Motif ID: TCF4_dimer.p2

Z-value: 1.920


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_53257033-0.461.1e-02Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_91505215 6.871 LUM
lumican
chr12_-_91505541 6.670 NM_002345
LUM
lumican
chr17_-_39274587 4.166 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr10_-_135150368 4.158 CALY
calcyon neuron-specific vesicular protein
chr10_-_135150474 3.963 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr5_+_148520985 3.270 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr8_+_102504661 3.175 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr8_+_102504836 2.955 GRHL2
grainyhead-like 2 (Drosophila)
chr5_+_173472692 2.722 NM_015980
HMP19
HMP19 protein
chr1_-_27339326 2.545 NM_052943
FAM46B
family with sequence similarity 46, member B
chr21_+_37507209 2.491 NM_001236
CBR3
carbonyl reductase 3
chr2_+_33359607 2.343 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr4_+_75310852 2.320 NM_001657
AREG
amphiregulin
chr17_-_39324423 2.202 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr3_-_111314181 2.117 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr20_-_590909 2.099 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr16_+_68771304 2.075 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chrX_+_16804531 2.068 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr1_+_182992694 2.066


chr6_-_45983279 2.065 NM_016929
CLIC5
chloride intracellular channel 5
chr12_+_4382882 2.019 NM_001759
CCND2
cyclin D2
chr4_+_54966197 2.008 NM_133267
GSX2
GS homeobox 2
chr2_+_79740059 1.964 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr1_-_27339448 1.962 FAM46B
family with sequence similarity 46, member B
chr11_-_66725790 1.927 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr20_+_58179601 1.915 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr22_+_30792929 1.874 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr11_+_71249070 1.866 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr1_-_47655603 1.839 PDZK1IP1
PDZK1 interacting protein 1
chr17_-_7165788 1.810 CLDN7
claudin 7
chr2_+_10861740 1.809 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr4_+_75480628 1.800 NM_001657
AREG
amphiregulin
chr13_-_20806533 1.768 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr2_-_7005764 1.766 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_-_64646053 1.755 NM_006795
EHD1
EH-domain containing 1
chr10_-_98945379 1.744 SLIT1
slit homolog 1 (Drosophila)
chrX_-_107018889 1.744 TSC22D3
TSC22 domain family, member 3
chr7_+_148036528 1.735 CNTNAP2
contactin associated protein-like 2
chr1_-_47655723 1.707 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr9_+_90112754 1.688 NM_004938
DAPK1
death-associated protein kinase 1
chr11_-_64645925 1.676 EHD1
EH-domain containing 1
chr6_-_35696359 1.669 NM_001145775
FKBP5
FK506 binding protein 5
chr15_-_44487237 1.652 NM_032892
FRMD5
FERM domain containing 5
chr15_-_44487468 1.638 FRMD5
FERM domain containing 5
chr12_-_33049664 1.630 NM_001005242
NM_004572
PKP2

plakophilin 2

chr1_-_205391180 1.624 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr2_-_224702300 1.613 NM_001039569
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr12_-_52845862 1.610 NM_005555
KRT6B
keratin 6B
chr9_+_131185129 1.603 CERCAM
cerebral endothelial cell adhesion molecule
chr9_+_34990715 1.592 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr1_+_155147051 1.589 TRIM46
tripartite motif containing 46
chr17_+_40811261 1.579 NM_016437
TUBG2
tubulin, gamma 2
chr12_-_91348950 1.560 NM_152638
C12orf12
chromosome 12 open reading frame 12
chr2_-_224702200 1.554 AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr14_-_100625931 1.535 NM_206918
DEGS2
delta(4)-desaturase, sphingolipid 2
chr3_-_45267620 1.526 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr8_+_86376130 1.526 NM_000067
CA2
carbonic anhydrase II
chr3_-_87040246 1.526 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr8_-_57026540 1.501 NM_005372
MOS
v-mos Moloney murine sarcoma viral oncogene homolog
chr17_-_8059637 1.487 PER1
period homolog 1 (Drosophila)
chr5_-_138725544 1.485 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr20_+_1246959 1.479 NM_014723
SNPH
syntaphilin
chr3_-_45267068 1.453 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr21_-_44845920 1.451 SIK1
salt-inducible kinase 1
chr9_+_124505063 1.446 NM_138709
DAB2IP
DAB2 interacting protein
chr5_+_96212167 1.446 ERAP2
endoplasmic reticulum aminopeptidase 2
chr3_-_195310985 1.442 NM_001647
APOD
apolipoprotein D
chr8_-_91094924 1.442 NM_004929
CALB1
calbindin 1, 28kDa
chr9_+_33795558 1.435 NM_002771
PRSS3
protease, serine, 3
chr17_-_7166263 1.433 NM_001185023
NM_001307
CLDN7

claudin 7

chr19_+_49055421 1.413 NM_177973
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr4_+_100871625 1.410 LOC256880
uncharacterized LOC256880
chr3_+_47021146 1.408 NM_015175
NBEAL2
neurobeachin-like 2
chr6_+_37137882 1.405 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr1_-_40098639 1.403 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr10_+_11206928 1.398 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr4_-_80994183 1.389


chr5_-_149669400 1.388 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chrX_-_128788913 1.381 NM_017413
APLN
apelin
chr7_-_130353490 1.369 COPG2
coatomer protein complex, subunit gamma 2
chr16_-_28074776 1.361 NM_001109763
GSG1L
GSG1-like
chr19_+_38755422 1.336 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755238 1.335 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr5_+_96211643 1.332 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr2_-_193059249 1.315 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr6_+_42883726 1.310 NM_001243168
NM_001243169
NM_001243170
NM_138296
PTCRA



pre T-cell antigen receptor alpha



chr2_+_231902194 1.304 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr18_-_31803514 1.302 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr13_+_28194846 1.299 NM_001206559
POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr11_-_694842 1.295 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr10_+_11060069 1.291 CELF2
CUGBP, Elav-like family member 2
chr10_-_98945580 1.287 SLIT1
slit homolog 1 (Drosophila)
chr16_+_68771214 1.283 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr10_+_11060105 1.276 CELF2
CUGBP, Elav-like family member 2
chr16_+_88705000 1.276 NM_013278
IL17C
interleukin 17C
chr8_-_49833823 1.274 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr20_+_44637539 1.272 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr19_+_38755097 1.266 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr14_+_72398816 1.263 NM_001204423
RGS6
regulator of G-protein signaling 6
chr10_+_11207053 1.248 CELF2
CUGBP, Elav-like family member 2
chr2_-_232790958 1.244 NM_024409
NPPC
natriuretic peptide C
chrX_-_107019001 1.235 NM_198057
TSC22D3
TSC22 domain family, member 3
chr1_+_152486977 1.233 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr1_-_144931707 1.233 PDE4DIP
phosphodiesterase 4D interacting protein
chr17_+_70117154 1.229 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr9_+_34990266 1.224 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr20_+_43029973 1.221 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_+_86046434 1.219 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr11_-_65667860 1.210 NM_005438
FOSL1
FOS-like antigen 1
chr10_-_103347978 1.210 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chr12_+_41086189 1.207 NM_001843
NM_175038
CNTN1

contactin 1

chr14_-_51411118 1.201 NM_001163940
NM_002863
PYGL

phosphorylase, glycogen, liver

chr20_-_33734894 1.194 EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr6_-_112194430 1.193 FYN
FYN oncogene related to SRC, FGR, YES
chr5_-_149669187 1.186 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr4_-_41216455 1.180 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr1_+_168250277 1.178 NM_005149
TBX19
T-box 19
chr3_+_30648372 1.176 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr9_-_131940481 1.176 IER5L
immediate early response 5-like
chr3_-_195310770 1.171 APOD
apolipoprotein D
chr10_-_103347882 1.169 POLL
polymerase (DNA directed), lambda
chr20_+_43029936 1.153 HNF4A
hepatocyte nuclear factor 4, alpha
chr19_+_54926721 1.146 TTYH1
tweety homolog 1 (Drosophila)
chr17_+_28705960 1.145 CPD
carboxypeptidase D
chr9_-_22009270 1.140 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr20_+_43030005 1.140 HNF4A
hepatocyte nuclear factor 4, alpha
chr19_+_54926604 1.128 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr17_+_16945766 1.126 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr19_-_45826131 1.124 CKM
creatine kinase, muscle
chr2_+_85980600 1.123 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr7_+_27135672 1.123 HOTAIRM1
HOXA transcript antisense RNA, myeloid-specific 1 (non-protein coding)
chr10_-_28591844 1.122 MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr2_+_27505296 1.119 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr7_+_80231503 1.112 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr11_-_65667809 1.109 FOSL1
FOS-like antigen 1
chr19_-_57183122 1.107 NM_001005850
ZNF835
zinc finger protein 835
chr19_+_48673936 1.107 C19orf68
chromosome 19 open reading frame 68
chr16_+_68679198 1.106 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr17_-_41174431 1.103 NM_006373
VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr12_+_110205816 1.101 C12orf34
chromosome 12 open reading frame 34
chr20_-_33735060 1.096 NM_001145025
NM_018217
EDEM2

ER degradation enhancer, mannosidase alpha-like 2

chr15_+_63340314 1.091 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr3_+_50712671 1.090 NM_004947
DOCK3
dedicator of cytokinesis 3
chr1_-_161520412 1.087 NM_001127593
NM_001127595
NM_001127596
FCGR3A


Fc fragment of IgG, low affinity IIIa, receptor (CD16a)


chr22_-_36635999 1.086 NM_145637
APOL2
apolipoprotein L, 2
chr19_-_2308155 1.084 NM_001101391
LINGO3
leucine rich repeat and Ig domain containing 3
chr16_+_68679229 1.082 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr10_+_11059854 1.080 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr5_-_44388666 1.077 NM_004465
FGF10
fibroblast growth factor 10
chr8_-_145016691 1.076 NM_201383
PLEC
plectin
chr11_-_65667858 1.076 FOSL1
FOS-like antigen 1
chr12_-_29936685 1.074 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chrX_+_1387692 1.073 NM_001161529
NM_001161531
NM_001161532
NM_006140
NM_172245
NM_172246
NM_172249
CSF2RA






colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)






chr19_+_41107220 1.072 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr16_+_11439279 1.070 NM_152308
RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr14_-_107083398 1.069 IGH@
IGHA1
IGHG1
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_-_136113832 1.067 NM_054021
GPR101
G protein-coupled receptor 101
chr16_+_11439311 1.067 RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr4_-_57522469 1.062 NM_001145459
NM_139211
HOPX

HOP homeobox

chr11_+_118401755 1.060 NM_001144034
NM_001144035
NM_001144036
NM_001144037
NM_001144038
NM_032780
TMEM25





transmembrane protein 25





chr2_+_223289285 1.060 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr19_+_16187047 1.058 NM_003290
TPM4
tropomyosin 4
chr17_-_41174402 1.056 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr1_+_110210643 1.053 NM_000848
NM_001142368
GSTM2

glutathione S-transferase mu 2 (muscle)

chr17_-_80042414 1.050 FASN
fatty acid synthase
chr7_-_1595746 1.048 NM_001097620
TMEM184A
transmembrane protein 184A
chr15_+_45722762 1.047 NM_032413
NM_197955
C15orf48

chromosome 15 open reading frame 48

chr9_-_104357202 1.044 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr14_+_72399149 1.044 NM_001204424
RGS6
regulator of G-protein signaling 6
chr6_+_47445440 1.042 NM_012120
CD2AP
CD2-associated protein
chr16_+_68771192 1.040 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr17_-_41174327 1.039 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr9_+_136399877 1.034 NM_014694
ADAMTSL2
ADAMTS-like 2
chr2_+_173600519 1.032 NM_007023
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr19_+_40146533 1.032 NM_001190441
LGALS16
lectin, galactoside-binding, soluble, 16
chr11_-_65314049 1.031 LTBP3
latent transforming growth factor beta binding protein 3
chr12_-_6484557 1.027 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr18_-_31803168 1.027 NOL4
nucleolar protein 4
chr8_+_144816287 1.025 LOC100128338
uncharacterized LOC100128338
chr17_+_1958354 1.022 NM_006497
HIC1
hypermethylated in cancer 1
chr4_-_25032306 1.018 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr21_-_38639593 1.018 DSCR3
Down syndrome critical region gene 3
chr1_+_183155393 1.014 LAMC2
laminin, gamma 2
chr1_-_22109669 1.010 NM_001032730
NM_032236
USP48

ubiquitin specific peptidase 48

chr16_+_127017 1.009 NM_001015054
MPG
N-methylpurine-DNA glycosylase
chr19_+_54385429 1.003 NM_002739
PRKCG
protein kinase C, gamma
chr20_-_23030141 1.003 NM_000361
THBD
thrombomodulin
chr14_+_105190533 1.000 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr22_-_19512001 1.000 CLDN5
claudin 5
chr3_-_178789535 1.000 ZMAT3
zinc finger, matrin-type 3
chr11_-_59612925 0.995 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr7_-_155604815 0.994 NM_000193
SHH
sonic hedgehog
chr14_-_106877689 0.993 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr7_+_1580009 0.992 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr1_-_32707198 0.992 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr5_-_134787987 0.990 NM_001099221
TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B
chr21_+_30517897 0.985 C21orf7
chromosome 21 open reading frame 7
chr17_-_76921205 0.984 TIMP2
TIMP metallopeptidase inhibitor 2
chr20_+_44044706 0.984 NM_001184728
NM_001184729
NM_001184730
NM_015937
PIGT



phosphatidylinositol glycan anchor biosynthesis, class T



chr15_-_38856830 0.983 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 3.94e-15 GO:0048856 anatomical structure development
1.25 1.40e-14 GO:0048731 system development
1.21 1.34e-13 GO:0023052 signaling
1.20 2.04e-13 GO:0032502 developmental process
1.08 6.60e-13 GO:0009987 cellular process
1.21 9.92e-13 GO:0007275 multicellular organismal development
1.11 6.29e-11 GO:0065007 biological regulation
1.30 3.45e-10 GO:0023051 regulation of signaling
1.19 7.87e-10 GO:0007165 signal transduction
1.18 1.76e-09 GO:0051179 localization
1.26 1.08e-08 GO:0048583 regulation of response to stimulus
1.30 1.57e-08 GO:0009966 regulation of signal transduction
1.24 2.40e-08 GO:0030154 cell differentiation
1.25 5.39e-08 GO:0048513 organ development
1.22 5.77e-08 GO:0042221 response to chemical stimulus
1.28 6.96e-08 GO:0009653 anatomical structure morphogenesis
1.10 7.49e-08 GO:0050789 regulation of biological process
1.11 1.08e-07 GO:0050794 regulation of cellular process
1.23 1.20e-07 GO:0048869 cellular developmental process
1.33 1.72e-07 GO:0010646 regulation of cell communication
1.18 8.61e-07 GO:0006810 transport
1.21 1.62e-06 GO:0065008 regulation of biological quality
1.37 2.25e-06 GO:0007267 cell-cell signaling
1.46 2.42e-06 GO:0048585 negative regulation of response to stimulus
1.32 2.47e-06 GO:0007154 cell communication
1.32 2.74e-06 GO:0032879 regulation of localization
1.18 2.76e-06 GO:0048518 positive regulation of biological process
1.17 3.18e-06 GO:0051234 establishment of localization
1.23 4.48e-06 GO:0007166 cell surface receptor linked signaling pathway
1.14 4.60e-06 GO:0051716 cellular response to stimulus
1.19 7.87e-06 GO:0048519 negative regulation of biological process
1.12 1.69e-05 GO:0032501 multicellular organismal process
1.20 1.86e-05 GO:0048523 negative regulation of cellular process
1.10 3.91e-05 GO:0050896 response to stimulus
1.24 5.81e-05 GO:0007399 nervous system development
1.31 8.30e-05 GO:0040011 locomotion
1.30 1.00e-04 GO:0048468 cell development
1.24 1.26e-04 GO:0035556 intracellular signal transduction
1.31 1.64e-04 GO:0055085 transmembrane transport
1.25 1.66e-04 GO:0051239 regulation of multicellular organismal process
1.35 2.02e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.44 3.35e-04 GO:0009968 negative regulation of signal transduction
1.42 4.71e-04 GO:0010648 negative regulation of cell communication
1.29 5.29e-04 GO:0009888 tissue development
1.41 6.77e-04 GO:0023057 negative regulation of signaling
1.16 8.63e-04 GO:0048522 positive regulation of cellular process
1.66 9.48e-04 GO:0071902 positive regulation of protein serine/threonine kinase activity
1.47 1.02e-03 GO:0044057 regulation of system process
1.31 1.16e-03 GO:2000026 regulation of multicellular organismal development
1.36 1.35e-03 GO:0006928 cellular component movement
1.27 1.52e-03 GO:0022008 neurogenesis
1.38 1.65e-03 GO:0019226 transmission of nerve impulse
1.38 1.65e-03 GO:0035637 multicellular organismal signaling
1.30 2.06e-03 GO:0016192 vesicle-mediated transport
1.37 2.39e-03 GO:0000904 cell morphogenesis involved in differentiation
1.28 2.66e-03 GO:0048699 generation of neurons
1.27 3.35e-03 GO:0006811 ion transport
1.40 3.43e-03 GO:0016477 cell migration
1.61 3.45e-03 GO:0003012 muscle system process
1.48 4.25e-03 GO:0040012 regulation of locomotion
1.46 4.51e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.30 4.62e-03 GO:0030182 neuron differentiation
1.38 4.74e-03 GO:0007268 synaptic transmission
1.35 5.84e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.62 6.01e-03 GO:0006936 muscle contraction
1.29 6.18e-03 GO:0007155 cell adhesion
1.29 6.18e-03 GO:0022610 biological adhesion
1.37 6.36e-03 GO:0048870 cell motility
1.37 6.36e-03 GO:0051674 localization of cell
1.26 6.94e-03 GO:0050793 regulation of developmental process
1.27 7.75e-03 GO:0044093 positive regulation of molecular function
1.45 7.93e-03 GO:0045860 positive regulation of protein kinase activity
1.22 8.35e-03 GO:0050790 regulation of catalytic activity
1.46 9.89e-03 GO:0051270 regulation of cellular component movement
1.37 1.02e-02 GO:0061024 membrane organization
1.52 1.02e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.29 1.06e-02 GO:0051049 regulation of transport
1.24 1.09e-02 GO:0009605 response to external stimulus
1.44 1.10e-02 GO:0033674 positive regulation of kinase activity
1.43 1.14e-02 GO:0001501 skeletal system development
1.55 1.16e-02 GO:0010817 regulation of hormone levels
1.43 1.22e-02 GO:0051347 positive regulation of transferase activity
1.32 1.27e-02 GO:0048666 neuron development
1.34 1.50e-02 GO:0006935 chemotaxis
1.34 1.50e-02 GO:0042330 taxis
1.50 1.57e-02 GO:0006897 endocytosis
1.50 1.57e-02 GO:0010324 membrane invagination
1.36 1.95e-02 GO:0016044 cellular membrane organization
1.42 2.03e-02 GO:0051046 regulation of secretion
1.36 2.17e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.63 2.26e-02 GO:0043406 positive regulation of MAP kinase activity
1.46 2.26e-02 GO:0030334 regulation of cell migration
1.28 2.38e-02 GO:0043085 positive regulation of catalytic activity
1.19 2.49e-02 GO:0065009 regulation of molecular function
2.49 2.65e-02 GO:0050999 regulation of nitric-oxide synthase activity
1.22 3.35e-02 GO:0042981 regulation of apoptosis
1.35 3.91e-02 GO:0007409 axonogenesis
1.30 4.10e-02 GO:0009887 organ morphogenesis
1.45 4.35e-02 GO:2000145 regulation of cell motility
1.69 4.62e-02 GO:0031098 stress-activated protein kinase signaling cascade

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 1.64e-14 GO:0005737 cytoplasm
1.13 2.60e-10 GO:0044444 cytoplasmic part
1.23 1.24e-09 GO:0044459 plasma membrane part
1.09 4.50e-08 GO:0016020 membrane
1.20 6.32e-07 GO:0031090 organelle membrane
1.34 6.72e-07 GO:0005626 insoluble fraction
1.34 1.37e-06 GO:0005624 membrane fraction
1.22 7.85e-06 GO:0012505 endomembrane system
1.33 9.21e-06 GO:0031410 cytoplasmic vesicle
1.33 1.36e-05 GO:0031988 membrane-bounded vesicle
1.32 1.51e-05 GO:0031982 vesicle
1.27 1.60e-05 GO:0000267 cell fraction
1.33 1.78e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
1.19 2.60e-05 GO:0005829 cytosol
1.51 1.28e-04 GO:0012506 vesicle membrane
1.11 1.55e-04 GO:0071944 cell periphery
1.46 2.22e-04 GO:0044433 cytoplasmic vesicle part
1.25 2.45e-04 GO:0044421 extracellular region part
1.11 3.44e-04 GO:0005886 plasma membrane
1.49 4.03e-04 GO:0030659 cytoplasmic vesicle membrane
1.52 5.44e-04 GO:0016323 basolateral plasma membrane
1.20 3.01e-03 GO:0031226 intrinsic to plasma membrane
1.20 4.00e-03 GO:0005887 integral to plasma membrane
1.25 4.25e-03 GO:0005615 extracellular space
1.63 7.44e-03 GO:0043292 contractile fiber
1.36 7.96e-03 GO:0031012 extracellular matrix
1.65 9.74e-03 GO:0030016 myofibril
1.15 1.08e-02 GO:0005576 extracellular region
1.53 1.26e-02 GO:0070161 anchoring junction
1.33 2.61e-02 GO:0043005 neuron projection
1.26 3.13e-02 GO:0030054 cell junction
1.07 3.58e-02 GO:0044425 membrane part
1.33 3.92e-02 GO:0009986 cell surface
1.70 4.90e-02 GO:0030139 endocytic vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 2.32e-11 GO:0005515 protein binding
1.29 3.18e-05 GO:0022857 transmembrane transporter activity
1.29 1.26e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.25 5.57e-04 GO:0005102 receptor binding
1.28 1.29e-03 GO:0015075 ion transmembrane transporter activity
1.24 1.42e-03 GO:0022892 substrate-specific transporter activity
1.24 2.99e-03 GO:0030234 enzyme regulator activity
1.21 4.19e-03 GO:0005215 transporter activity
1.30 7.37e-03 GO:0008324 cation transmembrane transporter activity
1.32 1.82e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.04 2.13e-02 GO:0005488 binding
1.31 2.76e-02 GO:0030695 GTPase regulator activity
1.24 2.92e-02 GO:0042802 identical protein binding
1.28 3.81e-02 GO:0008092 cytoskeletal protein binding
1.52 4.32e-02 GO:0005085 guanyl-nucleotide exchange factor activity