Motif ID: NKX6-1,2.p2

Z-value: 0.999


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-1chr4_-_85419386-0.393.5e-02Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_361365 4.046 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr4_-_100273831 3.877 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr1_+_104159953 3.062 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr7_+_23286384 3.050 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_150738232 2.808 CTSS
cathepsin S
chr7_+_23286386 2.769 GPNMB
glycoprotein (transmembrane) nmb
chr4_-_23891608 2.705 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_-_150738292 2.609 NM_001199739
NM_004079
CTSS

cathepsin S

chr19_-_9092017 2.526 NM_024690
MUC16
mucin 16, cell surface associated
chr5_+_94727047 2.409 NM_152548
FAM81B
family with sequence similarity 81, member B
chr13_+_24144402 2.376 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr18_+_61370193 2.341 NM_080475
SERPINB11
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr1_-_150738255 2.320 CTSS
cathepsin S
chr21_-_35884503 2.307 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr7_+_23286390 2.298 GPNMB
glycoprotein (transmembrane) nmb
chr18_-_24722757 2.226 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr1_+_210501595 2.073 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr7_-_137028533 2.043 NM_002825
PTN
pleiotrophin
chr19_-_3029611 1.944 NM_001144762
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr16_+_78062985 1.942 NM_001244755
CLEC3A
C-type lectin domain family 3, member A
chr1_+_79115476 1.779 NM_006417
IFI44
interferon-induced protein 44
chr20_-_18477811 1.770 NM_006606
RBBP9
retinoblastoma binding protein 9
chr7_+_23286277 1.756 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr7_+_23286420 1.755 GPNMB
glycoprotein (transmembrane) nmb
chr8_-_7212868 1.753 FAM66B
family with sequence similarity 66, member B
chr7_+_150065330 1.719 REPIN1
replication initiator 1
chr17_+_68100994 1.674 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr2_-_135782246 1.667 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr16_-_52581713 1.625 NM_001146188
TOX3
TOX high mobility group box family member 3
chr4_-_17806820 1.619 DCAF16
DDB1 and CUL4 associated factor 16
chr4_-_70725792 1.592 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr1_+_104198301 1.542 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr9_-_75568232 1.497 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr12_+_20963637 1.469 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr2_+_169757749 1.450 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr3_-_151102536 1.443 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr4_-_110723334 1.435 NM_000204
CFI
complement factor I
chr4_+_41700736 1.422 LIMCH1
LIM and calponin homology domains 1
chr22_-_36562224 1.378 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr3_-_120401401 1.375 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr1_+_61869699 1.347 NFIA
nuclear factor I/A
chr13_-_36429798 1.331 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr2_+_132285469 1.317 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr1_+_104292439 1.303 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr5_+_42565562 1.293 NM_001242406
GHR
growth hormone receptor
chr1_-_207095198 1.291 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr4_-_110723127 1.272 CFI
complement factor I
chr20_+_51801821 1.256 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr1_+_104097321 1.228 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr9_-_34397786 1.219 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr1_-_46089638 1.215 NM_001114938
NM_001190182
CCDC17

coiled-coil domain containing 17

chr8_+_76452202 1.214 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr6_-_33041266 1.179 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr5_-_160279045 1.171 NM_025153
ATP10B
ATPase, class V, type 10B
chr21_-_36421630 1.140 RUNX1
runt-related transcription factor 1
chr5_+_42565963 1.132 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr3_-_79817058 1.095 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_+_244214576 1.086 ZNF238
zinc finger protein 238
chr17_+_68071386 1.085 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr20_+_9198036 1.076 NM_182797
PLCB4
phospholipase C, beta 4
chr1_+_196621007 1.035 NM_000186
NM_001014975
CFH

complement factor H

chr8_-_133772808 1.024 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr7_+_23286401 1.020 GPNMB
glycoprotein (transmembrane) nmb
chr20_-_20036685 0.996 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr4_+_166299942 0.996 NM_001873
CPE
carboxypeptidase E
chr1_-_161337663 0.993 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chrX_-_10535476 0.964 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chrX_+_70765479 0.962 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr2_-_217560247 0.955 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chrX_+_36254050 0.942 NM_001098843
CXorf30
chromosome X open reading frame 30
chr22_-_36013303 0.940 NM_005368
NM_203378
MB

myoglobin

chr8_-_110661007 0.936 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chrX_+_35937850 0.935 NM_152632
CXorf22
chromosome X open reading frame 22
chr11_+_17332454 0.931


chr5_+_42548144 0.929 NM_001242402
GHR
growth hormone receptor
chr6_-_154651214 0.909 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr16_-_21289571 0.896 CRYM
crystallin, mu
chr21_-_36421586 0.886 NM_001754
RUNX1
runt-related transcription factor 1
chr11_+_103907307 0.882 NM_001001711
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr2_+_102770401 0.874 NM_000877
IL1R1
interleukin 1 receptor, type I
chr4_-_16085666 0.843 PROM1
prominin 1
chr6_+_26402464 0.834 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr3_-_112564789 0.791 NM_001008784
NM_001199215
CD200R1L

CD200 receptor 1-like

chr4_-_16085593 0.790 NM_001145847
NM_001145848
PROM1

prominin 1

chr1_+_15256295 0.786 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr16_-_21314371 0.775 NM_001014444
NM_001888
CRYM

crystallin, mu

chr11_+_94277005 0.773 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr4_-_100356449 0.762 NM_000673
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr7_-_137028275 0.761 PTN
pleiotrophin
chr1_-_149858114 0.749 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr11_+_7618416 0.748 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_27953046 0.744 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr6_+_87969619 0.743 ZNF292
zinc finger protein 292
chr12_+_50156977 0.738 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr1_-_183622447 0.737 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr6_+_26440699 0.735 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr21_-_36421578 0.725 RUNX1
runt-related transcription factor 1
chr16_+_25228282 0.724 NM_001169
AQP8
aquaporin 8
chr1_-_236445294 0.718 NM_019891
ERO1LB
ERO1-like beta (S. cerevisiae)
chr1_-_223853400 0.715 NM_001143962
CAPN8
calpain 8
chr16_-_21289637 0.709 CRYM
crystallin, mu
chr3_-_121379757 0.704 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr5_+_166711842 0.700 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr8_+_40010986 0.694 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr12_+_62954275 0.682 MON2
MON2 homolog (S. cerevisiae)
chr8_+_132991171 0.680 EFR3A
EFR3 homolog A (S. cerevisiae)
chr16_+_69680959 0.668 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr6_-_165723074 0.663 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr6_-_79675672 0.661 PHIP
pleckstrin homology domain interacting protein
chr3_-_121379701 0.661 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr5_+_140220811 0.657 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr20_+_19915716 0.630 RIN2
Ras and Rab interactor 2
chr3_+_171561138 0.629 NM_001164436
TMEM212
transmembrane protein 212
chr12_-_25348031 0.622 NM_001082972
NM_001082973
NM_001204101
NM_001204102
NM_018272
CASC1




cancer susceptibility candidate 1




chr7_-_137686814 0.621 NM_001253775
NM_194071
CREB3L2

cAMP responsive element binding protein 3-like 2

chr5_+_140729723 0.621 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr3_-_15839674 0.620 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr1_-_223853359 0.619 CAPN8
calpain 8
chr5_+_140261792 0.616 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr1_+_15272414 0.612 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr2_-_175712276 0.610 NM_001206602
CHN1
chimerin (chimaerin) 1
chr4_+_15471488 0.609 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr1_+_244214552 0.607 NM_205768
ZNF238
zinc finger protein 238
chr6_+_147527102 0.606 STXBP5
syntaxin binding protein 5 (tomosyn)
chr4_-_70518964 0.602 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr7_-_137028370 0.573 PTN
pleiotrophin
chr14_-_78083109 0.573 NM_004863
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr1_+_170904611 0.570 NM_001163629
NM_025063
C1orf129

chromosome 1 open reading frame 129

chr1_+_180601164 0.563 XPR1
xenotropic and polytropic retrovirus receptor 1
chr12_+_25205488 0.563 LRMP
lymphoid-restricted membrane protein
chr1_+_207002221 0.561 NM_013371
IL19
interleukin 19
chr3_-_114790221 0.553 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chrX_-_10544852 0.551 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr2_-_178483677 0.546 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr17_+_38975343 0.546 NM_001195387
NM_145274
NM_001195386
TMEM99


transmembrane protein 99


chr9_-_3223007 0.546


chr10_+_72163860 0.542 NM_004096
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr4_-_170077807 0.539 SH3RF1
SH3 domain containing ring finger 1
chr11_-_62521533 0.536 NM_024784
ZBTB3
zinc finger and BTB domain containing 3
chr6_+_26365397 0.533 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr5_-_41261539 0.528 NM_001115131
C6
complement component 6
chr1_+_59775749 0.526 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr5_-_75013209 0.523 NM_001099271
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr1_-_92351613 0.518 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr2_+_234826042 0.516 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr5_-_111091947 0.516 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr4_-_87374282 0.516 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr3_-_105421044 0.510 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr10_-_116286661 0.510 NM_006720
ABLIM1
actin binding LIM protein 1
chr1_-_190446701 0.503 NM_199051
FAM5C
family with sequence similarity 5, member C
chr3_-_141747434 0.497 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr2_+_61389628 0.496 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chrX_-_10851808 0.496 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr8_-_82395401 0.492 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr22_-_39268214 0.488 CBX6
chromobox homolog 6
chr9_+_82187469 0.488 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_+_72163914 0.485 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr21_-_36421461 0.483 RUNX1
runt-related transcription factor 1
chr19_+_41281281 0.482 NM_006533
MIA
melanoma inhibitory activity
chr19_-_55677919 0.482 NM_178837
C19orf51
chromosome 19 open reading frame 51
chr12_+_131438451 0.477 NM_198827
GPR133
G protein-coupled receptor 133
chr6_+_35226685 0.476 ZNF76
zinc finger protein 76
chr18_+_55816546 0.473 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr16_+_19422056 0.470 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr12_-_113772900 0.470 NM_024959
SLC24A6
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
chr6_+_7402879 0.465 NM_153005
RIOK1
RIO kinase 1 (yeast)
chr1_-_217250230 0.463 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr16_-_46782104 0.461 NM_182493
MYLK3
myosin light chain kinase 3
chr21_-_31588242 0.459 NM_199328
CLDN8
claudin 8
chr22_-_39268169 0.458 CBX6
chromobox homolog 6
chr6_+_132859426 0.457 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr18_+_32870252 0.451 ZNF271
zinc finger protein 271
chr2_-_144994905 0.447 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr5_-_121814781 0.440


chr3_-_47957475 0.435


chr3_-_151058439 0.429 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr13_+_52598678 0.426 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr14_-_61115906 0.425 NM_005982
SIX1
SIX homeobox 1
chr7_-_137028433 0.424 PTN
pleiotrophin
chr10_+_74870209 0.423 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr10_-_123353330 0.418 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr1_-_49242406 0.415 NM_024603
BEND5
BEN domain containing 5
chr20_+_57022460 0.414 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr22_-_39268230 0.411 NM_014292
CBX6
chromobox homolog 6
chr6_+_159070994 0.411 NM_001009991
NM_001242384
NM_001242394
NM_001242395
SYTL3



synaptotagmin-like 3



chr12_+_119772516 0.410 NM_178499
CCDC60
coiled-coil domain containing 60
chr18_-_3219846 0.410 MYOM1
myomesin 1, 185kDa
chr15_-_55800431 0.409 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr1_-_152131703 0.406 NM_001122965
RPTN
repetin
chr1_+_180601121 0.404 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chrX_+_80457302 0.398 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr5_+_95066628 0.394 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr9_+_82187599 0.392 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr6_-_46922533 0.390 NM_015234
GPR116
G protein-coupled receptor 116
chr15_+_89739234 0.390 ABHD2
abhydrolase domain containing 2
chr5_-_88199868 0.390 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr5_+_67586466 0.389 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr18_-_53089722 0.387 NM_001243233
TCF4
transcription factor 4
chr12_+_9980076 0.386 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr12_+_121647850 0.385 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.44 4.53e-03 GO:0007156 homophilic cell adhesion

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
23.69 3.34e-02 GO:0004556 alpha-amylase activity
23.69 3.34e-02 GO:0016160 amylase activity