Motif ID: RBPJ.p2

Z-value: 0.971


Transcription factors associated with RBPJ.p2:

Gene SymbolEntrez IDGene Name
RBPJ 3516 recombination signal binding protein for immunoglobulin kappa J region

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RBPJchr4_+_263213070.769.0e-07Click!


Activity profile for motif RBPJ.p2.

activity profile for motif RBPJ.p2


Sorted Z-values histogram for motif RBPJ.p2

Sorted Z-values for motif RBPJ.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RBPJ.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_72435730 10.204 NM_001010940
C9orf135
chromosome 9 open reading frame 135
chr3_-_19975671 4.258 NM_144715
EFHB
EF-hand domain family, member B
chr16_+_23765947 4.062 NM_022097
CHP2
calcineurin B homologous protein 2
chr20_-_3149070 3.492 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr19_+_55888203 3.436 NM_139172
TMEM190
transmembrane protein 190
chr7_-_16921596 3.283 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr6_+_126070813 2.600 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr3_-_112564789 2.571 NM_001008784
NM_001199215
CD200R1L

CD200 receptor 1-like

chr5_-_693413 2.542 NM_007030
TPPP
tubulin polymerization promoting protein
chr16_-_67427335 2.424 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr19_-_50528683 2.351 NM_001025778
NM_016440
VRK3

vaccinia related kinase 3

chr6_+_126070724 2.306 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr1_-_223537400 2.293 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr8_-_144699716 2.292 NM_003313
TSTA3
tissue specific transplantation antigen P35B
chr14_-_54421269 2.217 NM_130851
BMP4
bone morphogenetic protein 4
chr8_-_144699695 2.194 TSTA3
tissue specific transplantation antigen P35B
chr2_+_120189342 2.175 NM_183240
TMEM37
transmembrane protein 37
chr11_-_2292181 2.061 NM_005170
ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr10_-_44144151 2.026 NM_001005368
ZNF32
zinc finger protein 32
chr5_+_42423811 2.013 NM_000163
GHR
growth hormone receptor
chr8_-_144699621 1.967 TSTA3
tissue specific transplantation antigen P35B
chr19_-_50528627 1.940 VRK3
vaccinia related kinase 3
chr2_-_160761266 1.821 NM_001198759
NM_001198760
NM_002349
LY75-CD302

LY75
LY75-CD302 readthrough

lymphocyte antigen 75
chr19_-_37064102 1.756 ZNF529
zinc finger protein 529
chr2_-_160761192 1.749 LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chr11_+_111789600 1.740 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr19_+_54024176 1.684 NM_018555
ZNF331
zinc finger protein 331
chr5_+_131630065 1.670 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr11_-_75379651 1.656 MAP6
microtubule-associated protein 6
chr6_+_126070738 1.598 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr14_-_23285011 1.583 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr13_+_37006628 1.570 CCNA1
cyclin A1
chr7_+_138818489 1.566 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr10_+_22634373 1.561 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chr3_-_51533906 1.552 VPRBP
Vpr (HIV-1) binding protein
chr19_-_50528576 1.544 VRK3
vaccinia related kinase 3
chr3_+_171561138 1.466 NM_001164436
TMEM212
transmembrane protein 212
chr11_-_2291809 1.449 ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr19_+_5681016 1.444 NM_198704
NM_198705
NM_198533
NM_198707
NM_198706
NM_198708
HSD11B1L





hydroxysteroid (11-beta) dehydrogenase 1-like





chr13_+_37006408 1.428 NM_001111045
NM_003914
CCNA1

cyclin A1

chr19_+_58816714 1.394 ERVK3-1
endogenous retrovirus group K3, member 1
chr1_+_161068150 1.391 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr19_-_55690717 1.379 SYT5
synaptotagmin V
chr2_+_102770401 1.361 NM_000877
IL1R1
interleukin 1 receptor, type I
chr19_+_58816757 1.355 ERVK3-1
endogenous retrovirus group K3, member 1
chr17_-_6735007 1.350 NM_053285
TEKT1
tektin 1
chr7_+_120590816 1.349 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr19_+_14544100 1.332 NM_002741
PKN1
protein kinase N1
chr11_+_71903172 1.329 NM_016729
FOLR1
folate receptor 1 (adult)
chr19_+_44645728 1.325 ZNF234
zinc finger protein 234
chr15_+_40697977 1.323 IVD
isovaleryl-CoA dehydrogenase
chr19_+_35168558 1.308 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr8_+_18067614 1.302 NM_000662
NM_001160170
NM_001160171
NM_001160172
NM_001160173
NM_001160175
NM_001160176
NAT1






N-acetyltransferase 1 (arylamine N-acetyltransferase)






chr15_+_40698000 1.293 IVD
isovaleryl-CoA dehydrogenase
chr22_-_50970542 1.253 ODF3B
outer dense fiber of sperm tails 3B
chr2_-_220110116 1.246 NM_024506
GLB1L
galactosidase, beta 1-like
chr16_+_84178864 1.237 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr14_+_77648127 1.228 TMEM63C
transmembrane protein 63C
chr10_+_114154522 1.226 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_+_32726659 1.221 NM_015442
CNOT10
CCR4-NOT transcription complex, subunit 10
chr10_-_61469322 1.215 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr6_+_17281773 1.172 NM_001143942
RBM24
RNA binding motif protein 24
chrX_-_19140581 1.171 NM_001079858
NM_001079859
NM_001079860
NM_001184833
NM_001184834
NM_001184835
NM_001184836
NM_001184837
NM_005756
GPR64








G protein-coupled receptor 64








chr5_-_139943829 1.156 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr11_+_94245694 1.155 NM_001190462
LOC643037
uncharacterized LOC643037
chr6_+_32811895 1.150


chr19_+_50529211 1.144 NM_001006656
NM_015428
ZNF473

zinc finger protein 473

chr19_-_54676813 1.140 NM_001145303
NM_144686
TMC4

transmembrane channel-like 4

chr14_-_106926393 1.134 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_-_44144266 1.104 NM_006973
ZNF32
zinc finger protein 32
chr19_+_50706868 1.096 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr17_+_7761310 1.057 CYB5D1
cytochrome b5 domain containing 1
chr21_+_42676176 1.052 FAM3B
family with sequence similarity 3, member B
chr14_-_90798253 1.051 NM_017970
C14orf102
chromosome 14 open reading frame 102
chr1_-_2461683 1.051 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr11_-_111250156 1.042 NM_006235
POU2AF1
POU class 2 associating factor 1
chr5_+_36608430 1.032 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_77648082 1.030 NM_020431
TMEM63C
transmembrane protein 63C
chr19_+_44716683 1.015 NM_182490
ZNF227
zinc finger protein 227
chr19_+_41594367 1.012 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr7_-_138363789 1.006 NM_001139456
SVOPL
SVOP-like
chr19_+_5681139 0.994 HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr11_+_61129407 0.977 NM_016464
TMEM138
transmembrane protein 138
chr7_+_150065968 0.973 REPIN1
replication initiator 1
chr22_-_37164073 0.970 NM_001177702
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr4_-_1685717 0.965 NM_001013622
NM_001174070
FAM53A

family with sequence similarity 53, member A

chr19_-_44809126 0.964 NM_004234
ZNF235
zinc finger protein 235
chr6_-_27440459 0.951 NM_007149
ZNF184
zinc finger protein 184
chr19_+_14544216 0.945 PKN1
protein kinase N1
chr20_-_44175995 0.945 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr6_+_31895201 0.944 NM_000063
NM_001145903
C2

complement component 2

chr22_+_30163351 0.944 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr1_-_186344383 0.914 TPR
translocated promoter region (to activated MET oncogene)
chr9_-_117156684 0.913 NM_030767
AKNA
AT-hook transcription factor
chr9_+_136325086 0.910 NM_001135775
NM_001242369
NM_001242370
NM_017586
C9orf7



chromosome 9 open reading frame 7



chr12_-_25348031 0.907 NM_001082972
NM_001082973
NM_001204101
NM_001204102
NM_018272
CASC1




cancer susceptibility candidate 1




chr19_-_10946866 0.898 NM_006858
TMED1
transmembrane emp24 protein transport domain containing 1
chr12_+_104609501 0.895 NM_001093771
TXNRD1
thioredoxin reductase 1
chr11_-_111249902 0.886 POU2AF1
POU class 2 associating factor 1
chr4_-_168155732 0.886 NM_001040159
NM_001204352
NM_001204354
NM_001204355
NM_001204356
NM_001204358
NM_001251967
NM_016950
SPOCK3







sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3







chr12_+_119772516 0.873 NM_178499
CCDC60
coiled-coil domain containing 60
chr19_-_58514713 0.868 NM_025027
ZNF606
zinc finger protein 606
chr3_+_49027281 0.867 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr5_-_179498598 0.865 RNF130
ring finger protein 130
chr1_-_186344389 0.859 NM_003292
TPR
translocated promoter region (to activated MET oncogene)
chr18_-_47814024 0.856 CXXC1
CXXC finger protein 1
chr8_+_96145968 0.856 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr5_-_149792276 0.855 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr9_-_139923214 0.849 NM_212533
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr4_-_168155576 0.837 NM_001204353
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr16_+_23313590 0.836 NM_000336
SCNN1B
sodium channel, nonvoltage-gated 1, beta
chr7_+_150065859 0.836 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr11_+_61129831 0.831 TMEM138
transmembrane protein 138
chr18_-_47814005 0.831 CXXC1
CXXC finger protein 1
chr2_+_233562031 0.831 GIGYF2
GRB10 interacting GYF protein 2
chr18_-_47814187 0.830 CXXC1
CXXC finger protein 1
chrX_-_15620191 0.824 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr11_+_827584 0.818 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr12_+_6561176 0.813 NM_018009
TAPBPL
TAP binding protein-like
chr14_-_92302612 0.811 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr5_+_140213968 0.805 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chrX_-_112084006 0.804 NM_133265
AMOT
angiomotin
chr10_+_114133775 0.802 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_+_130014828 0.799 NM_173487
C4orf33
chromosome 4 open reading frame 33
chr11_-_75379414 0.797 NM_033063
NM_207577
MAP6

microtubule-associated protein 6

chr1_-_186344330 0.786 TPR
translocated promoter region (to activated MET oncogene)
chr9_-_85678042 0.777 NM_152573
RASEF
RAS and EF-hand domain containing
chr13_+_24144402 0.772 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr2_+_233561997 0.771 NM_001103146
NM_001103147
NM_001103148
NM_015575
GIGYF2



GRB10 interacting GYF protein 2



chr19_+_9434447 0.770 NM_001202406
NM_001202407
NM_001202408
NM_001202409
NM_001202410
NM_001202411
NM_032497
ZNF559






zinc finger protein 559






chr15_+_40697685 0.770 NM_001159508
NM_002225
IVD

isovaleryl-CoA dehydrogenase

chr6_-_32805819 0.761 TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_-_7044664 0.761 NM_153376
CCDC96
coiled-coil domain containing 96
chr1_-_186344241 0.761 TPR
translocated promoter region (to activated MET oncogene)
chr12_+_12224401 0.754 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr7_-_16844606 0.750 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr15_-_49255640 0.749 NM_203349
SHC4
SHC (Src homology 2 domain containing) family, member 4
chr12_-_59314069 0.747 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr17_+_7608413 0.745 NM_001406
EFNB3
ephrin-B3
chr1_-_23810627 0.740 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr12_-_59314297 0.736 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr19_-_44143943 0.734 NM_145296
CADM4
cell adhesion molecule 4
chr8_+_96146097 0.732 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr14_-_61115906 0.721 NM_005982
SIX1
SIX homeobox 1
chr15_+_59730272 0.715 NM_152450
FAM81A
family with sequence similarity 81, member A
chr19_+_47778099 0.712 NM_178511
PRR24
proline rich 24
chr19_+_37569307 0.705 NM_144689
ZNF420
zinc finger protein 420
chr15_-_43622687 0.694 NM_014793
LCMT2
leucine carboxyl methyltransferase 2
chr19_+_9434854 0.691 NM_001172650
NM_001202412
ZNF559-ZNF177
ZNF559
ZNF559-ZNF177 readthrough
zinc finger protein 559
chr19_+_50529276 0.688 ZNF473
zinc finger protein 473
chr19_-_40596781 0.687 NM_001010880
NM_001142577
NM_001142578
NM_001142579
ZNF780A



zinc finger protein 780A



chr4_-_84256012 0.687 NM_001098540
HPSE
heparanase
chr11_-_61129273 0.685 CYBASC3
cytochrome b, ascorbate dependent 3
chr16_+_640172 0.685 NM_021168
RAB40C
RAB40C, member RAS oncogene family
chr22_+_31003069 0.683 NM_000355
NM_001184726
TCN2

transcobalamin II

chrX_-_151999259 0.683 NM_004344
CETN2
centrin, EF-hand protein, 2
chr3_+_99357439 0.682 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr14_+_57735605 0.682 NM_018229
MUDENG
MU-2/AP1M2 domain containing, death-inducing
chr15_-_65503786 0.680 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr7_+_102987970 0.679 NM_001204453
NM_002803
PSMC2

proteasome (prosome, macropain) 26S subunit, ATPase, 2

chr17_-_80231240 0.673 CSNK1D
casein kinase 1, delta
chr20_-_1165116 0.670 NM_018354
TMEM74B
transmembrane protein 74B
chr11_+_61248584 0.669 NM_001170753
NM_145017
PPP1R32

protein phosphatase 1, regulatory subunit 32

chr1_-_60392324 0.667 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr22_-_39268169 0.664 CBX6
chromobox homolog 6
chr9_-_130712866 0.664 NM_203305
FAM102A
family with sequence similarity 102, member A
chr1_-_935352 0.663 HES4
hairy and enhancer of split 4 (Drosophila)
chr6_-_32812189 0.658 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr14_-_105261850 0.652 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr9_+_100174369 0.648 TDRD7
tudor domain containing 7
chrX_+_19362010 0.642 NM_000284
NM_001173454
NM_001173455
NM_001173456
PDHA1



pyruvate dehydrogenase (lipoamide) alpha 1



chr10_+_38383218 0.638 NM_001007094
NM_001178101
NM_003421
ZNF37A


zinc finger protein 37A


chr1_-_91487543 0.632 ZNF644
zinc finger protein 644
chr16_-_68482373 0.628 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr4_-_168155691 0.627 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_-_84256304 0.623 NM_001166498
NM_006665
HPSE

heparanase

chr2_+_32853086 0.621 NM_001193509
NM_017735
TTC27

tetratricopeptide repeat domain 27

chr10_-_43048029 0.607 ZNF37BP
zinc finger protein 37B, pseudogene
chr17_-_62502236 0.603 DDX5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr1_-_186344801 0.597 TPR
translocated promoter region (to activated MET oncogene)
chr11_+_8102691 0.596 NM_177972
TUB
tubby homolog (mouse)
chr1_+_36690038 0.594 THRAP3
thyroid hormone receptor associated protein 3
chr19_+_50180408 0.590 NM_001207042
NM_001536
NM_198318
PRMT1


protein arginine methyltransferase 1


chr5_+_178450775 0.590 NM_001136116
ZNF879
zinc finger protein 879
chr3_+_49027770 0.575 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr8_+_123794043 0.571 ZHX2
zinc fingers and homeoboxes 2
chr19_+_35225095 0.571 ZNF181
zinc finger protein 181
chr1_+_155100304 0.569 NM_004428
NM_182685
EFNA1

ephrin-A1

chr5_-_76382905 0.568 NM_032367
ZBED3
zinc finger, BED-type containing 3
chr17_+_26698986 0.568 NM_015077
SARM1
sterile alpha and TIR motif containing 1
chr11_+_537521 0.567 NM_198075
LRRC56
leucine rich repeat containing 56
chr15_-_55800431 0.565 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr12_+_6898705 0.564 CD4
CD4 molecule
chr12_-_7245048 0.563 C1R
complement component 1, r subcomponent
chr19_+_50529294 0.562 ZNF473
zinc finger protein 473
chr3_+_58223228 0.560 NM_020676
ABHD6
abhydrolase domain containing 6
chr16_+_639356 0.558 NM_001172663
RAB40C
RAB40C, member RAS oncogene family
chr2_-_154335181 0.555 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr12_-_7245006 0.554 NM_001733
C1R
complement component 1, r subcomponent
chr2_+_230787195 0.553 NM_174899
FBXO36
F-box protein 36

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 1.81e-05 GO:0006355 regulation of transcription, DNA-dependent
1.43 4.06e-05 GO:0051252 regulation of RNA metabolic process
1.33 6.64e-05 GO:0060255 regulation of macromolecule metabolic process
1.39 1.06e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.39 1.61e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.36 5.28e-04 GO:0010468 regulation of gene expression
1.33 2.49e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.27 2.93e-03 GO:0031323 regulation of cellular metabolic process
1.28 3.33e-03 GO:0080090 regulation of primary metabolic process
1.31 7.99e-03 GO:0009889 regulation of biosynthetic process
1.31 1.04e-02 GO:0031326 regulation of cellular biosynthetic process
1.24 1.46e-02 GO:0019222 regulation of metabolic process
1.31 1.49e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 2.84e-06 GO:0005634 nucleus
1.15 7.34e-06 GO:0043227 membrane-bounded organelle
1.15 8.18e-06 GO:0043231 intracellular membrane-bounded organelle
1.10 1.58e-04 GO:0005622 intracellular
1.10 1.66e-04 GO:0044424 intracellular part
1.12 1.70e-04 GO:0043226 organelle
1.12 2.18e-04 GO:0043229 intracellular organelle
3.33 1.09e-02 GO:0000123 histone acetyltransferase complex
1.55 2.53e-02 GO:0044451 nucleoplasm part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.47 1.35e-06 GO:0008270 zinc ion binding
1.42 4.14e-06 GO:0046914 transition metal ion binding
1.37 1.86e-04 GO:0003677 DNA binding
1.28 9.85e-04 GO:0003676 nucleic acid binding
1.08 7.67e-03 GO:0005488 binding
1.22 9.41e-03 GO:0046872 metal ion binding
1.22 1.38e-02 GO:0043169 cation binding
1.21 1.70e-02 GO:0043167 ion binding