Motif ID: NFE2L2.p2

Z-value: 0.721


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L2chr2_-_1781298580.412.3e-02Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_34397786 3.327 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr7_+_23286384 1.886 GPNMB
glycoprotein (transmembrane) nmb
chr12_+_56075329 1.799 NM_152637
METTL7B
methyltransferase like 7B
chr7_+_37960418 1.772 EPDR1
ependymin related protein 1 (zebrafish)
chr12_+_56075418 1.688 METTL7B
methyltransferase like 7B
chr7_+_23286277 1.677 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr7_+_37960920 1.645 NM_001242948
EPDR1
ependymin related protein 1 (zebrafish)
chr4_-_16077740 1.612 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr19_+_50706868 1.509 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr7_+_23286386 1.488 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_162838550 1.429 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr7_+_23286390 1.241 GPNMB
glycoprotein (transmembrane) nmb
chr14_-_21572374 1.224


chr16_+_80574853 1.145 NM_130897
DYNLRB2
dynein, light chain, roadblock-type 2
chr5_-_35938736 1.132 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr9_+_140135738 1.130 TUBB4B
tubulin, beta 4B class IVb
chr10_+_114136014 1.111 ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_+_2083264 1.107 NM_001252073
NM_001252075
NM_001252076
SLC9A3R2


solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2


chr19_+_56347943 1.082 NM_134444
NLRP4
NLR family, pyrin domain containing 4
chr9_+_139921915 1.045 NM_207511
C9orf139
chromosome 9 open reading frame 139
chr16_-_28620648 1.025 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr9_+_140135698 0.978 NM_006088
TUBB4B
tubulin, beta 4B class IVb
chr14_-_106926393 0.915 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_53133063 0.906 CHD9
chromodomain helicase DNA binding protein 9
chr2_+_120189342 0.883 NM_183240
TMEM37
transmembrane protein 37
chr16_-_28607694 0.846 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_-_94374986 0.775 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr14_-_106641585 0.768 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_120401401 0.765 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr9_+_34458810 0.757 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr1_+_223889253 0.753 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr8_-_26724748 0.748 ADRA1A
adrenergic, alpha-1A-, receptor
chrX_+_133371076 0.746 NM_001101357
CCDC160
coiled-coil domain containing 160
chr3_-_120400957 0.725 HGD
homogentisate 1,2-dioxygenase
chr5_+_176875325 0.716 NM_001174102
PRR7
proline rich 7 (synaptic)
chr1_-_203155813 0.704 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr13_+_113698907 0.690 MCF2L
MCF.2 cell line derived transforming sequence-like
chr22_+_45072936 0.686 PRR5
proline rich 5 (renal)
chr14_+_23352430 0.682 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr10_+_114135937 0.682 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_94856926 0.680 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr12_-_10151689 0.680 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr1_+_154966061 0.671 NM_018655
LENEP
lens epithelial protein
chr8_-_11204998 0.670 LOC100129129
uncharacterized LOC100129129
chr9_-_139922705 0.647 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr9_-_139922595 0.647 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_-_114302093 0.646 PHTF1
putative homeodomain transcription factor 1
chr16_+_78056411 0.632 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr2_-_111334677 0.630 NM_005054
RGPD5
RANBP2-like and GRIP domain containing 5
chr1_-_109969058 0.630 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr16_-_28621279 0.629 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr7_+_23286420 0.626 GPNMB
glycoprotein (transmembrane) nmb
chr6_-_134496833 0.617 SGK1
serum/glucocorticoid regulated kinase 1
chr14_-_106774311 0.615 IGHA1
immunoglobulin heavy constant alpha 1
chr9_-_97402530 0.605 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr16_+_31366529 0.600 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr22_+_22735202 0.586


chr10_+_95848811 0.583 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr10_+_114135965 0.579 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_114343791 0.575 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr15_-_83240499 0.551 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr16_+_1386197 0.549 NM_001199096
BAIAP3
BAI1-associated protein 3
chr12_-_25801487 0.535 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr16_+_31366519 0.526 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr19_-_7764283 0.526 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr2_+_110551965 0.524 NM_005054
RGPD5
RANBP2-like and GRIP domain containing 5
chr22_+_45072687 0.524 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr17_+_14204326 0.513 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr12_-_56101667 0.499 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr5_+_61714710 0.490 NM_001134779
IPO11
importin 11
chrX_+_9431314 0.489 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr12_-_6809965 0.486 NM_001244014
NM_153685
C12orf53

chromosome 12 open reading frame 53

chr6_-_31745048 0.483 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr1_-_94374949 0.475 GCLM
glutamate-cysteine ligase, modifier subunit
chr3_+_48507621 0.459 TREX1
three prime repair exonuclease 1
chr9_-_140083034 0.458 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr22_-_36013303 0.457 NM_005368
NM_203378
MB

myoglobin

chr22_+_23040394 0.456 IGL@
immunoglobulin lambda locus
chr3_-_58200397 0.453 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr21_-_35828038 0.446 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr2_-_86565205 0.444 NM_001164730
REEP1
receptor accessory protein 1
chr12_-_56101465 0.441 ITGA7
integrin, alpha 7
chr2_-_113191106 0.440 NM_001164463
NM_005054
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr9_-_97402556 0.433 FBP1
fructose-1,6-bisphosphatase 1
chr1_-_42921676 0.423 ZMYND12
zinc finger, MYND-type containing 12
chr2_-_11484699 0.416 NM_004850
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr3_+_48507209 0.416 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr12_-_70083055 0.413 NM_152439
BEST3
bestrophin 3
chr22_-_39268214 0.410 CBX6
chromobox homolog 6
chr12_+_111051831 0.407 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr6_-_24877453 0.404 NM_015864
FAM65B
family with sequence similarity 65, member B
chr6_-_154677868 0.404 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr17_+_30771522 0.401 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr5_-_137911039 0.397 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr17_+_30771485 0.396 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr3_+_184038445 0.395 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr6_-_134497069 0.394 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr2_+_231921625 0.393 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr7_+_116312412 0.393 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr17_+_30771494 0.392 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771532 0.392 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr12_-_15114495 0.386 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chrX_-_53310748 0.383 NM_001243197
NM_015075
IQSEC2

IQ motif and Sec7 domain 2

chr22_+_38035447 0.383


chr7_+_23286401 0.383 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_107084800 0.380 NM_001144013
RGPD3
RANBP2-like and GRIP domain containing 3
chr1_+_14075931 0.380 PRDM2
PR domain containing 2, with ZNF domain
chr9_-_140082983 0.379 ANAPC2
anaphase promoting complex subunit 2
chr19_+_13135809 0.376 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_69201704 0.376 NM_019617
GKN1
gastrokine 1
chr11_+_10477480 0.374 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr9_+_140135742 0.374 TUBB4B
tubulin, beta 4B class IVb
chr22_+_22723972 0.372


chr3_+_184038050 0.371 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr22_-_27013959 0.371 NM_001887
CRYBB1
crystallin, beta B1
chr3_-_39234071 0.371 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr5_-_137911005 0.367 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr17_+_30771520 0.366 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr5_+_179247911 0.361 SQSTM1
sequestosome 1
chr19_+_13135368 0.360 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_+_10476665 0.358 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr14_-_106967528 0.349 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr17_+_79651052 0.345


chr8_-_82395401 0.345 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr16_-_30124829 0.341 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr1_+_14075917 0.339 PRDM2
PR domain containing 2, with ZNF domain
chr1_-_42921923 0.336 NM_001146192
NM_032257
ZMYND12

zinc finger, MYND-type containing 12

chr11_+_35684418 0.334 TRIM44
tripartite motif containing 44
chr11_+_35684342 0.330 NM_017583
TRIM44
tripartite motif containing 44
chr9_-_116840604 0.330 AMBP
alpha-1-microglobulin/bikunin precursor
chr19_-_4559713 0.330 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr16_+_22308722 0.328 NM_018119
POLR3E
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr3_-_170587947 0.327 NM_001099645
RPL22L1
ribosomal protein L22-like 1
chr22_+_22735134 0.323 CYAT1
immunoglobulin lambda light chain-like
chr1_-_94375028 0.322 GCLM
glutamate-cysteine ligase, modifier subunit
chr18_-_267987 0.318 NM_005131
THOC1
THO complex 1
chrX_-_110513750 0.318 NM_014289
CAPN6
calpain 6
chr19_+_41430123 0.315 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr22_+_22735207 0.314 IGLJ3
immunoglobulin lambda joining 3
chr3_-_150920946 0.310 NM_013308
GPR171
G protein-coupled receptor 171
chr1_+_27719151 0.309 NM_005281
GPR3
G protein-coupled receptor 3
chr1_-_177939347 0.306 SEC16B
SEC16 homolog B (S. cerevisiae)
chr10_+_695887 0.305 C10orf108
chromosome 10 open reading frame 108
chr2_+_18059923 0.304 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr10_-_13544944 0.298 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr22_+_22569155 0.295


chr7_-_102985068 0.292 NM_001129887
NM_014377
DNAJC2

DnaJ (Hsp40) homolog, subfamily C, member 2

chr1_-_93257950 0.292 NM_005665
EVI5
ecotropic viral integration site 5
chr14_-_24777064 0.290


chr17_-_72889704 0.289 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr11_-_62474810 0.287 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_65150107 0.286 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr1_+_22351984 0.286 LINC00339
long intergenic non-protein coding RNA 339
chr18_+_61637262 0.284 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr5_+_179247903 0.284 SQSTM1
sequestosome 1
chr3_+_183903970 0.278 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chrX_-_153210057 0.278 NM_002910
RENBP
renin binding protein
chr10_+_85899184 0.277 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr18_-_40695483 0.275 NM_002930
RIT2
Ras-like without CAAX 2
chr1_-_114301753 0.274 NM_006608
PHTF1
putative homeodomain transcription factor 1
chr2_-_219134795 0.273 AAMP
angio-associated, migratory cell protein
chr16_+_57662301 0.271 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr3_+_183903862 0.270 NM_018358
ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr2_-_238499317 0.267 RAB17
RAB17, member RAS oncogene family
chr17_-_39334439 0.266 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr22_-_27014037 0.264 CRYBB1
crystallin, beta B1
chr17_+_73598139 0.264 MYO15B
myosin XVB pseudogene
chr19_+_3366589 0.263 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr18_-_58040000 0.263 NM_005912
MC4R
melanocortin 4 receptor
chr5_-_149535420 0.263 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr10_-_123356158 0.263 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr19_-_49658645 0.262 NM_002152
HRC
histidine rich calcium binding protein
chr9_-_116840551 0.260 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_114493766 0.260 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr22_-_39268230 0.258 NM_014292
CBX6
chromobox homolog 6
chr2_-_219134865 0.258 NM_001087
AAMP
angio-associated, migratory cell protein
chr12_-_71182699 0.257 NM_001207015
PTPRR
protein tyrosine phosphatase, receptor type, R
chr2_-_28113954 0.257 LOC100302650
uncharacterized LOC100302650
chr11_-_62474666 0.256 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr8_-_143823823 0.255 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr16_-_66959418 0.255 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr16_+_30419363 0.254 ZNF771
zinc finger protein 771
chr6_+_44195008 0.254 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr16_+_71560022 0.252 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr9_+_132251403 0.251 LOC100506190
uncharacterized LOC100506190
chr22_+_22764094 0.251


chr2_-_219134846 0.250 AAMP
angio-associated, migratory cell protein
chr14_-_23284565 0.249 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr17_+_2497233 0.248 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr7_+_150434435 0.247 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr2_+_109335906 0.243 NM_006267
RANBP2
RAN binding protein 2
chr19_+_13135745 0.242 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr16_-_27899477 0.241 NM_144675
GSG1L
GSG1-like
chrX_-_64754594 0.238 LAS1L
LAS1-like (S. cerevisiae)
chr14_-_23284617 0.238 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr7_-_1498961 0.237 MICALL2
MICAL-like 2
chr9_+_130922471 0.237 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr3_+_132373289 0.236 NM_198329
UBA5
ubiquitin-like modifier activating enzyme 5
chr17_+_48610077 0.236 EPN3
epsin 3
chr6_-_56258891 0.233 COL21A1
collagen, type XXI, alpha 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.47 6.05e-06 GO:0051351 positive regulation of ligase activity
5.86 1.56e-05 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
5.43 1.85e-05 GO:0051443 positive regulation of ubiquitin-protein ligase activity
6.13 2.38e-05 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
6.13 2.38e-05 GO:0072395 signal transduction involved in cell cycle checkpoint
6.13 2.38e-05 GO:0072401 signal transduction involved in DNA integrity checkpoint
6.13 2.38e-05 GO:0072404 signal transduction involved in G1/S transition checkpoint
6.13 2.38e-05 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
6.13 2.38e-05 GO:0072422 signal transduction involved in DNA damage checkpoint
6.13 2.38e-05 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
6.13 2.38e-05 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
6.58 2.69e-05 GO:0006521 regulation of cellular amino acid metabolic process
5.61 3.03e-05 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.17 4.12e-05 GO:2000045 regulation of G1/S transition of mitotic cell cycle
5.84 4.82e-05 GO:0071158 positive regulation of cell cycle arrest
4.77 5.92e-05 GO:0051340 regulation of ligase activity
5.18 1.03e-04 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.11 1.25e-04 GO:0031575 mitotic cell cycle G1/S transition checkpoint
5.11 1.25e-04 GO:0071779 G1/S transition checkpoint
4.71 1.76e-04 GO:0051438 regulation of ubiquitin-protein ligase activity
4.98 1.82e-04 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
5.45 3.55e-04 GO:0033238 regulation of cellular amine metabolic process
4.23 4.03e-04 GO:0000077 DNA damage checkpoint
4.15 5.40e-04 GO:0031398 positive regulation of protein ubiquitination
5.21 6.49e-04 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.79 7.81e-04 GO:0000216 M/G1 transition of mitotic cell cycle
3.97 1.08e-03 GO:0031570 DNA integrity checkpoint
4.98 1.15e-03 GO:0051352 negative regulation of ligase activity
4.98 1.15e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
4.03 1.76e-03 GO:0090068 positive regulation of cell cycle process
3.92 2.64e-03 GO:0000084 S phase of mitotic cell cycle
4.35 2.89e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.00 3.27e-03 GO:0006915 apoptosis
3.85 3.43e-03 GO:0051320 S phase
1.97 5.12e-03 GO:0012501 programmed cell death
3.36 7.15e-03 GO:0031396 regulation of protein ubiquitination
2.53 9.25e-03 GO:0031401 positive regulation of protein modification process
3.73 1.06e-02 GO:0042770 signal transduction in response to DNA damage
4.01 1.70e-02 GO:0031397 negative regulation of protein ubiquitination
3.42 1.81e-02 GO:0007093 mitotic cell cycle checkpoint
3.07 2.62e-02 GO:0010498 proteasomal protein catabolic process
3.07 2.62e-02 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.78 4.24e-02 GO:0008219 cell death
5.61 4.35e-02 GO:0051899 membrane depolarization
1.77 4.89e-02 GO:0016265 death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.72 8.67e-08 GO:0000502 proteasome complex
1.16 2.38e-02 GO:0005737 cytoplasm
1.41 4.21e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.19 1.38e-02 GO:0030246 carbohydrate binding