Motif ID: HOXA9_MEIS1.p2

Z-value: 0.597


Transcription factors associated with HOXA9_MEIS1.p2:

Gene SymbolEntrez IDGene Name
HOXA9 3205 homeobox A9
MEIS1 4211 Meis homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEIS1chr2_+_66662692-0.622.6e-04Click!
HOXA9chr7_-_27205123,
chr7_-_27205148
0.532.5e-03Click!


Activity profile for motif HOXA9_MEIS1.p2.

activity profile for motif HOXA9_MEIS1.p2


Sorted Z-values histogram for motif HOXA9_MEIS1.p2

Sorted Z-values for motif HOXA9_MEIS1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA9_MEIS1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_78109808 2.183 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chrX_+_135278912 1.967 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr12_+_8975149 1.377 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr1_-_205391180 1.250 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr2_-_113594325 1.197 NM_000576
IL1B
interleukin 1, beta
chr4_+_69313166 1.190 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr16_+_29690464 1.150 QPRT
quinolinate phosphoribosyltransferase
chr10_-_75401492 0.981 NM_021245
MYOZ1
myozenin 1
chr9_+_6215785 0.966 NM_001199640
NM_001199641
NM_033439
IL33


interleukin 33


chr2_-_216259197 0.866 FN1
fibronectin 1
chr11_-_105010460 0.833 NM_021571
CARD18
caspase recruitment domain family, member 18
chr18_-_31628557 0.824 NM_001198549
NOL4
nucleolar protein 4
chr19_+_10828813 0.805 DNM2
dynamin 2
chr19_+_10828725 0.804 NM_001005360
NM_001005361
NM_001005362
NM_001190716
NM_004945
DNM2




dynamin 2




chr1_-_115238091 0.751 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr16_+_29690328 0.711 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr2_+_169923531 0.702 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_115572414 0.696 NM_000549
TSHB
thyroid stimulating hormone, beta
chr19_-_15590203 0.681 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr2_-_161056573 0.678 NM_000888
ITGB6
integrin, beta 6
chr7_+_80267972 0.666 CD36
CD36 molecule (thrombospondin receptor)
chr15_+_66694216 0.652 MAP2K1
mitogen-activated protein kinase kinase 1
chr17_-_38210888 0.650 NM_001079518
NM_014815
MED24

mediator complex subunit 24

chr19_+_10828763 0.612 DNM2
dynamin 2
chr6_+_125304509 0.611 NM_152553
RNF217
ring finger protein 217
chr19_+_10828772 0.599 DNM2
dynamin 2
chr17_-_29641068 0.565 EVI2B
ecotropic viral integration site 2B
chr3_-_138478184 0.561 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr19_-_39235113 0.558 NM_144691
CAPN12
calpain 12
chr2_+_115199898 0.551 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr17_+_16120465 0.544 NM_004278
PIGL
phosphatidylinositol glycan anchor biosynthesis, class L
chr18_+_9885722 0.521 NM_001098529
NM_032243
TXNDC2

thioredoxin domain containing 2 (spermatozoa)

chr5_+_161275897 0.518 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr3_-_27498244 0.514 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr1_-_622033 0.506 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr18_+_56530060 0.500 NM_018181
ZNF532
zinc finger protein 532
chr5_+_140800536 0.469 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr2_-_165424993 0.467 GRB14
growth factor receptor-bound protein 14
chr7_+_80267782 0.449 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr10_+_32856650 0.444 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr1_-_198510074 0.422 NM_133262
NM_133326
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr3_+_130569368 0.416 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr3_-_190167597 0.394 NM_207316
TMEM207
transmembrane protein 207
chr8_+_143781527 0.384 NM_001160354
NM_001160355
NM_017527
LY6K


lymphocyte antigen 6 complex, locus K


chr2_+_204732509 0.373 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr4_+_88896899 0.369 SPP1
secreted phosphoprotein 1
chr5_-_22853435 0.364 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr19_-_44174497 0.362 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr1_-_247171302 0.356 ZNF695
zinc finger protein 695
chr20_+_33759773 0.353 NM_006404
PROCR
protein C receptor, endothelial
chr10_+_70847817 0.337 NM_002727
SRGN
serglycin
chr6_-_131321868 0.335 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr12_+_41086189 0.333 NM_001843
NM_175038
CNTN1

contactin 1

chr22_+_38092994 0.326 NM_001039141
TRIOBP
TRIO and F-actin binding protein
chr5_+_132432880 0.325 HSPA4
heat shock 70kDa protein 4
chr8_-_117023 0.310 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr3_-_113897849 0.310 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr5_-_22853730 0.305 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_198608216 0.301 PTPRC
protein tyrosine phosphatase, receptor type, C
chr3_-_52569021 0.297 NM_022908
NT5DC2
5'-nucleotidase domain containing 2
chr6_+_35200627 0.290 SCUBE3
signal peptide, CUB domain, EGF-like 3
chr16_+_88636810 0.289 ZC3H18
zinc finger CCCH-type containing 18
chrX_-_6145887 0.287 NM_020742
NLGN4X
neuroligin 4, X-linked
chr3_+_121796695 0.283 NM_006889
NM_176892
CD86

CD86 molecule

chr18_-_29340698 0.275 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr1_+_367639 0.274 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr7_+_115863004 0.267 NM_152829
TES
testis derived transcript (3 LIM domains)
chr10_+_98740987 0.267 NM_015652
C10orf12
chromosome 10 open reading frame 12
chr2_+_29038862 0.267 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr15_+_97326629 0.253 NM_173499
SPATA8
spermatogenesis associated 8
chr1_-_155774769 0.250 GON4L
gon-4-like (C. elegans)
chr6_-_138539626 0.245 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr13_-_78493902 0.243 NM_001201397
EDNRB
endothelin receptor type B
chr3_+_151985828 0.242 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr12_-_109027654 0.238 NM_003006
SELPLG
selectin P ligand
chr19_-_3772208 0.238 NM_032753
RAX2
retina and anterior neural fold homeobox 2
chr4_-_53617781 0.236 NM_001242690
NM_024534
ERVMER34-1

endogenous retrovirus group MER34, member 1

chr2_+_201473942 0.234 AOX1
aldehyde oxidase 1
chr5_+_180794268 0.229 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr18_-_47806361 0.228 NM_001204151
MBD1
methyl-CpG binding domain protein 1
chr2_-_128439359 0.227 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr17_-_29641094 0.227 NM_006495
EVI2B
ecotropic viral integration site 2B
chr7_-_107443631 0.226 NM_000111
SLC26A3
solute carrier family 26, member 3
chr3_+_14716605 0.223 NM_001184957
NM_001184958
NM_032137
C3orf20


chromosome 3 open reading frame 20


chr7_-_84751246 0.222 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr7_+_128578246 0.216 NM_032643
IRF5
interferon regulatory factor 5
chr19_+_42212612 0.212 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr12_-_109027615 0.211 SELPLG
selectin P ligand
chr10_-_46619935 0.210 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr4_+_88896801 0.209 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr1_+_153232178 0.208 NM_000427
LOR
loricrin
chr16_+_55515468 0.208 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr7_+_151653463 0.207 NM_145292
GALNTL5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
chr19_-_14224979 0.203 NM_207518
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr14_+_68168602 0.201 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr7_-_92747317 0.199 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr18_-_22930826 0.198


chrX_-_105282714 0.198 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_+_98216447 0.194 NM_001004737
OR5K2
olfactory receptor, family 5, subfamily K, member 2
chr12_-_10562142 0.189 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr7_+_44646120 0.189 NM_001003941
NM_001165036
NM_002541
OGDH


oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)


chr12_-_121476770 0.186 NM_003733
NM_198213
OASL

2'-5'-oligoadenylate synthetase-like

chr1_+_40713572 0.185 NM_001008740
TMCO2
transmembrane and coiled-coil domains 2
chr19_+_15052298 0.181 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr4_-_152147520 0.180 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr6_-_27880173 0.179 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr1_+_24649529 0.178 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr6_-_111888520 0.171 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr7_-_92747269 0.169 SAMD9
sterile alpha motif domain containing 9
chrX_+_48336379 0.165 NM_177434
FTSJ1
FtsJ homolog 1 (E. coli)
chr17_-_41739261 0.164 NM_001040002
MEOX1
mesenchyme homeobox 1
chr1_-_155211049 0.162 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr2_+_219724545 0.161 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chrX_-_83757398 0.161 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr12_-_53045947 0.161 NM_000423
KRT2
keratin 2
chr11_-_49003246 0.158 NM_001206625
LOC120824
tripartite motif-containing protein ENSP00000309378-like
chr4_+_39408472 0.157 NM_175737
KLB
klotho beta
chr3_-_150966901 0.156 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr2_+_88824168 0.155 NM_152670
C2orf51
chromosome 2 open reading frame 51
chr18_+_20735788 0.154 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr7_+_143657019 0.154 NM_012369
OR2F1
olfactory receptor, family 2, subfamily F, member 1
chr6_-_49604524 0.154 NM_000324
RHAG
Rh-associated glycoprotein
chr4_+_71494460 0.153 NM_031889
ENAM
enamelin
chr18_-_65182507 0.150 DSEL
dermatan sulfate epimerase-like
chr7_+_63774378 0.148 ZNF736
zinc finger protein 736
chr1_-_84326673 0.148


chr1_-_205744543 0.145 NM_001135662
NM_001135663
NM_001135664
NM_003929
RAB7L1



RAB7, member RAS oncogene family-like 1



chr14_-_73453651 0.144 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr4_-_122137781 0.141 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr1_-_19578030 0.139 KIAA0090
KIAA0090
chr21_-_48024985 0.138 NM_006272
S100B
S100 calcium binding protein B
chr12_-_109027565 0.135 SELPLG
selectin P ligand
chr4_-_40936640 0.135 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr4_+_95376396 0.133 PDLIM5
PDZ and LIM domain 5
chr9_+_93589704 0.133 NM_001174167
SYK
spleen tyrosine kinase
chr1_-_169555710 0.132 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr9_-_21207141 0.131 NM_002171
IFNA10
interferon, alpha 10
chr16_-_20702577 0.130 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr5_-_142815076 0.130 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr12_-_102591547 0.129 NM_002674
PMCH
pro-melanin-concentrating hormone
chrX_+_123234462 0.128 STAG2
stromal antigen 2
chr1_+_198608244 0.126 PTPRC
protein tyrosine phosphatase, receptor type, C
chr13_+_32313678 0.126 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr12_+_10457044 0.125 NM_001114396
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr6_-_117747017 0.123 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr1_-_169599349 0.122 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr11_-_8964579 0.122 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr16_-_24942662 0.121 ARHGAP17
Rho GTPase activating protein 17
chr17_-_29641087 0.121 EVI2B
ecotropic viral integration site 2B
chr19_+_39989534 0.119 NM_016941
NM_203486
DLL3

delta-like 3 (Drosophila)

chr19_+_39989603 0.119 DLL3
delta-like 3 (Drosophila)
chr2_-_2334887 0.117 NM_015025
MYT1L
myelin transcription factor 1-like
chr21_-_34185943 0.116 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr17_+_56232493 0.116 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr11_-_7847518 0.115 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr1_+_33004771 0.113 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr10_-_99052358 0.112 ARHGAP19
Rho GTPase activating protein 19
chr1_-_155210887 0.111 GBA
glucosidase, beta, acid
chr17_-_8424217 0.109 MYH10
myosin, heavy chain 10, non-muscle
chr2_+_68592432 0.108 PLEK
pleckstrin
chr8_-_99129385 0.108 NM_005836
HRSP12
heat-responsive protein 12
chrX_+_49216616 0.107 NM_012196
NM_001472
NM_001474
NM_001475
NM_021123
NM_001477
NM_001127200
NM_001127212
GAGE8
GAGE1
GAGE2C
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE2E
GAGE12B
GAGE2A
G antigen 8
G antigen 1
G antigen 2C
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 2E
G antigen 12B
G antigen 2A
chr21_-_36252872 0.107 RUNX1
runt-related transcription factor 1
chr6_+_47749774 0.106 NM_181744
OPN5
opsin 5
chr1_+_145413190 0.106 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr8_-_101965554 0.106 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr17_-_10452939 0.105 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_+_186990308 0.104 NM_003265
TLR3
toll-like receptor 3
chr17_+_39555993 0.104 GAST
gastrin
chr9_-_21385258 0.104 NM_000605
IFNA2
interferon, alpha 2
chr1_-_169555624 0.104 F5
coagulation factor V (proaccelerin, labile factor)
chr10_-_101945787 0.104 NM_001100626
ERLIN1
ER lipid raft associated 1
chr11_+_55578842 0.104 NM_001004738
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr20_-_39928708 0.104 NM_015035
ZHX3
zinc fingers and homeoboxes 3
chr3_-_71179736 0.103 FOXP1
forkhead box P1
chr17_+_40172086 0.103 NM_001144927
NM_001144928
NM_001144929
NM_017595
NKIRAS2



NFKB inhibitor interacting Ras-like 2



chr1_+_196946666 0.102 NM_030787
CFHR5
complement factor H-related 5
chrX_-_130964633 0.102 LOC286467
family with sequence similarity 195, member A pseudogene
chr3_+_82035288 0.101


chr2_+_68592317 0.101 NM_002664
PLEK
pleckstrin
chr6_+_155538096 0.101 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr3_-_10332408 0.100 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr20_+_20037289 0.100 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr3_-_69037498 0.099 C3orf64
chromosome 3 open reading frame 64
chr5_-_160112266 0.097 ATP10B
ATPase, class V, type 10B
chr12_+_93096618 0.096 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr12_-_71182699 0.096 NM_001207015
PTPRR
protein tyrosine phosphatase, receptor type, R
chr8_+_10383055 0.095 NM_001197020
NM_198464
PRSS55

protease, serine, 55

chr11_-_111782447 0.094 NM_001885
CRYAB
crystallin, alpha B
chr12_-_99548471 0.092 NM_001204068
NM_001204069
NM_001204070
NM_020140
NM_181670
NM_001204066
ANKS1B





ankyrin repeat and sterile alpha motif domain containing 1B





chr5_+_126984712 0.091 NM_001048252
CTXN3
cortexin 3
chr1_+_198608136 0.091 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr17_+_39411635 0.090 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr3_+_111260925 0.090 NM_005816
NM_198196
CD96

CD96 molecule

chr5_+_68800003 0.090 NM_001205255
OCLN
occludin
chr20_+_16728997 0.089 NM_020157
OTOR
otoraplin
chr2_+_33661392 0.088 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr10_-_50732142 0.086 NM_170753
PGBD3
piggyBac transposable element derived 3
chr7_-_99766238 0.086 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr6_-_29055048 0.086 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 2.67e-04 GO:0032501 multicellular organismal process
1.36 5.80e-03 GO:0050896 response to stimulus
2.92 1.31e-02 GO:0050776 regulation of immune response
25.45 1.32e-02 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production
2.55 4.22e-02 GO:0050878 regulation of body fluid levels
2.25 4.23e-02 GO:0006952 defense response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 6.54e-03 GO:0005886 plasma membrane
1.41 1.17e-02 GO:0071944 cell periphery
1.62 2.71e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.69 8.37e-03 GO:0004871 signal transducer activity
1.69 8.37e-03 GO:0060089 molecular transducer activity
1.98 2.93e-02 GO:0005102 receptor binding