Motif ID: STAT1,3.p3

Z-value: 0.714


Transcription factors associated with STAT1,3.p3:

Gene SymbolEntrez IDGene Name
STAT1 6772 signal transducer and activator of transcription 1, 91kDa
STAT3 6774 signal transducer and activator of transcription 3 (acute-phase response factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT1chr2_-_1918789080.451.3e-02Click!
STAT3chr17_-_405403590.154.4e-01Click!


Activity profile for motif STAT1,3.p3.

activity profile for motif STAT1,3.p3


Sorted Z-values histogram for motif STAT1,3.p3

Sorted Z-values for motif STAT1,3.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT1,3.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_55515468 4.942 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_-_113594325 3.033 NM_000576
IL1B
interleukin 1, beta
chr1_-_153521717 2.456 NM_002960
S100A3
S100 calcium binding protein A3
chr12_-_76425375 1.895 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr19_-_11689591 1.885 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr10_-_90750955 1.793 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr7_+_80275634 1.499 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr19_+_10381763 1.449 ICAM1
intercellular adhesion molecule 1
chr11_+_62623466 1.322 NM_001012662
NM_001012664
NM_002394
SLC3A2


solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2


chr2_-_215896809 1.275 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr16_-_24968856 1.263 ARHGAP17
Rho GTPase activating protein 17
chr6_+_36646455 1.126 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr11_-_121986800 1.122 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr19_-_51845377 1.114 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr20_-_43280359 0.900 NM_000022
ADA
adenosine deaminase
chr1_-_6580068 0.889 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr16_-_3109335 0.881 LOC100507419
uncharacterized LOC100507419
chr22_+_25003610 0.854 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr1_+_111770280 0.850 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr22_+_20861875 0.831 MED15
mediator complex subunit 15
chr22_+_20861886 0.805 MED15
mediator complex subunit 15
chr22_+_20861884 0.803 NM_001003891
NM_015889
MED15

mediator complex subunit 15

chr17_-_76183074 0.740 NM_003258
TK1
thymidine kinase 1, soluble
chr8_-_143859177 0.731 LYNX1
Ly6/neurotoxin 1
chr10_+_90751044 0.715 FAS
Fas (TNF receptor superfamily, member 6)
chr8_+_27183062 0.694 NM_173175
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr1_+_153388999 0.675 NM_176823
S100A7A
S100 calcium binding protein A7A
chr19_-_4831711 0.674 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr1_-_161519526 0.661 FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr5_+_149887673 0.650 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr22_+_20861898 0.632 MED15
mediator complex subunit 15
chr8_-_143859638 0.627 NM_023946
NM_177457
LYNX1

Ly6/neurotoxin 1

chr5_-_138725544 0.605 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chrX_-_106146546 0.591 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr4_-_21546278 0.566 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr11_-_62623212 0.561 SNHG1
small nucleolar RNA host gene 1 (non-protein coding)
chr12_-_122231554 0.555 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr5_-_140013285 0.555 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr8_+_25316714 0.530 CDCA2
cell division cycle associated 2
chr19_+_44488331 0.517 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr6_+_36646489 0.506 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr9_+_132897342 0.502 GPR107
G protein-coupled receptor 107
chr3_-_119582422 0.491 GSK3B
glycogen synthase kinase 3 beta
chr2_-_70189396 0.489 NM_152792
ASPRV1
aspartic peptidase, retroviral-like 1
chr12_-_120687956 0.478 NM_025157
PXN
paxillin
chr19_+_44576266 0.477 NM_001037813
ZNF284
zinc finger protein 284
chr11_+_114167168 0.469 NNMT
nicotinamide N-methyltransferase
chr11_+_114167197 0.461 NNMT
nicotinamide N-methyltransferase
chr17_+_47923271 0.459 NM_001242791
FLJ45513
uncharacterized LOC729220
chr1_-_43833689 0.457 NM_022821
ELOVL1
ELOVL fatty acid elongase 1
chr11_-_102668822 0.448 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr6_-_30899926 0.446 NM_205854
SFTA2
surfactant associated 2
chr9_+_137004913 0.430 NM_052821
WDR5
WD repeat domain 5
chr19_-_44617271 0.426 LOC100379224
uncharacterized LOC100379224
chr17_-_76356153 0.416 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr8_+_25316736 0.411 CDCA2
cell division cycle associated 2
chr14_+_24836144 0.410 NM_001136022
NM_001198967
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr1_-_161519817 0.406 NM_000569
NM_001127592
FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

chr12_+_56211862 0.401 ORMDL2
ORM1-like 2 (S. cerevisiae)
chr20_+_34203746 0.400 NM_003116
SPAG4
sperm associated antigen 4
chr6_+_74405505 0.397 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr19_-_36001336 0.385 NM_001126059
DMKN
dermokine
chrX_-_100548044 0.380 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr19_+_10381516 0.377 NM_000201
ICAM1
intercellular adhesion molecule 1
chr3_-_50360109 0.369 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr12_-_75603214 0.366 KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr5_+_145826866 0.362 NM_001040006
NM_006706
TCERG1

transcription elongation regulator 1

chr17_+_5972425 0.355 WSCD1
WSC domain containing 1
chr10_-_75415748 0.328 NM_001114133
SYNPO2L
synaptopodin 2-like
chr20_+_35973083 0.321 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr12_+_56211718 0.320 NM_014182
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr3_-_52864687 0.319 NM_001166449
NM_002218
ITIH4

inter-alpha-trypsin inhibitor heavy chain family, member 4

chr3_-_170626425 0.318 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr12_-_69357019 0.279 NM_001874
CPM
carboxypeptidase M
chr16_-_67260900 0.267 NM_001004055
LRRC29
leucine rich repeat containing 29
chr19_-_40331153 0.265 FBL
fibrillarin
chr1_+_901876 0.264 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr1_-_154946830 0.259 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr1_-_163113938 0.258 RGS5
regulator of G-protein signaling 5
chr5_+_55062712 0.255 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr19_-_15590203 0.236 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr2_-_46384 0.235 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr6_+_54711568 0.235 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr1_-_16539103 0.234 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr11_-_102668892 0.228 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr3_+_115342302 0.227 GAP43
growth associated protein 43
chr11_+_844111 0.226 TSPAN4
tetraspanin 4
chr1_-_154946859 0.219 NM_001130041
NM_001202859
NM_003029
SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr6_-_35696359 0.216 NM_001145775
FKBP5
FK506 binding protein 5
chr6_-_111136616 0.214 CDK19
cyclin-dependent kinase 19
chr5_-_140012730 0.213 CD14
CD14 molecule
chr20_+_34556528 0.213 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr9_+_136287119 0.209 NM_139025
NM_139026
NM_139027
ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif, 13


chr19_+_44507076 0.204 NM_006300
ZNF230
zinc finger protein 230
chr11_-_118966175 0.204 NM_002105
H2AFX
H2A histone family, member X
chr1_-_144994908 0.204 PDE4DIP
phosphodiesterase 4D interacting protein
chr9_+_5450455 0.203 NM_014143
CD274
CD274 molecule
chr22_+_36044412 0.192 NM_030641
APOL6
apolipoprotein L, 6
chr1_-_155959860 0.190 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr6_+_36644236 0.188 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr11_+_130318457 0.185 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr18_-_52626636 0.182 NM_025214
CCDC68
coiled-coil domain containing 68
chr2_+_218989997 0.181 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr17_+_5323471 0.180 RPAIN
RPA interacting protein
chr3_+_115342150 0.173 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr1_-_52499432 0.173 NM_138417
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr19_+_17530856 0.171 NM_138401
FAM125A
family with sequence similarity 125, member A
chr22_+_20861964 0.170 MED15
mediator complex subunit 15
chr6_+_53883713 0.168 NM_138569
MLIP
muscular LMNA-interacting protein
chr11_+_75479766 0.167 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr9_-_137809710 0.167 NM_002003
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr8_-_8239188 0.164 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr12_+_3068989 0.162 TEAD4
TEA domain family member 4
chr16_-_3767449 0.162 NM_016292
TRAP1
TNF receptor-associated protein 1
chr4_-_76957139 0.160 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr6_-_35480635 0.159 NM_003322
TULP1
tubby like protein 1
chr2_-_86094792 0.156 NM_001042437
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr19_+_44455379 0.153 NM_013359
ZNF221
zinc finger protein 221
chr19_+_17530841 0.153 FAM125A
family with sequence similarity 125, member A
chr4_-_122148620 0.153 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr5_+_175875372 0.152 FAF2
Fas associated factor family member 2
chr11_-_124310980 0.152 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr17_-_27467395 0.150 MYO18A
myosin XVIIIA
chrX_+_48432740 0.149 NM_006743
RBM3
RNA binding motif (RNP1, RRM) protein 3
chr19_+_10828813 0.149 DNM2
dynamin 2
chr19_+_44556163 0.143 NM_013361
ZNF223
zinc finger protein 223
chr3_+_12330336 0.142 NM_138711
PPARG
peroxisome proliferator-activated receptor gamma
chr14_+_67707825 0.141 NM_022474
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr1_-_6453773 0.141 NM_007274
ACOT7
acyl-CoA thioesterase 7
chr16_-_67517715 0.139 NM_001138
AGRP
agouti related protein homolog (mouse)
chr19_+_10828763 0.139 DNM2
dynamin 2
chr11_-_64703334 0.138 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr1_-_175161832 0.136 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr6_-_27440459 0.136 NM_007149
ZNF184
zinc finger protein 184
chr20_+_2795613 0.135 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr2_+_166150340 0.135 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr19_+_11200146 0.135 LDLR
low density lipoprotein receptor
chr8_+_22853360 0.132 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr12_+_93964801 0.132 SOCS2
suppressor of cytokine signaling 2
chr14_+_55168831 0.131 SAMD4A
sterile alpha motif domain containing 4A
chr12_-_56211503 0.128 SARNP
SAP domain containing ribonucleoprotein
chr1_-_226497415 0.125 LIN9
lin-9 homolog (C. elegans)
chr1_+_113010039 0.123 NM_004185
WNT2B
wingless-type MMTV integration site family, member 2B
chr11_+_75479802 0.120 DGAT2
diacylglycerol O-acyltransferase 2
chr3_-_170626381 0.119 EIF5A2
eukaryotic translation initiation factor 5A2
chr5_+_33441046 0.118 TARS
threonyl-tRNA synthetase
chr5_+_178368193 0.118 NM_001178089
NM_001178090
NM_182594
ZNF454


zinc finger protein 454


chr12_-_56211511 0.117 NM_033082
SARNP
SAP domain containing ribonucleoprotein
chr22_-_50699687 0.116 MAPK12
mitogen-activated protein kinase 12
chr9_-_86571652 0.115 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr17_+_42422490 0.115 NM_002087
GRN
granulin
chr6_+_152126807 0.114 NM_001122741
ESR1
estrogen receptor 1
chr12_-_56211484 0.112 SARNP
SAP domain containing ribonucleoprotein
chr19_-_14049167 0.109 NM_024825
PODNL1
podocan-like 1
chr3_+_128598520 0.108 ACAD9
acyl-CoA dehydrogenase family, member 9
chr3_+_50649292 0.107 NM_001243926
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr12_+_22778085 0.107 ETNK1
ethanolamine kinase 1
chr19_+_48867650 0.107 NM_012451
SYNGR4
synaptogyrin 4
chr9_-_35618300 0.106 NM_001782
CD72
CD72 molecule
chr9_-_23821477 0.103 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_+_176432306 0.102 NM_020318
NM_021936
PAPPA2

pappalysin 2

chrX_-_134185978 0.101 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr11_+_111944967 0.101 NM_001082969
NM_001082970
NM_018195
C11orf57


chromosome 11 open reading frame 57


chr9_+_130186652 0.098 NM_007135
ZNF79
zinc finger protein 79
chr6_-_28304151 0.097 NM_001243241
NM_001243242
NM_001243244
NM_030899
ZNF323



zinc finger protein 323



chr15_+_41625152 0.096 NUSAP1
nucleolar and spindle associated protein 1
chrX_+_119738542 0.095 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr19_-_11450254 0.095 NM_004283
RAB3D
RAB3D, member RAS oncogene family
chr5_+_175875386 0.094 FAF2
Fas associated factor family member 2
chr8_-_57906143 0.092 IMPAD1
inositol monophosphatase domain containing 1
chr11_-_118966103 0.092 H2AFX
H2A histone family, member X
chr11_-_64490654 0.092 NM_015080
NM_138732
NRXN2

neurexin 2

chr2_+_171785780 0.091 GORASP2
golgi reassembly stacking protein 2, 55kDa
chr10_+_71029755 0.090 NM_033497
NM_033498
NM_033500
HK1


hexokinase 1


chr19_+_37959981 0.090 NM_144694
ZNF570
zinc finger protein 570
chr6_+_41303527 0.088 NM_001199509
NM_001199510
NM_004828
NCR2


natural cytotoxicity triggering receptor 2


chr14_-_93214873 0.088 NM_001008530
NM_005606
LGMN

legumain

chr3_+_48481706 0.088 CCDC72
coiled-coil domain containing 72
chr6_-_28303910 0.087 NM_001135216
NM_001243243
ZNF323

zinc finger protein 323

chr3_-_42744318 0.086 NM_020707
HHATL
hedgehog acyltransferase-like
chrX_-_100662905 0.084 NM_000169
GLA
galactosidase, alpha
chr1_+_116519118 0.084 NM_018420
SLC22A15
solute carrier family 22, member 15
chr3_-_169587598 0.083 NM_024727
LRRC31
leucine rich repeat containing 31
chr3_-_81810914 0.082 NM_000158
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr16_-_66952729 0.081 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr3_+_37284680 0.081 NM_001172713
NM_002078
GOLGA4

golgin A4

chrX_-_138914384 0.081 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr4_+_3443659 0.080 HGFAC
HGF activator
chr12_-_1920892 0.079 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr22_-_24096551 0.078 NM_013378
VPREB3
pre-B lymphocyte 3
chr4_-_99850242 0.078 NM_001130678
EIF4E
eukaryotic translation initiation factor 4E
chr5_+_109025135 0.078 NM_002372
MAN2A1
mannosidase, alpha, class 2A, member 1
chr3_-_81810618 0.077 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_-_144994839 0.077 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_+_130612806 0.075 NM_001199179
NM_001001485
NM_001199183
NM_001199184
NM_001199185
NM_014382
NM_001001486
NM_001001487
ATP2C1







ATPase, Ca++ transporting, type 2C, member 1







chr19_+_44598479 0.075 NM_013398
ZNF224
zinc finger protein 224
chr12_-_52967608 0.075 NM_175053
KRT74
keratin 74
chr5_-_177659800 0.074 NM_153373
AGXT2L2
alanine-glyoxylate aminotransferase 2-like 2
chr20_+_37101457 0.072 NM_020336
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
chr8_+_1772095 0.072 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.01 7.65e-03 GO:0005976 polysaccharide metabolic process
4.65 3.09e-02 GO:0070482 response to oxygen levels

Nothing significant found in compartment category.

Nothing significant found in function category.