Motif ID: LHX3,4.p2

Z-value: 1.086


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX4chr1_+_180199432-0.523.2e-03Click!
LHX3chr9_-_139094886-0.232.1e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_31870940 9.508 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr13_+_36050885 8.616 NM_001204197
NBEA
neurobeachin
chr7_+_23286384 6.346 GPNMB
glycoprotein (transmembrane) nmb
chr8_+_17396285 6.261 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr7_+_23286386 5.691 GPNMB
glycoprotein (transmembrane) nmb
chr6_-_29527701 5.652 NM_006398
UBD
ubiquitin D
chr8_-_7212868 5.504 FAM66B
family with sequence similarity 66, member B
chr4_-_100273831 4.920 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr7_+_23286390 4.751 GPNMB
glycoprotein (transmembrane) nmb
chr5_-_137475076 4.382 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr3_+_238274 4.108 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr8_-_110661007 4.079 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr11_+_71900958 4.009 NM_000802
FOLR1
folate receptor 1 (adult)
chr20_+_9198036 3.838 NM_182797
PLCB4
phospholipase C, beta 4
chr5_+_156696351 3.782 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_-_152131703 3.778 NM_001122965
RPTN
repetin
chr8_-_110693233 3.749 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr7_+_23286420 3.539 GPNMB
glycoprotein (transmembrane) nmb
chr9_-_75567915 3.444 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr14_-_106926393 3.420 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_104198140 3.377 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr10_+_695887 3.376 C10orf108
chromosome 10 open reading frame 108
chr5_-_160279045 3.283 NM_025153
ATP10B
ATPase, class V, type 10B
chr22_-_50971007 3.252 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr5_+_36608430 3.173 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr18_-_53089722 3.158 NM_001243233
TCF4
transcription factor 4
chr3_-_112564789 3.136 NM_001008784
NM_001199215
CD200R1L

CD200 receptor 1-like

chr1_-_150738255 3.048 CTSS
cathepsin S
chr3_+_113616317 3.045 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr1_-_150738232 2.995 CTSS
cathepsin S
chr12_-_10282680 2.994 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_-_150738292 2.942 NM_001199739
NM_004079
CTSS

cathepsin S

chr1_+_12806162 2.876 NM_152290
C1orf158
chromosome 1 open reading frame 158
chr1_+_244214576 2.803 ZNF238
zinc finger protein 238
chr4_+_15471488 2.790 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr20_+_5987897 2.645 NM_001127458
CRLS1
cardiolipin synthase 1
chr21_-_43735705 2.592 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr5_+_36606667 2.443 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_+_141695678 2.347 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr7_+_23286277 2.340 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr10_+_91152321 2.273 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr11_-_26593667 2.265 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr1_+_244216506 2.264 NM_006352
ZNF238
zinc finger protein 238
chr17_-_39165343 2.212 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr1_+_104292278 2.151 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr9_-_14086901 2.134 NFIB
nuclear factor I/B
chr19_+_49199227 2.133 NM_000511
NM_001097638
FUT2

fucosyltransferase 2 (secretor status included)

chr4_+_186350543 2.119 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr7_+_133812051 2.096 NM_144648
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr7_-_92777657 2.049 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr7_+_23286401 2.049 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_36606456 1.936 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr9_-_4152182 1.908 NM_152629
GLIS3
GLIS family zinc finger 3
chr15_+_34261088 1.907 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr7_+_90339146 1.903 CDK14
cyclin-dependent kinase 14
chr13_-_70682458 1.893 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr3_+_132318980 1.857 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr3_+_69812961 1.848 NM_006722
MITF
microphthalmia-associated transcription factor
chr6_+_31913708 1.848 NM_001710
CFB
complement factor B
chr6_+_31913852 1.826 CFB
complement factor B
chr1_-_217113007 1.823 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr1_+_61547625 1.817 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr1_+_61869699 1.813 NFIA
nuclear factor I/A
chr6_-_33041266 1.791 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr6_+_31913763 1.781 CFB
complement factor B
chr1_+_180601164 1.772 XPR1
xenotropic and polytropic retrovirus receptor 1
chr20_-_20036685 1.766 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr7_+_90338711 1.763 NM_012395
CDK14
cyclin-dependent kinase 14
chr11_+_71900601 1.724 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr1_-_161337663 1.699 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr1_+_244214552 1.690 NM_205768
ZNF238
zinc finger protein 238
chr15_-_55800431 1.673 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chrX_-_10851808 1.655 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr16_+_10522724 1.624 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr1_+_59775749 1.619 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr22_+_23487512 1.597 NM_004914
RAB36
RAB36, member RAS oncogene family
chr1_+_61547388 1.582 NM_001145512
NFIA
nuclear factor I/A
chr5_-_13944588 1.562 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr20_-_18477811 1.525 NM_006606
RBBP9
retinoblastoma binding protein 9
chr4_-_23891608 1.503 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_+_41614911 1.503 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_+_180601121 1.497 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr18_+_61582744 1.489 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr1_+_155853546 1.482 SYT11
synaptotagmin XI
chr1_+_104292439 1.475 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr20_-_34117447 1.449 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr11_-_124973204 1.447 NM_001080546
TMEM218
transmembrane protein 218
chr8_-_102803196 1.391 NCALD
neurocalcin delta
chr18_-_45663667 1.369 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr7_-_64023454 1.367 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr3_+_361365 1.326 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr5_-_41213513 1.323 NM_000065
C6
complement component 6
chr5_-_124080773 1.302 NM_020747
ZNF608
zinc finger protein 608
chrX_+_70765479 1.248 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr4_+_70861647 1.227 NM_001009181
NM_003154
STATH

statherin

chr18_-_24722757 1.225 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr3_+_195447751 1.199 NM_152673
MUC20
mucin 20, cell surface associated
chr1_+_79115476 1.186 NM_006417
IFI44
interferon-induced protein 44
chr1_+_151630710 1.177 SNX27
sorting nexin family member 27
chr7_-_25268057 1.152 NM_022150
NPVF
neuropeptide VF precursor
chr3_-_12941547 1.139 IQSEC1
IQ motif and Sec7 domain 1
chr11_+_89392464 1.135 NM_153696
FOLH1B
folate hydrolase 1B
chr5_-_111093792 1.133 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr9_-_117265452 1.133 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr11_+_99426872 1.125 NM_175566
CNTN5
contactin 5
chr16_-_52581713 1.103 NM_001146188
TOX3
TOX high mobility group box family member 3
chr19_+_41430123 1.099 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr1_+_196621007 1.091 NM_000186
NM_001014975
CFH

complement factor H

chr11_-_59633942 1.086 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr12_-_42983412 1.079 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr3_+_171561138 1.076 NM_001164436
TMEM212
transmembrane protein 212
chr3_+_186739643 1.065 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr3_-_114478117 1.063 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr5_+_140247767 1.055 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chrX_-_102531673 1.052 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr8_+_105352050 1.032 NM_030788
TM7SF4
transmembrane 7 superfamily member 4
chr2_+_103089761 1.030 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr21_+_25801042 0.992 FLJ42200
FLJ42200 protein
chr5_+_42565963 0.983 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr3_-_195310985 0.966 NM_001647
APOD
apolipoprotein D
chr6_+_26440699 0.964 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr2_+_234826042 0.952 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr4_+_41614933 0.946 LIMCH1
LIM and calponin homology domains 1
chr6_-_24583454 0.938 NM_001252328
KIAA0319
KIAA0319
chr6_-_52774460 0.934 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr5_+_140235594 0.909 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr2_-_175712276 0.902 NM_001206602
CHN1
chimerin (chimaerin) 1
chr3_-_93692898 0.901 NM_000313
PROS1
protein S (alpha)
chr6_-_47253962 0.878 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr12_-_9760481 0.866 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr16_+_2809933 0.856


chr4_+_72204769 0.850 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr21_-_43735462 0.848 TFF3
trefoil factor 3 (intestinal)
chrX_+_144908927 0.844 NM_004709
CXorf1
chromosome X open reading frame 1
chr10_+_118305427 0.840 NM_000936
PNLIP
pancreatic lipase
chr10_-_61900659 0.838 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr20_+_57022460 0.838 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr6_-_79675672 0.820 PHIP
pleckstrin homology domain interacting protein
chr9_-_215892 0.811 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr4_-_170077807 0.808 SH3RF1
SH3 domain containing ring finger 1
chr12_-_25706177 0.807 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr12_+_131438451 0.806 NM_198827
GPR133
G protein-coupled receptor 133
chr11_+_101918168 0.794 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr1_-_92952429 0.782 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr3_-_114102488 0.778 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_149192367 0.769 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr18_+_61370193 0.767 NM_080475
SERPINB11
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr2_-_216946463 0.766 NM_018441
PECR
peroxisomal trans-2-enoyl-CoA reductase
chr16_-_12010518 0.757 NM_001130007
GSPT1
G1 to S phase transition 1
chr3_-_151058439 0.754 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr1_-_149900143 0.752 NM_005850
SF3B4
splicing factor 3b, subunit 4, 49kDa
chrX_-_132162297 0.750 NM_031907
USP26
ubiquitin specific peptidase 26
chr18_-_53177999 0.749 NM_001243231
TCF4
transcription factor 4
chr17_+_4692226 0.739 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr10_+_94594469 0.734 NM_001013848
EXOC6
exocyst complex component 6
chr7_+_138144847 0.723 NM_003852
NM_015905
TRIM24

tripartite motif containing 24

chr3_-_11623829 0.719 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr6_+_26402464 0.709 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr1_-_144997110 0.708 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr10_+_15001437 0.707 NM_001080836
MEIG1
meiosis expressed gene 1 homolog (mouse)
chr9_+_12693385 0.707 NM_000550
TYRP1
tyrosinase-related protein 1
chr1_+_174417211 0.705 NM_005684
GPR52
G protein-coupled receptor 52
chr3_+_132036276 0.698 ACPP
acid phosphatase, prostate
chr7_+_129269916 0.698 NM_001040110
NRF1
nuclear respiratory factor 1
chr11_-_71524890 0.688 LOC285407
asparagine-linked glycosylation 1 homolog pseudogene
chr4_-_54424345 0.688 LNX1
ligand of numb-protein X 1
chr5_-_35938736 0.686 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr3_-_105421044 0.685 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr16_+_69726751 0.685 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr7_-_139763520 0.684 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr4_-_54424402 0.683 NM_032622
LNX1
ligand of numb-protein X 1
chr12_+_75784878 0.669 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr6_-_32908583 0.667 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr12_+_56414688 0.663 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr21_-_43346780 0.659 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr4_+_187070326 0.659 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr7_-_37024664 0.657 NM_001039459
ELMO1
engulfment and cell motility 1
chr2_+_183943286 0.655 NM_001142314
NM_080876
DUSP19

dual specificity phosphatase 19

chr5_+_71502700 0.655 MAP1B
microtubule-associated protein 1B
chr15_-_43877043 0.647 NM_014659
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr2_-_99279935 0.645 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr10_+_102222797 0.644 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr1_+_206643830 0.627 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr16_-_4896197 0.622 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr4_+_36283243 0.619 NM_001136536
DTHD1
death domain containing 1
chr13_+_99058147 0.616


chrX_+_36254050 0.615 NM_001098843
CXorf30
chromosome X open reading frame 30
chr12_-_48745020 0.613 NM_001172682
ZNF641
zinc finger protein 641
chr10_-_75335415 0.609 NM_152586
USP54
ubiquitin specific peptidase 54
chr11_-_31014232 0.607 NM_020869
DCDC5
doublecortin domain containing 5
chrX_-_13835012 0.601 GPM6B
glycoprotein M6B
chr6_+_73076431 0.599 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr20_+_43990576 0.597 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr12_-_89920038 0.596 NM_001199781
NM_001199782
NM_172240
POC1B-GALNT4

POC1B
POC1B-GALNT4 readthrough

POC1 centriolar protein homolog B (Chlamydomonas)
chr8_-_102803438 0.594 NM_032041
NCALD
neurocalcin delta
chr8_-_102803178 0.594 NCALD
neurocalcin delta
chr14_-_61115906 0.593 NM_005982
SIX1
SIX homeobox 1
chr2_+_162272892 0.591 TBR1
T-box, brain, 1
chrX_-_154250769 0.589 NM_000132
F8
coagulation factor VIII, procoagulant component
chr20_-_7921068 0.587 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
27.11 1.90e-02 GO:0034056 estrogen response element binding