Motif ID: HSF1,2.p2

Z-value: 0.840


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF1chr8_+_145515288-0.242.0e-01Click!
HSF2chr6_+_1227207500.086.7e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_31870940 3.330 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr6_+_32709162 2.741 NM_020056
HLA-DQA1
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 2
chr4_-_16077740 1.633 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr16_+_3115638 1.356 NM_001012634
IL32
interleukin 32
chr6_+_32605182 1.354 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr16_+_3115611 1.244 NM_001012635
IL32
interleukin 32
chr16_+_3115312 1.221 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr16_+_3115641 1.177 NM_001012632
NM_001012636
IL32

interleukin 32

chr17_-_74137370 1.117 NM_001454
FOXJ1
forkhead box J1
chr16_+_3115639 1.015 IL32
interleukin 32
chr19_-_49567123 1.012 NM_006179
NTF4
neurotrophin 4
chr6_+_29364331 0.980 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr8_+_39771327 0.962 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr12_+_51318515 0.923 NM_014033
METTL7A
methyltransferase like 7A
chr10_+_95848811 0.860 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr5_-_110062365 0.838 NM_001039763
TMEM232
transmembrane protein 232
chr19_-_41388656 0.827 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr7_-_76038894 0.827 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr20_+_18794369 0.792 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr8_-_110620220 0.786 SYBU
syntabulin (syntaxin-interacting)
chr11_+_27062508 0.781 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr10_+_115511212 0.752 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr3_-_19975671 0.722 NM_144715
EFHB
EF-hand domain family, member B
chr6_-_33041266 0.688 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr9_-_69202203 0.684 NM_001085476
FOXD4L6
forkhead box D4-like 6
chr11_+_101918168 0.680 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr12_+_51318743 0.677 METTL7A
methyltransferase like 7A
chr9_-_91793375 0.640 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr4_+_110834039 0.636 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr11_-_63381840 0.634 PLA2G16
phospholipase A2, group XVI
chr20_+_9198036 0.629 NM_182797
PLCB4
phospholipase C, beta 4
chr11_-_63381907 0.629 NM_007069
PLA2G16
phospholipase A2, group XVI
chr2_+_26624776 0.624 NM_145038
CCDC164
coiled-coil domain containing 164
chr3_+_133495925 0.616 TF
transferrin
chr5_+_36608430 0.614 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_+_1127722 0.595 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr11_-_63381485 0.581 PLA2G16
phospholipase A2, group XVI
chr22_-_36556781 0.569 NM_145640
APOL3
apolipoprotein L, 3
chr2_+_228678556 0.563 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr5_+_42549657 0.557 NM_001242404
GHR
growth hormone receptor
chr3_-_74570262 0.553 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr3_+_238274 0.543 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr9_+_139921915 0.542 NM_207511
C9orf139
chromosome 9 open reading frame 139
chr16_+_3550916 0.529 NM_015041
CLUAP1
clusterin associated protein 1
chr13_+_24144402 0.525 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr9_+_33025207 0.507 NM_001539
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_+_156785470 0.500 NM_001007792
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr9_+_42717233 0.496 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr7_-_120498128 0.494 NM_012338
TSPAN12
tetraspanin 12
chr9_+_33025270 0.493 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr16_+_3559893 0.485 NM_024793
CLUAP1
clusterin associated protein 1
chr7_-_99573637 0.485 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr9_+_33025302 0.457 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_+_183774214 0.454 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr15_+_78556901 0.445 NM_001130182
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr9_-_91793681 0.444 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr6_+_33043702 0.443 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr3_-_36781351 0.442 NM_033403
DCLK3
doublecortin-like kinase 3
chr17_+_1646129 0.441 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr10_+_7745354 0.439 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_+_85980600 0.436 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr1_-_117753476 0.433 NM_001253850
NM_024626
VTCN1

V-set domain containing T cell activation inhibitor 1

chr10_+_7745229 0.432 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_12973752 0.430 NM_001164271
DLC1
deleted in liver cancer 1
chr10_-_21435487 0.428 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr4_+_77356252 0.426 NM_020859
SHROOM3
shroom family member 3
chr2_+_106682111 0.417 NM_032411
C2orf40
chromosome 2 open reading frame 40
chr19_+_55888203 0.415 NM_139172
TMEM190
transmembrane protein 190
chr7_-_92777657 0.404 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr3_+_122334461 0.402 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr1_-_175712669 0.395 NM_003285
TNR
tenascin R (restrictin, janusin)
chr4_+_71494460 0.394 NM_031889
ENAM
enamelin
chr1_-_36915969 0.393 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr16_+_55689899 0.392 SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr2_-_97405799 0.388 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr20_+_55904814 0.385 NM_012444
NM_198265
SPO11

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

chr2_+_10861740 0.382 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr9_-_88715024 0.380 NM_177937
GOLM1
golgi membrane protein 1
chr8_-_7274353 0.377 NM_001205266
DEFB4B
defensin, beta 4B
chr3_-_165555252 0.365 NM_000055
BCHE
butyrylcholinesterase
chr4_+_41614933 0.358 LIMCH1
LIM and calponin homology domains 1
chr10_+_7745325 0.355 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_-_134496833 0.350 SGK1
serum/glucocorticoid regulated kinase 1
chr19_-_14260728 0.350 LPHN1
latrophilin 1
chr5_+_131630065 0.349 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr1_-_184006828 0.348 NM_015101
GLT25D2
glycosyltransferase 25 domain containing 2
chr2_-_97405775 0.346 LMAN2L
lectin, mannose-binding 2-like
chr12_+_105153258 0.344 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr7_+_30960914 0.343 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr9_-_118416 0.343 NM_207305
FOXD4
forkhead box D4
chr17_+_7184978 0.341 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr11_-_102714240 0.337 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr6_-_31782786 0.331 NM_005527
HSPA1L
heat shock 70kDa protein 1-like
chr10_+_135340865 0.327 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr17_-_38073792 0.326 NM_018530
GSDMB
gasdermin B
chr6_-_76203256 0.322 NM_015687
FILIP1
filamin A interacting protein 1
chr7_-_51384458 0.321 NM_015198
COBL
cordon-bleu homolog (mouse)
chr6_+_44126547 0.321 NM_007058
CAPN11
calpain 11
chr6_+_29913400 0.320


chr3_+_195451097 0.319 NM_001098516
MUC20
mucin 20, cell surface associated
chr21_+_35445808 0.316 NM_032476
NM_006933
MRPS6
SLC5A3
mitochondrial ribosomal protein S6
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr7_-_6474584 0.314 DAGLB
diacylglycerol lipase, beta
chr10_+_7745341 0.311 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr14_-_88460008 0.311 NM_001201402
GALC
galactosylceramidase
chr5_+_42550181 0.310 NM_001242405
GHR
growth hormone receptor
chr11_-_114466397 0.307 FAM55D
family with sequence similarity 55, member D
chr11_+_60467046 0.306 NM_031457
MS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
chr9_+_2717525 0.305 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr4_-_122085475 0.302 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr1_-_55089068 0.301 NM_176782
FAM151A
family with sequence similarity 151, member A
chr3_+_39509069 0.301 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr20_+_9458460 0.301 PLCB4
phospholipase C, beta 4
chr6_-_130544098 0.300 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr12_+_119772516 0.296 NM_178499
CCDC60
coiled-coil domain containing 60
chr4_-_69886112 0.296 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr12_-_14996381 0.295 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr15_-_65503786 0.291 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr9_-_70178814 0.291 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr14_-_25103365 0.290 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr3_-_165555167 0.290 BCHE
butyrylcholinesterase
chr6_+_31913708 0.288 NM_001710
CFB
complement factor B
chr6_+_31082526 0.287 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr1_+_12806162 0.287 NM_152290
C1orf158
chromosome 1 open reading frame 158
chrX_-_8700170 0.287 NM_000216
KAL1
Kallmann syndrome 1 sequence
chrX_+_119029799 0.286 NM_001008534
NM_001008535
NM_178813
AKAP14


A kinase (PRKA) anchor protein 14


chr6_+_31913763 0.285 CFB
complement factor B
chr11_+_73359734 0.285 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr9_+_74764266 0.285 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr9_+_70917782 0.284 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr6_+_31913852 0.282 CFB
complement factor B
chr19_+_14142572 0.281 IL27RA
interleukin 27 receptor, alpha
chr6_-_134497069 0.281 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr5_+_140254930 0.280 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr10_-_116444112 0.275 ABLIM1
actin binding LIM protein 1
chr17_+_38171613 0.273 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chrX_-_15683153 0.273 NM_020665
TMEM27
transmembrane protein 27
chr3_-_151102536 0.272 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr3_+_133464883 0.270 NM_001063
TF
transferrin
chr18_-_71814948 0.270 NM_152676
NM_001142958
FBXO15

F-box protein 15

chr1_+_27248249 0.269 NUDC
nuclear distribution gene C homolog (A. nidulans)
chr10_+_122216465 0.269 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr19_+_14142459 0.269 IL27RA
interleukin 27 receptor, alpha
chr6_+_28234787 0.268 NM_001023560
NM_001111039
NM_152736
ZNF187


zinc finger protein 187


chr11_+_36422546 0.267 NM_001160169
PRR5L
proline rich 5 like
chr8_-_57026540 0.265 NM_005372
MOS
v-mos Moloney murine sarcoma viral oncogene homolog
chr1_+_247579457 0.264 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr11_-_34535302 0.263 NM_001243080
NM_001422
ELF5

E74-like factor 5 (ets domain transcription factor)

chr9_-_97090903 0.263 NM_017561
FAM22F
family with sequence similarity 22, member F
chr1_-_173638970 0.262 NM_198493
ANKRD45
ankyrin repeat domain 45
chr8_-_95229530 0.261 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr17_+_76227390 0.261 NM_001204210
NM_001204211
NM_001204212
TMEM235


transmembrane protein 235


chr16_-_67965754 0.261 NM_001907
CTRL
chymotrypsin-like
chr11_+_45868668 0.258 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr18_+_55862577 0.258 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_42917191 0.257 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr7_-_51384331 0.257 COBL
cordon-bleu homolog (mouse)
chr4_-_74904329 0.256 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr15_+_74466887 0.254 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr1_+_104159953 0.254 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr4_-_48136245 0.253 NM_003328
TXK
TXK tyrosine kinase
chr5_+_140213968 0.251 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr7_+_150264457 0.250 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr10_+_102222797 0.249 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr1_+_27248236 0.246 NUDC
nuclear distribution gene C homolog (A. nidulans)
chrY_-_20935503 0.246 NM_001001877
NM_153716
NM_152584
NM_033108
HSFY2

HSFY1

heat shock transcription factor, Y linked 2

heat shock transcription factor, Y-linked 1

chr5_-_44388666 0.246 NM_004465
FGF10
fibroblast growth factor 10
chr11_+_6897855 0.245 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr19_+_16059817 0.245 NM_001004465
OR10H4
olfactory receptor, family 10, subfamily H, member 4
chr5_+_56469851 0.245 GPBP1
GC-rich promoter binding protein 1
chr19_+_14142611 0.245 IL27RA
interleukin 27 receptor, alpha
chr2_+_114256660 0.245 NM_012184
FOXD4L1
forkhead box D4-like 1
chr6_-_39197225 0.242 NM_003740
KCNK5
potassium channel, subfamily K, member 5
chr15_+_42651697 0.242 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr3_-_183273407 0.242 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr4_-_122148620 0.239 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr1_+_156830606 0.239 NM_001012331
NM_002529
NTRK1

neurotrophic tyrosine kinase, receptor, type 1

chr16_+_66600293 0.238 NM_181269
NM_181270
NM_181271
NM_181272
NM_181283
NM_181296
NM_052999
NM_181268
CMTM1







CKLF-like MARVEL transmembrane domain containing 1







chr17_+_68071386 0.236 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chrX_+_152801579 0.236 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr19_-_6720585 0.236 NM_000064
C3
complement component 3
chr4_+_187148624 0.235 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr8_+_99956630 0.234 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr15_+_78556485 0.234 NM_018602
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr17_-_46035109 0.233 NM_024320
PRR15L
proline rich 15-like
chr11_-_5462782 0.233 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr12_+_10460416 0.232 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr2_+_85581840 0.232 NM_001135021
NM_001135022
NM_001135023
NM_032213
ELMOD3



ELMO/CED-12 domain containing 3



chr12_+_49297892 0.232 NM_033124
CCDC65
coiled-coil domain containing 65
chr8_-_110657745 0.231 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr3_-_133648517 0.231 NM_025041
C3orf36
chromosome 3 open reading frame 36
chr19_-_17014407 0.230 CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr1_+_27248212 0.230 NM_006600
NUDC
nuclear distribution gene C homolog (A. nidulans)
chr10_-_116444374 0.229 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr7_+_142829169 0.229 NM_002652
PIP
prolactin-induced protein
chr14_+_56585147 0.229 PELI2
pellino homolog 2 (Drosophila)
chr6_+_31783280 0.227 NM_005345
HSPA1A
heat shock 70kDa protein 1A
chr15_+_41786055 0.226 NM_002220
ITPKA
inositol-trisphosphate 3-kinase A
chr5_+_139060058 0.226 CXXC5
CXXC finger protein 5
chrX_-_102531673 0.225 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr3_-_42917632 0.225 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 4.08e-05 GO:0007275 multicellular organismal development
1.23 1.30e-03 GO:0032502 developmental process
1.27 1.71e-03 GO:0048731 system development
1.57 2.05e-03 GO:2000026 regulation of multicellular organismal development
8.16 3.69e-03 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
1.24 5.88e-03 GO:0048856 anatomical structure development
6.78 6.67e-03 GO:0060600 dichotomous subdivision of an epithelial terminal unit
1.39 1.25e-02 GO:0051239 regulation of multicellular organismal process
7.25 1.51e-02 GO:0048880 sensory system development
7.25 1.51e-02 GO:0048892 lateral line nerve development
7.25 1.51e-02 GO:0048895 lateral line nerve glial cell differentiation
7.25 1.51e-02 GO:0048925 lateral line system development
7.25 1.51e-02 GO:0048937 lateral line nerve glial cell development
7.25 1.51e-02 GO:0050935 iridophore differentiation
1.16 1.58e-02 GO:0032501 multicellular organismal process
1.45 2.42e-02 GO:0050793 regulation of developmental process
1.27 2.87e-02 GO:0042221 response to chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 1.26e-03 GO:0044421 extracellular region part
1.30 1.28e-03 GO:0005576 extracellular region
1.71 3.41e-03 GO:0009986 cell surface

Nothing significant found in function category.