Motif ID: MYBL2.p2

Z-value: 1.042


Transcription factors associated with MYBL2.p2:

Gene SymbolEntrez IDGene Name
MYBL2 4605 v-myb myeloblastosis viral oncogene homolog (avian)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MYBL2chr20_+_422957080.504.7e-03Click!


Activity profile for motif MYBL2.p2.

activity profile for motif MYBL2.p2


Sorted Z-values histogram for motif MYBL2.p2

Sorted Z-values for motif MYBL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYBL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_17270257 4.782 NM_003380
VIM
vimentin
chr10_+_17270469 3.398 VIM
vimentin
chr3_-_123339178 2.901 MYLK
myosin light chain kinase
chr1_-_93342706 2.336 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr6_+_151561094 2.137 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr3_-_123339423 2.036 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr1_+_84630014 2.029 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr13_-_60325073 1.959


chr10_-_121296044 1.954 NM_002925
RGS10
regulator of G-protein signaling 10
chr2_-_190044330 1.728 NM_000393
COL5A2
collagen, type V, alpha 2
chr17_-_49124128 1.617 NM_001251971
SPAG9
sperm associated antigen 9
chr1_-_197036350 1.588 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr9_+_116356199 1.563 NM_144489
RGS3
regulator of G-protein signaling 3
chrX_+_135278912 1.531 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr3_+_121774208 1.525 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr2_+_210444364 1.498 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr22_+_38071612 1.410 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr10_-_105845619 1.377 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr1_+_84630374 1.351 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_107078476 1.331 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr10_+_91498724 1.328 KIF20B
kinesin family member 20B
chr10_-_106098161 1.314 ITPRIP
inositol 1,4,5-trisphosphate receptor interacting protein
chr6_-_131321868 1.284 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr11_+_33037727 1.260 NM_139160
DEPDC7
DEP domain containing 7
chr12_+_56915587 1.248 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr6_+_100054649 1.157 NM_021620
PRDM13
PR domain containing 13
chr10_-_105845556 1.154 COL17A1
collagen, type XVII, alpha 1
chr2_+_210444154 1.141 MAP2
microtubule-associated protein 2
chr7_+_139528951 1.136 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_+_134233848 1.111 NM_001080538
AKR1B15
aldo-keto reductase family 1, member B15
chr21_+_30517897 1.102 C21orf7
chromosome 21 open reading frame 7
chr14_-_73453651 1.081 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr9_+_116356407 1.077 RGS3
regulator of G-protein signaling 3
chr4_-_123377471 1.070 NM_000586
IL2
interleukin 2
chr3_-_112358758 1.017 CCDC80
coiled-coil domain containing 80
chr19_+_48828627 1.013 NM_001425
EMP3
epithelial membrane protein 3
chr1_+_119957553 0.993 NM_001166120
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_+_17575592 0.992 NM_016233
PADI3
peptidyl arginine deiminase, type III
chr9_-_95298251 0.988 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr2_+_102508377 0.987 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr14_+_62462540 0.973 NM_031914
SYT16
synaptotagmin XVI
chr1_-_153521717 0.961 NM_002960
S100A3
S100 calcium binding protein A3
chr4_-_47983430 0.958 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr4_-_48014960 0.953 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr5_-_149669400 0.945 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr22_-_37403838 0.912 NM_001163857
NM_178552
C22orf33

chromosome 22 open reading frame 33

chr2_-_165424993 0.904 GRB14
growth factor receptor-bound protein 14
chr1_-_150780705 0.895 NM_000396
CTSK
cathepsin K
chr3_-_172858959 0.891 NM_031955
SPATA16
spermatogenesis associated 16
chr12_+_13043955 0.889 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr9_-_74675498 0.888 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr1_-_154943001 0.875 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr2_+_169929009 0.870 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_+_28452143 0.868 NM_182898
CREB5
cAMP responsive element binding protein 5
chr4_-_39033981 0.865 NM_024943
TMEM156
transmembrane protein 156
chr19_+_41869848 0.854 NM_001098825
TMEM91
transmembrane protein 91
chr18_+_22040592 0.840 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr11_+_33563772 0.838 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr12_-_120315074 0.836 NM_001206999
NM_007174
CIT

citron (rho-interacting, serine/threonine kinase 21)

chr19_+_48828820 0.829 EMP3
epithelial membrane protein 3
chr17_-_48264039 0.828 COL1A1
collagen, type I, alpha 1
chr2_+_143886969 0.824 ARHGAP15
Rho GTPase activating protein 15
chr11_-_123756339 0.807 NM_001013743
TMEM225
transmembrane protein 225
chr1_-_113498828 0.805 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr5_-_157002739 0.795 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr6_+_27292539 0.792 NM_032030
FKSG83
FKSG83
chrX_+_17755562 0.787 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr4_+_69313166 0.772 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr4_+_15341559 0.769 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr17_-_42908178 0.768 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr12_-_54867346 0.755 GTSF1
gametocyte specific factor 1
chr11_+_128563993 0.754 FLI1
Friend leukemia virus integration 1
chr1_-_23342342 0.747 NM_001242521
LOC729059
uncharacterized LOC729059
chr5_-_39424930 0.739 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr12_-_52845862 0.728 NM_005555
KRT6B
keratin 6B
chr5_-_39425297 0.720 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr10_+_32856650 0.718 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr5_-_39425030 0.717 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_+_228356287 0.673 AGFG1
ArfGAP with FG repeats 1
chr2_-_134326030 0.670 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr3_-_27498244 0.668 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr17_+_18647325 0.666 NM_031456
FBXW10
F-box and WD repeat domain containing 10
chr2_+_37571752 0.662 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr13_-_46425756 0.647 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr2_+_143886898 0.641 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr22_+_44568835 0.629 NM_001137605
PARVG
parvin, gamma
chr5_+_55062712 0.628 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr17_-_15554809 0.625 TRIM16
tripartite motif containing 16
chr7_+_80267782 0.614 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr3_-_112358510 0.609 CCDC80
coiled-coil domain containing 80
chr12_-_71031174 0.608 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr2_+_182850550 0.605 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr13_+_32313678 0.600 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr19_-_51537996 0.597 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr5_-_149669187 0.583 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr17_+_3118911 0.583 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr11_+_128563973 0.581 FLI1
Friend leukemia virus integration 1
chr4_+_3315873 0.578 NM_002926
NM_198229
RGS12

regulator of G-protein signaling 12

chr11_+_128563772 0.571 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr7_+_80267922 0.570 CD36
CD36 molecule (thrombospondin receptor)
chr1_+_84630575 0.566 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr4_-_156787377 0.559 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr10_-_98031154 0.541 NM_001114094
NM_013314
BLNK

B-cell linker

chr17_-_67138013 0.537 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr3_-_149086884 0.533 TM4SF1
transmembrane 4 L six family member 1
chr4_+_148402068 0.517 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr1_-_193155723 0.515 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr1_+_113498984 0.507 LOC100506392
uncharacterized LOC100506392
chr4_-_159093717 0.507 NM_016613
FAM198B
family with sequence similarity 198, member B
chr2_+_29038862 0.501 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr21_+_43823970 0.496 NM_001001895
NM_001243467
NM_018961
UBASH3A


ubiquitin associated and SH3 domain containing A


chr4_-_76928601 0.496 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr9_+_118916069 0.493 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chrX_+_118108575 0.482 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr10_+_94352873 0.477 KIF11
kinesin family member 11
chr15_-_80263460 0.476 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chrX_+_118108595 0.466 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chrX_-_52386015 0.459 NM_001079538
XAGE2B
XAGE2
X antigen family, member 2B
X antigen family, member 2
chr2_+_33701678 0.459 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chrX_-_115594136 0.454 NM_001017978
CXorf61
chromosome X open reading frame 61
chr19_+_11200037 0.453 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr2_+_191002485 0.452 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr19_-_43032525 0.452 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr7_+_80267972 0.452 CD36
CD36 molecule (thrombospondin receptor)
chr8_-_95274540 0.451 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr11_+_131240370 0.444 NM_001048209
NTM
neurotrimin
chr3_-_112359277 0.444 CCDC80
coiled-coil domain containing 80
chr1_-_42384370 0.444 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr17_-_48227873 0.443 NM_032595
PPP1R9B
protein phosphatase 1, regulatory subunit 9B
chr1_-_110933635 0.443 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr2_-_161056573 0.443 NM_000888
ITGB6
integrin, beta 6
chr1_-_149908098 0.440 NM_181873
MTMR11
myotubularin related protein 11
chr3_-_112359443 0.439 CCDC80
coiled-coil domain containing 80
chr16_+_12058963 0.436 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_-_113498615 0.435 NM_001166496
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr12_-_26277807 0.432 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr10_+_94833231 0.432 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr12_-_54867372 0.430 NM_144594
GTSF1
gametocyte specific factor 1
chr6_+_153019029 0.428 NM_025107
MYCT1
myc target 1
chr6_+_35265654 0.428 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr10_-_99052358 0.428 ARHGAP19
Rho GTPase activating protein 19
chr4_+_148402117 0.421 EDNRA
endothelin receptor type A
chr3_-_112359251 0.421 CCDC80
coiled-coil domain containing 80
chr3_+_8775485 0.417 NM_001234
NM_033337
CAV3

caveolin 3

chr10_+_94352809 0.417 NM_004523
KIF11
kinesin family member 11
chr8_+_22225173 0.417 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr4_-_39979549 0.416 NM_001100399
NM_001100400
PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chr1_+_161676761 0.416 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr15_+_63334753 0.416 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr8_-_95274520 0.415 GEM
GTP binding protein overexpressed in skeletal muscle
chr6_-_152702329 0.415 SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_-_128457452 0.414 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr12_-_4754275 0.411 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr22_+_44395090 0.408 NM_001003828
PARVB
parvin, beta
chr2_+_68961912 0.396 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr4_+_15429628 0.393 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chrX_+_52113157 0.387 NM_001079538
XAGE2B
XAGE2
X antigen family, member 2B
X antigen family, member 2
chr4_+_184427224 0.384 ING2
inhibitor of growth family, member 2
chr10_+_99332197 0.384 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr3_+_189507448 0.381 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr16_+_81528953 0.381 NM_030629
CMIP
c-Maf inducing protein
chr10_-_90750955 0.380 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_-_112824526 0.379 NM_001085377
MCC
mutated in colorectal cancers
chr9_+_96846710 0.377 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr16_+_3405888 0.374 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr17_-_64225496 0.373 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr22_+_20377668 0.372 NM_001242313
TMEM191B
transmembrane protein 191B
chr9_+_131709970 0.371 NM_015354
NUP188
nucleoporin 188kDa
chr18_+_61254533 0.369 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr14_+_23305792 0.368 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr6_-_43655539 0.367 NM_001193343
NM_018135
MRPS18A

mitochondrial ribosomal protein S18A

chr9_+_131709991 0.367 NUP188
nucleoporin 188kDa
chr13_-_101185944 0.366 NM_033110
A2LD1
AIG2-like domain 1
chrX_-_125686792 0.360 NM_178470
DCAF12L1
DDB1 and CUL4 associated factor 12-like 1
chr11_-_36619776 0.358 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr21_+_37507209 0.358 NM_001236
CBR3
carbonyl reductase 3
chr22_-_37584254 0.356 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr1_+_144614958 0.356 NM_001037675
NBPF9
NBPF8
neuroblastoma breakpoint family, member 9
neuroblastoma breakpoint family, member 8
chr22_+_40322609 0.352 GRAP2
GRB2-related adaptor protein 2
chr3_-_112359565 0.351 CCDC80
coiled-coil domain containing 80
chr6_-_111888520 0.350 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr7_+_18535351 0.349 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr3_-_56698073 0.348 NM_015224
FAM208A
family with sequence similarity 208, member A
chr11_-_83984230 0.346 NM_001142700
DLG2
discs, large homolog 2 (Drosophila)
chr12_+_21284127 0.346 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr20_-_7921068 0.343 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr17_+_12569305 0.342 MYOCD
myocardin
chr1_-_110933683 0.341 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr10_+_94833646 0.338 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr2_-_10942642 0.335 PDIA6
protein disulfide isomerase family A, member 6
chrX_-_106960268 0.334 NM_004089
TSC22D3
TSC22 domain family, member 3
chr11_-_67450536 0.333 RPL37
ribosomal protein L37
chr2_-_228244005 0.331 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr13_+_73301980 0.328 NM_024808
BORA
bora, aurora kinase A activator
chr3_-_112359863 0.328 CCDC80
coiled-coil domain containing 80
chr15_+_67418053 0.327 NM_001145102
SMAD3
SMAD family member 3
chr13_-_20346398 0.325 PSPC1
paraspeckle component 1
chrX_+_79675945 0.322 NM_152630
FAM46D
family with sequence similarity 46, member D
chr6_-_117747017 0.320 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr3_-_48672807 0.320 SLC26A6
solute carrier family 26, member 6

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.09 4.72e-05 GO:0044449 contractile fiber part
3.76 1.85e-04 GO:0043292 contractile fiber
3.78 3.39e-04 GO:0030016 myofibril
3.97 6.67e-04 GO:0030017 sarcomere
1.27 2.81e-02 GO:0005886 plasma membrane
1.26 3.33e-02 GO:0071944 cell periphery
4.56 3.70e-02 GO:0031674 I band
2.15 4.83e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
24.33 1.30e-03 GO:0047023 androsterone dehydrogenase activity
7.10 1.65e-02 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
11.06 1.99e-02 GO:0030553 cGMP binding
10.14 3.30e-02 GO:0019002 GMP binding
6.08 4.90e-02 GO:0016229 steroid dehydrogenase activity