Motif ID: TP53.p2

Z-value: 0.840


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TP53chr17_-_7578810-0.077.3e-01Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_11784355 6.807 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr6_+_36644236 2.934 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr8_-_10587942 2.753 NM_031439
SOX7
SRY (sex determining region Y)-box 7
chr12_-_76424474 2.458 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr17_+_76210329 1.956 BIRC5
baculoviral IAP repeat containing 5
chr17_+_76210276 1.769 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr10_-_105212149 1.508 NM_015916
CALHM2
calcium homeostasis modulator 2
chr10_-_105212022 1.486 CALHM2
calcium homeostasis modulator 2
chr10_+_5566923 1.403 NM_005185
CALML3
calmodulin-like 3
chr18_-_28622624 1.383 NM_001941
NM_024423
DSC3

desmocollin 3

chr8_-_23021447 1.374 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr8_+_22960326 1.369 NM_003841
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr8_-_22926406 1.325 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chrX_-_106959597 1.296 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr11_+_706607 1.099 EPS8L2
EPS8-like 2
chr2_-_110874142 1.094 NM_005434
MALL
mal, T-cell differentiation protein-like
chr14_+_68086633 1.075 ARG2
arginase, type II
chr19_+_39687600 1.008 NM_001001414
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr19_+_45174723 0.991 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr8_-_22926490 0.958 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr7_+_100770378 0.950 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chrX_-_109561427 0.920 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr6_-_48078909 0.914 C6orf138
chromosome 6 open reading frame 138
chr20_-_32891075 0.907 NM_000687
AHCY
adenosylhomocysteinase
chr9_+_116037913 0.899 NM_001244926
NM_004697
PRPF4

PRP4 pre-mRNA processing factor 4 homolog (yeast)

chr22_+_37447615 0.885 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr1_+_150521786 0.877 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr2_-_24307179 0.874 NM_001206802
TP53I3
tumor protein p53 inducible protein 3
chr8_-_23082572 0.846 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr7_+_43622638 0.835 NM_004760
STK17A
serine/threonine kinase 17a
chr19_-_42928152 0.819 LIPE
lipase, hormone-sensitive
chr21_-_44846927 0.794 NM_173354
SIK1
salt-inducible kinase 1
chr2_-_26205437 0.765 NM_002254
KIF3C
kinesin family member 3C
chr3_+_44380003 0.745 C3orf23
chromosome 3 open reading frame 23
chr2_-_74756838 0.735 AUP1
ancient ubiquitous protein 1
chr5_-_112824526 0.727 NM_001085377
MCC
mutated in colorectal cancers
chr7_+_48128225 0.725 NM_181597
UPP1
uridine phosphorylase 1
chr6_-_30712294 0.721 NM_003897
IER3
immediate early response 3
chrX_-_106960028 0.713 TSC22D3
TSC22 domain family, member 3
chrX_-_15683153 0.712 NM_020665
TMEM27
transmembrane protein 27
chr1_-_6453362 0.709 ACOT7
acyl-CoA thioesterase 7
chr5_-_176831385 0.706 F12
coagulation factor XII (Hageman factor)
chrX_+_152086408 0.700 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr2_-_26205327 0.690 KIF3C
kinesin family member 3C
chr14_+_68086655 0.681 ARG2
arginase, type II
chr10_-_90750955 0.680 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr20_-_52790511 0.667 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr16_-_15149827 0.660 NM_173474
NTAN1
N-terminal asparagine amidase
chr1_+_23695441 0.651 C1orf213
chromosome 1 open reading frame 213
chr2_-_74756823 0.648 AUP1
ancient ubiquitous protein 1
chr10_+_47746919 0.640 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr16_+_447175 0.632 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr3_+_127771342 0.630


chr10_+_90751044 0.624 FAS
Fas (TNF receptor superfamily, member 6)
chr3_+_44379590 0.611 NM_001029840
C3orf23
chromosome 3 open reading frame 23
chr18_+_33877630 0.611 NM_025135
FHOD3
formin homology 2 domain containing 3
chr2_-_74756815 0.607 AUP1
ancient ubiquitous protein 1
chr2_-_172290435 0.606 METTL8
methyltransferase like 8
chr7_+_48128738 0.600 NM_003364
UPP1
uridine phosphorylase 1
chr16_+_28891234 0.588 ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr16_-_31105922 0.570


chr9_+_116037955 0.570 PRPF4
PRP4 pre-mRNA processing factor 4 homolog (yeast)
chr19_+_49458151 0.562 BAX
BCL2-associated X protein
chr9_+_139846767 0.562 NM_178536
LCN12
lipocalin 12
chr1_+_41444968 0.561 NM_001905
CTPS
CTP synthase
chr4_-_10118286 0.560


chr1_-_202936333 0.559 NM_016243
CYB5R1
cytochrome b5 reductase 1
chr19_+_49458129 0.553 BAX
BCL2-associated X protein
chr17_+_80332152 0.552 NM_018949
UTS2R
urotensin 2 receptor
chr18_+_9913954 0.535 NM_003574
NM_194434
VAPA

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

chr3_-_12800739 0.535 NM_018306
TMEM40
transmembrane protein 40
chr16_-_90076528 0.533 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr2_-_74756755 0.532 AUP1
ancient ubiquitous protein 1
chr12_+_56498334 0.525 PA2G4
proliferation-associated 2G4, 38kDa
chr19_-_11373117 0.521 NM_020812
DOCK6
dedicator of cytokinesis 6
chr19_+_49458031 0.519 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr5_+_135364583 0.515 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr1_-_26197743 0.513 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr19_-_8809054 0.510 NM_178525
ACTL9
actin-like 9
chr12_+_56498365 0.497 PA2G4
proliferation-associated 2G4, 38kDa
chr5_-_176831183 0.493 F12
coagulation factor XII (Hageman factor)
chr1_+_43824598 0.485 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr6_-_101329006 0.484 ASCC3
activating signal cointegrator 1 complex subunit 3
chr19_+_2785464 0.481 NM_003249
THOP1
thimet oligopeptidase 1
chr13_+_48877886 0.476 RB1
retinoblastoma 1
chr1_+_156052330 0.472 LMNA
lamin A/C
chr3_+_127771287 0.469 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr19_+_38865424 0.469 PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr13_+_52158483 0.469 NM_052950
WDFY2
WD repeat and FYVE domain containing 2
chr4_-_10118358 0.460 WDR1
WD repeat domain 1
chr9_-_95527002 0.460 NM_001003800
NM_015250
BICD2

bicaudal D homolog 2 (Drosophila)

chr15_+_40453209 0.455 NM_001211
BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr1_+_224544590 0.455 NM_014184
CNIH4
cornichon homolog 4 (Drosophila)
chr1_-_10532513 0.453 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr2_-_242447449 0.449 STK25
serine/threonine kinase 25
chr5_-_138775189 0.447 DNAJC18
DnaJ (Hsp40) homolog, subfamily C, member 18
chr1_-_10532603 0.447 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr14_+_68086570 0.447 NM_001172
ARG2
arginase, type II
chr2_-_47168902 0.447 NM_001171508
NM_001171511
MCFD2

multiple coagulation factor deficiency 2

chr2_+_169312755 0.443 CERS6
ceramide synthase 6
chr2_-_47168870 0.433 MCFD2
multiple coagulation factor deficiency 2
chr4_-_10118378 0.432 WDR1
WD repeat domain 1
chr19_-_4817502 0.428 TICAM1
toll-like receptor adaptor molecule 1
chrX_-_109561298 0.415 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr3_+_44380213 0.408 C3orf23
chromosome 3 open reading frame 23
chr4_-_103422436 0.406


chrX_-_109561314 0.404 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr8_-_144650998 0.404 C8orf73
chromosome 8 open reading frame 73
chr1_-_93645903 0.400 TMED5
transmembrane emp24 protein transport domain containing 5
chr16_-_67997948 0.395 NM_001145963
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr19_-_2456954 0.394 NM_032737
LMNB2
lamin B2
chr7_+_48128939 0.392 UPP1
uridine phosphorylase 1
chr6_+_36098261 0.382 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr15_+_89164522 0.382 NM_022767
AEN
apoptosis enhancing nuclease
chr3_+_127771126 0.381 NM_013336
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr20_-_23807297 0.378 NM_001322
CST2
cystatin SA
chr1_-_27930360 0.376 AHDC1
AT hook, DNA binding motif, containing 1
chr16_+_71392637 0.376 CALB2
calbindin 2
chr2_-_24307529 0.376 NM_004881
NM_147184
TP53I3

tumor protein p53 inducible protein 3

chr3_+_14166552 0.375 TMEM43
transmembrane protein 43
chr3_+_14166582 0.373 TMEM43
transmembrane protein 43
chr6_+_42018264 0.370 TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr1_+_16085245 0.369 NM_017556
FBLIM1
filamin binding LIM protein 1
chr1_+_114447906 0.367 NM_022836
DCLRE1B
DNA cross-link repair 1B
chr7_+_116166346 0.365 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr6_+_151561653 0.364 AKAP12
A kinase (PRKA) anchor protein 12
chr7_-_72742084 0.362 NM_178125
TRIM50
tripartite motif containing 50
chr2_-_74756973 0.358 NM_181575
AUP1
ancient ubiquitous protein 1
chr20_+_59827452 0.353 NM_001794
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr6_+_34204690 0.348 HMGA1
high mobility group AT-hook 1
chr12_+_22778085 0.347 ETNK1
ethanolamine kinase 1
chr7_-_99766191 0.346 GAL3ST4
galactose-3-O-sulfotransferase 4
chr11_+_125439370 0.345 EI24
etoposide induced 2.4 mRNA
chr22_+_21336508 0.339 NM_006767
LZTR1
leucine-zipper-like transcription regulator 1
chr1_-_249152893 0.335 NM_001136036
ZNF692
zinc finger protein 692
chr10_+_90750384 0.333 FAS
Fas (TNF receptor superfamily, member 6)
chr16_+_30194730 0.331 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr3_+_14166543 0.330 TMEM43
transmembrane protein 43
chr2_+_24272627 0.330 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr16_-_68000696 0.329 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr7_+_23145403 0.327 KLHL7
kelch-like 7 (Drosophila)
chr12_+_56498414 0.323 PA2G4
proliferation-associated 2G4, 38kDa
chr1_+_224544550 0.322 CNIH4
cornichon homolog 4 (Drosophila)
chr16_+_71392615 0.320 NM_001740
NM_007088
CALB2

calbindin 2

chr12_+_69202796 0.318 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr3_+_183415540 0.316 NM_018023
YEATS2
YEATS domain containing 2
chr3_+_44379923 0.312 NM_001029839
NM_173826
C3orf23

chromosome 3 open reading frame 23

chr7_-_45128492 0.312 NM_001146334
NACAD
NAC alpha domain containing
chr6_-_109775423 0.311 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr16_-_1470709 0.310 C16orf91
chromosome 16 open reading frame 91
chr11_+_33061291 0.308 TCP11L1
t-complex 11 (mouse)-like 1
chr9_+_33750463 0.306 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr4_-_10118444 0.301 WDR1
WD repeat domain 1
chr3_+_14166439 0.298 NM_024334
TMEM43
transmembrane protein 43
chr6_+_4776826 0.295 CDYL
chromodomain protein, Y-like
chr3_-_113465101 0.295 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_+_116519175 0.295 SLC22A15
solute carrier family 22, member 15
chr1_-_209825673 0.293 NM_001127641
LAMB3
laminin, beta 3
chr1_+_32671235 0.292 NM_001160042
NM_018134
IQCC

IQ motif containing C

chr11_+_64126616 0.292 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chr11_+_119039415 0.291 NM_024618
NM_170722
NLRX1

NLR family member X1

chr16_-_31106125 0.290 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr6_-_101329197 0.289 NM_006828
NM_022091
ASCC3

activating signal cointegrator 1 complex subunit 3

chr19_-_14048877 0.289 PODNL1
podocan-like 1
chr20_-_1373702 0.288 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 readthrough (non-protein coding)
FK506 binding protein 1A, 12kDa
chr19_-_5790913 0.284 DUS3L
dihydrouridine synthase 3-like (S. cerevisiae)
chr4_+_148653452 0.284 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr7_-_99766238 0.281 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr10_-_104262404 0.281 NM_005736
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr4_+_41937368 0.280 TMEM33
transmembrane protein 33
chr2_+_47168362 0.276 TTC7A
tetratricopeptide repeat domain 7A
chr17_-_14140149 0.276 NM_001007530
CDRT15
CMT1A duplicated region transcript 15
chr18_+_34409058 0.274 NM_020776
KIAA1328
KIAA1328
chr9_+_131102925 0.273 SLC27A4
solute carrier family 27 (fatty acid transporter), member 4
chr11_-_64570621 0.272 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr1_-_1243246 0.272 NM_030649
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr10_-_88854645 0.271 GLUD1
glutamate dehydrogenase 1
chrX_+_48368063 0.269 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr9_+_80911990 0.263 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr19_-_14228560 0.263 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr14_-_24732344 0.263 NM_000359
TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr19_-_42746743 0.263 GSK3A
glycogen synthase kinase 3 alpha
chr17_-_42767016 0.263 NM_001099225
NM_144609
CCDC43

coiled-coil domain containing 43

chr1_+_224544597 0.263 CNIH4
cornichon homolog 4 (Drosophila)
chr22_+_21336616 0.262 LZTR1
leucine-zipper-like transcription regulator 1
chr19_+_48216600 0.260 NM_014601
EHD2
EH-domain containing 2
chr7_+_23145342 0.259 NM_001031710
NM_001172428
KLHL7

kelch-like 7 (Drosophila)

chr14_-_35183722 0.259 NM_001243645
NM_138638
CFL2

cofilin 2 (muscle)

chr2_-_47142880 0.258 MCFD2
multiple coagulation factor deficiency 2
chr2_+_197504277 0.258 NM_001080539
CCDC150
coiled-coil domain containing 150
chr11_+_33279859 0.258 HIPK3
homeodomain interacting protein kinase 3
chr19_+_35491329 0.257 GRAMD1A
GRAM domain containing 1A
chr3_+_183892647 0.256 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr6_+_15245702 0.255 JARID2
jumonji, AT rich interactive domain 2
chr7_-_100254048 0.255 NM_016188
ACTL6B
actin-like 6B
chr7_-_1544007 0.254 NM_001080453
INTS1
integrator complex subunit 1
chr17_+_40610940 0.252 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr2_-_69870976 0.251 NM_014911
AAK1
AP2 associated kinase 1
chr6_-_167571315 0.251 NM_005299
GPR31
G protein-coupled receptor 31
chr3_+_183892569 0.251 NM_001025205
NM_004068
AP2M1

adaptor-related protein complex 2, mu 1 subunit


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 1.39e-05 GO:0044444 cytoplasmic part
1.20 2.74e-04 GO:0005737 cytoplasm
1.49 2.37e-03 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
24.51 1.28e-03 GO:0045569 TRAIL binding