Motif ID: TFAP4.p2

Z-value: 1.764


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_4323000,
chr16_-_4322695
-0.461.1e-02Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_20915440 6.221 NM_001785
CDA
cytidine deaminase
chr6_+_37137882 5.954 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr12_-_54812936 5.212 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_54813002 5.062 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_-_15343194 4.266 NM_024794
EPHX3
epoxide hydrolase 3
chr2_+_95691428 4.260 NM_002371
NM_022438
NM_022439
NM_022440
MAL



mal, T-cell differentiation protein



chr17_-_76921076 3.957 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_55658310 3.882 TNNT1
troponin T type 1 (skeletal, slow)
chr12_-_54813010 3.869 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr18_+_33877630 3.723 NM_025135
FHOD3
formin homology 2 domain containing 3
chr18_-_47339854 3.708 ACAA2
acetyl-CoA acyltransferase 2
chr10_+_88718287 3.688 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr19_-_19051112 3.625 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr1_+_32050510 3.619 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr6_-_35696359 3.544 NM_001145775
FKBP5
FK506 binding protein 5
chr5_-_136834887 3.510 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr17_+_70117177 3.376 SOX9
SRY (sex determining region Y)-box 9
chr3_-_87040246 3.284 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr10_-_103347978 3.275 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chr8_-_6735438 3.229 NM_005218
DEFB1
defensin, beta 1
chr10_-_103347882 3.220 POLL
polymerase (DNA directed), lambda
chr17_+_70117168 3.137 SOX9
SRY (sex determining region Y)-box 9
chr17_-_39324423 3.043 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr17_+_70117154 2.910 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr8_+_90770201 2.889 RIPK2
receptor-interacting serine-threonine kinase 2
chr11_+_65779461 2.888 NM_001323
CST6
cystatin E/M
chr1_+_182992694 2.863


chr3_+_122785855 2.850 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr12_-_52845862 2.806 NM_005555
KRT6B
keratin 6B
chrX_-_54522318 2.771 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr12_+_107712151 2.760 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr17_-_76921205 2.709 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_30652434 2.686 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr12_-_124018428 2.672 RILPL1
Rab interacting lysosomal protein-like 1
chr3_+_150125983 2.643 TSC22D2
TSC22 domain family, member 2
chr22_+_31489343 2.602 SMTN
smoothelin
chr11_+_43963809 2.576 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr12_-_76424474 2.565 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr17_-_39274587 2.479 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr5_-_140013034 2.465 NM_000591
CD14
CD14 molecule
chr3_-_139258531 2.454 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr19_-_55720812 2.446 NM_001161440
NM_002842
PTPRH

protein tyrosine phosphatase, receptor type, H

chr22_+_38071612 2.412 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr12_-_52585686 2.406 NM_001081492
NM_182507
KRT80

keratin 80

chrX_-_106959597 2.399 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr11_+_5617330 2.303 NM_058166
TRIM6
tripartite motif containing 6
chr17_-_39553796 2.287 NM_002277
KRT31
keratin 31
chr10_-_3827205 2.279 KLF6
Kruppel-like factor 6
chr16_-_87903028 2.249 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr3_+_5021305 2.245 BHLHE40
basic helix-loop-helix family, member e40
chr17_-_39254374 2.197 NM_031960
KRTAP4-8
keratin associated protein 4-8
chr1_+_90098643 2.169 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr1_-_94147201 2.148 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chrX_-_106960028 2.099 TSC22D3
TSC22 domain family, member 3
chr17_+_74380676 2.069 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr19_-_51845377 2.064 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr19_-_11689765 2.017 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr12_+_13349720 2.007 EMP1
epithelial membrane protein 1
chr10_-_43762366 2.000 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr17_+_39968961 1.999 NM_021939
FKBP10
FK506 binding protein 10, 65 kDa
chr1_-_6580068 1.974 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_-_17559375 1.925 NM_001190844
TMEM221
transmembrane protein 221
chr3_+_150126705 1.921 NM_014779
TSC22D2
TSC22 domain family, member 2
chr17_+_40811261 1.916 NM_016437
TUBG2
tubulin, gamma 2
chr1_-_22263676 1.902 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr17_+_74380943 1.820 SPHK1
sphingosine kinase 1
chr10_+_102106958 1.805 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_-_6479880 1.803 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr4_+_8200918 1.783 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr1_+_55505207 1.768 PCSK9
proprotein convertase subtilisin/kexin type 9
chr11_-_627172 1.768 NM_021920
SCT
secretin
chr1_+_90098693 1.765 LRRC8C
leucine rich repeat containing 8 family, member C
chr1_+_55505148 1.747 NM_174936
PCSK9
proprotein convertase subtilisin/kexin type 9
chr12_-_53242716 1.723 NM_173352
KRT78
keratin 78
chr12_-_124018066 1.723 NM_178314
RILPL1
Rab interacting lysosomal protein-like 1
chr9_-_72287097 1.707 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr16_+_46919101 1.688 NM_001142466
GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr12_+_13349601 1.679 NM_001423
EMP1
epithelial membrane protein 1
chrX_-_46618596 1.659 SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr8_+_31497267 1.640 NM_013962
NRG1
neuregulin 1
chr15_+_89182038 1.624 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr17_+_42081913 1.622 NM_153006
NAGS
N-acetylglutamate synthase
chr1_+_37940074 1.617 NM_025079
ZC3H12A
zinc finger CCCH-type containing 12A
chr11_-_66725790 1.611 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr18_-_21166378 1.605 NPC1
Niemann-Pick disease, type C1
chr17_-_80009649 1.596 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr21_-_28217692 1.585 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_+_37940180 1.584 ZC3H12A
zinc finger CCCH-type containing 12A
chr7_-_128045995 1.575 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr1_+_37940129 1.571 ZC3H12A
zinc finger CCCH-type containing 12A
chr2_+_113885145 1.549 IL1RN
interleukin 1 receptor antagonist
chrX_-_38079980 1.546 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr17_-_202617 1.540 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr4_+_8582216 1.537 NM_080819
GPR78
G protein-coupled receptor 78
chr2_+_238536183 1.507 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr1_-_6662681 1.501 KLHL21
kelch-like 21 (Drosophila)
chr19_-_11689591 1.499 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr1_+_182992329 1.499 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr4_+_7194317 1.495 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr16_+_71392637 1.485 CALB2
calbindin 2
chr2_+_113885137 1.482 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr5_+_159848876 1.479 PTTG1
pituitary tumor-transforming 1
chr19_+_54376975 1.476 MYADM
myeloid-associated differentiation marker
chr5_+_159848835 1.465 NM_004219
PTTG1
pituitary tumor-transforming 1
chr2_+_11886739 1.463 NM_145693
LPIN1
lipin 1
chr8_+_90769974 1.460 NM_003821
RIPK2
receptor-interacting serine-threonine kinase 2
chr17_-_74581881 1.445 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr9_-_35689902 1.444 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr5_-_140012730 1.443 CD14
CD14 molecule
chr21_-_28217272 1.436 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr20_-_52790511 1.431 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr4_-_56502358 1.431 NM_006681
NMU
neuromedin U
chr8_+_37887990 1.418 NM_004095
EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1
chr21_+_30452872 1.409 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr18_-_21166440 1.400 NM_000271
NPC1
Niemann-Pick disease, type C1
chr9_-_35689799 1.390 TPM2
tropomyosin 2 (beta)
chr19_+_38810461 1.386 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr8_-_28243589 1.369 ZNF395
zinc finger protein 395
chr6_-_144385647 1.364 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr1_+_209848659 1.362 NM_015714
G0S2
G0/G1switch 2
chr1_-_6551759 1.327 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr20_+_37555055 1.327 FAM83D
family with sequence similarity 83, member D
chr14_+_24867926 1.324 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr9_-_123639462 1.322 PHF19
PHD finger protein 19
chr4_-_159093717 1.314 NM_016613
FAM198B
family with sequence similarity 198, member B
chr7_+_86273867 1.312 GRM3
glutamate receptor, metabotropic 3
chr9_-_139890984 1.312 NM_004669
CLIC3
chloride intracellular channel 3
chr10_+_102107001 1.311 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr19_-_51017765 1.309 NM_001024656
ASPDH
aspartate dehydrogenase domain containing
chr3_+_5021141 1.296 BHLHE40
basic helix-loop-helix family, member e40
chr5_-_134369841 1.296 NM_002653
PITX1
paired-like homeodomain 1
chr12_-_8043743 1.295 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr9_-_129884961 1.290 ANGPTL2
angiopoietin-like 2
chr11_-_67120943 1.286 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr8_-_145669796 1.285 NM_013432
TONSL
tonsoku-like, DNA repair protein
chr7_+_73703704 1.285 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr11_-_119187811 1.283 NM_006500
MCAM
melanoma cell adhesion molecule
chr8_-_144650884 1.280 C8orf73
chromosome 8 open reading frame 73
chr2_-_216003068 1.277 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr6_-_99797530 1.275 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr8_-_28243941 1.273 NM_018660
ZNF395
zinc finger protein 395
chr19_-_36001336 1.270 NM_001126059
DMKN
dermokine
chr19_-_46999149 1.251 NM_020709
PNMAL2
PNMA-like 2
chr8_+_22022872 1.251 BMP1
bone morphogenetic protein 1
chr17_-_39092714 1.250 KRT23
keratin 23 (histone deacetylase inducible)
chr10_+_124220990 1.248 NM_002775
HTRA1
HtrA serine peptidase 1
chr22_+_38302085 1.247 NM_033386
MICALL1
MICAL-like 1
chr17_-_202557 1.246 RPH3AL
rabphilin 3A-like (without C2 domains)
chr1_-_8086392 1.245 NM_018948
ERRFI1
ERBB receptor feedback inhibitor 1
chr19_-_36004553 1.241 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr8_+_22022677 1.240 BMP1
bone morphogenetic protein 1
chr2_-_31361591 1.235 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr5_-_112630301 1.235 MCC
mutated in colorectal cancers
chr1_+_150521786 1.234 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr13_+_110959592 1.233 NM_001846
COL4A2
collagen, type IV, alpha 2
chr10_+_73156650 1.224 NM_001171930
NM_001171931
NM_001171932
NM_022124
NM_052836
CDH23




cadherin-related 23




chr7_-_50861114 1.224 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr7_-_24797052 1.222 NM_001127453
DFNA5
deafness, autosomal dominant 5
chr19_+_531737 1.220 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr3_-_139258477 1.212 RBP1
retinol binding protein 1, cellular
chr15_-_42264687 1.212 EHD4
EH-domain containing 4
chr17_-_17740309 1.206 NM_001005291
NM_004176
SREBF1

sterol regulatory element binding transcription factor 1

chr20_+_23471765 1.203 NM_005492
CST8
cystatin 8 (cystatin-related epididymal specific)
chr17_-_76921453 1.199 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr20_+_62328068 1.198 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr11_+_126275947 1.195 ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr4_-_15939949 1.192 FGFBP1
fibroblast growth factor binding protein 1
chr17_+_74381419 1.188 SPHK1
sphingosine kinase 1
chr8_-_144650998 1.187 C8orf73
chromosome 8 open reading frame 73
chr7_+_86274076 1.187 GRM3
glutamate receptor, metabotropic 3
chr8_-_145669771 1.184 TONSL
tonsoku-like, DNA repair protein
chr20_+_37554954 1.182 NM_030919
FAM83D
family with sequence similarity 83, member D
chr17_+_58499854 1.180 NM_181707
C17orf64
chromosome 17 open reading frame 64
chr4_-_15940362 1.177 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr11_+_842821 1.176 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr16_+_88923490 1.175 NM_016209
TRAPPC2L
trafficking protein particle complex 2-like
chr11_+_133938965 1.173 JAM3
junctional adhesion molecule 3
chr6_-_26124130 1.167 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr1_-_47655723 1.166 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr8_+_22022644 1.162 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr16_-_2770551 1.161 NM_031948
PRSS27
protease, serine 27
chr9_+_131185129 1.155 CERCAM
cerebral endothelial cell adhesion molecule
chr7_+_18126543 1.146 NM_001204144
HDAC9
histone deacetylase 9
chr6_+_26199712 1.144 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr6_+_151646634 1.140 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr2_-_26205437 1.138 NM_002254
KIF3C
kinesin family member 3C
chr7_+_129074235 1.136 NM_001134336
NM_020704
FAM40B

family with sequence similarity 40, member B

chr9_+_43684800 1.134 NM_001201380
CNTNAP3B
contactin associated protein-like 3B
chr1_-_6662898 1.126 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr17_-_62207362 1.124 ERN1
endoplasmic reticulum to nucleus signaling 1
chr11_+_63580922 1.123 NM_138471
C11orf84
chromosome 11 open reading frame 84
chr11_+_124735281 1.115 NM_022370
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr11_+_62648340 1.113 NM_001013251
SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_-_120612260 1.109 NOTCH2
notch 2
chr10_-_77161424 1.109 NM_032772
ZNF503
zinc finger protein 503
chr12_+_5153084 1.108 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr17_-_8055684 1.104 NM_002616
PER1
period homolog 1 (Drosophila)
chr1_-_8086347 1.103 ERRFI1
ERBB receptor feedback inhibitor 1
chr10_+_99332197 1.103 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr10_-_74856656 1.103 NM_000917
NM_001017962
NM_001142595
NM_001142596
P4HA1



prolyl 4-hydroxylase, alpha polypeptide I




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 5.52e-09 GO:0023052 signaling
1.26 1.59e-07 GO:0007165 signal transduction
1.20 1.25e-05 GO:0051716 cellular response to stimulus
1.12 1.29e-05 GO:0065007 biological regulation
1.12 1.54e-04 GO:0050789 regulation of biological process
1.08 1.61e-04 GO:0009987 cellular process
1.12 3.51e-04 GO:0050794 regulation of cellular process
1.29 2.78e-03 GO:0023051 regulation of signaling
1.44 1.97e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.22 2.12e-02 GO:0042221 response to chemical stimulus
1.34 4.27e-02 GO:0032879 regulation of localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 1.88e-03 GO:0005737 cytoplasm
1.54 8.07e-03 GO:0009986 cell surface
1.50 2.75e-02 GO:0031012 extracellular matrix
1.28 2.84e-02 GO:0000267 cell fraction
4.90 3.57e-02 GO:0043256 laminin complex
1.28 4.97e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 1.19e-08 GO:0005515 protein binding
1.05 4.48e-02 GO:0005488 binding