chr6_-_52109226 0.280 NM_052872
IL17F
interleukin 17F
chr15_+_91411884 0.280 NM_002569
FURIN
furin (paired basic amino acid cleaving enzyme)
chr1_-_93342706 0.278 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr20_-_5591487 0.277 NM_019593
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr17_-_4607198 0.277 PELP1
proline, glutamate and leucine rich protein 1
chr17_-_4607414 0.276 PELP1
proline, glutamate and leucine rich protein 1
chr20_+_23471765 0.273 NM_005492
CST8
cystatin 8 (cystatin-related epididymal specific)
chr21_-_45079327 0.273 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr3_-_48130283 0.272 MAP4
microtubule-associated protein 4
chr12_-_71148383 0.272 NM_130846
NM_001207016
PTPRR

protein tyrosine phosphatase, receptor type, R

chr1_-_178840079 0.272 NM_004673
ANGPTL1
angiopoietin-like 1
chr19_+_35773409 0.271 NM_021175
HAMP
hepcidin antimicrobial peptide
chr12_-_6982448 0.268 NM_001146316
NM_032641
SPSB2

splA/ryanodine receptor domain and SOCS box containing 2

chr2_+_169926084 0.268 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr4_+_71062241 0.268 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr16_+_31711914 0.266 KIAA0664L3
KIAA0664-like 3
chr4_-_153273683 0.263 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr9_-_95055966 0.261 NM_013417
IARS
isoleucyl-tRNA synthetase
chr10_-_14372807 0.260 NM_018027
FRMD4A
FERM domain containing 4A
chr7_+_129015483 0.260 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr6_+_26204779 0.259 NM_003545
HIST1H4E
histone cluster 1, H4e
chr12_-_123201319 0.259 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chrX_+_44732402 0.258 NM_021140
KDM6A
lysine (K)-specific demethylase 6A
chr17_-_77813049 0.258 NM_003655
CBX4
chromobox homolog 4
chr17_+_3379295 0.257 NM_000049
ASPA
aspartoacylase
chr17_-_7835146 0.257 NM_021210
NM_001166621
TRAPPC1

trafficking protein particle complex 1

chr21_+_45079375 0.256 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr12_-_10605928 0.255 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr19_-_48614013 0.254 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr1_-_67266930 0.252 NM_005478
INSL5
insulin-like 5
chr11_+_1463674 0.252 BRSK2
BR serine/threonine kinase 2
chr7_+_5632435 0.250 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chrX_-_138724851 0.248 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr22_-_29457793 0.247 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr3_-_16306283 0.244 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr15_-_74495093 0.244 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr2_+_68694669 0.241 NM_173545
APLF
aprataxin and PNKP like factor
chr9_-_73029539 0.239 NM_001206
KLF9
Kruppel-like factor 9
chrX_+_43514157 0.237 MAOA
monoamine oxidase A
chr8_+_24298442 0.237 NM_003817
ADAM7
ADAM metallopeptidase domain 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.14 9.73e-06 GO:0006954 inflammatory response
1.99 1.74e-04 GO:0009611 response to wounding
18.99 1.75e-04 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
16.88 5.08e-04 GO:0048880 sensory system development
16.88 5.08e-04 GO:0048892 lateral line nerve development
16.88 5.08e-04 GO:0048895 lateral line nerve glial cell differentiation
16.88 5.08e-04 GO:0048925 lateral line system development
16.88 5.08e-04 GO:0048937 lateral line nerve glial cell development
16.88 5.08e-04 GO:0050935 iridophore differentiation
11.82 1.28e-03 GO:0048485 sympathetic nervous system development
1.95 1.69e-03 GO:0006952 defense response
13.81 2.61e-03 GO:0060600 dichotomous subdivision of an epithelial terminal unit
1.82 4.25e-03 GO:0009605 response to external stimulus
12.66 5.05e-03 GO:0048846 axon extension involved in axon guidance
12.66 5.05e-03 GO:0090184 positive regulation of kidney development
6.33 1.43e-02 GO:0021675 nerve development
7.24 1.57e-02 GO:0021545 cranial nerve development
10.13 2.47e-02 GO:0030513 positive regulation of BMP signaling pathway
10.13 2.47e-02 GO:0048484 enteric nervous system development
1.42 4.80e-02 GO:0006950 response to stress

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.21 3.81e-07 GO:0005615 extracellular space
1.88 3.75e-05 GO:0044421 extracellular region part
1.54 2.84e-04 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.95 2.78e-02 GO:0008009 chemokine activity