Motif ID: ZEB1.p2

Z-value: 1.097


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZEB1chr10_+_316074190.105.9e-01Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_97401588 4.199 FBP1
fructose-1,6-bisphosphatase 1
chr9_-_97401746 3.063 FBP1
fructose-1,6-bisphosphatase 1
chr9_-_97401833 2.565 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr11_-_2018568 1.887 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chrX_-_152939256 1.849 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr11_-_2018703 1.842 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr2_-_165477818 1.823 GRB14
growth factor receptor-bound protein 14
chr2_-_165477986 1.785 GRB14
growth factor receptor-bound protein 14
chr11_-_2019070 1.578 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr19_+_917285 1.476 NM_032551
KISS1R
KISS1 receptor
chr17_+_40811261 1.367 NM_016437
TUBG2
tubulin, gamma 2
chr17_-_43510279 1.326 NM_174919
ARHGAP27
Rho GTPase activating protein 27
chrX_-_152938742 1.323 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr18_+_77623667 1.312 NM_012283
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr9_+_17578952 1.302 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr1_+_65991390 1.250 LEPR
leptin receptor
chr7_+_26331493 1.226 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr12_+_6420098 1.193 NM_001144856
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr9_+_139839697 1.146 NM_000606
C8G
complement component 8, gamma polypeptide
chr11_-_2018446 1.136 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr3_-_133614296 1.136 RAB6B
RAB6B, member RAS oncogene family
chr8_-_143867931 1.114 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr22_+_41777932 1.085 NM_003216
TEF
thyrotrophic embryonic factor
chr11_-_63933493 1.080 NM_014067
MACROD1
MACRO domain containing 1
chr2_+_209271555 1.074 NM_005048
PTH2R
parathyroid hormone 2 receptor
chr7_+_26331611 1.034 SNX10
sorting nexin 10
chr2_-_96781887 1.012 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr22_+_40390935 1.005 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_+_65991357 1.000 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr19_-_51487070 0.988 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr19_-_51472816 0.972 NM_002774
KLK6
kallikrein-related peptidase 6
chr19_-_46974789 0.962 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr19_-_46974663 0.960 PNMAL1
PNMA-like 1
chr4_+_1723233 0.938 TACC3
transforming, acidic coiled-coil containing protein 3
chr3_+_47021146 0.934 NM_015175
NBEAL2
neurobeachin-like 2
chr4_+_2420671 0.920 NM_001193282
LOC402160
uncharacterized LOC402160
chr1_+_36771962 0.914 NM_001162530
SH3D21
SH3 domain containing 21
chr2_-_133427624 0.909 LYPD1
LY6/PLAUR domain containing 1
chr16_-_4466607 0.904 CORO7
coronin 7
chr8_+_86376130 0.902 NM_000067
CA2
carbonic anhydrase II
chr12_+_7023490 0.901 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr6_-_80656870 0.893 NM_022726
ELOVL4
ELOVL fatty acid elongase 4
chr11_+_69924407 0.890 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr11_-_63933204 0.881 MACROD1
MACRO domain containing 1
chr1_+_78511588 0.873 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr4_-_75719686 0.866 NM_001729
BTC
betacellulin
chr17_+_37894212 0.860 GRB7
growth factor receptor-bound protein 7
chr1_+_24645811 0.858 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr7_-_21985421 0.849 NM_001127370
NM_001127371
NM_018719
CDCA7L


cell division cycle associated 7-like


chr5_+_612454 0.846 CEP72
centrosomal protein 72kDa
chr19_-_11689591 0.832 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr17_-_43510204 0.830 ARHGAP27
Rho GTPase activating protein 27
chr11_-_125366048 0.823 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr11_-_441956 0.815 ANO9
anoctamin 9
chr5_+_612404 0.814 NM_018140
CEP72
centrosomal protein 72kDa
chr9_+_131185129 0.813 CERCAM
cerebral endothelial cell adhesion molecule
chr11_-_441995 0.809 NM_001012302
ANO9
anoctamin 9
chrX_-_13956530 0.809 GPM6B
glycoprotein M6B
chr5_+_68462948 0.795 CCNB1
cyclin B1
chr5_+_55033844 0.785 NM_001142549
NM_001166533
NM_024415
DDX4


DEAD (Asp-Glu-Ala-Asp) box polypeptide 4


chr1_+_24645914 0.766 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr12_-_57634474 0.759 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr3_-_160167525 0.755 TRIM59
tripartite motif containing 59
chrX_-_20135015 0.753 NM_001168465
NM_001168466
NM_152780
MAP7D2


MAP7 domain containing 2


chr15_-_101084871 0.753 NM_178842
CERS3
ceramide synthase 3
chr11_+_65779461 0.752 NM_001323
CST6
cystatin E/M
chr3_-_160167600 0.748 NM_173084
TRIM59
tripartite motif containing 59
chr22_+_30792929 0.745 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr1_-_249152893 0.744 NM_001136036
ZNF692
zinc finger protein 692
chrY_+_21729214 0.739 TXLNG2P
taxilin gamma 2, pseudogene
chr10_+_71211215 0.736 NM_012339
TSPAN15
tetraspanin 15
chr11_-_2017822 0.735 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr12_+_6419601 0.733 NM_018173
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr11_-_2018334 0.730 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_+_1072274 0.715 LOC254099
uncharacterized LOC254099
chr1_+_7844713 0.711 NM_016831
PER3
period homolog 3 (Drosophila)
chr17_-_36413177 0.709 LOC440434
aminopeptidase puromycin sensitive pseudogene
chr17_-_33416238 0.708 RFFL
ring finger and FYVE-like domain containing 1
chr5_+_68462836 0.708 NM_031966
CCNB1
cyclin B1
chr5_+_68462985 0.708 CCNB1
cyclin B1
chr19_+_7660698 0.701 NM_001080429
NM_020902
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr2_+_173420873 0.696 PDK1
pyruvate dehydrogenase kinase, isozyme 1
chrX_-_51239426 0.695 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr19_-_35992798 0.691 NM_001035516
DMKN
dermokine
chr5_+_68788387 0.686 NM_001205254
OCLN
occludin
chr19_-_36001336 0.685 NM_001126059
DMKN
dermokine
chr2_-_165478357 0.685 NM_004490
GRB14
growth factor receptor-bound protein 14
chr1_-_44497028 0.685 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr3_-_189838673 0.684 LEPREL1
leprecan-like 1
chr12_-_57630867 0.663 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr6_-_144385647 0.658 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr14_-_34419957 0.658 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr12_+_27485767 0.651 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2




chrX_-_20134749 0.648 NM_001168467
MAP7D2
MAP7 domain containing 2
chr17_-_16256824 0.629 CENPV
centromere protein V
chr19_+_55591759 0.625 NM_017729
EPS8L1
EPS8-like 1
chr11_-_115375065 0.623 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr11_+_129245834 0.623 NM_003658
BARX2
BARX homeobox 2
chr14_+_105941061 0.613 NM_001312
CRIP2
cysteine-rich protein 2
chr11_+_19734821 0.608 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr2_-_216878314 0.608 NM_018000
MREG
melanoregulin
chr5_+_176560056 0.607 NM_172349
NSD1
nuclear receptor binding SET domain protein 1
chr9_+_140119643 0.603 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr4_-_120987890 0.595 NM_002358
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
chr3_-_49055916 0.594 NM_001009996
DALRD3
DALR anticodon binding domain containing 3
chr8_-_28243941 0.594 NM_018660
ZNF395
zinc finger protein 395
chr8_-_144654921 0.593 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr19_-_11266451 0.591 NM_182513
SPC24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_-_93405066 0.585 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr1_+_10057254 0.585 NM_052960
RBP7
retinol binding protein 7, cellular
chr19_-_51537996 0.585 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr11_-_65667858 0.583 FOSL1
FOS-like antigen 1
chr4_+_1723212 0.581 NM_006342
TACC3
transforming, acidic coiled-coil containing protein 3
chr8_+_95653272 0.577 ESRP1
epithelial splicing regulatory protein 1
chr1_-_249153285 0.574 NM_001193328
NM_017865
ZNF692

zinc finger protein 692

chr3_-_50336258 0.573 NM_001200018
NM_001200029
NAT6
HYAL3
N-acetyltransferase 6 (GCN5-related)
hyaluronoglucosaminidase 3
chr2_+_173420794 0.565 PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr15_-_34630203 0.559 NM_001042495
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr16_-_3142839 0.557 NM_032805
ZSCAN10
zinc finger and SCAN domain containing 10
chr19_+_45281125 0.556 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr11_-_2019007 0.549 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr16_+_88705000 0.549 NM_013278
IL17C
interleukin 17C
chr3_-_50336662 0.549 NM_001200016
NM_012191
NM_001200030
NM_001200031
NM_001200032
NM_003549
NAT6

HYAL3



N-acetyltransferase 6 (GCN5-related)

hyaluronoglucosaminidase 3



chr20_+_34203746 0.547 NM_003116
SPAG4
sperm associated antigen 4
chr1_-_27286875 0.546 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr3_-_185826332 0.544 ETV5
ets variant 5
chr1_-_44497132 0.544 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_+_726074 0.537 NM_003961
RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr16_-_88729487 0.533 NM_002461
MVD
mevalonate (diphospho) decarboxylase
chr18_+_18822168 0.532 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr11_-_560706 0.532 NM_173573
C11orf35
chromosome 11 open reading frame 35
chr10_-_103347978 0.531 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chr2_+_65216526 0.530 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr17_+_37894161 0.529 NM_005310
GRB7
growth factor receptor-bound protein 7
chr20_+_43030005 0.529 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_-_6341708 0.528 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr15_+_40453209 0.524 NM_001211
BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr10_+_103348040 0.524 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr17_-_62777621 0.521 LOC146880
Rho GTPase activating protein 27 pseudogene
chr8_-_28243589 0.520 ZNF395
zinc finger protein 395
chr18_-_5630629 0.518 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr2_+_97001463 0.518 NM_015341
NCAPH
non-SMC condensin I complex, subunit H
chr19_-_11689765 0.514 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr16_-_2390737 0.514 NM_001089
ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr10_-_93392857 0.513 NM_005398
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr2_-_241835572 0.512 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr2_-_170550859 0.512 NM_001085447
C2orf77
chromosome 2 open reading frame 77
chr10_-_93392744 0.509 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr15_-_60884615 0.504 NM_134262
RORA
RAR-related orphan receptor A
chr8_+_120220554 0.503 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chrX_-_15872905 0.502


chr16_+_725679 0.501 RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr22_+_35796294 0.500 MCM5
minichromosome maintenance complex component 5
chr13_+_21277481 0.498 NM_138284
IL17D
interleukin 17D
chrX_-_15872921 0.495 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr12_-_6756597 0.495 ACRBP
acrosin binding protein
chr9_+_33795558 0.493 NM_002771
PRSS3
protease, serine, 3
chr11_+_1330977 0.488 LOC255512
uncharacterized LOC255512
chr15_+_67358194 0.487 NM_005902
SMAD3
SMAD family member 3
chr7_-_28220342 0.487 NM_175061
JAZF1
JAZF zinc finger 1
chr2_-_71454200 0.486 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr12_-_25055966 0.486 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_+_1958354 0.486 NM_006497
HIC1
hypermethylated in cancer 1
chr18_+_77659446 0.484


chr20_+_44441247 0.483 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr15_+_40453263 0.481 BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr1_-_3528058 0.481 NM_001409
MEGF6
multiple EGF-like-domains 6
chr10_-_103347882 0.477 POLL
polymerase (DNA directed), lambda
chr5_+_177558008 0.477 RMND5B
required for meiotic nuclear division 5 homolog B (S. cerevisiae)
chr1_-_26232890 0.472 NM_001145454
NM_005563
STMN1

stathmin 1

chr14_-_51134862 0.468 SAV1
salvador homolog 1 (Drosophila)
chr2_-_166650770 0.466 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr7_+_150020269 0.465 NM_001142928
NM_023942
LRRC61

leucine rich repeat containing 61

chr22_+_17565920 0.465 IL17RA
interleukin 17 receptor A
chr9_+_135457974 0.464 NM_020064
BARHL1
BarH-like homeobox 1
chr20_+_44441334 0.462 UBE2C
ubiquitin-conjugating enzyme E2C
chr1_+_214776494 0.461 NM_016343
CENPF
centromere protein F, 350/400kDa (mitosin)
chr11_-_35547144 0.460 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr4_+_148653452 0.458 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr6_+_33359604 0.457 KIFC1
kinesin family member C1
chr6_+_33359620 0.452 KIFC1
kinesin family member C1
chr2_-_237416091 0.450 NM_024726
IQCA1
IQ motif containing with AAA domain 1
chr11_-_65667860 0.450 NM_005438
FOSL1
FOS-like antigen 1
chr11_-_46939908 0.449 NM_002334
LRP4
low density lipoprotein receptor-related protein 4
chr17_+_65936590 0.446 BPTF
bromodomain PHD finger transcription factor
chr17_+_47209821 0.444 NM_001159388
B4GALNT2
beta-1,4-N-acetyl-galactosaminyl transferase 2
chr15_+_45722762 0.444 NM_032413
NM_197955
C15orf48

chromosome 15 open reading frame 48

chr14_-_51135021 0.443 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr2_-_230579198 0.441 NM_139072
DNER
delta/notch-like EGF repeat containing
chr7_-_47621741 0.440 NM_022748
TNS3
tensin 3
chr16_-_30022300 0.438 NM_003586
DOC2A
double C2-like domains, alpha
chr16_-_74808474 0.438 FA2H
fatty acid 2-hydroxylase
chr6_+_7541892 0.436 DSP
desmoplakin
chr16_+_89753093 0.436 CDK10
cyclin-dependent kinase 10
chr8_-_144815888 0.436 NM_198488
FAM83H
family with sequence similarity 83, member H
chr7_-_22396511 0.436 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr19_-_39466290 0.433 NM_024907
FBXO17
F-box protein 17
chr18_+_43913906 0.433 RNF165
ring finger protein 165
chr2_+_97001506 0.432 NCAPH
non-SMC condensin I complex, subunit H
chr1_-_40254510 0.431 BMP8B
bone morphogenetic protein 8b

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.63e-06 GO:0009987 cellular process
1.11 6.09e-04 GO:0050794 regulation of cellular process
1.16 2.80e-03 GO:0051716 cellular response to stimulus
1.30 3.20e-03 GO:0035556 intracellular signal transduction
1.10 3.64e-03 GO:0065007 biological regulation
1.10 3.85e-03 GO:0050789 regulation of biological process
1.17 4.34e-03 GO:0007165 signal transduction
1.26 6.49e-03 GO:0023051 regulation of signaling
1.22 1.39e-02 GO:0048523 negative regulation of cellular process
1.27 1.58e-02 GO:0009966 regulation of signal transduction
1.17 1.77e-02 GO:0048856 anatomical structure development
1.15 2.35e-02 GO:0023052 signaling
1.85 3.80e-02 GO:0034330 cell junction organization
1.36 4.63e-02 GO:0006468 protein phosphorylation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 2.19e-16 GO:0005737 cytoplasm
1.09 6.29e-10 GO:0005622 intracellular
1.08 1.20e-08 GO:0044424 intracellular part
1.14 4.15e-06 GO:0044444 cytoplasmic part
1.25 6.19e-05 GO:0005829 cytosol
1.29 7.90e-05 GO:0005856 cytoskeleton
1.33 6.67e-04 GO:0044430 cytoskeletal part
1.39 3.71e-03 GO:0015630 microtubule cytoskeleton
1.82 5.95e-03 GO:0005912 adherens junction
1.40 6.67e-03 GO:0030054 cell junction
1.75 1.24e-02 GO:0070161 anchoring junction
1.67 1.67e-02 GO:0005911 cell-cell junction
1.06 3.80e-02 GO:0043229 intracellular organelle
2.69 3.94e-02 GO:0042641 actomyosin
1.78 4.81e-02 GO:0005938 cell cortex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 1.12e-11 GO:0005515 protein binding
1.06 2.31e-04 GO:0005488 binding
1.32 5.68e-03 GO:0030234 enzyme regulator activity
1.32 8.90e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.35 1.16e-02 GO:0016301 kinase activity
1.45 1.49e-02 GO:0030695 GTPase regulator activity
1.54 1.70e-02 GO:0003779 actin binding
1.46 1.96e-02 GO:0004674 protein serine/threonine kinase activity
1.44 2.01e-02 GO:0060589 nucleoside-triphosphatase regulator activity
2.01 3.20e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.54 4.01e-02 GO:0005083 small GTPase regulator activity
1.37 4.27e-02 GO:0005198 structural molecule activity
1.39 4.40e-02 GO:0008092 cytoskeletal protein binding