Motif ID: NHLH1,2.p2

Z-value: 0.820


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_-_1163833230.356.2e-02Click!
NHLH1chr1_+_1603368560.105.9e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_122746544 2.119 SEMA5B
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr2_-_7005764 1.845 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr13_-_26625164 1.765 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr4_+_75858205 1.560 NM_015393
PARM1
prostate androgen-regulated mucin-like protein 1
chr17_-_39280377 1.467 NM_031854
KRTAP4-12
keratin associated protein 4-12
chr16_+_67465019 1.435 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr11_+_113930430 1.050 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr8_-_17271015 0.919 NM_004686
MTMR7
myotubularin related protein 7
chr6_-_90121966 0.862 NM_021244
RRAGD
Ras-related GTP binding D
chr19_+_18111923 0.858 NM_001025604
ARRDC2
arrestin domain containing 2
chr17_-_39316982 0.835 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr6_-_90121656 0.832 RRAGD
Ras-related GTP binding D
chr10_+_94833646 0.802 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr12_-_63328857 0.795 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_+_102091399 0.793 NM_020244
CHPT1
choline phosphotransferase 1
chr17_+_39261640 0.776 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr12_-_63328663 0.767 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr21_+_42688660 0.749 NM_058186
NM_206964
FAM3B

family with sequence similarity 3, member B

chr6_-_46138584 0.736 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr10_-_13043570 0.734 NM_031455
CCDC3
coiled-coil domain containing 3
chr12_-_29936685 0.708 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr17_-_39334439 0.688 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr5_+_156693051 0.687 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr19_-_14316980 0.680 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr6_-_90121911 0.677 RRAGD
Ras-related GTP binding D
chr11_+_113930296 0.663 ZBTB16
zinc finger and BTB domain containing 16
chr6_+_126112057 0.659 NCOA7
nuclear receptor coactivator 7
chr1_-_22469414 0.651 NM_030761
WNT4
wingless-type MMTV integration site family, member 4
chr5_+_76114832 0.648 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr7_-_139762339 0.635 PARP12
poly (ADP-ribose) polymerase family, member 12
chr5_+_76114881 0.623 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr14_-_65438794 0.620 NM_198686
RAB15
RAB15, member RAS onocogene family
chrX_+_68725077 0.612 NM_015686
FAM155B
family with sequence similarity 155, member B
chr2_+_10861740 0.602 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr7_+_17338182 0.602 NM_001621
AHR
aryl hydrocarbon receptor
chr11_-_46867788 0.591 CKAP5
cytoskeleton associated protein 5
chr6_-_154831652 0.588 CNKSR3
CNKSR family member 3
chr17_+_39382878 0.584 NM_031961
KRTAP9-2
keratin associated protein 9-2
chrX_+_16964730 0.577 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr16_-_55866972 0.575 CES1
carboxylesterase 1
chr7_-_131241321 0.565 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr6_-_154831788 0.564 CNKSR3
CNKSR family member 3
chr5_-_94620277 0.558 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr14_+_73957608 0.550 NM_024644
C14orf169
chromosome 14 open reading frame 169
chr17_-_27278324 0.546 PHF12
PHD finger protein 12
chr2_-_9563584 0.545 ITGB1BP1
integrin beta 1 binding protein 1
chr20_+_44637539 0.542 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr3_-_195306274 0.540 APOD
apolipoprotein D
chr20_+_58179601 0.536 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr20_+_37434294 0.534 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr17_+_72732958 0.516 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr3_-_45267068 0.515 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr14_+_73957657 0.513 C14orf169
chromosome 14 open reading frame 169
chr14_+_73957685 0.510 C14orf169
chromosome 14 open reading frame 169
chr17_-_4689508 0.510 NM_001144939
NM_001144940
NM_001144941
NM_182566
VMO1



vitelline membrane outer layer 1 homolog (chicken)



chr1_+_233749917 0.509 KCNK1
potassium channel, subfamily K, member 1
chr10_-_42863435 0.504 LOC441666
zinc finger protein 91 pseudogene
chr14_+_73957670 0.485 C14orf169
chromosome 14 open reading frame 169
chr16_-_55867016 0.483 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr8_-_17270800 0.481 MTMR7
myotubularin related protein 7
chr11_+_46299554 0.471 CREB3L1
cAMP responsive element binding protein 3-like 1
chr16_+_330605 0.469 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr6_+_147524866 0.464 STXBP5
syntaxin binding protein 5 (tomosyn)
chr6_-_154831704 0.460 NM_173515
CNKSR3
CNKSR family member 3
chr12_+_90102639 0.458 LOC338758
uncharacterized LOC338758
chr11_-_66335958 0.445 NM_003793
CTSF
cathepsin F
chr1_-_38273852 0.441 NM_024640
YRDC
yrdC domain containing (E. coli)
chr21_+_34442550 0.434 OLIG1
oligodendrocyte transcription factor 1
chr1_-_38273823 0.425 YRDC
yrdC domain containing (E. coli)
chr21_+_27011588 0.423 NM_021219
JAM2
junctional adhesion molecule 2
chr15_+_41062158 0.423 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr2_-_233352530 0.422 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr5_+_67511578 0.418 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr20_-_3154169 0.417 ProSAPiP1
ProSAPiP1 protein
chr8_+_17014006 0.416 ZDHHC2
zinc finger, DHHC-type containing 2
chr22_+_29279573 0.412 NM_001206998
ZNRF3
zinc and ring finger 3
chr15_-_27018216 0.410 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr6_-_46703042 0.408 PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr9_+_37650996 0.404 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr1_+_87797371 0.404 LMO4
LIM domain only 4
chr11_+_94277566 0.400 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr1_+_87794548 0.399 LMO4
LIM domain only 4
chr1_+_218519576 0.392 TGFB2
transforming growth factor, beta 2
chr10_-_135150474 0.391 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr5_+_43603312 0.386 NNT
nicotinamide nucleotide transhydrogenase
chrX_-_63425484 0.385 NM_152424
FAM123B
family with sequence similarity 123B
chr5_+_43603216 0.382 NM_182977
NNT
nicotinamide nucleotide transhydrogenase
chr13_-_36705432 0.381 DCLK1
doublecortin-like kinase 1
chr11_-_207324 0.381 BET1L
blocked early in transport 1 homolog (S. cerevisiae)-like
chr6_-_167040700 0.380 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr7_-_137531585 0.380 NM_004717
DGKI
diacylglycerol kinase, iota
chr19_+_3094528 0.379 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr4_-_149363498 0.377 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr1_+_87794150 0.377 NM_006769
LMO4
LIM domain only 4
chr3_-_42305438 0.372 NM_001174138
CCK
cholecystokinin
chr16_-_69373406 0.371 COG8
component of oligomeric golgi complex 8
chr4_+_41362750 0.362 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr9_-_75568232 0.361 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr10_-_135150368 0.360 CALY
calcyon neuron-specific vesicular protein
chr9_-_112970412 0.358 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr1_-_38273846 0.354 YRDC
yrdC domain containing (E. coli)
chr20_+_42086533 0.354 SRSF6
serine/arginine-rich splicing factor 6
chr15_-_27018917 0.353 NM_021912
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr10_+_123923104 0.352 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr11_+_27062508 0.351 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr13_+_35516390 0.351 NM_015678
NBEA
neurobeachin
chr5_+_141016987 0.350 RELL2
RELT-like 2
chr10_+_123922940 0.346 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_-_120068077 0.346 NM_001099678
LRRC58
leucine rich repeat containing 58
chr16_+_30406711 0.342 NM_152652
ZNF48
zinc finger protein 48
chr17_-_27278471 0.342 NM_001033561
NM_020889
PHF12

PHD finger protein 12

chr1_+_38273817 0.341 C1orf122
chromosome 1 open reading frame 122
chr12_-_120554558 0.340 RAB35
RAB35, member RAS oncogene family
chr8_-_16859540 0.338 NM_019851
FGF20
fibroblast growth factor 20
chr1_+_233749749 0.337 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr17_-_72968750 0.331


chr14_-_89020888 0.329 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr16_+_19179534 0.327 NM_016524
SYT17
synaptotagmin XVII
chr21_+_36041687 0.327 NM_053277
CLIC6
chloride intracellular channel 6
chr5_+_141016567 0.325 RELL2
RELT-like 2
chr10_+_93170086 0.324 NM_173497
NM_182765
HECTD2

HECT domain containing 2

chr6_-_167040659 0.323 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_+_229761988 0.321 URB2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr8_-_98290072 0.321 TSPYL5
TSPY-like 5
chr3_+_69788562 0.316 NM_198159
MITF
microphthalmia-associated transcription factor
chr9_+_71320105 0.314 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr17_+_3539761 0.312 NM_001031681
NM_004937
CTNS

cystinosin, lysosomal cystine transporter

chr1_-_117753476 0.307 NM_001253850
NM_024626
VTCN1

V-set domain containing T cell activation inhibitor 1

chr12_+_56137063 0.306 NM_005811
GDF11
growth differentiation factor 11
chr1_-_47184790 0.306


chr5_+_141016516 0.306 NM_001130029
NM_173828
RELL2

RELT-like 2

chr2_+_97481977 0.303 NM_017623
NM_199078
CNNM3

cyclin M3

chr1_+_46269283 0.302 NM_015112
MAST2
microtubule associated serine/threonine kinase 2
chr8_-_98290171 0.300 NM_033512
TSPYL5
TSPY-like 5
chr16_-_69373473 0.300 NM_032382
COG8
component of oligomeric golgi complex 8
chr9_+_90340973 0.299 NM_001912
NM_145918
CTSL1

cathepsin L1

chr1_-_6662681 0.299 KLHL21
kelch-like 21 (Drosophila)
chr15_-_78369825 0.297 NM_015079
NM_144572
TBC1D2B

TBC1 domain family, member 2B

chr5_+_43603287 0.293 NNT
nicotinamide nucleotide transhydrogenase
chr5_+_67511601 0.292 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_+_12250818 0.292 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr9_+_132251403 0.292 LOC100506190
uncharacterized LOC100506190
chr17_+_80693398 0.291 NM_022158
FN3K
fructosamine 3 kinase
chr17_+_72733350 0.290 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr6_-_35696359 0.287 NM_001145775
FKBP5
FK506 binding protein 5
chr7_-_73184535 0.285 NM_001306
CLDN3
claudin 3
chr2_+_191745912 0.284 GLS
glutaminase
chr7_+_23636970 0.284 NM_138771
CCDC126
coiled-coil domain containing 126
chr7_-_95225802 0.283 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr7_-_120498009 0.282 TSPAN12
tetraspanin 12
chr11_+_62104773 0.282 NM_001083926
NM_025080
ASRGL1

asparaginase like 1

chr16_-_66730466 0.281 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr3_+_30648372 0.281 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr16_+_58059469 0.281 MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr1_+_87794576 0.280 LMO4
LIM domain only 4
chr13_-_114566951 0.280 GAS6
growth arrest-specific 6
chr19_+_4304590 0.279 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr3_-_48470715 0.278 NM_002673
PLXNB1
plexin B1
chr19_+_17416476 0.276 NM_023937
MRPL34
mitochondrial ribosomal protein L34
chr2_+_85980600 0.276 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr9_-_104357202 0.275 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr12_+_93771607 0.274 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr19_+_18118921 0.274 NM_015683
ARRDC2
arrestin domain containing 2
chr3_-_195538699 0.273 NM_004532
NM_018406
NM_138297
MUC4


mucin 4, cell surface associated


chr16_+_53133063 0.273 CHD9
chromodomain helicase DNA binding protein 9
chr16_-_49315682 0.273 NM_004352
CBLN1
cerebellin 1 precursor
chr7_-_2883649 0.272 NM_007353
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr4_-_1685717 0.271 NM_001013622
NM_001174070
FAM53A

family with sequence similarity 53, member A

chr11_+_62104882 0.270 ASRGL1
asparaginase like 1
chr22_-_18923654 0.270 PRODH
proline dehydrogenase (oxidase) 1
chr16_+_83932729 0.268 NM_012213
MLYCD
malonyl-CoA decarboxylase
chr9_+_74764394 0.268 GDA
guanine deaminase
chr1_+_1167622 0.268 NM_080605
B3GALT6
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
chr1_+_151584514 0.265 NM_030918
SNX27
sorting nexin family member 27
chr16_+_22825481 0.265 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr12_+_120554692 0.264


chr13_-_29292961 0.263 NM_001135919
NM_181785
SLC46A3

solute carrier family 46, member 3

chr12_-_120554453 0.262 RAB35
RAB35, member RAS oncogene family
chr4_+_7045142 0.262 NM_152293
TADA2B
transcriptional adaptor 2B
chr16_+_22825806 0.261 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr8_-_110657745 0.260 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr17_+_3540004 0.260 CTNS
cystinosin, lysosomal cystine transporter
chr9_+_74764382 0.257 GDA
guanine deaminase
chr6_-_32551993 0.257 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr5_+_149109850 0.256 PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_-_32403975 0.255 NM_080391
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr15_-_27018160 0.254 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr3_-_133614421 0.254 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr1_+_25943958 0.253 NM_020379
MAN1C1
mannosidase, alpha, class 1C, member 1
chr14_+_74003817 0.253 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr1_-_177133818 0.253 ASTN1
astrotactin 1
chr9_+_90341123 0.252 CTSL1
cathepsin L1
chr1_+_151584665 0.251 SNX27
sorting nexin family member 27
chr17_+_14204326 0.251 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr8_+_42995628 0.251 HGSNAT
heparan-alpha-glucosaminide N-acetyltransferase
chr7_+_45197366 0.250 NM_005856
RAMP3
receptor (G protein-coupled) activity modifying protein 3
chr7_+_150026877 0.249 NM_138434
C7orf29
chromosome 7 open reading frame 29
chr1_-_144994943 0.248 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr1_-_144994908 0.248 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_-_118753665 0.248 NM_001015887
IGSF11
immunoglobulin superfamily, member 11

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 1.17e-05 GO:0009987 cellular process
1.28 1.94e-04 GO:0007399 nervous system development
2.14 1.20e-02 GO:0050770 regulation of axonogenesis
1.09 4.08e-02 GO:0044237 cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 1.47e-10 GO:0044424 intracellular part
1.08 3.29e-10 GO:0005622 intracellular
1.08 4.21e-07 GO:0043226 organelle
1.09 5.23e-07 GO:0043227 membrane-bounded organelle
1.09 6.55e-07 GO:0043231 intracellular membrane-bounded organelle
1.08 7.42e-07 GO:0043229 intracellular organelle
1.09 1.63e-06 GO:0005737 cytoplasm
1.72 2.28e-06 GO:0000323 lytic vacuole
1.72 2.28e-06 GO:0005764 lysosome
1.62 1.73e-05 GO:0005773 vacuole
1.03 6.92e-05 GO:0044464 cell part
1.03 7.37e-05 GO:0005623 cell
1.97 1.65e-04 GO:0005765 lysosomal membrane
1.81 4.19e-04 GO:0005774 vacuolar membrane
1.78 4.71e-04 GO:0044437 vacuolar part
1.10 6.48e-04 GO:0044444 cytoplasmic part
1.26 1.44e-02 GO:0005794 Golgi apparatus
1.16 3.07e-02 GO:0031090 organelle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 4.25e-04 GO:0005515 protein binding
1.44 2.10e-03 GO:0019904 protein domain specific binding