Motif ID: NR1H4.p2

Z-value: 1.102


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR1H4chr12_+_1008971370.383.9e-02Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_32042085 2.851 NM_001204414
NM_022164
TINAGL1

tubulointerstitial nephritis antigen-like 1

chr1_+_32042122 2.815 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_32042125 2.734 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_158114109 2.543 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr8_-_125740378 2.439 MTSS1
metastasis suppressor 1
chr1_-_50489489 2.422 AGBL4
ATP/GTP binding protein-like 4
chr9_+_131191206 2.383 CERCAM
cerebral endothelial cell adhesion molecule
chr3_+_50316517 2.195 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr19_-_11689765 2.143 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr3_-_50340979 2.075 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr2_-_85637486 2.029 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr22_+_30792929 2.018 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr17_+_7942351 2.015 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr9_+_33795558 1.982 NM_002771
PRSS3
protease, serine, 3
chr11_-_123065836 1.947 CLMP
CXADR-like membrane protein
chrX_+_7137471 1.838 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr19_-_11689591 1.810 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr12_-_25055966 1.749 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_89746238 1.640 DUSP6
dual specificity phosphatase 6
chr14_-_75078669 1.518 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr1_-_149908098 1.472 NM_181873
MTMR11
myotubularin related protein 11
chr11_-_6341708 1.368 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr2_-_91847961 1.312


chr14_+_55168831 1.297 SAMD4A
sterile alpha motif domain containing 4A
chr10_-_75634219 1.264 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr19_+_676346 1.252 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr15_+_39873276 1.235 NM_003246
THBS1
thrombospondin 1
chr19_+_7741934 1.220 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr12_+_57623355 1.217 NM_001166356
NM_005412
SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chr2_-_85637473 1.175 CAPG
capping protein (actin filament), gelsolin-like
chr9_+_116343169 1.155 RGS3
regulator of G-protein signaling 3
chr1_+_84647342 1.145 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr17_-_73840422 1.140 UNC13D
unc-13 homolog D (C. elegans)
chr2_-_110874142 1.125 NM_005434
MALL
mal, T-cell differentiation protein-like
chr2_-_208031570 1.121 KLF7
Kruppel-like factor 7 (ubiquitous)
chr9_+_35673852 1.118 NM_001216
CA9
carbonic anhydrase IX
chr1_+_86046434 1.118 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_38859976 1.106 NM_019016
KRT24
keratin 24
chr7_+_142457318 1.080 NM_002769
PRSS1
PRSS2
protease, serine, 1 (trypsin 1)
protease, serine, 2 (trypsin 2)
chr1_+_17575592 1.063 NM_016233
PADI3
peptidyl arginine deiminase, type III
chr2_+_192542860 1.059 NM_001031716
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A
chr20_+_43803539 1.052 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr7_+_2671582 1.049 NM_025250
TTYH3
tweety homolog 3 (Drosophila)
chr12_-_89746244 1.003 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr2_-_190044330 0.994 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_-_150849062 0.986 ARNT
aryl hydrocarbon receptor nuclear translocator
chr17_-_74023481 0.980 NM_001988
EVPL
envoplakin
chr7_+_2671630 0.977 TTYH3
tweety homolog 3 (Drosophila)
chr22_+_44422183 0.976 NM_001243386
PARVB
parvin, beta
chr5_+_79330990 0.957 NM_003248
THBS4
thrombospondin 4
chr17_-_74023311 0.952 EVPL
envoplakin
chr9_+_74526369 0.948 NM_182505
C9orf85
chromosome 9 open reading frame 85
chr2_+_210288668 0.930 NM_001039538
MAP2
microtubule-associated protein 2
chr16_+_30194730 0.919 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr16_+_30194925 0.886 CORO1A
coronin, actin binding protein, 1A
chr15_+_90728118 0.875 NM_020210
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr19_+_1026608 0.846 CNN2
calponin 2
chr1_-_6418966 0.833 NM_181866
ACOT7
acyl-CoA thioesterase 7
chr5_-_177423242 0.833 NM_006261
PROP1
PROP paired-like homeobox 1
chr11_+_117857123 0.831 IL10RA
interleukin 10 receptor, alpha
chr12_+_53442732 0.828 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr21_+_46707949 0.826 LOC642852
uncharacterized LOC642852
chr11_-_64377332 0.823


chr18_-_28681885 0.816 NM_004949
NM_024422
DSC2

desmocollin 2

chr17_+_2680349 0.812 RAP1GAP2
RAP1 GTPase activating protein 2
chr19_-_50143350 0.811 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr8_+_7738908 0.809 NM_018661
DEFB103B
defensin, beta 103B
chr21_-_46707748 0.802 NM_015227
NM_133635
POFUT2

protein O-fucosyltransferase 2

chrX_-_153640358 0.800 NM_001009932
NM_001009933
NM_001009934
DNASE1L1


deoxyribonuclease I-like 1


chr1_+_150521786 0.797 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr10_-_121302149 0.797 NM_001005339
RGS10
regulator of G-protein signaling 10
chr22_-_30234253 0.794 NM_001242906
NM_032204
ASCC2

activating signal cointegrator 1 complex subunit 2

chr1_+_152881022 0.794 NM_005547
IVL
involucrin
chr9_+_131183225 0.789 CERCAM
cerebral endothelial cell adhesion molecule
chr6_+_43737937 0.786 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr11_+_118827007 0.785 NM_006760
UPK2
uroplakin 2
chr1_-_150849043 0.778 ARNT
aryl hydrocarbon receptor nuclear translocator
chr16_+_67700704 0.777 NM_001012984
C16orf86
chromosome 16 open reading frame 86
chr5_+_149569519 0.776 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr11_-_67450536 0.772 RPL37
ribosomal protein L37
chr19_+_36239261 0.765 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr5_+_131593388 0.762 PDLIM4
PDZ and LIM domain 4
chr19_-_46526555 0.756 NM_005091
PGLYRP1
peptidoglycan recognition protein 1
chr3_-_48632592 0.753 NM_000094
COL7A1
collagen, type VII, alpha 1
chr19_+_1026271 0.752 NM_004368
NM_201277
CNN2

calponin 2

chr17_-_73840495 0.751 UNC13D
unc-13 homolog D (C. elegans)
chr9_-_139890984 0.743 NM_004669
CLIC3
chloride intracellular channel 3
chr17_-_45928530 0.742 SP6
Sp6 transcription factor
chr2_+_48541767 0.739 NM_002158
FOXN2
forkhead box N2
chr10_+_112404104 0.738 NM_001134363
RBM20
RNA binding motif protein 20
chr12_-_57914287 0.731 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr11_-_58345593 0.725 NM_001143995
LPXN
leupaxin
chr5_-_171615239 0.724 STK10
serine/threonine kinase 10
chr11_-_89653575 0.720 NM_001105522
TRIM49L1
tripartite motif containing 49-like 1
chr12_-_53242716 0.720 NM_173352
KRT78
keratin 78
chr11_+_89657231 0.710 NM_001105522
TRIM49L1
tripartite motif containing 49-like 1
chr5_+_137419580 0.709 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr6_+_43738757 0.707 VEGFA
vascular endothelial growth factor A
chr1_+_154300275 0.700 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr7_+_99156263 0.697 ZNF655
zinc finger protein 655
chr1_-_150849147 0.693 ARNT
aryl hydrocarbon receptor nuclear translocator
chr19_-_36001336 0.691 NM_001126059
DMKN
dermokine
chr11_+_119076974 0.691 NM_005188
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr19_+_1026627 0.689 CNN2
calponin 2
chr19_-_43032525 0.689 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr9_-_71155729 0.686 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr12_-_117742856 0.686 NM_001204213
NOS1
nitric oxide synthase 1 (neuronal)
chr17_+_7533452 0.679 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr1_+_179334854 0.673 NM_144696
AXDND1
axonemal dynein light chain domain containing 1
chr16_-_67217825 0.670 NM_001040715
KIAA0895L
KIAA0895-like
chr5_+_131593331 0.664 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr5_+_131593377 0.658 PDLIM4
PDZ and LIM domain 4
chr11_+_72983246 0.652 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr6_+_43738177 0.647 VEGFA
vascular endothelial growth factor A
chr17_-_34756980 0.629 NM_001123392
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3H
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3H
chr12_-_27167332 0.628 NM_016551
TM7SF3
transmembrane 7 superfamily member 3
chr12_-_27167033 0.619 TM7SF3
transmembrane 7 superfamily member 3
chr18_-_47340208 0.614 NM_006111
ACAA2
acetyl-CoA acyltransferase 2
chr1_+_150954498 0.613 NM_003568
ANXA9
annexin A9
chr20_+_62496580 0.611 NM_001243891
NM_001243892
NM_001243894
NM_001243895
NM_003288
NM_199359
NM_199360
NM_199361
NM_199362
NM_199363
TPD52L2









tumor protein D52-like 2









chr9_-_137809710 0.611 NM_002003
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr12_+_58013692 0.603 NM_133489
SLC26A10
solute carrier family 26, member 10
chr7_+_63773185 0.602 NM_001170905
ZNF736
zinc finger protein 736
chr20_+_62496634 0.593 TPD52L2
tumor protein D52-like 2
chr6_+_53883713 0.593 NM_138569
MLIP
muscular LMNA-interacting protein
chrX_-_118827116 0.585 SEPT6
septin 6
chr12_-_52779362 0.584 NM_033045
KRT84
keratin 84
chr3_-_196756572 0.583 MFI2
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr19_-_4817502 0.581 TICAM1
toll-like receptor adaptor molecule 1
chr6_-_133084585 0.575 NM_078488
VNN2
vanin 2
chr17_+_74381186 0.572 NM_001142602
SPHK1
sphingosine kinase 1
chr22_+_24999113 0.570 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr17_+_9745847 0.569 GLP2R
glucagon-like peptide 2 receptor
chr2_+_238600780 0.568 NM_001137551
NM_001137552
NM_001137553
NM_004735
LRRFIP1



leucine rich repeat (in FLII) interacting protein 1



chr10_-_90750955 0.556 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_45792544 0.556 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr4_-_176733413 0.554 GPM6A
glycoprotein M6A
chr20_+_62496650 0.553 TPD52L2
tumor protein D52-like 2
chr10_+_77542518 0.548 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr17_-_33390676 0.545 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr1_-_150849211 0.545 NM_001197325
NM_001668
NM_178427
ARNT


aryl hydrocarbon receptor nuclear translocator


chr3_-_196014519 0.544 PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr17_-_62207362 0.539 ERN1
endoplasmic reticulum to nucleus signaling 1
chr2_+_173420776 0.539 NM_002610
PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr10_-_76995685 0.539 NM_144589
COMTD1
catechol-O-methyltransferase domain containing 1
chr11_+_7041699 0.535 NM_176822
NLRP14
NLR family, pyrin domain containing 14
chr1_-_205744543 0.531 NM_001135662
NM_001135663
NM_001135664
NM_003929
RAB7L1



RAB7, member RAS oncogene family-like 1



chr3_+_52828783 0.528 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr20_+_62496678 0.521 TPD52L2
tumor protein D52-like 2
chr11_+_119077021 0.519 CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr3_+_50654868 0.517 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr19_-_15590203 0.516 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr17_-_36348585 0.516 NM_001123391
NM_032258
TBC1D3C
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr15_-_34212523 0.516


chr20_-_29993955 0.515 NM_001011878
DEFB121
defensin, beta 121
chr5_-_149669187 0.512 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr5_+_36152221 0.512 SKP2
S-phase kinase-associated protein 2 (p45)
chr1_-_150978879 0.511 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr22_+_24979717 0.510 NM_013430
GGT1
gamma-glutamyltransferase 1
chr5_+_149569810 0.509 SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr15_+_40453263 0.509 BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr7_+_128312345 0.509 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr17_-_44895962 0.508 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr19_-_42894419 0.508 NM_032488
CNFN
cornifelin
chr16_+_70557688 0.505 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chr16_+_23847271 0.503 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr14_-_91710851 0.502 NM_001177676
GPR68
G protein-coupled receptor 68
chr22_+_21321446 0.502 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_+_77333121 0.500 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_-_57113292 0.495 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr17_-_73975443 0.494 ACOX1
acyl-CoA oxidase 1, palmitoyl
chr1_+_156785470 0.492 NM_001007792
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr10_+_106034886 0.491 NM_001191014
NM_001191015
GSTO2

glutathione S-transferase omega 2

chrX_+_91090459 0.491 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr1_-_151804225 0.490 NM_005060
RORC
RAR-related orphan receptor C
chr3_-_28390506 0.489 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr17_+_36283959 0.486 NM_001123391
NM_032258
TBC1D3C
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr5_-_136834887 0.485 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr17_-_34503914 0.484 NM_001001417
TBC1D3B
TBC1D3C
TBC1D3G
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
chr11_-_72353435 0.482 NM_001143839
NM_001243784
PDE2A

phosphodiesterase 2A, cGMP-stimulated

chr17_-_72855884 0.482 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr17_-_73840587 0.482 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr12_-_6756597 0.479 ACRBP
acrosin binding protein
chr8_-_7287651 0.473 NM_018661
DEFB103B
defensin, beta 103B
chr8_-_143695812 0.464 NM_015193
ARC
activity-regulated cytoskeleton-associated protein
chr9_+_138437984 0.463 NM_014582
OBP2A
odorant binding protein 2A
chr1_-_204121144 0.461 NM_018208
ETNK2
ethanolamine kinase 2
chr17_+_58499854 0.460 NM_181707
C17orf64
chromosome 17 open reading frame 64
chr7_+_155089614 0.459 INSIG1
insulin induced gene 1
chr19_+_589849 0.458 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr19_+_917285 0.458 NM_032551
KISS1R
KISS1 receptor
chr5_+_145317297 0.456 SH3RF2
SH3 domain containing ring finger 2
chr1_-_153585504 0.455 NM_080388
S100A16
S100 calcium binding protein A16
chr7_+_134576150 0.452 NM_033139
NM_033140
CALD1

caldesmon 1

chr17_+_18281078 0.450 NM_001145127
EVPLL
envoplakin-like
chr20_+_44509847 0.450 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr17_+_73717556 0.448 ITGB4
integrin, beta 4
chr12_+_75874512 0.445 NM_006851
GLIPR1
GLI pathogenesis-related 1
chrX_+_68048792 0.444 NM_004429
EFNB1
ephrin-B1
chr11_+_114167197 0.441 NNMT
nicotinamide N-methyltransferase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 4.33e-04 GO:0023052 signaling
1.26 4.98e-03 GO:0007165 signal transduction
1.13 1.36e-02 GO:0065007 biological regulation
1.14 3.10e-02 GO:0050789 regulation of biological process
1.21 3.68e-02 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 3.63e-04 GO:0005829 cytosol
1.63 3.36e-03 GO:0030054 cell junction
2.17 1.18e-02 GO:0070161 anchoring junction
2.45 2.64e-02 GO:0005924 cell-substrate adherens junction
2.45 3.67e-02 GO:0005925 focal adhesion
2.36 4.76e-02 GO:0030055 cell-substrate junction
1.26 4.97e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.05 2.37e-03 GO:0003823 antigen binding
1.12 3.22e-02 GO:0005515 protein binding
1.86 4.61e-02 GO:0032403 protein complex binding