Motif ID: HMGA1,2.p2

Z-value: 1.423


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMGA1chr6_+_34204690-0.613.5e-04Click!
HMGA2chr12_+_66218141-0.441.5e-02Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_161337663 14.556 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr7_-_16921596 11.345 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr4_+_70861647 8.167 NM_001009181
NM_003154
STATH

statherin

chr7_+_23286384 6.965 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_142829169 6.920 NM_002652
PIP
prolactin-induced protein
chr8_-_110693233 6.078 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr13_+_43355685 6.014 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr7_+_23286277 5.778 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr19_-_9092017 5.431 NM_024690
MUC16
mucin 16, cell surface associated
chr5_+_140247767 5.401 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr1_+_79115476 5.239 NM_006417
IFI44
interferon-induced protein 44
chr16_-_21289571 5.197 CRYM
crystallin, mu
chr3_+_361365 4.784 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr18_-_24722757 4.685 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr5_+_94727047 4.474 NM_152548
FAM81B
family with sequence similarity 81, member B
chr16_-_21289637 4.470 CRYM
crystallin, mu
chr5_-_160279045 4.305 NM_025153
ATP10B
ATPase, class V, type 10B
chr12_-_71551564 4.273 TSPAN8
tetraspanin 8
chr16_-_21314371 4.253 NM_001014444
NM_001888
CRYM

crystallin, mu

chr13_+_36050885 4.144 NM_001204197
NBEA
neurobeachin
chr1_-_150738255 4.133 CTSS
cathepsin S
chr7_+_23286386 3.982 GPNMB
glycoprotein (transmembrane) nmb
chr3_+_113616317 3.878 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr7_+_23286420 3.841 GPNMB
glycoprotein (transmembrane) nmb
chr13_-_39564857 3.840 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr7_+_23286390 3.830 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_140165875 3.713 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr5_-_35938736 3.712 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr6_+_150690027 3.591 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr12_+_20963637 3.576 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr2_-_135782246 3.477 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr12_-_25801487 3.464 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr5_+_96211643 3.433 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr6_-_52774460 3.270 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr5_-_41261539 3.257 NM_001115131
C6
complement component 6
chr13_-_20110884 3.189 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr20_+_9458460 3.071 PLCB4
phospholipase C, beta 4
chr16_-_52581713 2.963 NM_001146188
TOX3
TOX high mobility group box family member 3
chr1_-_150738232 2.956 CTSS
cathepsin S
chr10_-_21435487 2.941 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr20_+_58251715 2.905 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr5_+_36608430 2.903 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_91505541 2.867 NM_002345
LUM
lumican
chr1_-_150738292 2.865 NM_001199739
NM_004079
CTSS

cathepsin S

chr3_+_97158453 2.696 NM_173655
EPHA6
EPH receptor A6
chr11_-_108464344 2.674 NM_015065
EXPH5
exophilin 5
chr19_+_13134782 2.667 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_32497925 2.624 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr4_-_110723127 2.574 CFI
complement factor I
chr21_-_35828038 2.527 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr5_+_36606667 2.485 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_32709162 2.470 NM_020056
HLA-DQA1
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 2
chr7_+_106685007 2.426 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr4_-_100356449 2.421 NM_000673
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr17_+_68100994 2.363 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr1_+_196621007 2.351 NM_000186
NM_001014975
CFH

complement factor H

chr6_+_32407618 2.340 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr17_+_68071386 2.328 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr1_+_244216506 2.290 NM_006352
ZNF238
zinc finger protein 238
chr5_+_156696351 2.271 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr4_-_23891608 2.230 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr3_-_165555252 2.195 NM_000055
BCHE
butyrylcholinesterase
chr1_+_207002221 2.189 NM_013371
IL19
interleukin 19
chr4_-_110723334 2.184 NM_000204
CFI
complement factor I
chr16_+_78062985 2.179 NM_001244755
CLEC3A
C-type lectin domain family 3, member A
chr13_-_46679143 2.120 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr6_-_29012951 2.110 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr4_+_41700736 2.110 LIMCH1
LIM and calponin homology domains 1
chr22_-_18923963 2.093 NM_001195226
NM_016335
PRODH

proline dehydrogenase (oxidase) 1

chr5_+_42548314 2.064 NM_001242403
GHR
growth hormone receptor
chr16_+_19422056 2.060 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr8_+_76452202 2.049 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr3_-_42843217 1.976


chr7_+_80275634 1.959 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr3_+_63638343 1.935 NM_001080537
SNTN
sentan, cilia apical structure protein
chr2_+_169757749 1.933 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr19_+_41620336 1.932 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr11_-_114466471 1.913 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr3_-_112693711 1.905 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr7_+_121513158 1.898 NM_001206838
NM_001206839
NM_002851
PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr4_+_72204769 1.866 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr11_-_114466397 1.850 FAM55D
family with sequence similarity 55, member D
chr8_+_74903563 1.848 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr17_+_41158741 1.848 NM_005533
IFI35
interferon-induced protein 35
chr8_-_110661007 1.806 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr12_-_10282680 1.793 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr12_-_71551778 1.785 NM_004616
TSPAN8
tetraspanin 8
chr3_-_151102536 1.780 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr11_-_102401430 1.777 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr5_+_42548144 1.744 NM_001242402
GHR
growth hormone receptor
chr11_+_27015833 1.744 FIBIN
fin bud initiation factor homolog (zebrafish)
chr5_+_36606456 1.740 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr3_-_57530067 1.726 NM_178504
NM_198564
DNAH12

dynein, axonemal, heavy chain 12

chr4_-_38806410 1.711 NM_003263
TLR1
toll-like receptor 1
chr14_-_70883680 1.664 NM_001202547
NM_001202548
NM_001202549
NM_018373
SYNJ2BP-COX16


SYNJ2BP
SYNJ2BP-COX16 readthrough


synaptojanin 2 binding protein
chr11_+_61976139 1.652 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr4_+_159131400 1.650 NM_018342
TMEM144
transmembrane protein 144
chr5_+_140602914 1.639 NM_018934
PCDHB14
protocadherin beta 14
chr11_-_47736896 1.631 NM_024783
AGBL2
ATP/GTP binding protein-like 2
chr6_+_131958441 1.622 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr11_+_101918168 1.599 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr6_-_134639195 1.597 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_104159953 1.592 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr11_+_27015627 1.579 NM_203371
FIBIN
fin bud initiation factor homolog (zebrafish)
chr5_-_16509106 1.567 NM_019000
FAM134B
family with sequence similarity 134, member B
chr10_+_7745325 1.528 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_+_48211054 1.521 NM_152701
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chrX_+_105412297 1.519 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr11_+_101785720 1.498 NM_020802
KIAA1377
KIAA1377
chr1_-_117746457 1.443 NM_001253849
VTCN1
V-set domain containing T cell activation inhibitor 1
chr11_+_27062508 1.443 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr5_+_140254930 1.440 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr9_-_5968367 1.428


chr10_+_7745354 1.428 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_72102249 1.426 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr7_+_90338711 1.426 NM_012395
CDK14
cyclin-dependent kinase 14
chr18_+_61370193 1.424 NM_080475
SERPINB11
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr19_-_41388656 1.418 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr15_-_45670955 1.413 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr3_-_120401401 1.404 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr7_-_92777657 1.397 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr10_+_115511212 1.392 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr4_-_100273831 1.381 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr11_+_65266980 1.372


chr4_+_41614911 1.369 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr2_-_238499317 1.350 RAB17
RAB17, member RAS oncogene family
chr4_+_187070326 1.346 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr7_+_150382783 1.338 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr14_-_21271002 1.324 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr18_-_61329113 1.323 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr6_+_29364331 1.311 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr5_+_61874561 1.303 NM_181506
LRRC70
leucine rich repeat containing 70
chr11_+_36397534 1.300 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr1_-_144997110 1.298 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr7_+_23286401 1.292 GPNMB
glycoprotein (transmembrane) nmb
chr4_+_170581212 1.289 NM_001243374
CLCN3
chloride channel 3
chr2_-_242556883 1.289 NM_001164356
THAP4
THAP domain containing 4
chr5_+_140346053 1.286 PCDHAC2
protocadherin alpha subfamily C, 2
chr4_-_88450243 1.264 SPARCL1
SPARC-like 1 (hevin)
chr11_+_65266642 1.259


chr12_-_91505215 1.248 LUM
lumican
chr6_-_46889620 1.246 NM_001098518
GPR116
G protein-coupled receptor 116
chr4_-_70518964 1.245 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr5_+_140213968 1.243 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr17_-_67311773 1.241 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr7_+_116660291 1.219 ST7
suppression of tumorigenicity 7
chr2_-_175712276 1.203 NM_001206602
CHN1
chimerin (chimaerin) 1
chr9_+_34458810 1.200 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr4_-_104020964 1.198 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr5_-_41213513 1.188 NM_000065
C6
complement component 6
chr17_-_34329083 1.183 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr7_+_123249076 1.175 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr10_+_695887 1.169 C10orf108
chromosome 10 open reading frame 108
chr2_+_113993082 1.168 LOC654433
uncharacterized LOC654433
chr13_-_86373328 1.162 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr1_-_223853400 1.157 NM_001143962
CAPN8
calpain 8
chr3_-_167098070 1.157 NM_001199202
NM_001199201
NM_024687
ZBBX


zinc finger, B-box domain containing


chr1_-_27998719 1.147 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr3_+_108541544 1.138 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr5_-_121814781 1.130


chr3_+_151488214 1.110 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr5_+_140474198 1.107 NM_018936
PCDHB2
protocadherin beta 2
chr18_+_55714457 1.106 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_20620945 1.100 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr14_-_23285011 1.086 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr11_+_17332454 1.081


chr11_+_86085777 1.081 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr5_-_135231504 1.078 NM_000590
IL9
interleukin 9
chr7_+_80267972 1.077 CD36
CD36 molecule (thrombospondin receptor)
chr12_-_10151689 1.071 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr10_+_7745229 1.069 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr13_+_52436116 1.067 NM_031290
CCDC70
coiled-coil domain containing 70
chr4_-_70725792 1.064 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr4_+_86851425 1.062 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chrX_-_80457440 1.060 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chr1_+_79086087 1.060 NM_006820
IFI44L
interferon-induced protein 44-like
chr5_-_150603615 1.050 CCDC69
coiled-coil domain containing 69
chr8_-_71581419 1.044 NM_016027
LACTB2
lactamase, beta 2
chr11_-_26593667 1.041 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr11_-_33890931 1.036 LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_+_116660263 1.035 ST7
suppression of tumorigenicity 7
chr8_-_95229530 1.033 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr7_+_102987970 1.025 NM_001204453
NM_002803
PSMC2

proteasome (prosome, macropain) 26S subunit, ATPase, 2

chr9_-_75567915 1.014 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr16_+_69680959 1.012 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr5_-_150603649 1.011 NM_015621
CCDC69
coiled-coil domain containing 69
chr5_+_43609261 1.010 NNT
nicotinamide nucleotide transhydrogenase
chr15_+_59908908 1.008 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr10_+_114135013 1.006 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_+_48821106 0.999 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr1_+_111889194 0.997 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr10_+_7745341 0.995 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_69886112 0.992 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr7_+_141695678 0.992 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr12_-_8219001 0.991 C3AR1
complement component 3a receptor 1
chr16_+_10522724 0.979 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr1_-_169703178 0.969 NM_000450
SELE
selectin E
chr1_+_218518675 0.957 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr11_-_3400307 0.956 NM_001130519
NM_001130520
NM_001242841
NM_001242842
NM_001242843
NM_007152
ZNF195





zinc finger protein 195





chr6_-_52926486 0.955 ICK
intestinal cell (MAK-like) kinase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.67 1.18e-06 GO:0006955 immune response
1.43 2.01e-04 GO:0002376 immune system process
1.63 1.38e-02 GO:0050776 regulation of immune response
1.47 4.62e-02 GO:0002682 regulation of immune system process

Nothing significant found in compartment category.

Nothing significant found in function category.