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Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.163

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr4_+_69313166	7.369	NM_014058	TMPRSS11E	transmembrane protease, serine 11E
chr1_+_84630575	5.439	NM_001242860 NM_001242861	PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr2_+_102953716	4.879	NM_003856	IL1RL1	interleukin 1 receptor-like 1
chr2_+_210444364	4.556	NM_002374 NM_031845 NM_031847	MAP2	microtubule-associated protein 2
chr4_+_169013687	4.474	NM_007193	ANXA10	annexin A10
chr1_-_153044083	4.177	NM_001017418	SPRR2B	small proline-rich protein 2B
chr2_-_31352489	4.112	NM_001253827	GALNT14	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr10_-_105845619	4.009	NM_000494	COL17A1	collagen, type XVII, alpha 1
chr7_-_14025826	3.933	NM_001163150 NM_001163151 NM_001163152	ETV1	ets variant 1
chr10_+_102123420	3.871
chr10_-_105845556	3.700		COL17A1	collagen, type XVII, alpha 1
chr12_+_8975149	3.673	NM_144670	A2ML1	alpha-2-macroglobulin-like 1
chr4_-_39033981	3.651	NM_024943	TMEM156	transmembrane protein 156
chr1_+_151032866	3.574		MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_-_68749698	3.439	NM_004262	TMPRSS11D	transmembrane protease, serine 11D
chr12_-_91505541	3.374	NM_002345	LUM	lumican
chr12_-_91505215	3.317		LUM	lumican
chr12_+_15699277	3.301	NM_030668 NM_030669 NM_030670 NM_030671	PTPRO	protein tyrosine phosphatase, receptor type, O
chr1_+_209878135	3.240	NM_005525	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1
chr15_+_93443559	3.137		CHD2	chromodomain helicase DNA binding protein 2
chr1_+_151032880	2.965		MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_12693385	2.789	NM_000550	TYRP1	tyrosinase-related protein 1
chr1_+_151032683	2.787		MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr2_-_163008913	2.699	NM_002054	GCG	glucagon
chr1_+_84630014	2.601	NM_001242857 NM_001242858 NM_001242859	PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr12_+_41086189	2.503	NM_001843 NM_175038	CNTN1	contactin 1
chr4_-_57547845	2.328	NM_001145460 NM_032495 NM_139212	HOPX	HOP homeobox
chr5_-_39219578	2.241	NM_001465 NM_199335	FYB	FYN binding protein
chr17_-_38859976	2.198	NM_019016	KRT24	keratin 24
chrX_-_48327739	2.191		SLC38A5	solute carrier family 38, member 5
chr7_+_94297448	2.146		PEG10	paternally expressed 10
chr1_-_153085963	2.128	NM_001014450	SPRR2A SPRR2F	small proline-rich protein 2A small proline-rich protein 2F
chr13_+_78109808	2.079	NM_001160706 NM_003843 NM_144777	SCEL	sciellin
chr13_-_36050758	2.065	NM_005584	MAB21L1	mab-21-like 1 (C. elegans)
chr2_-_216003068	2.008	NM_173076	ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12
chr13_-_60587298	1.970	NM_030932	DIAPH3	diaphanous homolog 3 (Drosophila)
chr20_+_20037289	1.944	NM_001167816	C20orf26	chromosome 20 open reading frame 26
chr2_+_158114109	1.897	NM_014568	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr3_-_52090090	1.892	NM_001947	DUSP7	dual specificity phosphatase 7
chr1_+_152974222	1.859	NM_001097589 NM_005416	SPRR3	small proline-rich protein 3
chr6_+_100054649	1.806	NM_021620	PRDM13	PR domain containing 13
chr20_+_3776385	1.771	NM_004358 NM_021872 NM_021873	CDC25B	cell division cycle 25 homolog B (S. pombe)
chr4_-_152149042	1.727	NM_001243349	SH3D19	SH3 domain containing 19
chr2_+_102508333	1.680		MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr22_-_17747520	1.633		CECR3	cat eye syndrome chromosome region, candidate 3 (non-protein coding)
chr7_-_41742666	1.622	NM_002192	INHBA	inhibin, beta A
chr6_-_39290315	1.621	NM_001135105 NM_001135106 NM_001135107 NM_032115	KCNK16	potassium channel, subfamily K, member 16
chr2_+_210444154	1.616		MAP2	microtubule-associated protein 2
chr2_-_65593866	1.604	NM_001128210	SPRED2	sprouty-related, EVH1 domain containing 2
chr19_+_45409003	1.603	NM_000041	APOE	apolipoprotein E
chr4_-_40936640	1.597		APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2
chrX_+_28605558	1.575	NM_014271	IL1RAPL1	interleukin 1 receptor accessory protein-like 1
chr2_-_192016293	1.575	NM_001243835	STAT4	signal transducer and activator of transcription 4
chr2_+_102508377	1.517		MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr10_-_75401199	1.501		MYOZ1	myozenin 1
chr14_+_92788924	1.446	NM_153648	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr3_-_74570262	1.446	NM_020872	CNTN3	contactin 3 (plasmacytoma associated)
chr1_+_84630374	1.439		PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr5_-_22853730	1.437	NM_004061	CDH12	cadherin 12, type 2 (N-cadherin 2)
chr13_+_53035227	1.429		CKAP2	cytoskeleton associated protein 2
chr17_+_39261640	1.375	NM_001146041	KRTAP4-9	keratin associated protein 4-9
chr5_-_149669400	1.351	NM_015981 NM_171825	CAMK2A	calcium/calmodulin-dependent protein kinase II alpha
chr7_+_100770378	1.350	NM_000602 NM_001165413	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr9_+_130026755	1.319	NM_032293	GARNL3	GTPase activating Rap/RanGAP domain-like 3
chr5_+_31193761	1.307	NM_004932	CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)
chr20_-_7921068	1.289	NM_017545	HAO1	hydroxyacid oxidase (glycolate oxidase) 1
chr3_-_57234279	1.287	NM_003865	HESX1	HESX homeobox 1
chr2_-_161056573	1.286	NM_000888	ITGB6	integrin, beta 6
chr1_+_84647342	1.277	NM_001242862	PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr12_-_89746238	1.275		DUSP6	dual specificity phosphatase 6
chr12_-_28124915	1.261	NM_002820 NM_198965	PTHLH	parathyroid hormone-like hormone
chr3_-_149095413	1.259		TM4SF1	transmembrane 4 L six family member 1
chr1_+_179560747	1.257	NM_001199091 NM_001199085 NM_173533	TDRD5	tudor domain containing 5
chr12_-_16760935	1.253	NM_001001395 NM_001243609	LMO3	LIM domain only 3 (rhombotin-like 2)
chr17_-_39211462	1.249	NM_033032	KRTAP2-2	keratin associated protein 2-2
chr12_+_119616594	1.240	NM_014365	HSPB8	heat shock 22kDa protein 8
chrX_-_153602998	1.223	NM_001110556 NM_001456	FLNA	filamin A, alpha
chr15_-_56209305	1.210	NM_198400	NEDD4	neural precursor cell expressed, developmentally down-regulated 4
chr3_-_149095333	1.201		TM4SF1	transmembrane 4 L six family member 1
chr9_+_118916069	1.197	NM_002581	PAPPA	pregnancy-associated plasma protein A, pappalysin 1
chr13_-_60325073	1.188
chr15_+_93443418	1.181	NM_001042572 NM_001271	CHD2	chromodomain helicase DNA binding protein 2
chr2_-_69098502	1.146	NM_014482	BMP10	bone morphogenetic protein 10
chr3_+_121796695	1.142	NM_006889 NM_176892	CD86	CD86 molecule
chr12_+_105153258	1.124		CHST11	carbohydrate (chondroitin 4) sulfotransferase 11
chr2_+_201390848	1.122	NM_001160033 NM_001160046 NM_152524	SGOL2	shugoshin-like 2 (S. pombe)
chr3_-_113897849	1.115	NM_000796 NM_033663	DRD3	dopamine receptor D3
chr2_+_33738941	1.103	NM_015376	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_+_158787040	1.092	NM_001197113 NM_001197114 NM_001042705 NM_001042706 NM_001197100	IQCJ-SCHIP1 IQCJ	IQCJ-SCHIP1 readthrough IQ motif containing J
chr5_-_149669187	1.073		CAMK2A	calcium/calmodulin-dependent protein kinase II alpha
chr19_+_48828820	1.070		EMP3	epithelial membrane protein 3
chr12_-_4488707	1.067	NM_020638	FGF23	fibroblast growth factor 23
chr19_-_14889347	1.067	NM_013447 NM_152916 NM_152917 NM_152918 NM_152919 NM_152920 NM_152921	EMR2	egf-like module containing, mucin-like, hormone receptor-like 2
chr12_-_16759430	1.066		LMO3	LIM domain only 3 (rhombotin-like 2)
chr2_+_29038862	1.053	NM_001008779	SPDYA	speedy homolog A (Xenopus laevis)
chr13_+_109248499	1.050	NM_015011	MYO16	myosin XVI
chr14_+_32798478	1.044	NM_004274	AKAP6	A kinase (PRKA) anchor protein 6
chr5_+_31193852	1.043		CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)
chr10_+_91498724	1.034		KIF20B	kinesin family member 20B
chr6_+_134758840	1.025		LOC154092	uncharacterized LOC154092
chr17_-_42908178	1.016	NM_001080383	GJC1	gap junction protein, gamma 1, 45kDa
chr15_-_34610928	0.997	NM_005135	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6
chrX_-_15333726	0.964	NM_001201583 NM_080873	ASB11	ankyrin repeat and SOCS box containing 11
chr12_+_75874512	0.958	NM_006851	GLIPR1	GLI pathogenesis-related 1
chr11_-_5323174	0.957	NM_033179	OR51B4	olfactory receptor, family 51, subfamily B, member 4
chr6_-_114384008	0.956	NM_153612	HS3ST5	heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr14_+_62462540	0.939	NM_031914	SYT16	synaptotagmin XVI
chr7_-_14029641	0.937	NM_001163147 NM_004956	ETV1	ets variant 1
chr18_+_28898051	0.937	NM_001942	DSG1	desmoglein 1
chr1_-_152131703	0.931	NM_001122965	RPTN	repetin
chr19_+_48828627	0.931	NM_001425	EMP3	epithelial membrane protein 3
chr17_-_39203423	0.929	NM_001123387	KRTAP2-1	keratin associated protein 2-1
chr6_-_33754712	0.928	NM_001143944	LEMD2	LEM domain containing 2
chr17_+_39411635	0.926	NM_030975	KRTAP9-9	keratin associated protein 9-9
chr1_+_50574601	0.923		ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr19_-_43032525	0.919	NM_001024912 NM_001184813 NM_001184815 NM_001184816 NM_001205344 NM_001712	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr6_+_50681256	0.911	NM_172238	TFAP2D	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr7_-_27205148	0.901	NM_152739	HOXA9	homeobox A9
chr2_-_31361591	0.892	NM_001253826 NM_024572	GALNT14	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr11_-_16497917	0.883	NM_033326	SOX6	SRY (sex determining region Y)-box 6
chr6_+_155538096	0.874	NM_001010927	TIAM2	T-cell lymphoma invasion and metastasis 2
chr4_+_71494460	0.873	NM_031889	ENAM	enamelin
chr10_-_75401492	0.867	NM_021245	MYOZ1	myozenin 1
chr2_+_90211704	0.859
chr5_+_140782367	0.856	NM_018921 NM_032089	PCDHGA9	protocadherin gamma subfamily A, 9
chr1_+_192127591	0.851	NM_130782	RGS18	regulator of G-protein signaling 18
chr6_-_32374899	0.845	NM_019602	BTNL2	butyrophilin-like 2 (MHC class II associated)
chr11_-_18258383	0.833	NM_006512	SAA4	serum amyloid A4, constitutive
chr7_-_37024664	0.829	NM_001039459	ELMO1	engulfment and cell motility 1
chr1_-_93342706	0.829	NM_001252271	FAM69A	family with sequence similarity 69, member A
chr5_+_52776479	0.827		FST	follistatin
chr17_-_9694613	0.826	NM_001105571 NM_001220493	DHRS7C	dehydrogenase/reductase (SDR family) member 7C
chr6_+_121756744	0.818	NM_000165	GJA1	gap junction protein, alpha 1, 43kDa
chr10_-_98031154	0.810	NM_001114094 NM_013314	BLNK	B-cell linker
chr2_-_65593763	0.806		SPRED2	sprouty-related, EVH1 domain containing 2
chr5_-_148758787	0.790	NM_014443	IL17B	interleukin 17B
chrX_+_107288199	0.786	NM_001170553 NM_182607	VSIG1	V-set and immunoglobulin domain containing 1
chr1_+_35246789	0.782	NM_024009	GJB3	gap junction protein, beta 3, 31kDa
chr12_-_10021932	0.775		CLEC2B	C-type lectin domain family 2, member B
chr1_+_64088886	0.775	NM_001172818	PGM1	phosphoglucomutase 1
chr13_+_46276445	0.770	NM_152719	SPERT	spermatid associated
chrX_+_38211735	0.764	NM_000531	OTC	ornithine carbamoyltransferase
chr17_+_39555993	0.752		GAST	gastrin
chr17_+_39405938	0.749	NM_033191	KRTAP9-4	keratin associated protein 9-4
chr1_-_42384370	0.747	NM_001127714 NM_024503	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3
chr11_-_18258315	0.744		SAA4	serum amyloid A4, constitutive
chr12_-_89745997	0.741		DUSP6	dual specificity phosphatase 6
chr2_-_165424993	0.741		GRB14	growth factor receptor-bound protein 14
chr1_-_225616556	0.739	NM_194442	LBR	lamin B receptor
chr6_-_46293404	0.737		RCAN2	regulator of calcineurin 2
chr2_+_234601511	0.736	NM_001072	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6
chr3_+_14860468	0.734	NM_152536	FGD5	FYVE, RhoGEF and PH domain containing 5
chr2_+_143886969	0.730		ARHGAP15	Rho GTPase activating protein 15
chr7_+_134576187	0.729		CALD1	caldesmon 1
chr1_-_75199091	0.728	NM_001130042 NM_001130043 NM_001134759 NM_001889	CRYZ	crystallin, zeta (quinone reductase)
chr12_-_52886971	0.727	NM_005554	KRT6A	keratin 6A
chr10_-_14372807	0.726	NM_018027	FRMD4A	FERM domain containing 4A
chr16_+_7382750	0.724	NM_145891 NM_145892 NM_145893	RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_156254069	0.722	NM_032323	TMEM79	transmembrane protein 79
chr13_-_103719195	0.717	NM_000452	SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr8_+_7738908	0.709	NM_018661	DEFB103B	defensin, beta 103B
chr13_+_109281569	0.705	NM_001198950	MYO16	myosin XVI
chr12_-_102512277	0.700	NM_024057	NUP37	nucleoporin 37kDa
chr17_+_59489111	0.694	NM_203425	C17orf82	chromosome 17 open reading frame 82
chr5_-_88119604	0.693	NM_001193348 NM_001193349	MEF2C	myocyte enhancer factor 2C
chr3_+_85775631	0.692	NM_153184	CADM2	cell adhesion molecule 2
chr19_-_51537996	0.687	NM_019598 NM_145894 NM_145895	KLK12	kallikrein-related peptidase 12
chr12_-_16759531	0.684	NM_018640	LMO3	LIM domain only 3 (rhombotin-like 2)
chr6_-_49604524	0.684	NM_000324	RHAG	Rh-associated glycoprotein
chr6_-_48078909	0.680		C6orf138	chromosome 6 open reading frame 138
chr8_+_21900389	0.672	NM_003867	FGF17	fibroblast growth factor 17
chr11_+_87032428	0.668		TMEM135	transmembrane protein 135
chr4_+_71200670	0.665	NM_033122	CABS1	calcium-binding protein, spermatid-specific 1
chr13_-_46756291	0.664		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr7_+_28452143	0.658	NM_182898	CREB5	cAMP responsive element binding protein 5
chr3_-_99833348	0.657	NM_001042459 NM_182909	FILIP1L	filamin A interacting protein 1-like
chr12_-_102872329	0.653	NM_001111284	IGF1	insulin-like growth factor 1 (somatomedin C)
chr17_+_74553845	0.645		LOC100507246	uncharacterized LOC100507246
chr12_-_53994783	0.642	NM_001130059	ATF7	activating transcription factor 7
chr1_-_6420719	0.642	NM_181865	ACOT7	acyl-CoA thioesterase 7
chr8_-_7287651	0.641	NM_018661	DEFB103B	defensin, beta 103B
chr17_-_49124128	0.637	NM_001251971	SPAG9	sperm associated antigen 9
chr1_+_157963062	0.635	NM_018240	KIRREL	kin of IRRE like (Drosophila)
chr7_+_141463896	0.634	NM_016943	TAS2R3	taste receptor, type 2, member 3
chr2_+_228356287	0.631		AGFG1	ArfGAP with FG repeats 1
chr3_-_123411185	0.629		MYLK	myosin light chain kinase
chr12_-_71148063	0.628		PTPRR	protein tyrosine phosphatase, receptor type, R
chr9_-_23826062	0.623	NM_004432	ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_-_39347258	0.622	NM_030772	GJA9-MYCBP GJA9	GJA9-MYCBP readthrough gap junction protein, alpha 9, 59kDa
chr14_+_51955854	0.622	NM_001042481	FRMD6	FERM domain containing 6
chr2_+_201473942	0.621		AOX1	aldehyde oxidase 1
chr6_-_131321868	0.619	NM_001252660	EPB41L2	erythrocyte membrane protein band 4.1-like 2
chr6_-_53013581	0.618	NM_003643	GCM1	glial cells missing homolog 1 (Drosophila)
chr7_+_129847699	0.615	NM_145268	C7orf45	chromosome 7 open reading frame 45
chr7_+_37723378	0.613
chr1_+_100316530	0.611	NM_000646	AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr9_+_706744	0.610	NM_153186	KANK1	KN motif and ankyrin repeat domains 1
chr7_-_87342569	0.610	NM_000927	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_-_10452939	0.609	NM_001100112 NM_017534	MYH2	myosin, heavy chain 2, skeletal muscle, adult
chr8_+_104831415	0.607	NM_014677	RIMS2	regulating synaptic membrane exocytosis 2

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.45	1.91e-14	GO:0032501	multicellular organismal process
1.41	5.82e-07	GO:0032502	developmental process
1.43	1.43e-06	GO:0007275	multicellular organismal development
1.38	1.14e-05	GO:0023052	signaling
1.38	8.58e-05	GO:0007165	signal transduction
1.23	4.11e-04	GO:0050896	response to stimulus
1.31	4.46e-04	GO:0051716	cellular response to stimulus
1.37	4.91e-04	GO:0048856	anatomical structure development
1.52	6.33e-04	GO:0007166	cell surface receptor linked signaling pathway
1.39	7.23e-04	GO:0048731	system development
1.85	9.84e-04	GO:0007267	cell-cell signaling
1.50	3.69e-03	GO:0003008	system process
2.74	6.04e-03	GO:0003012	muscle system process
1.42	1.24e-02	GO:0030154	cell differentiation
2.47	1.40e-02	GO:0007601	visual perception
2.47	1.40e-02	GO:0050953	sensory perception of light stimulus
1.63	1.53e-02	GO:0007154	cell communication
1.68	2.22e-02	GO:0009888	tissue development
2.53	2.59e-02	GO:0072503	cellular divalent inorganic cation homeostasis
1.72	2.74e-02	GO:0007155	cell adhesion
1.72	2.74e-02	GO:0022610	biological adhesion
1.42	3.16e-02	GO:0048513	organ development
1.85	3.53e-02	GO:0007186	G-protein coupled receptor protein signaling pathway
2.64	4.20e-02	GO:0006936	muscle contraction
2.51	4.24e-02	GO:0006874	cellular calcium ion homeostasis
2.85	4.54e-02	GO:0034329	cell junction assembly

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.53	4.92e-06	GO:0005576	extracellular region
1.32	1.40e-05	GO:0071944	cell periphery
1.31	4.10e-05	GO:0005886	plasma membrane
1.45	1.45e-04	GO:0044459	plasma membrane part
1.61	2.68e-04	GO:0005887	integral to plasma membrane
1.60	3.62e-04	GO:0031226	intrinsic to plasma membrane
1.67	4.11e-04	GO:0044421	extracellular region part
2.68	2.15e-03	GO:0005882	intermediate filament
3.53	3.01e-03	GO:0045095	keratin filament
1.65	9.93e-03	GO:0005615	extracellular space
2.32	2.55e-02	GO:0045111	intermediate filament cytoskeleton
6.03	3.10e-02	GO:0001533	cornified envelope
7.24	3.13e-02	GO:0034706	sodium channel complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.83	9.13e-03	GO:0008092	cytoskeletal protein binding
1.38	1.21e-02	GO:0004871	signal transducer activity
1.38	1.21e-02	GO:0060089	molecular transducer activity
2.02	3.01e-02	GO:0003779	actin binding
7.24	4.50e-02	GO:0008527	taste receptor activity