Motif ID: NKX2-1,4.p2

Z-value: 0.308


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36988902-0.057.8e-01Click!
NKX2-4chr20_-_21378046-0.058.1e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_140186658 0.274 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr4_-_69111333 0.245 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr12_+_50451486 0.190 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr5_+_147443534 0.183 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr12_+_109826523 0.178 NM_001101421
MYO1H
myosin IH
chr5_+_156820161 0.172 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr12_-_7848324 0.153 NM_020634
GDF3
growth differentiation factor 3
chr5_-_13944588 0.149 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chrX_+_78200828 0.148 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr17_-_34329083 0.142 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr20_+_31823801 0.130 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr19_+_50796820 0.130 MYH14
myosin, heavy chain 14, non-muscle
chr4_+_110834039 0.128 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr11_+_56949220 0.118 NM_001005210
LRRC55
leucine rich repeat containing 55
chr5_+_139505519 0.114 NM_001007189
IGIP
IgA-inducing protein homolog (Bos taurus)
chr4_+_70861647 0.113 NM_001009181
NM_003154
STATH

statherin

chr2_+_179184970 0.112 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr20_+_2276612 0.109 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr3_+_97158453 0.108 NM_173655
EPHA6
EPH receptor A6
chr19_+_50706868 0.107 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chrX_-_72434656 0.104 NAP1L2
nucleosome assembly protein 1-like 2
chr20_-_21494663 0.093 NM_002509
NKX2-2
NK2 homeobox 2
chr17_-_56606710 0.092 NM_004574
SEPT4
septin 4
chr1_+_174417211 0.089 NM_005684
GPR52
G protein-coupled receptor 52
chr1_-_197036350 0.088 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr16_+_12058963 0.084 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_-_144994839 0.084 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_+_190105660 0.084 NM_006580
CLDN16
claudin 16
chrX_-_72434667 0.084 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr1_-_144994943 0.079 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr5_+_140235594 0.079 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr14_-_95599794 0.079 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_-_144994908 0.077 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_-_149510609 0.077 NM_001144960
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr12_+_41086189 0.076 NM_001843
NM_175038
CNTN1

contactin 1

chr19_-_16045669 0.076 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr11_+_34642651 0.075 EHF
ets homologous factor
chr19_-_40440532 0.075 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr12_+_62954275 0.074 MON2
MON2 homolog (S. cerevisiae)
chr3_+_186358148 0.074 NM_014375
FETUB
fetuin B
chrX_-_72434623 0.074 NAP1L2
nucleosome assembly protein 1-like 2
chr3_-_58563070 0.073 FAM107A
family with sequence similarity 107, member A
chr12_+_8975149 0.073 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr16_+_58010338 0.072 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr12_-_53600999 0.071 NM_000889
ITGB7
integrin, beta 7
chr9_+_115631814 0.070 SNX30
sorting nexin family member 30
chr10_+_70980058 0.068 NM_025130
HKDC1
hexokinase domain containing 1
chr16_-_71748697 0.067 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr1_+_152974222 0.065 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr1_+_61869699 0.064 NFIA
nuclear factor I/A
chrX_-_132162297 0.064 NM_031907
USP26
ubiquitin specific peptidase 26
chr10_-_104211244 0.062 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr11_+_6866882 0.062 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr12_+_15699277 0.061 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_-_217250230 0.059 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr7_+_143174965 0.059 NM_176883
TAS2R41
taste receptor, type 2, member 41
chr9_-_3223007 0.059


chr19_+_41620336 0.058 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr7_+_94539209 0.056 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr1_+_84609941 0.056 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_75335415 0.055 NM_152586
USP54
ubiquitin specific peptidase 54
chr5_+_140247767 0.055 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr9_-_124984018 0.054 NM_001242335
LHX6
LIM homeobox 6
chr19_+_6135650 0.053 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr18_-_45663667 0.052 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr1_-_240775448 0.051 NM_022469
GREM2
gremlin 2
chr19_-_55668956 0.051 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr12_+_131438451 0.051 NM_198827
GPR133
G protein-coupled receptor 133
chr11_-_19223516 0.050 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr12_-_53601051 0.050 ITGB7
integrin, beta 7
chr7_-_107443631 0.050 NM_000111
SLC26A3
solute carrier family 26, member 3
chr17_-_53800074 0.050 NM_018286
TMEM100
transmembrane protein 100
chr4_-_123542165 0.049 NM_001207006
NM_021803
IL21

interleukin 21

chr5_-_138718941 0.048 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr3_+_63428752 0.048 NM_144642
SYNPR
synaptoporin
chr10_-_69455926 0.047 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr17_-_10452939 0.046 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr10_-_13544944 0.045 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr20_+_33462765 0.045 NM_001242393
ACSS2
acyl-CoA synthetase short-chain family member 2
chr16_-_71318761 0.045 FTSJD1
FtsJ methyltransferase domain containing 1
chr5_+_140213968 0.044 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr11_-_114466471 0.043 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr20_-_34243118 0.043 RBM12
RNA binding motif protein 12
chr2_+_143886898 0.042 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr14_+_75988765 0.042 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr10_+_86131546 0.042 FAM190B
family with sequence similarity 190, member B
chrX_+_49160124 0.041 NM_001098413
GAGE10
G antigen 10
chr3_-_165555252 0.039 NM_000055
BCHE
butyrylcholinesterase
chrX_+_49593905 0.039 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr7_-_37024664 0.039 NM_001039459
ELMO1
engulfment and cell motility 1
chr3_-_74570262 0.039 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr1_-_203198772 0.039 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr9_+_127119114 0.038


chr2_-_105467912 0.037 LOC100506421
uncharacterized LOC100506421
chr9_-_33395265 0.037 AQP7
aquaporin 7
chr3_-_114102488 0.037 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_165555167 0.037 BCHE
butyrylcholinesterase
chr1_-_21437875 0.037 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_+_1417232 0.037 NM_000547
NM_001206744
NM_001206745
NM_175719
TPO



thyroid peroxidase



chr8_-_7321028 0.036 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




sperm associated antigen 11B




chr2_+_1418179 0.036 NM_175721
NM_175722
TPO

thyroid peroxidase

chr3_-_195538699 0.035 NM_004532
NM_018406
NM_138297
MUC4


mucin 4, cell surface associated


chr2_-_133539627 0.035 NCKAP5
NCK-associated protein 5
chr2_-_100758970 0.035 NM_002285
AFF3
AF4/FMR2 family, member 3
chr11_-_1629614 0.035 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chrX_-_109561427 0.034 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr17_-_56606534 0.033 SEPT4
septin 4
chrX_+_30261847 0.033 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr16_+_570731 0.033


chr2_+_143886969 0.032 ARHGAP15
Rho GTPase activating protein 15
chr5_-_131879172 0.032 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr8_+_7705401 0.032 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr11_+_34642587 0.032 NM_001206615
NM_012153
EHF

ets homologous factor

chr3_+_2933898 0.031 NM_001206956
NM_175613
CNTN4

contactin 4

chr20_+_44657812 0.031 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr5_+_175298604 0.031 CPLX2
complexin 2
chr7_-_115608366 0.031 NM_001244583
TFEC
transcription factor EC
chr12_-_52886971 0.030 NM_005554
KRT6A
keratin 6A
chr12_+_113416267 0.030 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr21_-_36421195 0.029 RUNX1
runt-related transcription factor 1
chr1_+_212475147 0.029 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr2_+_38155901 0.029 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chrX_+_49363615 0.028 NM_001040663
NM_001468
GAGE1

G antigen 1

chr6_-_116381765 0.028 NM_002031
FRK
fyn-related kinase
chr14_+_51955854 0.028 NM_001042481
FRMD6
FERM domain containing 6
chr19_-_10291056 0.028


chr9_+_35042222 0.027 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr6_+_30104509 0.027 NM_138700
TRIM40
tripartite motif containing 40
chr1_+_84864214 0.027 NM_021233
DNASE2B
deoxyribonuclease II beta
chrX_+_49325433 0.027 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chrX_+_49334991 0.027 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chr11_+_36589562 0.027 NM_000448
RAG1
recombination activating gene 1
chr1_-_21377452 0.026 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_152850797 0.026 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chrX_+_22050920 0.026 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr6_+_30951484 0.026 NM_001010909
MUC21
mucin 21, cell surface associated
chr12_+_50497790 0.026 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr1_+_50571963 0.025 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_155853546 0.025 SYT11
synaptotagmin XI
chr17_-_56406120 0.025 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr1_-_161337663 0.025 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr6_+_45296053 0.025 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr1_+_212797788 0.024 NM_153606
FAM71A
family with sequence similarity 71, member A
chr15_-_55563091 0.024 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr12_-_75603510 0.024 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr6_-_132910824 0.024 NM_003967
TAAR5
trace amine associated receptor 5
chr12_-_56106061 0.024 NM_001144997
ITGA7
integrin, alpha 7
chr10_+_11047274 0.024 CELF2
CUGBP, Elav-like family member 2
chr20_+_44657858 0.024 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr2_+_105954008 0.023 NM_024093
C2orf49
chromosome 2 open reading frame 49
chrX_+_49216616 0.023 NM_012196
NM_001472
NM_001474
NM_001475
NM_021123
NM_001477
NM_001127200
NM_001127212
GAGE8
GAGE1
GAGE2C
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE2E
GAGE12B
GAGE2A
G antigen 8
G antigen 1
G antigen 2C
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 2E
G antigen 12B
G antigen 2A
chr3_+_108015392 0.023 HHLA2
HERV-H LTR-associating 2
chr15_+_40650411 0.023 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr19_+_4769144 0.023 MIR7-3HG
MIR7-3 host gene (non-protein coding)
chr12_-_49488570 0.023 NM_021044
DHH
desert hedgehog
chr14_+_75988838 0.022 BATF
basic leucine zipper transcription factor, ATF-like
chr10_+_114154522 0.022 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_24981769 0.022 NM_173463
CCDC149
coiled-coil domain containing 149
chr1_-_89488412 0.022 NM_018284
GBP3
guanylate binding protein 3
chr1_-_203320287 0.022 NM_002023
FMOD
fibromodulin
chr21_-_15918635 0.022 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_-_116392099 0.022 ABLIM1
actin binding LIM protein 1
chr9_+_140119643 0.021 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr11_-_36619776 0.021 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr5_-_121814781 0.021


chr16_+_72088507 0.021 NM_001126102
NM_005143
HP

haptoglobin

chr5_-_35118223 0.021 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr1_-_59147727 0.020


chr11_+_89764273 0.020 NM_001195234
TRIM49L2
tripartite motif containing 49-like 2
chr10_+_94594469 0.020 NM_001013848
EXOC6
exocyst complex component 6
chr3_+_98188323 0.019 NM_001004736
OR5K1
olfactory receptor, family 5, subfamily K, member 1
chr16_-_81253974 0.019 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr11_-_89541742 0.019 NM_020358
TRIM49
tripartite motif containing 49
chr5_-_148016576 0.019 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr9_-_73736513 0.019 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr14_+_64682671 0.019 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr13_-_103346847 0.019 NM_001010977
METTL21C
methyltransferase like 21C
chr1_-_226926875 0.019 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr22_-_38714088 0.018 NM_001894
CSNK1E
casein kinase 1, epsilon
chr18_+_6834431 0.018 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr7_+_28725597 0.018 NM_001011666
CREB5
cAMP responsive element binding protein 5
chrX_-_153979796 0.018 GAB3
GRB2-associated binding protein 3
chr5_-_87969135 0.018 LINC00461
long intergenic non-protein coding RNA 461
chr17_+_3377346 0.018 NM_001128085
ASPA
aspartoacylase
chr1_+_165513439 0.018 NM_001005214
LRRC52
leucine rich repeat containing 52
chr10_+_114135013 0.018 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_41204509 0.018 NFYC
nuclear transcription factor Y, gamma
chr3_-_17782398 0.018 NM_014744
TBC1D5
TBC1 domain family, member 5
chr8_+_67039130 0.017 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr16_-_20364029 0.017 NM_001008389
NM_003361
UMOD

uromodulin

chr17_+_39555993 0.017 GAST
gastrin
chr3_+_119500930 0.017 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr6_+_73076431 0.017 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr12_-_48499840 0.017 SENP1
SUMO1/sentrin specific peptidase 1
chr18_-_3011944 0.017 NM_014646
LPIN2
lipin 2
chr1_+_32716839 0.016 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chrX_-_48216100 0.016 NM_021014
NM_175711
SSX3

synovial sarcoma, X breakpoint 3

chr6_+_158733691 0.016 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr5_-_94417185 0.016 MCTP1
multiple C2 domains, transmembrane 1
chr1_-_153585504 0.016 NM_080388
S100A16
S100 calcium binding protein A16

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.