Motif ID: IRF1,2,7.p3

Z-value: 3.185


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF1chr5_-_1318264260.914.9e-12Click!
IRF7chr11_-_6159200.144.6e-01Click!
IRF2chr4_-_1853956160.077.3e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_39771327 21.538 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr6_-_29527701 19.663 NM_006398
UBD
ubiquitin D
chr1_-_27998719 19.152 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr4_+_70861647 18.846 NM_001009181
NM_003154
STATH

statherin

chr1_-_27998658 18.824 IFI6
interferon, alpha-inducible protein 6
chr1_-_27998700 18.585 IFI6
interferon, alpha-inducible protein 6
chr6_-_29527477 18.292 UBD
ubiquitin D
chr2_-_7005764 16.124 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr5_-_149792276 15.873 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr21_+_42733916 15.846 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr5_-_149792370 12.495 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr16_-_21289637 12.453 CRYM
crystallin, mu
chr8_-_110655418 12.195 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr10_+_91152321 11.487 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_+_79086087 11.459 NM_006820
IFI44L
interferon-induced protein 44-like
chr4_-_169239816 10.971 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_+_142829169 10.654 NM_002652
PIP
prolactin-induced protein
chr1_+_948846 10.640 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr9_-_32526164 10.386 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_+_79115476 10.009 NM_006417
IFI44
interferon-induced protein 44
chr6_+_32821924 9.641 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr10_+_91087601 9.078 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91092238 8.864 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr19_-_17516383 8.163 NM_004335
BST2
bone marrow stromal cell antigen 2
chr7_-_122526781 7.955 NM_001009571
NM_001167940
NM_017954
CADPS2


Ca++-dependent secretion activator 2


chr21_+_42792441 7.173 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr6_+_31913852 7.015 CFB
complement factor B
chr16_-_67970651 6.879 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr4_+_89300110 6.790 HERC6
hect domain and RLD 6
chr17_+_6659155 6.789 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr6_+_31913763 6.722 CFB
complement factor B
chr6_+_26440699 6.548 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr4_-_100356449 6.331 NM_000673
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr17_-_40264687 6.313 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr12_+_6561176 6.244 NM_018009
TAPBPL
TAP binding protein-like
chr17_+_4643318 6.177 NM_001136046
NM_032265
ZMYND15

zinc finger, MYND-type containing 15

chr6_-_46889620 6.127 NM_001098518
GPR116
G protein-coupled receptor 116
chr6_+_31913708 6.091 NM_001710
CFB
complement factor B
chr11_+_63304272 6.010 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr15_+_71184781 5.942 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr16_-_67970734 5.916 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr9_+_74764266 5.867 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr11_-_63330854 5.721 NM_017878
HRASLS2
HRAS-like suppressor 2
chr22_+_18632841 5.652 USP18
ubiquitin specific peptidase 18
chr19_-_41388656 5.557 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr3_+_187086167 5.542 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr18_-_45663667 5.439 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr5_+_156696351 5.315 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr10_+_115511212 5.304 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr2_+_7017795 5.293 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr22_+_18632704 5.272 NM_017414
USP18
ubiquitin specific peptidase 18
chr7_+_150382783 5.075 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr17_-_4643162 5.062 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr2_+_231191877 5.018 NM_138402
SP140L
SP140 nuclear body protein-like
chr1_+_47533046 4.993 NM_178134
CYP4Z1
cytochrome P450, family 4, subfamily Z, polypeptide 1
chr9_+_74764382 4.977 GDA
guanine deaminase
chr6_+_26402464 4.971 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr19_-_47735858 4.833 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr17_+_6659356 4.823 XAF1
XIAP associated factor 1
chr17_-_4642638 4.729 CXCL16
chemokine (C-X-C motif) ligand 16
chr10_+_91061705 4.695 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr20_-_25038501 4.692 NM_001252675
NM_001252677
NM_032501
ACSS1


acyl-CoA synthetase short-chain family member 1


chr11_-_57335080 4.684 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr6_+_26365397 4.655 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr20_+_58533470 4.614 NM_177980
CDH26
cadherin 26
chr12_+_12224401 4.598 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr5_+_36606667 4.537 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_172241060 4.527 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr11_+_113931228 4.496 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr6_+_126240369 4.480 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr4_-_156874993 4.318 NM_001334
CTSO
cathepsin O
chr7_+_100728719 4.192 NM_030961
TRIM56
tripartite motif containing 56
chr7_-_122526410 4.189 CADPS2
Ca++-dependent secretion activator 2
chr3_-_167371701 4.187 WDR49
WD repeat domain 49
chr1_+_118148506 4.083 NM_017709
FAM46C
family with sequence similarity 46, member C
chr5_+_96212167 3.860 ERAP2
endoplasmic reticulum aminopeptidase 2
chr1_+_161068150 3.795 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr9_+_74764394 3.775 GDA
guanine deaminase
chr22_-_36556781 3.677 NM_145640
APOL3
apolipoprotein L, 3
chr5_+_42565963 3.638 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr17_+_25958257 3.495 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_-_38074842 3.494 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr1_-_161337663 3.462 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr17_+_25958245 3.392 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_-_49851356 3.369 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr14_+_73525267 3.355 RBM25
RNA binding motif protein 25
chr15_+_45003659 3.325 NM_004048
B2M
beta-2-microglobulin
chr6_-_32812189 3.314 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr3_-_49851217 3.284 UBA7
ubiquitin-like modifier activating enzyme 7
chr7_-_92777657 3.248 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr2_-_152146133 3.215 NMI
N-myc (and STAT) interactor
chr7_+_134832765 3.102 NM_018295
TMEM140
transmembrane protein 140
chr14_+_91580467 3.088 C14orf159
chromosome 14 open reading frame 159
chr14_+_91580967 3.078 NM_001102367
C14orf159
chromosome 14 open reading frame 159
chr14_+_91580713 3.071 C14orf159
chromosome 14 open reading frame 159
chr1_-_60392461 3.068 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr3_-_51533906 3.060 VPRBP
Vpr (HIV-1) binding protein
chr3_+_122399665 3.031 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr17_-_80291639 3.029 SECTM1
secreted and transmembrane 1
chr17_+_18380097 2.988 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr3_-_100712248 2.942 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr5_+_36606456 2.915 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr12_+_102271082 2.909 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr19_+_18284619 2.906 IFI30
interferon, gamma-inducible protein 30
chr6_-_32821743 2.892 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_-_80291610 2.878 SECTM1
secreted and transmembrane 1
chr9_-_97402530 2.856 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr17_+_25958217 2.852 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_-_114478117 2.849 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr19_+_18284578 2.847 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr16_+_28303622 2.812 NM_001024401
SBK1
SH3-binding domain kinase 1
chr11_+_65193498 2.809 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr3_-_114343052 2.807 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_48507621 2.773 TREX1
three prime repair exonuclease 1
chr17_+_72427535 2.773 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_25958192 2.762 LGALS9
lectin, galactoside-binding, soluble, 9
chr6_-_32811773 2.757 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr9_-_97402556 2.751 FBP1
fructose-1,6-bisphosphatase 1
chr4_+_187112635 2.740 NM_207352
CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr19_+_10196757 2.726 NM_018381
C19orf66
chromosome 19 open reading frame 66
chr14_+_73525187 2.721 NM_021239
RBM25
RNA binding motif protein 25
chr17_+_25958151 2.711 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr8_+_18079176 2.696 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr1_-_60392324 2.681 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr1_+_210502188 2.669 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr6_-_32821592 2.649 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr19_+_10196972 2.647 C19orf66
chromosome 19 open reading frame 66
chr21_+_42797977 2.628 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr19_+_18284631 2.622 IFI30
interferon, gamma-inducible protein 30
chr3_+_51976274 2.613 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr11_-_4414887 2.580 NM_003141
TRIM21
tripartite motif containing 21
chr11_-_4629371 2.565 NM_018073
TRIM68
tripartite motif containing 68
chr3_+_51977286 2.556 PARP3
poly (ADP-ribose) polymerase family, member 3
chr2_-_55920947 2.544 NM_033109
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr8_-_23540401 2.540 NM_006167
NKX3-1
NK3 homeobox 1
chr9_-_100881515 2.505 TRIM14
tripartite motif containing 14
chr18_+_61575203 2.491 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chrX_-_15620191 2.488 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr2_-_229046313 2.486 NM_001142644
NM_030623
SPHKAP

SPHK1 interactor, AKAP domain containing

chr13_-_30423599 2.439 UBL3
ubiquitin-like 3
chr6_-_56258891 2.420 COL21A1
collagen, type XXI, alpha 1
chr19_+_17516502 2.412 LOC100507535
uncharacterized LOC100507535
chr11_+_111789658 2.408 C11orf52
chromosome 11 open reading frame 52
chr8_+_143808593 2.394 NM_016647
C8orf55
chromosome 8 open reading frame 55
chr1_-_89530890 2.388 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr4_+_187112936 2.382 CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr6_-_133119625 2.372 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr9_-_33264458 2.367 NM_001172415
NM_004323
BAG1

BCL2-associated athanogene

chr7_-_139762339 2.345 PARP12
poly (ADP-ribose) polymerase family, member 12
chr13_-_43566301 2.344 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr2_-_152146373 2.329 NM_004688
NMI
N-myc (and STAT) interactor
chr1_+_179051111 2.319 NM_022371
TOR3A
torsin family 3, member A
chr19_+_50432399 2.317 NM_001193646
ATF5
activating transcription factor 5
chr3_+_48507209 2.295 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr3_+_97483563 2.292 NM_032146
NM_177976
ARL6

ADP-ribosylation factor-like 6

chr17_-_20370819 2.291 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr7_+_142552547 2.274 NM_004445
EPHB6
EPH receptor B6
chr1_-_156252613 2.261 SMG5
smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr1_+_36387788 2.250 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr14_-_23284565 2.249 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr10_+_92980507 2.246 PCGF5
polycomb group ring finger 5
chr12_+_113416267 2.232 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_-_154580481 2.225 ADAR
adenosine deaminase, RNA-specific
chr11_-_124190092 2.221 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr3_+_108021331 2.203 NM_007072
HHLA2
HERV-H LTR-associating 2
chr8_-_72459891 2.177


chr6_+_131958441 2.147 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr1_-_156252617 2.108 NM_015327
SMG5
smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr1_-_156252601 2.086 SMG5
smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr1_-_156252470 2.075 SMG5
smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr1_-_154580632 2.071 ADAR
adenosine deaminase, RNA-specific
chr22_-_32651317 2.064 NM_014227
SLC5A4
solute carrier family 5 (low affinity glucose cotransporter), member 4
chr12_-_59314297 2.049 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr8_+_105352050 2.026 NM_030788
TM7SF4
transmembrane 7 superfamily member 4
chr11_+_111789600 2.024 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr6_-_31239489 2.024 HLA-B
HLA-C
major histocompatibility complex, class I, B
major histocompatibility complex, class I, C
chr19_+_50431958 2.009 NM_012068
ATF5
activating transcription factor 5
chr2_-_220252569 1.987 DNPEP
aspartyl aminopeptidase
chr4_-_682967 1.968 NM_032219
MFSD7
major facilitator superfamily domain containing 7
chr14_+_73525302 1.967 RBM25
RNA binding motif protein 25
chr17_-_43339433 1.962 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr8_+_97657592 1.945 PGCP
plasma glutamate carboxypeptidase
chr6_-_121655606 1.915 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr3_-_145968819 1.913 PLSCR4
phospholipid scramblase 4
chr19_+_10197023 1.893 C19orf66
chromosome 19 open reading frame 66
chr12_-_15374290 1.891 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr2_-_231084600 1.890 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr7_-_16921596 1.883 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr10_+_92980322 1.883 NM_032373
PCGF5
polycomb group ring finger 5
chr5_-_114631964 1.882 NM_152549
CCDC112
coiled-coil domain containing 112
chr12_-_25706177 1.876 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr1_-_89488412 1.868 NM_018284
GBP3
guanylate binding protein 3
chr4_+_187070326 1.842 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr2_-_220252627 1.840 NM_012100
DNPEP
aspartyl aminopeptidase
chr16_+_57769667 1.811 KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr1_+_210502639 1.809 NM_001170580
HHAT
hedgehog acyltransferase
chr1_+_174843523 1.795 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr6_-_170599568 1.792 NM_005618
DLL1
delta-like 1 (Drosophila)
chr4_-_122148620 1.792 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr7_+_154720154 1.784 LOC100132707
uncharacterized LOC100132707

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.10 1.09e-11 GO:0034340 response to type I interferon
2.41 2.29e-11 GO:0006955 immune response
6.92 7.91e-11 GO:0060337 type I interferon-mediated signaling pathway
6.92 7.91e-11 GO:0071357 cellular response to type I interferon
3.04 1.49e-10 GO:0045087 innate immune response
2.25 9.91e-10 GO:0006952 defense response
3.65 2.32e-08 GO:0019221 cytokine-mediated signaling pathway
1.91 2.58e-08 GO:0002376 immune system process
3.90 5.20e-08 GO:0009615 response to virus
2.90 3.81e-07 GO:0034097 response to cytokine stimulus
3.29 4.97e-07 GO:0071345 cellular response to cytokine stimulus
1.94 8.38e-06 GO:0051704 multi-organism process
2.22 4.74e-05 GO:0009607 response to biotic stimulus
11.47 1.39e-04 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
2.31 1.57e-04 GO:0051707 response to other organism
15.98 3.23e-04 GO:0019883 antigen processing and presentation of endogenous antigen
8.39 7.20e-04 GO:0048002 antigen processing and presentation of peptide antigen
18.64 9.03e-04 GO:0002483 antigen processing and presentation of endogenous peptide antigen
18.64 9.03e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
2.28 1.51e-03 GO:0044419 interspecies interaction between organisms
5.05 1.95e-03 GO:0032479 regulation of type I interferon production
1.40 9.33e-03 GO:0006950 response to stress
2.96 2.54e-02 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
5.59 3.77e-02 GO:0032480 negative regulation of type I interferon production
2.87 4.08e-02 GO:0001819 positive regulation of cytokine production
3.50 4.09e-02 GO:0034341 response to interferon-gamma

Nothing significant found in compartment category.

Nothing significant found in function category.