Motif ID: NR3C1.p2

Z-value: 0.794


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR3C1chr5_-_142783200-0.271.5e-01Click!


Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_23286386 5.654 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286384 5.588 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286390 5.379 GPNMB
glycoprotein (transmembrane) nmb
chr3_-_19975671 4.038 NM_144715
EFHB
EF-hand domain family, member B
chr11_+_73358593 3.599 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr7_+_105603656 3.158 NM_152750
CDHR3
cadherin-related family member 3
chr5_+_94727047 3.081 NM_152548
FAM81B
family with sequence similarity 81, member B
chr12_-_71551564 2.363 TSPAN8
tetraspanin 8
chr7_+_23286401 2.253 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286277 2.092 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr1_-_117753476 2.014 NM_001253850
NM_024626
VTCN1

V-set domain containing T cell activation inhibitor 1

chr8_-_110655418 1.946 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr2_-_233877901 1.900 NGEF
neuronal guanine nucleotide exchange factor
chr1_-_183622447 1.827 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr6_-_52668599 1.634 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr10_+_114154522 1.627 ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_94539209 1.374 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr16_-_21314371 1.335 NM_001014444
NM_001888
CRYM

crystallin, mu

chr2_-_233877920 1.170 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr10_+_695887 1.120 C10orf108
chromosome 10 open reading frame 108
chr21_-_46340776 1.098 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_-_238499317 1.085 RAB17
RAB17, member RAS oncogene family
chr21_-_46340821 1.012 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_-_71551778 1.007 NM_004616
TSPAN8
tetraspanin 8
chr19_+_15783827 0.935 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr14_-_106774311 0.926 IGHA1
immunoglobulin heavy constant alpha 1
chr8_-_110657745 0.908 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr10_-_92680784 0.867 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_+_36285643 0.845 NM_001170700
DTHD1
death domain containing 1
chr20_+_51801821 0.836 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr15_-_45670955 0.798 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr1_-_10856704 0.776 NM_001079843
NM_017766
CASZ1

castor zinc finger 1

chr3_+_151488214 0.762 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr11_-_59633942 0.744 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr6_+_150690027 0.743 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr10_-_92681025 0.743 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr16_-_68482373 0.742 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr6_-_31648140 0.740 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr17_-_4689508 0.737 NM_001144939
NM_001144940
NM_001144941
NM_182566
VMO1



vitelline membrane outer layer 1 homolog (chicken)



chr6_-_29527477 0.712 UBD
ubiquitin D
chr10_+_91152321 0.704 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr21_-_35828038 0.700 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr3_-_187463227 0.690 BCL6
B-cell CLL/lymphoma 6
chr17_-_39165343 0.673 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr20_+_138121 0.655 NM_139074
DEFB127
defensin, beta 127
chr14_-_92333856 0.651 NM_001128596
TC2N
tandem C2 domains, nuclear
chr5_+_10441973 0.649 NM_001201466
NM_031916
ROPN1L

rhophilin associated tail protein 1-like

chr11_+_60048013 0.625 NM_001243266
NM_024021
NM_148975
MS4A4A


membrane-spanning 4-domains, subfamily A, member 4


chr12_+_69742130 0.618 NM_000239
LYZ
lysozyme
chr5_+_10442065 0.613 ROPN1L
rhophilin associated tail protein 1-like
chr2_+_159651828 0.585 NM_001017920
DAPL1
death associated protein-like 1
chr6_-_13295817 0.552 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr1_+_162602308 0.541 DDR2
discoidin domain receptor tyrosine kinase 2
chr9_+_66553254 0.536 MGC21881
uncharacterized locus MGC21881
chr14_-_23755232 0.535 HOMEZ
homeobox and leucine zipper encoding
chr8_-_146202727 0.535 ZNF252
zinc finger protein 252
chr10_-_123353330 0.516 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr6_-_52628272 0.505 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr21_+_30400229 0.504 USP16
ubiquitin specific peptidase 16
chr3_+_132316080 0.491 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr10_+_114133775 0.488 ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_-_20693122 0.486 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr17_+_11786218 0.468 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr16_+_90089007 0.467 NM_001481
GAS8
growth arrest-specific 8
chr1_-_94586678 0.467 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr6_-_154831788 0.466 CNKSR3
CNKSR family member 3
chr19_-_14992166 0.459 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr12_+_15125955 0.451 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr12_+_51318515 0.450 NM_014033
METTL7A
methyltransferase like 7A
chr5_+_121465214 0.447 NM_207317
ZNF474
zinc finger protein 474
chr14_-_23755308 0.447 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr2_-_238499713 0.437 NM_022449
RAB17
RAB17, member RAS oncogene family
chr17_-_9929567 0.436 NM_001130831
GAS7
growth arrest-specific 7
chr19_-_45826232 0.433 NM_001824
CKM
creatine kinase, muscle
chr3_-_146213721 0.429 NM_001199979
PLSCR2
phospholipid scramblase 2
chr20_-_55100980 0.427 NM_080615
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr19_+_15121538 0.420 NM_173482
CCDC105
coiled-coil domain containing 105
chr6_-_132967141 0.408 NM_138327
TAAR1
trace amine associated receptor 1
chr6_-_154831704 0.395 NM_173515
CNKSR3
CNKSR family member 3
chr12_+_69742140 0.392 LYZ
lysozyme
chr11_-_8739398 0.385 ST5
suppression of tumorigenicity 5
chr14_-_24616429 0.381 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_+_44115828 0.380 KDM4A
lysine (K)-specific demethylase 4A
chr3_-_45267068 0.369 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr1_+_210001363 0.366 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr12_-_91572328 0.365 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr5_+_180467224 0.361 NM_152547
BTNL9
butyrophilin-like 9
chr7_+_102987970 0.361 NM_001204453
NM_002803
PSMC2

proteasome (prosome, macropain) 26S subunit, ATPase, 2

chr6_-_6320875 0.358 F13A1
coagulation factor XIII, A1 polypeptide
chr18_-_53068755 0.349 TCF4
transcription factor 4
chr16_+_4674829 0.347 MGRN1
mahogunin, ring finger 1
chr10_-_123353771 0.340 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr12_+_51318743 0.340 METTL7A
methyltransferase like 7A
chr4_-_146095891 0.336 NM_017493
OTUD4
OTU domain containing 4
chr3_+_171561138 0.335 NM_001164436
TMEM212
transmembrane protein 212
chr6_-_6320897 0.326 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr5_-_42811959 0.326 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_-_165555252 0.322 NM_000055
BCHE
butyrylcholinesterase
chr6_-_32908583 0.322 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_44115804 0.320 KDM4A
lysine (K)-specific demethylase 4A
chr5_-_135231504 0.319 NM_000590
IL9
interleukin 9
chrX_-_131261871 0.317 NM_194277
FRMD7
FERM domain containing 7
chr3_+_51860898 0.316 NM_001085479
NM_001207023
IQCF3

IQ motif containing F3

chr6_-_134496833 0.316 SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_18807423 0.314 NM_152375
KLHDC7A
kelch domain containing 7A
chr7_-_92777657 0.306 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr1_-_55089068 0.302 NM_176782
FAM151A
family with sequence similarity 151, member A
chr5_-_149324282 0.301 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr20_+_20033157 0.297 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr1_-_207095198 0.294 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr20_+_9198036 0.293 NM_182797
PLCB4
phospholipase C, beta 4
chr6_+_134210264 0.286 TCF21
transcription factor 21
chr6_-_32191779 0.285 NM_004557
NOTCH4
notch 4
chr20_+_62367945 0.280 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr16_-_5115939 0.279 C16orf89
chromosome 16 open reading frame 89
chr22_-_50971007 0.279 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr13_+_113777112 0.277 NM_000504
F10
coagulation factor X
chr12_-_57443858 0.269 NM_005379
MYO1A
myosin IA
chr13_+_78315294 0.269 NM_001242869
NM_001242870
NM_001242871
NM_144595
SLAIN1



SLAIN motif family, member 1



chr19_-_35625989 0.268 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr4_-_2420252 0.267 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr1_-_27998700 0.266 IFI6
interferon, alpha-inducible protein 6
chr10_+_91087601 0.265 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr4_+_71494460 0.264 NM_031889
ENAM
enamelin
chr3_-_187452669 0.264 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr7_+_99621083 0.262 ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr1_+_35225341 0.261 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr8_-_110661007 0.258 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr6_-_52774460 0.258 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr6_+_32605182 0.256 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr3_-_49314281 0.255 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr8_-_12973752 0.254 NM_001164271
DLC1
deleted in liver cancer 1
chr17_-_38073792 0.248 NM_018530
GSDMB
gasdermin B
chr8_+_110346549 0.246 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr1_+_210001351 0.243 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr14_+_68168602 0.243 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr8_-_29120571 0.242 NM_015254
KIF13B
kinesin family member 13B
chr8_+_103563847 0.241 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr7_-_99680170 0.239


chr3_-_149375584 0.237 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr7_-_37393271 0.236 NM_001206482
ELMO1
engulfment and cell motility 1
chrX_+_65382627 0.235 HEPH
hephaestin
chr4_-_110723127 0.234 CFI
complement factor I
chr11_+_66610882 0.232 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein protease (S. cerevisiae)

chr7_+_117864711 0.227 NM_019644
ANKRD7
ankyrin repeat domain 7
chr1_+_162602198 0.227 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr15_+_67000929 0.224 NM_001142861
SMAD6
SMAD family member 6
chr6_-_39072412 0.221 C6orf64
chromosome 6 open reading frame 64
chr2_-_214016332 0.220 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr11_-_65150107 0.218 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr6_+_134210247 0.218 NM_198392
NM_003206
TCF21

transcription factor 21

chr11_+_10482677 0.217 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr2_-_158731622 0.214 NM_001105
ACVR1
activin A receptor, type I
chr4_-_100356290 0.213 NM_001166504
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr12_+_54955226 0.211 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr1_-_111743261 0.209 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr5_-_139943829 0.208 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr5_-_134914968 0.206 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr2_-_68384575 0.205 NM_138458
WDR92
WD repeat domain 92
chr12_+_49932842 0.204 NM_012284
KCNH3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr19_+_15052298 0.202 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr7_-_124405029 0.193 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_+_210001267 0.192 NM_014388
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr1_+_174843523 0.191 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr1_+_32645322 0.191 NM_175852
TXLNA
taxilin alpha
chr9_+_129724503 0.190 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr8_-_17555158 0.188 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr1_+_117544371 0.186 NM_004258
CD101
CD101 molecule
chr6_-_47009992 0.182 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr3_+_16974581 0.181 NM_015184
PLCL2
phospholipase C-like 2
chr8_+_62200524 0.178 NM_173519
CLVS1
clavesin 1
chr14_+_23067128 0.177 NM_022060
ABHD4
abhydrolase domain containing 4
chr17_+_68071386 0.176 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr9_-_41954687 0.175 MGC21881
uncharacterized locus MGC21881
chr5_-_13944588 0.175 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr1_+_32645259 0.174 TXLNA
taxilin alpha
chr6_-_130544098 0.171 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chrX_-_135749436 0.171 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_23521221 0.171 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr1_+_173793817 0.170 DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr17_+_7387773 0.168 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr1_-_111743297 0.167 DENND2D
DENN/MADD domain containing 2D
chr16_+_4674819 0.166 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr1_-_109204035 0.166 NM_144584
HENMT1
HEN1 methyltransferase homolog 1 (Arabidopsis)
chr6_-_46922533 0.162 NM_015234
GPR116
G protein-coupled receptor 116
chr20_-_20033005 0.162 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr1_+_210001399 0.161 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr22_+_35462125 0.160 NM_001008494
ISX
intestine-specific homeobox
chr14_+_63671101 0.158 NM_020663
RHOJ
ras homolog gene family, member J
chr11_+_61160098 0.156 TMEM216
transmembrane protein 216
chr17_-_56621682 0.156 NM_001038704
C17orf47
chromosome 17 open reading frame 47
chr7_+_107301079 0.155 NM_000441
SLC26A4
solute carrier family 26, member 4
chr8_-_101315457 0.154 NM_015435
RNF19A
ring finger protein 19A
chr1_-_226128872 0.153 NM_001172425
NM_003240
LEFTY2

left-right determination factor 2

chr11_-_47545539 0.152 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr19_+_11466173 0.152 LPPR2
lipid phosphate phosphatase-related protein type 2
chr5_-_138718941 0.152 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr19_-_3500937 0.151 NM_001145165
DOHH
deoxyhypusine hydroxylase/monooxygenase
chr16_+_28303622 0.150 NM_001024401
SBK1
SH3-binding domain kinase 1
chr10_+_96522457 0.150 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.33 3.30e-02 GO:0005769 early endosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
6.41 2.95e-02 GO:0003823 antigen binding