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Motif ID: TFEB.p2

Z-value: 0.920

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_+_23286384	4.697		GPNMB	glycoprotein (transmembrane) nmb
chr7_+_23286386	4.658		GPNMB	glycoprotein (transmembrane) nmb
chr19_-_10764449	4.300		LOC147727	uncharacterized LOC147727
chr7_+_23286390	4.244		GPNMB	glycoprotein (transmembrane) nmb
chr22_+_35777087	3.121		HMOX1	heme oxygenase (decycling) 1
chr1_-_207119707	2.910	NM_002644	PIGR	polymeric immunoglobulin receptor
chr7_+_23286401	2.317		GPNMB	glycoprotein (transmembrane) nmb
chr9_-_138391696	2.268	NM_001048265 NM_144654	C9orf116	chromosome 9 open reading frame 116
chr7_+_23286420	2.251		GPNMB	glycoprotein (transmembrane) nmb
chr5_+_172483285	2.011	NM_001168393 NM_001168394 NM_153607	C5orf41	chromosome 5 open reading frame 41
chr22_-_41593466	1.891
chr1_+_183605207	1.842	NM_015149	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr4_-_149363498	1.831	NM_000901 NM_001166104	NR3C2	nuclear receptor subfamily 3, group C, member 2
chr19_+_45504686	1.805	NM_006509	RELB	v-rel reticuloendotheliosis viral oncogene homolog B
chr1_+_150255228	1.748	NM_144697	C1orf51	chromosome 1 open reading frame 51
chr22_+_35777051	1.606	NM_002133	HMOX1	heme oxygenase (decycling) 1
chr4_+_37455551	1.544	NM_001104629	C4orf19	chromosome 4 open reading frame 19
chr11_+_120894756	1.507	NM_001130047 NM_152715	TBCEL	tubulin folding cofactor E-like
chrX_+_152240726	1.445	NM_001170944 NM_001242319 NM_032882	PNMA6C PNMA6D PNMA6A	paraneoplastic antigen like 6C paraneoplastic antigen like 6D paraneoplastic antigen like 6A
chrX_+_55744049	1.431	NM_006064 NM_016656	RRAGB	Ras-related GTP binding B
chr2_-_238499317	1.390		RAB17	RAB17, member RAS oncogene family
chr1_-_150738255	1.357		CTSS	cathepsin S
chr1_+_20512577	1.337	NM_152376	UBXN10	UBX domain protein 10
chr18_+_9136742	1.332	NM_001083625 NM_015208	ANKRD12	ankyrin repeat domain 12
chr20_-_39317875	1.285	NM_005461	MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr9_-_90589593	1.258	NM_001039803 NM_001170639 NM_001170640 NM_012119 NM_178432	CDK20	cyclin-dependent kinase 20
chr11_+_18344113	1.257		GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr12_-_63328663	1.247	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr17_+_3540004	1.244		CTNS	cystinosin, lysosomal cystine transporter
chr8_-_71581354	1.228		LACTB2	lactamase, beta 2
chr6_-_90121966	1.223	NM_021244	RRAGD	Ras-related GTP binding D
chr7_+_23286277	1.200	NM_001005340 NM_002510	GPNMB	glycoprotein (transmembrane) nmb
chr2_+_85980600	1.179	NM_032827	ATOH8	atonal homolog 8 (Drosophila)
chr10_-_32217687	1.145		ARHGAP12	Rho GTPase activating protein 12
chr19_+_14544100	1.138	NM_002741	PKN1	protein kinase N1
chr13_+_43355685	1.136	NM_182508	C13orf30	chromosome 13 open reading frame 30
chr16_+_84178864	1.118	NM_178452	DNAAF1	dynein, axonemal, assembly factor 1
chr4_-_657424	1.113
chr20_+_44519924	1.112		CTSA	cathepsin A
chr8_-_71581419	1.110	NM_016027	LACTB2	lactamase, beta 2
chr3_-_122512526	1.084	NM_024610	HSPBAP1	HSPB (heat shock 27kDa) associated protein 1
chr12_-_65153148	1.081		GNS	glucosamine (N-acetyl)-6-sulfatase
chr3_-_45883562	1.080	NM_020347	LZTFL1	leucine zipper transcription factor-like 1
chr6_-_90121911	1.070		RRAGD	Ras-related GTP binding D
chr17_-_38256905	1.060	NM_021724	NR1D1	nuclear receptor subfamily 1, group D, member 1
chr1_-_204329043	1.053	NM_014935	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr10_+_69644341	1.053	NM_012238	SIRT1	sirtuin 1
chr17_-_57184116	1.044		TRIM37	tripartite motif containing 37
chr9_-_90589360	1.011		CDK20	cyclin-dependent kinase 20
chr17_+_72270385	1.006	NM_001172810 NM_023036	DNAI2	dynein, axonemal, intermediate chain 2
chr5_-_131132715	1.003	NM_001008738 NM_133372	FNIP1	folliculin interacting protein 1
chr1_-_150738232	1.000		CTSS	cathepsin S
chr6_+_138188352	0.998	NM_006290	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr12_-_65153055	0.998		GNS	glucosamine (N-acetyl)-6-sulfatase
chr20_+_44520021	0.988		CTSA	cathepsin A
chr3_+_23986735	0.966	NM_005126	NR1D2	nuclear receptor subfamily 1, group D, member 2
chr17_-_35969401	0.959	NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882	SYNRG	synergin, gamma
chrX_+_101975641	0.955	NM_001142524 NM_001142525 NM_001142526 NM_001142527 NM_001142528 NM_030639	BHLHB9	basic helix-loop-helix domain containing, class B, 9
chr17_+_17876126	0.933	NM_001130090 NM_001130091 NM_001130092 NM_031294	LRRC48	leucine rich repeat containing 48
chr20_+_44519965	0.931		CTSA	cathepsin A
chr17_-_38256548	0.918		NR1D1	nuclear receptor subfamily 1, group D, member 1
chr1_-_42921676	0.899		ZMYND12	zinc finger, MYND-type containing 12
chr11_+_1330977	0.898		LOC255512	uncharacterized LOC255512
chr6_-_90121656	0.888		RRAGD	Ras-related GTP binding D
chr19_-_36545298	0.878		THAP8	THAP domain containing 8
chr6_-_84937313	0.868	NM_014895	KIAA1009	KIAA1009
chr4_+_39184023	0.862	NM_025132	WDR19	WD repeat domain 19
chr19_-_36545119	0.862		THAP8	THAP domain containing 8
chr16_-_88923233	0.861		GALNS	galactosamine (N-acetyl)-6-sulfate sulfatase
chr22_-_39268230	0.859	NM_014292	CBX6	chromobox homolog 6
chr14_+_45431333	0.857	NM_015091	FAM179B	family with sequence similarity 179, member B
chr3_+_51428698	0.856	NM_013286	RBM15B	RNA binding motif protein 15B
chr12_-_112450914	0.852	NM_001193453 NM_001193531 NM_138341	LOC728543 TMEM116	uncharacterized LOC728543 transmembrane protein 116
chr10_-_32217762	0.851	NM_018287	ARHGAP12	Rho GTPase activating protein 12
chr20_+_44520203	0.846		CTSA	cathepsin A
chr17_+_1628032	0.845	NM_001163809	WDR81	WD repeat domain 81
chr20_-_2821245	0.844	NM_022760	FAM113A	family with sequence similarity 113, member A
chr13_-_110438896	0.834	NM_003749	IRS2	insulin receptor substrate 2
chr14_+_77564570	0.832	NM_033426	KIAA1737	KIAA1737
chr22_-_39268214	0.823		CBX6	chromobox homolog 6
chr14_-_20929635	0.822	NM_001100814 NM_144568	TMEM55B	transmembrane protein 55B
chr19_+_14544216	0.815		PKN1	protein kinase N1
chr12_-_65153182	0.814		GNS	glucosamine (N-acetyl)-6-sulfatase
chr7_+_102074002	0.814		ORAI2	ORAI calcium release-activated calcium modulator 2
chr17_+_79885567	0.814		LOC92659	uncharacterized LOC92659
chr17_+_42977141	0.808	NM_213607	CCDC103	coiled-coil domain containing 103
chr19_-_11545900	0.808	NM_145045	CCDC151	coiled-coil domain containing 151
chr17_+_18218605	0.807		SMCR8	Smith-Magenis syndrome chromosome region, candidate 8
chr5_+_140220811	0.794	NM_018911 NM_031856	PCDHA8	protocadherin alpha 8
chr22_-_39268169	0.794		CBX6	chromobox homolog 6
chr13_-_50159628	0.792		RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr7_+_106685007	0.791	NM_002736	PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta
chr6_+_87865261	0.786	NM_015021	ZNF292	zinc finger protein 292
chr1_-_154928564	0.785	NM_020524	PBXIP1	pre-B-cell leukemia homeobox interacting protein 1
chr5_-_1112106	0.780	NM_006598	SLC12A7	solute carrier family 12 (potassium/chloride transporters), member 7
chr14_-_88459459	0.778		GALC	galactosylceramidase
chr3_-_187463474	0.773	NM_001706	BCL6	B-cell CLL/lymphoma 6
chr2_+_46926049	0.773	NM_014011	SOCS5	suppressor of cytokine signaling 5
chr9_+_6757919	0.773		KDM4C	lysine (K)-specific demethylase 4C
chr1_-_154928595	0.757		PBXIP1	pre-B-cell leukemia homeobox interacting protein 1
chr9_-_131709783	0.754	NM_014908	DOLK	dolichol kinase
chr19_-_5340700	0.752	NM_002850 NM_130853 NM_130854 NM_130855	PTPRS	protein tyrosine phosphatase, receptor type, S
chr11_-_66335958	0.746	NM_003793	CTSF	cathepsin F
chr7_+_102073953	0.741	NM_001126340 NM_032831	ORAI2	ORAI calcium release-activated calcium modulator 2
chr7_-_2354010	0.740		SNX8	sorting nexin 8
chr17_+_78075390	0.738		GAA	glucosidase, alpha; acid
chr1_-_40782924	0.738	NM_001852	COL9A2	collagen, type IX, alpha 2
chr5_-_131132642	0.738		FNIP1	folliculin interacting protein 1
chr17_+_48172508	0.726	NM_001199900 NM_002611 NM_001199899	PDK2	pyruvate dehydrogenase kinase, isozyme 2
chr11_-_6640645	0.722		TPP1	tripeptidyl peptidase I
chrX_+_10124984	0.718	NM_001830	CLCN4	chloride channel 4
chr10_+_46222647	0.713	NM_001169106 NM_001169107 NM_015262	FAM21C	family with sequence similarity 21, member C
chr20_-_2821120	0.713		FAM113A	family with sequence similarity 113, member A
chr15_-_50978921	0.704		TRPM7	transient receptor potential cation channel, subfamily M, member 7
chr12_-_63328857	0.703		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr3_+_183353355	0.700	NM_017644	KLHL24	kelch-like 24 (Drosophila)
chr9_-_126030854	0.692	NM_001171137	STRBP	spermatid perinuclear RNA binding protein
chr1_-_154193044	0.691		C1orf43	chromosome 1 open reading frame 43
chr20_-_62436855	0.686	NM_025224	ZBTB46	zinc finger and BTB domain containing 46
chr5_+_89854610	0.686	NM_032119	GPR98	G protein-coupled receptor 98
chr6_-_134497069	0.682	NM_001143678	SGK1	serum/glucocorticoid regulated kinase 1
chr10_-_100206657	0.679		HPS1	Hermansky-Pudlak syndrome 1
chr12_+_72233486	0.678	NM_001146213 NM_001146214 NM_022771	TBC1D15	TBC1 domain family, member 15
chr9_-_126030792	0.676	NM_018387	STRBP	spermatid perinuclear RNA binding protein
chr21_-_36421630	0.675		RUNX1	runt-related transcription factor 1
chr16_-_4897265	0.674	NM_032569	GLYR1	glyoxylate reductase 1 homolog (Arabidopsis)
chr17_+_79935493	0.671		ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1
chr19_+_41305100	0.667		EGLN2	egl nine homolog 2 (C. elegans)
chr4_+_668250	0.667		MYL5	myosin, light chain 5, regulatory
chr17_+_18218569	0.664	NM_144775	SMCR8	Smith-Magenis syndrome chromosome region, candidate 8
chr3_-_187463227	0.656		BCL6	B-cell CLL/lymphoma 6
chr22_-_21213069	0.655		PI4KA	phosphatidylinositol 4-kinase, catalytic, alpha
chr7_+_116593554	0.648		ST7	suppression of tumorigenicity 7
chr11_+_18343794	0.646	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr7_-_47622127	0.646		TNS3	tensin 3
chr11_-_6640578	0.645		TPP1	tripeptidyl peptidase I
chr12_-_65153189	0.641	NM_002076	GNS	glucosamine (N-acetyl)-6-sulfatase
chr16_-_1525020	0.640		CLCN7	chloride channel 7
chr4_-_100212085	0.640	NM_000667	ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide
chr8_+_75896707	0.638	NM_031461	CRISPLD1	cysteine-rich secretory protein LCCL domain containing 1
chr19_+_41305041	0.637	NM_080732	EGLN2	egl nine homolog 2 (C. elegans)
chr20_-_44519629	0.635	NM_080749	NEURL2	neuralized homolog 2 (Drosophila)
chr9_-_135819953	0.634		TSC1	tuberous sclerosis 1
chr19_+_7587436	0.631	NM_020533	MCOLN1	mucolipin 1
chr5_+_133706869	0.626	NM_003337	UBE2B	ubiquitin-conjugating enzyme E2B
chr6_-_26659913	0.624	NM_001242797 NM_001242798 NM_001242799 NM_024639	ZNF322	zinc finger protein 322
chr16_+_699277	0.624	NM_145294	WDR90	WD repeat domain 90
chr15_+_44084493	0.624		SERF2	small EDRK-rich factor 2
chr10_+_69644708	0.623		SIRT1	sirtuin 1
chr14_-_39901619	0.620	NM_203301	FBXO33	F-box protein 33
chr4_-_23891608	0.620	NM_013261	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr7_+_150065968	0.619		REPIN1	replication initiator 1
chr7_+_4815258	0.618	NM_014855	KIAA0415	KIAA0415
chr10_+_51827654	0.617	NM_001005751	FAM21C FAM21A	family with sequence similarity 21, member C family with sequence similarity 21, member A
chr7_+_4815277	0.615		KIAA0415	KIAA0415
chr3_+_158519911	0.615		MFSD1	major facilitator superfamily domain containing 1
chr4_-_76439479	0.612		RCHY1	ring finger and CHY zinc finger domain containing 1
chr14_-_88459469	0.608	NM_000153 NM_001201401	GALC	galactosylceramidase
chr17_-_42200957	0.603		HDAC5	histone deacetylase 5
chr19_+_5681139	0.603		HSD11B1L	hydroxysteroid (11-beta) dehydrogenase 1-like
chr7_+_97910978	0.598	NM_001159491 NM_015379	BRI3	brain protein I3
chr3_+_23987514	0.597	NM_001145425	NR1D2	nuclear receptor subfamily 1, group D, member 2
chr3_+_51428720	0.591		RBM15B	RNA binding motif protein 15B
chr16_-_70719854	0.590	NM_138383	MTSS1L	metastasis suppressor 1-like
chr7_+_150065859	0.587	NM_001099695 NM_001099696 NM_013400	REPIN1	replication initiator 1
chr4_+_668312	0.586		MYL5	myosin, light chain 5, regulatory
chr11_+_65479685	0.582		KAT5	K(lysine) acetyltransferase 5
chr7_+_99775346	0.580		STAG3	stromal antigen 3
chrX_-_102565805	0.579	NM_001168399 NM_001168400 NM_001168401 NM_032621	BEX2	brain expressed X-linked 2
chr17_-_42201009	0.575	NM_001015053 NM_005474	HDAC5	histone deacetylase 5
chr14_-_20929484	0.573		TMEM55B	transmembrane protein 55B
chr22_-_21213099	0.570	NM_058004	PI4KA	phosphatidylinositol 4-kinase, catalytic, alpha
chr2_-_133427624	0.568		LYPD1	LY6/PLAUR domain containing 1
chr11_+_65479472	0.566	NM_001206833 NM_006388 NM_182709 NM_182710	KAT5	K(lysine) acetyltransferase 5
chrX_+_134654546	0.556	NM_182540	DDX26B	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr1_+_92414927	0.555	NM_001242805 NM_001242806 NM_001242807 NM_001242808 NM_001242810 NM_207189	BRDT	bromodomain, testis-specific
chr14_-_68283293	0.550	NM_015346	ZFYVE26	zinc finger, FYVE domain containing 26
chr4_+_159690208	0.549		FNIP2	folliculin interacting protein 2
chr14_-_92572950	0.546	NM_001127696 NM_001127697 NM_001164774 NM_001164776 NM_001164777 NM_001164778 NM_001164779 NM_001164780 NM_001164781 NM_001164782 NM_004993 NM_030660	ATXN3	ataxin 3
chr5_+_150827204	0.544		SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr7_+_99775521	0.543	NM_012447	STAG3	stromal antigen 3
chrX_-_34675366	0.543	NM_031442	TMEM47	transmembrane protein 47
chr3_+_158519888	0.543		MFSD1	major facilitator superfamily domain containing 1
chr10_+_51827710	0.539		FAM21A	family with sequence similarity 21, member A
chr19_-_291335	0.539	NM_003712 NM_177526	PPAP2C	phosphatidic acid phosphatase type 2C
chrX_+_24167728	0.536	NM_001178086 NM_001178095 NM_001178084 NM_001178085 NM_003410	ZFX	zinc finger protein, X-linked
chr7_+_116593354	0.536	NM_018412 NM_021908	ST7	suppression of tumorigenicity 7
chr15_-_50978726	0.532		TRPM7	transient receptor potential cation channel, subfamily M, member 7
chr5_+_72921980	0.532	NM_001080479 NM_001177693	RGNEF	190 kDa guanine nucleotide exchange factor
chr12_+_112451261	0.531		ERP29	endoplasmic reticulum protein 29
chr8_-_126104007	0.530		KIAA0196	KIAA0196
chr18_-_53089722	0.528	NM_001243233	TCF4	transcription factor 4
chr15_+_44084517	0.523	NM_001199878	SERF2-C15ORF63 SERF2	SERF2-C15orf63 readthrough small EDRK-rich factor 2
chr6_+_42018250	0.521	NM_138572	TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr1_+_226016428	0.519		EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)
chr12_+_104458235	0.518	NM_013320	HCFC2	host cell factor C2
chr5_+_43603312	0.518		NNT	nicotinamide nucleotide transhydrogenase
chr1_-_166845533	0.517	NM_053053	TADA1	transcriptional adaptor 1
chr19_-_48018277	0.515		NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr22_-_21213012	0.514		PI4KA	phosphatidylinositol 4-kinase, catalytic, alpha

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
5.78	3.93e-04	GO:0007033	vacuole organization
1.70	5.99e-03	GO:0008104	protein localization
1.63	8.31e-03	GO:0051641	cellular localization
1.61	1.13e-02	GO:0033036	macromolecule localization
1.77	1.16e-02	GO:0045184	establishment of protein localization
6.41	1.20e-02	GO:0015682	ferric iron transport
6.41	1.20e-02	GO:0015988	energy coupled proton transport, against electrochemical gradient
6.41	1.20e-02	GO:0015991	ATP hydrolysis coupled proton transport
6.41	1.20e-02	GO:0033572	transferrin transport
1.77	1.27e-02	GO:0015031	protein transport
1.80	1.51e-02	GO:0046907	intracellular transport
2.00	1.91e-02	GO:0034613	cellular protein localization
1.99	2.24e-02	GO:0070727	cellular macromolecule localization
4.27	3.55e-02	GO:0006818	hydrogen transport
1.62	4.05e-02	GO:0051649	establishment of localization in cell
7.47	4.27e-02	GO:0032006	regulation of TOR signaling cascade

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
3.88	4.40e-16	GO:0005773	vacuole
3.60	3.88e-11	GO:0000323	lytic vacuole
3.60	3.88e-11	GO:0005764	lysosome
1.26	9.17e-11	GO:0043227	membrane-bounded organelle
1.26	1.26e-10	GO:0043231	intracellular membrane-bounded organelle
1.21	5.59e-09	GO:0043226	organelle
1.21	1.07e-08	GO:0043229	intracellular organelle
1.16	8.49e-08	GO:0044424	intracellular part
1.15	3.74e-07	GO:0005622	intracellular
3.87	4.32e-07	GO:0005774	vacuolar membrane
3.70	1.23e-06	GO:0044437	vacuolar part
1.20	4.55e-05	GO:0005737	cytoplasm
3.44	7.02e-05	GO:0005769	early endosome
1.28	7.06e-05	GO:0044446	intracellular organelle part
1.27	9.48e-05	GO:0044422	organelle part
1.26	1.81e-04	GO:0005634	nucleus
2.19	3.34e-04	GO:0005768	endosome
3.56	4.54e-04	GO:0005765	lysosomal membrane
8.54	5.65e-04	GO:0033176	proton-transporting V-type ATPase complex
2.59	5.89e-04	GO:0010008	endosome membrane
2.57	6.96e-04	GO:0044440	endosomal part
1.23	1.51e-03	GO:0044444	cytoplasmic part
3.29	2.75e-03	GO:0005770	late endosome
1.42	5.28e-03	GO:0044428	nuclear part
1.45	9.49e-03	GO:0031981	nuclear lumen
1.39	1.05e-02	GO:0043233	organelle lumen
4.00	1.19e-02	GO:0031902	late endosome membrane
1.39	1.43e-02	GO:0070013	intracellular organelle lumen
1.37	2.30e-02	GO:0031974	membrane-enclosed lumen

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.18	1.32e-02	GO:0005515	protein binding
5.69	2.44e-02	GO:0019829	cation-transporting ATPase activity
1.09	2.77e-02	GO:0005488	binding