Motif ID: NR4A2.p2

Z-value: 0.943


Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR4A2chr2_-_157189040-0.421.9e-02Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51568323 2.093 NM_015596
KLK13
kallikrein-related peptidase 13
chr3_-_50340979 1.967 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr19_-_11689765 1.818 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr3_-_123339423 1.674 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr19_-_51472003 1.664 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr2_-_31637598 1.664 NM_000379
XDH
xanthine dehydrogenase
chr2_+_210288668 1.558 NM_001039538
MAP2
microtubule-associated protein 2
chr2_-_31637553 1.525 XDH
xanthine dehydrogenase
chr3_+_121774208 1.510 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr1_+_152881022 1.340 NM_005547
IVL
involucrin
chr15_+_65204053 1.306 NM_182703
ANKDD1A
ankyrin repeat and death domain containing 1A
chr19_-_35992798 1.297 NM_001035516
DMKN
dermokine
chr3_+_100328432 1.296 NM_032787
GPR128
G protein-coupled receptor 128
chr19_-_11689591 1.290 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr22_+_44395090 1.260 NM_001003828
PARVB
parvin, beta
chr14_-_94442894 1.256 ASB2
ankyrin repeat and SOCS box containing 2
chr3_-_123339178 1.223 MYLK
myosin light chain kinase
chr1_-_27732069 1.122 WASF2
WAS protein family, member 2
chr20_+_43344005 1.027 WISP2
WNT1 inducible signaling pathway protein 2
chr22_+_30792929 1.014 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr12_-_53601051 1.012 ITGB7
integrin, beta 7
chr9_+_139839697 0.965 NM_000606
C8G
complement component 8, gamma polypeptide
chrX_-_47489243 0.957 NM_001145252
CFP
complement factor properdin
chr8_+_86376130 0.917 NM_000067
CA2
carbonic anhydrase II
chr20_-_23030141 0.911 NM_000361
THBD
thrombomodulin
chr11_-_64528186 0.824 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr5_+_147691988 0.823 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr8_-_125740378 0.804 MTSS1
metastasis suppressor 1
chr17_-_26903926 0.784 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr19_-_41858948 0.782 TGFB1
transforming growth factor, beta 1
chr10_+_11784355 0.773 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr10_-_101841593 0.768 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr9_+_112887780 0.763 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr9_+_131191206 0.761 CERCAM
cerebral endothelial cell adhesion molecule
chr17_-_39768939 0.758 NM_005557
KRT16
keratin 16
chr6_+_34206567 0.752 NM_145905
HMGA1
high mobility group AT-hook 1
chr7_+_37960162 0.737 NM_001242946
NM_017549
EPDR1

ependymin related protein 1 (zebrafish)

chr10_-_76995685 0.736 NM_144589
COMTD1
catechol-O-methyltransferase domain containing 1
chr20_-_1309809 0.736 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr19_+_54376975 0.723 MYADM
myeloid-associated differentiation marker
chr1_+_84609941 0.723 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr20_+_3776385 0.713 NM_004358
NM_021872
NM_021873
CDC25B


cell division cycle 25 homolog B (S. pombe)


chr17_-_26903854 0.691 ALDOC
aldolase C, fructose-bisphosphate
chr19_+_589849 0.677 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chrX_-_48328564 0.675 SLC38A5
solute carrier family 38, member 5
chr12_-_772525 0.667 NM_016533
NINJ2
ninjurin 2
chrX_+_135230736 0.663 NM_001159700
FHL1
four and a half LIM domains 1
chr20_-_62130390 0.659 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr12_+_119616594 0.656 NM_014365
HSPB8
heat shock 22kDa protein 8
chr5_-_149682447 0.648 NM_001012301
ARSI
arylsulfatase family, member I
chr16_+_31484497 0.645 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr19_-_49558996 0.643 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chrX_-_153640358 0.642 NM_001009932
NM_001009933
NM_001009934
DNASE1L1


deoxyribonuclease I-like 1


chr11_-_123756339 0.638 NM_001013743
TMEM225
transmembrane protein 225
chr4_-_111119752 0.636 NM_001130721
NM_024090
ELOVL6

ELOVL fatty acid elongase 6

chr19_+_46001730 0.626 NM_001080401
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr15_+_40453263 0.625 BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr20_+_3776905 0.624 CDC25B
cell division cycle 25 homolog B (S. pombe)
chr2_+_11886739 0.619 NM_145693
LPIN1
lipin 1
chr19_+_6739697 0.604 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr2_+_113885137 0.603 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr17_-_33416238 0.602 RFFL
ring finger and FYVE-like domain containing 1
chr20_+_43343884 0.602 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr2_+_113885145 0.601 IL1RN
interleukin 1 receptor antagonist
chr3_-_42744318 0.596 NM_020707
HHATL
hedgehog acyltransferase-like
chr4_-_39033981 0.592 NM_024943
TMEM156
transmembrane protein 156
chr9_+_78505514 0.592 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr16_-_46655303 0.591 NM_024745
SHCBP1
SHC SH2-domain binding protein 1
chr9_-_136344182 0.590 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr12_+_101188373 0.581 NM_178826
ANO4
anoctamin 4
chr11_+_47270433 0.579 NM_001130102
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr1_+_20915440 0.578 NM_001785
CDA
cytidine deaminase
chr10_-_50342052 0.572 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr1_+_152974222 0.567 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr5_-_131347518 0.555 NM_001205248
NM_001205251
NM_001205250
ACSL6


acyl-CoA synthetase long-chain family member 6


chr2_-_190044330 0.553 NM_000393
COL5A2
collagen, type V, alpha 2
chr13_-_46756291 0.552 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_+_76139744 0.550 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr4_+_77227178 0.547 NM_003943
STBD1
starch binding domain 1
chr6_-_2840683 0.546 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr7_+_48128225 0.544 NM_181597
UPP1
uridine phosphorylase 1
chrX_+_152954965 0.540 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr17_-_40575117 0.535 NM_012232
PTRF
polymerase I and transcript release factor
chr17_-_1613661 0.531 NM_001164407
TLCD2
TLC domain containing 2
chr19_-_49552362 0.530 NM_033183
CGB8
chorionic gonadotropin, beta polypeptide 8
chr19_-_49016418 0.527 NM_001080434
LMTK3
lemur tyrosine kinase 3
chr16_+_8807426 0.524 ABAT
4-aminobutyrate aminotransferase
chr1_-_152552962 0.524 NM_032563
LCE3D
late cornified envelope 3D
chr2_-_233877901 0.520 NGEF
neuronal guanine nucleotide exchange factor
chr1_+_159175048 0.517 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr4_-_21699317 0.510 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr13_+_111138079 0.509 COL4A2
collagen, type IV, alpha 2
chrX_-_47489703 0.507 NM_002621
CFP
complement factor properdin
chrX_-_54824672 0.507 NM_198510
ITIH6
inter-alpha-trypsin inhibitor heavy chain family, member 6
chr18_-_47339854 0.505 ACAA2
acetyl-CoA acyltransferase 2
chr1_+_32042122 0.505 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr10_-_50122279 0.502 NM_001006939
LRRC18
leucine rich repeat containing 18
chr8_-_144650998 0.502 C8orf73
chromosome 8 open reading frame 73
chr1_+_32050510 0.501 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr17_+_2680349 0.498 RAP1GAP2
RAP1 GTPase activating protein 2
chrX_+_72223351 0.497 NM_001042506
PABPC1L2B
poly(A) binding protein, cytoplasmic 1-like 2B
chr15_-_34630203 0.494 NM_001042495
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr10_+_75504145 0.494 SEC24C
SEC24 family, member C (S. cerevisiae)
chr17_-_33390676 0.488 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr19_-_46146984 0.488 NM_001193269
EML2
echinoderm microtubule associated protein like 2
chr2_-_208031570 0.483 KLF7
Kruppel-like factor 7 (ubiquitous)
chr19_+_49547101 0.483 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr19_+_41257086 0.477 SNRPA
small nuclear ribonucleoprotein polypeptide A
chr17_-_56358118 0.477 MPO
myeloperoxidase
chr8_+_134203281 0.475 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chr14_-_103988829 0.472 CKB
creatine kinase, brain
chr10_+_101542554 0.470 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr5_-_150537261 0.469 ANXA6
annexin A6
chr7_-_140624280 0.465 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr19_-_49527419 0.464 NM_000737
CGB
chorionic gonadotropin, beta polypeptide
chr12_+_26348268 0.459 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_+_55505207 0.459 PCSK9
proprotein convertase subtilisin/kexin type 9
chr19_+_16187315 0.455 TPM4
tropomyosin 4
chr12_+_26348488 0.453 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr14_-_69354900 0.453 ACTN1
actinin, alpha 1
chr8_+_1993157 0.451 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr1_+_192127591 0.451 NM_130782
RGS18
regulator of G-protein signaling 18
chr1_+_17531619 0.450 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr13_-_60325073 0.444


chr9_-_111618209 0.442 NM_006686
ACTL7B
actin-like 7B
chr1_-_154164551 0.441 NM_152263
TPM3
tropomyosin 3
chr3_-_46718898 0.440 NM_182775
ALS2CL
ALS2 C-terminal like
chr1_+_26348265 0.437 NM_004455
EXTL1
exostoses (multiple)-like 1
chr7_-_143059144 0.436 NM_014690
FAM131B
family with sequence similarity 131, member B
chr12_-_53600999 0.436 NM_000889
ITGB7
integrin, beta 7
chr8_-_125740650 0.435 NM_014751
MTSS1
metastasis suppressor 1
chr14_-_94443065 0.431 NM_001202429
ASB2
ankyrin repeat and SOCS box containing 2
chr17_-_48264039 0.429 COL1A1
collagen, type I, alpha 1
chr6_-_39290315 0.428 NM_001135105
NM_001135106
NM_001135107
NM_032115
KCNK16



potassium channel, subfamily K, member 16



chr3_-_197024879 0.428 DLG1
discs, large homolog 1 (Drosophila)
chr2_+_113763448 0.425 NM_014440
IL36A
interleukin 36, alpha
chr17_-_39743085 0.422 NM_000526
KRT14
keratin 14
chr1_+_119957553 0.419 NM_001166120
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr8_-_145018904 0.419 NM_201381
PLEC
plectin
chr1_+_236849753 0.416 NM_001103
ACTN2
actinin, alpha 2
chr2_-_219696511 0.411 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr1_-_27816676 0.408 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chr22_+_44420154 0.407 NM_013327
PARVB
parvin, beta
chr2_+_219745243 0.407 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr12_+_71833518 0.405 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr13_+_111134933 0.405 COL4A2
collagen, type IV, alpha 2
chr17_+_11786218 0.404 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr10_+_99185977 0.404 PGAM1
phosphoglycerate mutase 1 (brain)
chr11_-_10715503 0.403 NM_001100163
NM_001206880
NM_001206881
NM_130385
MRVI1



murine retrovirus integration site 1 homolog



chr19_+_54371150 0.402 MYADM
myeloid-associated differentiation marker
chr1_+_24649529 0.398 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr11_-_74442185 0.397 NM_015424
CHRDL2
chordin-like 2
chr3_+_47029453 0.396 NBEAL2
neurobeachin-like 2
chr1_+_32042125 0.396 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr6_-_34101272 0.394 NM_000841
GRM4
glutamate receptor, metabotropic 4
chrX_-_132092224 0.392 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr12_+_93963597 0.391 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr13_+_43136871 0.390 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr6_-_131321868 0.388 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr7_+_128312345 0.388 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr17_+_4854383 0.382 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr19_-_6375859 0.381 NM_004158
PSPN
persephin
chr9_-_140142165 0.381 NM_001001710
FAM166A
family with sequence similarity 166, member A
chr1_+_24840800 0.381 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr16_+_81040120 0.381 CENPN
centromere protein N
chr16_+_81040515 0.378 CENPN
centromere protein N
chr1_-_150693321 0.378 NM_001199829
NM_032132
HORMAD1

HORMA domain containing 1

chr15_-_78423556 0.378 NM_006383
CIB2
calcium and integrin binding family member 2
chrX_-_8700132 0.378 KAL1
Kallmann syndrome 1 sequence
chr15_-_75017710 0.376 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr7_+_86273219 0.375 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr18_-_28681429 0.373 DSC2
desmocollin 2
chr5_-_176831385 0.373 F12
coagulation factor XII (Hageman factor)
chr15_-_34629941 0.373 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr10_+_75504119 0.370 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr19_-_51504799 0.369 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr5_-_150537306 0.369 ANXA6
annexin A6
chr22_-_29711474 0.369 RASL10A
RAS-like, family 10, member A
chr22_-_29711650 0.369 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr19_+_54371125 0.368 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chrX_-_100914816 0.367 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr4_+_41614725 0.364 LIMCH1
LIM and calponin homology domains 1
chr11_+_66790189 0.363 NM_001177880
SYT12
synaptotagmin XII
chr15_-_74658498 0.362 NM_001099773
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr1_+_42619091 0.361 NM_007102
GUCA2B
guanylate cyclase activator 2B (uroguanylin)
chr14_+_93389491 0.360 CHGA
chromogranin A (parathyroid secretory protein 1)
chrX_-_132095422 0.360 NM_001077188
NM_147175
HS6ST2

heparan sulfate 6-O-sulfotransferase 2

chr12_+_32654976 0.358 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_+_150954498 0.358 NM_003568
ANXA9
annexin A9
chr10_+_99186012 0.358 PGAM1
phosphoglycerate mutase 1 (brain)
chr12_-_8088629 0.357 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr1_+_150480486 0.356 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chrX_+_135251795 0.356 NM_001167819
FHL1
four and a half LIM domains 1
chr19_-_1513187 0.355 NM_213604
ADAMTSL5
ADAMTS-like 5
chr5_-_16742336 0.354 MYO10
myosin X
chrX_+_106161589 0.354 NM_001171095
CLDN2
claudin 2
chr11_+_69455837 0.353 NM_053056
CCND1
cyclin D1
chr17_-_8066254 0.353 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr10_-_75634219 0.352 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr10_+_99186004 0.352 PGAM1
phosphoglycerate mutase 1 (brain)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.20 6.70e-08 GO:0032501 multicellular organismal process
1.47 2.93e-05 GO:0007154 cell communication
1.08 3.04e-05 GO:0009987 cellular process
1.20 1.98e-04 GO:0023052 signaling
1.20 3.55e-04 GO:0032502 developmental process
1.50 4.59e-04 GO:0007267 cell-cell signaling
2.08 1.09e-03 GO:0006936 muscle contraction
1.27 1.11e-03 GO:0065008 regulation of biological quality
1.20 1.18e-03 GO:0007275 multicellular organismal development
1.99 2.76e-03 GO:0003012 muscle system process
1.20 3.31e-03 GO:0048856 anatomical structure development
1.58 3.72e-03 GO:0007010 cytoskeleton organization
1.72 1.09e-02 GO:0030029 actin filament-based process
2.82 1.32e-02 GO:0030048 actin filament-based movement
1.28 3.05e-02 GO:0009653 anatomical structure morphogenesis
1.34 3.79e-02 GO:0022607 cellular component assembly
1.51 4.03e-02 GO:0019226 transmission of nerve impulse
1.51 4.03e-02 GO:0035637 multicellular organismal signaling
1.25 4.83e-02 GO:0007166 cell surface receptor linked signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.50 6.30e-07 GO:0043292 contractile fiber
2.48 3.19e-06 GO:0030016 myofibril
2.48 4.49e-06 GO:0044449 contractile fiber part
1.28 2.04e-05 GO:0044459 plasma membrane part
1.28 5.08e-05 GO:0005829 cytosol
1.80 8.82e-05 GO:0015629 actin cytoskeleton
2.38 2.79e-04 GO:0030017 sarcomere
1.16 9.24e-04 GO:0071944 cell periphery
1.16 1.64e-03 GO:0005886 plasma membrane
1.42 2.93e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.33 3.11e-03 GO:0000267 cell fraction
1.40 5.18e-03 GO:0031988 membrane-bounded vesicle
1.39 5.59e-03 GO:0031410 cytoplasmic vesicle
1.27 6.75e-03 GO:0005856 cytoskeleton
1.37 7.80e-03 GO:0005626 insoluble fraction
1.21 1.97e-02 GO:0005576 extracellular region
1.36 2.08e-02 GO:0031982 vesicle
1.30 3.44e-02 GO:0044430 cytoskeletal part
1.71 3.67e-02 GO:0030141 stored secretory granule
1.08 4.88e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 5.77e-07 GO:0005515 protein binding
2.99 3.22e-06 GO:0005200 structural constituent of cytoskeleton
1.55 1.33e-04 GO:0005198 structural molecule activity
1.53 1.23e-03 GO:0008092 cytoskeletal protein binding
1.66 3.83e-03 GO:0003779 actin binding
1.40 8.63e-03 GO:0042802 identical protein binding
1.51 2.28e-02 GO:0008289 lipid binding