Motif ID: NKX3-2.p2

Z-value: 1.231


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13546037-0.319.3e-02Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_32497925 7.828 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr16_+_57406398 6.493 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr5_-_149792370 6.163 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr20_+_31870940 5.325 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr4_-_16077740 5.024 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr9_-_34397786 5.021 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr17_-_74137370 4.964 NM_001454
FOXJ1
forkhead box J1
chr1_-_161337663 4.847 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr6_+_32407618 4.756 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr6_-_32557431 3.994 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr4_-_110723127 3.838 CFI
complement factor I
chr5_-_149792276 3.835 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr4_-_110723334 3.694 NM_000204
CFI
complement factor I
chr9_+_34458810 3.604 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr4_-_149363498 3.602 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr12_-_25348031 3.503 NM_001082972
NM_001082973
NM_001204101
NM_001204102
NM_018272
CASC1




cancer susceptibility candidate 1




chr5_-_35938736 3.393 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr11_+_65479685 3.313 KAT5
K(lysine) acetyltransferase 5
chr16_-_21289637 3.114 CRYM
crystallin, mu
chr16_+_82068830 3.040 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr19_+_55888203 3.022 NM_139172
TMEM190
transmembrane protein 190
chr7_-_99573637 2.880 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr14_+_105953531 2.648 CRIP1
cysteine-rich protein 1 (intestinal)
chr3_+_63638343 2.633 NM_001080537
SNTN
sentan, cilia apical structure protein
chr1_-_183622447 2.623 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr20_-_55841090 2.521 BMP7
bone morphogenetic protein 7
chr1_-_146697155 2.399 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr17_+_45908992 2.334 NM_033413
LRRC46
leucine rich repeat containing 46
chr5_+_156696351 2.328 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr13_+_35516390 2.239 NM_015678
NBEA
neurobeachin
chr16_-_21289571 2.173 CRYM
crystallin, mu
chr19_-_6720585 2.161 NM_000064
C3
complement component 3
chr12_-_48744553 2.153 NM_001172681
NM_152320
ZNF641

zinc finger protein 641

chr11_-_62474810 2.135 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr2_-_239148545 2.078 HES6
hairy and enhancer of split 6 (Drosophila)
chr16_+_80574853 2.046 NM_130897
DYNLRB2
dynein, light chain, roadblock-type 2
chr9_-_3223007 2.024


chr1_-_169336999 2.009 NM_013330
NM_197972
NME7

non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

chr10_-_123353771 1.953 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr3_+_108308528 1.937 DZIP3
DAZ interacting protein 3, zinc finger
chr11_-_63381485 1.913 PLA2G16
phospholipase A2, group XVI
chr13_-_26625164 1.911 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr7_+_142829169 1.877 NM_002652
PIP
prolactin-induced protein
chr4_+_72052354 1.766 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr20_-_25038501 1.733 NM_001252675
NM_001252677
NM_032501
ACSS1


acyl-CoA synthetase short-chain family member 1


chr12_-_113658826 1.717 NM_138451
IQCD
IQ motif containing D
chr11_-_8615412 1.684 NM_030906
STK33
serine/threonine kinase 33
chr3_-_187454247 1.659 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr13_+_43355685 1.652 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr14_+_62584120 1.639 FLJ43390
uncharacterized LOC646113
chr16_+_67465019 1.628 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr10_+_12391728 1.622 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr2_-_220436267 1.620 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr12_+_69742130 1.612 NM_000239
LYZ
lysozyme
chr19_+_14551080 1.591 NM_213560
PKN1
protein kinase N1
chr19_-_36705982 1.587 NM_001042474
ZNF565
zinc finger protein 565
chr12_+_113587547 1.569 NM_001144872
CCDC42B
coiled-coil domain containing 42B
chr11_+_73359734 1.564 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr17_-_39165343 1.549 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr20_+_44098392 1.523 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr11_-_59633942 1.519 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr3_+_69915374 1.514 NM_198177
MITF
microphthalmia-associated transcription factor
chrX_-_15620191 1.494 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr1_-_26644755 1.494 NM_145345
UBXN11
UBX domain protein 11
chr7_-_120498009 1.471 TSPAN12
tetraspanin 12
chr5_-_121412805 1.470 NM_001178102
LOX
lysyl oxidase
chr7_-_120498128 1.458 NM_012338
TSPAN12
tetraspanin 12
chr16_+_29471206 1.458 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr2_+_98703594 1.455 NM_144992
VWA3B
von Willebrand factor A domain containing 3B
chr12_-_63328663 1.453 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr10_+_12391708 1.439 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chrX_+_48660467 1.437 NM_006044
HDAC6
histone deacetylase 6
chr11_+_1889902 1.433 NM_001013253
LSP1
lymphocyte-specific protein 1
chr14_-_76448091 1.428 NM_003239
TGFB3
transforming growth factor, beta 3
chr3_-_52008012 1.413 ABHD14B
abhydrolase domain containing 14B
chr11_-_8615745 1.404 STK33
serine/threonine kinase 33
chr4_-_70505359 1.389 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr1_-_217262946 1.388 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr3_+_48507621 1.384 TREX1
three prime repair exonuclease 1
chr3_+_48507209 1.380 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr17_+_68071386 1.379 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr21_+_42688660 1.374 NM_058186
NM_206964
FAM3B

family with sequence similarity 3, member B

chr6_-_79787887 1.373 PHIP
pleckstrin homology domain interacting protein
chrX_-_44202834 1.369 NM_025184
EFHC2
EF-hand domain (C-terminal) containing 2
chr17_-_6735007 1.367 NM_053285
TEKT1
tektin 1
chr2_+_85766291 1.365 MAT2A
methionine adenosyltransferase II, alpha
chr19_+_14551087 1.361 PKN1
protein kinase N1
chr1_+_118148506 1.356 NM_017709
FAM46C
family with sequence similarity 46, member C
chr2_-_220436010 1.348 OBSL1
obscurin-like 1
chr1_+_47264669 1.339 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr1_+_118148668 1.332 FAM46C
family with sequence similarity 46, member C
chr5_-_42811959 1.331 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr17_-_19281494 1.330 NM_001243475
B9D1
B9 protein domain 1
chr2_-_86564632 1.326 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr6_-_79787784 1.325 PHIP
pleckstrin homology domain interacting protein
chr1_+_212738675 1.322 NM_001030287
ATF3
activating transcription factor 3
chr1_-_146696896 1.316 FMO5
flavin containing monooxygenase 5
chr10_+_7745354 1.315 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_+_105603656 1.315 NM_152750
CDHR3
cadherin-related family member 3
chr4_-_141348760 1.297 NM_001130675
NM_004362
CLGN

calmegin

chr20_-_21494663 1.292 NM_002509
NKX2-2
NK2 homeobox 2
chr4_+_55523906 1.280 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr3_+_133495925 1.280 TF
transferrin
chr2_+_114384811 1.277 NM_007082
NM_013412
RABL2A

RAB, member of RAS oncogene family-like 2A

chr12_+_41831484 1.276 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr17_+_4981754 1.256 ZFP3
zinc finger protein 3 homolog (mouse)
chr10_+_7745229 1.256 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr19_-_1876133 1.254


chr10_+_7745325 1.254 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_-_8615701 1.243 STK33
serine/threonine kinase 33
chr14_-_54421269 1.242 NM_130851
BMP4
bone morphogenetic protein 4
chr16_-_28621279 1.233 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr19_+_14551052 1.232 PKN1
protein kinase N1
chr17_+_1633754 1.230 WDR81
WD repeat domain 81
chr7_-_131241321 1.221 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr2_-_25194772 1.214 NM_001198559
NM_016544
DNAJC27

DnaJ (Hsp40) homolog, subfamily C, member 27

chr4_+_41700736 1.213 LIMCH1
LIM and calponin homology domains 1
chr16_-_28608367 1.210 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr2_+_106682111 1.207 NM_032411
C2orf40
chromosome 2 open reading frame 40
chr2_-_25016214 1.199 NM_001013663
PTRHD1
peptidyl-tRNA hydrolase domain containing 1
chr3_-_120400957 1.199 HGD
homogentisate 1,2-dioxygenase
chr20_+_43990576 1.187 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr16_+_82068958 1.184 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_148779172 1.180 NM_181742
ORC4
origin recognition complex, subunit 4
chr11_+_100557851 1.174 NM_152432
ARHGAP42
Rho GTPase activating protein 42
chr8_+_123793894 1.173 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr12_-_122107559 1.167 NM_173855
MORN3
MORN repeat containing 3
chr21_-_33984657 1.155 C21orf59
chromosome 21 open reading frame 59
chr1_-_150738255 1.154 CTSS
cathepsin S
chrX_-_132548994 1.145 NM_001448
GPC4
glypican 4
chr14_+_65016613 1.142 NM_172365
PPP1R36
protein phosphatase 1, regulatory subunit 36
chr1_+_32674694 1.132 NM_001099434
DCDC2B
doublecortin domain containing 2B
chr13_+_24144402 1.131 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr12_-_42983412 1.120 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr12_+_69742140 1.113 LYZ
lysozyme
chr16_-_4896197 1.113 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_+_46646199 1.107 TSPAN1
tetraspanin 1
chr8_+_18067614 1.105 NM_000662
NM_001160170
NM_001160171
NM_001160172
NM_001160173
NM_001160175
NM_001160176
NAT1






N-acetyltransferase 1 (arylamine N-acetyltransferase)






chr12_+_20963637 1.104 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr21_-_33984865 1.102 NM_021254
C21orf59
chromosome 21 open reading frame 59
chrX_-_151999259 1.101 NM_004344
CETN2
centrin, EF-hand protein, 2
chr10_+_12391471 1.094 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr4_-_105412466 1.092 NM_025212
CXXC4
CXXC finger protein 4
chr3_-_145968819 1.091 PLSCR4
phospholipid scramblase 4
chr7_-_25164902 1.091 NM_018947
CYCS
cytochrome c, somatic
chr6_-_165723074 1.083 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr9_-_75568232 1.075 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chrX_-_8700170 1.071 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr4_+_77356252 1.070 NM_020859
SHROOM3
shroom family member 3
chr8_-_27115935 1.068 STMN4
stathmin-like 4
chr9_-_75567915 1.066 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_+_146920135 1.062 NM_024694
C6orf103
chromosome 6 open reading frame 103
chr17_+_4981721 1.059 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr19_+_16999807 1.059 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr1_+_20512577 1.053 NM_152376
UBXN10
UBX domain protein 10
chr3_-_120401401 1.048 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr3_-_169530306 1.037 LRRC34
leucine rich repeat containing 34
chr15_-_68498373 1.035 NM_001031733
NM_033429
CALML4

calmodulin-like 4

chr1_-_217263195 1.029 NM_001243505
ESRRG
estrogen-related receptor gamma
chr8_+_123793988 1.024 ZHX2
zinc fingers and homeoboxes 2
chr6_-_46889620 1.012 NM_001098518
GPR116
G protein-coupled receptor 116
chr4_-_17806820 1.006 DCAF16
DDB1 and CUL4 associated factor 16
chr5_+_35617945 1.005 NM_024867
NM_144722
SPEF2

sperm flagellar 2

chr4_+_81256873 1.000 NM_001206997
NM_152770
C4orf22

chromosome 4 open reading frame 22

chr8_-_110657745 0.996 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr7_-_158380360 0.995 NM_002847
NM_130842
NM_130843
PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr2_+_190648810 0.991 NM_000534
NM_001128143
NM_001128144
PMS1


PMS1 postmeiotic segregation increased 1 (S. cerevisiae)


chr10_-_116286570 0.988 ABLIM1
actin binding LIM protein 1
chr2_-_158731622 0.987 NM_001105
ACVR1
activin A receptor, type I
chrX_+_48660561 0.984 HDAC6
histone deacetylase 6
chr8_+_123794043 0.976 ZHX2
zinc fingers and homeoboxes 2
chr22_-_38349533 0.966 NM_032561
NM_001207062
C22orf23

chromosome 22 open reading frame 23

chrX_-_112084006 0.964 NM_133265
AMOT
angiomotin
chr9_+_71320105 0.955 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr4_-_168155576 0.953 NM_001204353
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr1_-_75139421 0.950 NM_001002912
C1orf173
chromosome 1 open reading frame 173
chr6_-_52774460 0.949 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr3_-_114343791 0.947 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_122526410 0.940 CADPS2
Ca++-dependent secretion activator 2
chr13_-_31735718 0.940 HSPH1
heat shock 105kDa/110kDa protein 1
chr22_-_31503484 0.936 NM_080430
SELM
selenoprotein M
chr19_+_36236460 0.933 NM_172341
PSENEN
presenilin enhancer 2 homolog (C. elegans)
chr6_-_31324955 0.928 HLA-B
major histocompatibility complex, class I, B
chr3_-_182880463 0.923 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr20_+_18794369 0.918 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr5_+_42565963 0.917 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr3_-_145968958 0.915 NM_001128306
NM_001177304
NM_020353
PLSCR4


phospholipid scramblase 4


chr7_+_30960914 0.912 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr7_+_90339146 0.902 CDK14
cyclin-dependent kinase 14
chr2_+_39103102 0.901 NM_001145450
MORN2
MORN repeat containing 2
chr1_-_216978708 0.901 NM_001243514
ESRRG
estrogen-related receptor gamma
chr19_+_41284161 0.900 RAB4B-EGLN2
RAB4B
RAB4B-EGLN2 readthrough
RAB4B, member RAS oncogene family
chrX_+_48660286 0.890 HDAC6
histone deacetylase 6
chr5_-_41213513 0.888 NM_000065
C6
complement component 6
chr17_-_38721701 0.883 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr1_+_59775749 0.881 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr6_-_31324975 0.879 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr3_-_46506342 0.873 NM_002343
LTF
lactotransferrin
chr8_-_110704019 0.868 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr6_-_31324898 0.866 HLA-B
major histocompatibility complex, class I, B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 2.03e-06 GO:0016070 RNA metabolic process
1.31 1.08e-04 GO:0010467 gene expression
1.61 1.62e-04 GO:0016071 mRNA metabolic process
1.26 1.13e-03 GO:0090304 nucleic acid metabolic process
1.16 2.46e-03 GO:0044260 cellular macromolecule metabolic process
1.42 2.77e-03 GO:0016265 death
1.42 3.14e-03 GO:0008219 cell death
1.61 1.00e-02 GO:0006397 mRNA processing
1.39 1.26e-02 GO:0006351 transcription, DNA-dependent
1.14 1.54e-02 GO:0043170 macromolecule metabolic process
1.20 1.65e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.60 2.89e-02 GO:0016568 chromatin modification
1.06 2.98e-02 GO:0009987 cellular process
1.41 3.25e-02 GO:0012501 programmed cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 3.85e-10 GO:0043231 intracellular membrane-bounded organelle
1.13 5.89e-10 GO:0043227 membrane-bounded organelle
1.12 2.47e-09 GO:0043226 organelle
1.12 2.95e-09 GO:0043229 intracellular organelle
1.09 1.23e-08 GO:0044424 intracellular part
1.18 5.28e-08 GO:0005634 nucleus
1.08 7.05e-08 GO:0005622 intracellular
1.47 2.31e-04 GO:0044451 nucleoplasm part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.22 1.43e-05 GO:0003676 nucleic acid binding
1.06 3.29e-04 GO:0005488 binding
1.23 9.20e-04 GO:0003677 DNA binding
1.24 1.82e-03 GO:0008270 zinc ion binding
1.10 2.81e-03 GO:0005515 protein binding
1.20 2.43e-02 GO:0046914 transition metal ion binding