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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for IKZF2

Z-value: 0.77

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Transcription factors associated with IKZF2

Gene Symbol Gene ID Gene Info
ENSG00000030419.12 IKAROS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IKZF2hg19_v2_chr2_-_214014959_2140150580.106.1e-01Click!

Activity profile of IKZF2 motif

Sorted Z-values of IKZF2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_92219919 1.38 ENST00000252506.6
ENST00000375769.1
growth arrest and DNA-damage-inducible, gamma
chr20_+_58179582 1.37 ENST00000371015.1
ENST00000395639.4
phosphatase and actin regulator 3
chr6_+_32605195 1.06 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr1_-_161337662 0.78 ENST00000367974.1
chromosome 1 open reading frame 192
chr1_+_111889212 0.74 ENST00000369737.4
primary cilia formation
chr12_+_26348582 0.73 ENST00000535504.1
sarcospan
chr6_+_32605134 0.70 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
major histocompatibility complex, class II, DQ alpha 1
chrX_+_73164149 0.69 ENST00000602938.1
ENST00000602294.1
ENST00000602920.1
ENST00000602737.1
ENST00000602772.1
JPX transcript, XIST activator (non-protein coding)
chr1_+_111888890 0.69 ENST00000369738.4
primary cilia formation
chr15_-_90358048 0.61 ENST00000300060.6
ENST00000560137.1
alanyl (membrane) aminopeptidase
chr1_-_157014865 0.60 ENST00000361409.2
Rho guanine nucleotide exchange factor (GEF) 11
chr17_+_7387919 0.58 ENST00000572844.1
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr17_+_26369865 0.58 ENST00000582037.1
nemo-like kinase
chr14_+_32546145 0.57 ENST00000556611.1
ENST00000539826.2
Rho GTPase activating protein 5
chr9_-_3469181 0.54 ENST00000366116.2
Uncharacterized protein
chr5_+_43602750 0.54 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
nicotinamide nucleotide transhydrogenase
chr7_-_16505440 0.53 ENST00000307068.4
sclerostin domain containing 1
chr8_+_104831554 0.53 ENST00000408894.2
regulating synaptic membrane exocytosis 2
chr12_-_52867569 0.51 ENST00000252250.6
keratin 6C
chr12_-_81763127 0.49 ENST00000541017.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr12_-_81763184 0.49 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chrX_-_15683147 0.49 ENST00000380342.3
transmembrane protein 27
chr6_-_55739542 0.46 ENST00000446683.2
bone morphogenetic protein 5
chr3_+_238273 0.45 ENST00000256509.2
cell adhesion molecule L1-like
chr7_-_92848858 0.45 ENST00000440868.1
HEPACAM family member 2
chr7_-_92848878 0.45 ENST00000341723.4
HEPACAM family member 2
chr15_+_69373184 0.45 ENST00000558147.1
ENST00000440444.1
long intergenic non-protein coding RNA 277
chr1_+_104198377 0.44 ENST00000370083.4
amylase, alpha 1A (salivary)
chr22_+_40297105 0.44 ENST00000540310.1
GRB2-related adaptor protein 2
chr2_-_216257849 0.43 ENST00000456923.1
fibronectin 1
chr5_+_140180635 0.43 ENST00000522353.2
ENST00000532566.2
protocadherin alpha 3
chr22_+_40297079 0.43 ENST00000344138.4
ENST00000543252.1
GRB2-related adaptor protein 2
chr6_+_123110465 0.43 ENST00000539041.1
sphingomyelin phosphodiesterase, acid-like 3A
chr5_-_42811986 0.42 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
selenoprotein P, plasma, 1
chr17_+_77018896 0.41 ENST00000578229.1
C1q and tumor necrosis factor related protein 1
chr5_-_42812143 0.41 ENST00000514985.1
selenoprotein P, plasma, 1
chr10_-_79398250 0.40 ENST00000286627.5
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr1_+_21880560 0.40 ENST00000425315.2
alkaline phosphatase, liver/bone/kidney
chr17_+_77019030 0.39 ENST00000580454.1
C1q and tumor necrosis factor related protein 1
chr6_+_123110302 0.37 ENST00000368440.4
sphingomyelin phosphodiesterase, acid-like 3A
chr17_-_26127525 0.36 ENST00000313735.6
nitric oxide synthase 2, inducible
chr3_+_160559931 0.36 ENST00000464260.1
ENST00000295839.9
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr14_+_32546274 0.35 ENST00000396582.2
Rho GTPase activating protein 5
chr4_-_146859787 0.35 ENST00000508784.1
zinc finger protein 827
chr17_+_7387677 0.35 ENST00000322644.6
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr1_-_238649319 0.35 ENST00000400946.2
long intergenic non-protein coding RNA 1139
chr12_-_71551652 0.35 ENST00000546561.1
tetraspanin 8
chr5_+_17444119 0.35 ENST00000503267.1
ENST00000504998.1
RP11-321E2.4
chr6_+_105404899 0.34 ENST00000345080.4
lin-28 homolog B (C. elegans)
chr18_-_55253989 0.34 ENST00000262093.5
ferrochelatase
chr1_+_228870824 0.34 ENST00000366691.3
ras homolog family member U
chr12_-_91573316 0.33 ENST00000393155.1
decorin
chr20_+_4702548 0.32 ENST00000305817.2
prion protein 2 (dublet)
chr8_-_18541603 0.32 ENST00000428502.2
pleckstrin and Sec7 domain containing 3
chr19_+_44220247 0.32 ENST00000596627.1
immunity-related GTPase family, cinema
chrX_-_43741594 0.31 ENST00000536181.1
ENST00000378069.4
monoamine oxidase B
chr2_+_102686820 0.31 ENST00000409929.1
ENST00000424272.1
interleukin 1 receptor, type I
chrX_-_15619076 0.31 ENST00000252519.3
angiotensin I converting enzyme 2
chr6_+_27107053 0.31 ENST00000354348.2
histone cluster 1, H4i
chr10_-_11574274 0.31 ENST00000277575.5
USP6 N-terminal like
chr14_+_45431379 0.30 ENST00000361577.3
ENST00000361462.2
ENST00000382233.2
family with sequence similarity 179, member B
chr4_-_114900831 0.30 ENST00000315366.7
arylsulfatase family, member J
chr14_-_36988882 0.30 ENST00000498187.2
NK2 homeobox 1
chr9_+_5510558 0.30 ENST00000397747.3
programmed cell death 1 ligand 2
chr4_-_146859623 0.28 ENST00000379448.4
ENST00000513320.1
zinc finger protein 827
chr3_-_114035026 0.28 ENST00000570269.1
RP11-553L6.5
chr20_+_52105495 0.28 ENST00000439873.2
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr4_+_158141899 0.27 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr22_-_36220420 0.27 ENST00000473487.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr12_-_75603482 0.27 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr4_-_157892167 0.27 ENST00000541126.1
platelet derived growth factor C
chr7_+_107224364 0.27 ENST00000491150.1
B-cell receptor-associated protein 29
chr12_-_75603643 0.27 ENST00000549446.1
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr1_-_57045228 0.27 ENST00000371250.3
phosphatidic acid phosphatase type 2B
chr2_-_159237472 0.27 ENST00000409187.1
coiled-coil domain containing 148
chrX_+_80457442 0.26 ENST00000373212.5
SH3 domain binding glutamic acid-rich protein like
chr12_+_121570631 0.26 ENST00000546057.1
ENST00000377162.2
ENST00000328963.5
ENST00000535250.1
ENST00000541446.1
purinergic receptor P2X, ligand-gated ion channel, 7
chr10_-_100995603 0.26 ENST00000370552.3
ENST00000370549.1
heparanase 2
chr4_-_168155700 0.26 ENST00000357545.4
ENST00000512648.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr12_-_100656134 0.26 ENST00000548313.1
DEP domain containing 4
chrX_+_73164167 0.26 ENST00000414209.1
ENST00000602895.1
ENST00000453317.1
ENST00000602546.1
ENST00000602985.1
ENST00000415215.1
JPX transcript, XIST activator (non-protein coding)
chr12_-_91573132 0.26 ENST00000550563.1
ENST00000546370.1
decorin
chr4_+_86525299 0.26 ENST00000512201.1
Rho GTPase activating protein 24
chr16_-_33647696 0.25 ENST00000558425.1
ENST00000569103.2
Uncharacterized protein
chr4_-_83765613 0.25 ENST00000503937.1
SEC31 homolog A (S. cerevisiae)
chr9_+_125376948 0.25 ENST00000297913.2
olfactory receptor, family 1, subfamily Q, member 1
chr12_+_60058458 0.25 ENST00000548610.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr21_+_17909594 0.25 ENST00000441820.1
ENST00000602280.1
long intergenic non-protein coding RNA 478
chr5_+_1225470 0.24 ENST00000324642.3
ENST00000296821.4
solute carrier family 6 (neutral amino acid transporter), member 18
chr1_-_242612779 0.24 ENST00000427495.1
phospholipase D family, member 5
chr10_-_116444371 0.24 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr20_+_15177480 0.24 ENST00000402914.1
MACRO domain containing 2
chr3_+_148508845 0.24 ENST00000491148.1
carboxypeptidase B1 (tissue)
chr1_+_117963209 0.24 ENST00000449370.2
mannosidase, alpha, class 1A, member 2
chr4_-_157892498 0.24 ENST00000502773.1
platelet derived growth factor C
chr12_-_110511424 0.24 ENST00000548191.1
chromosome 12 open reading frame 76
chr21_-_36421535 0.24 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
runt-related transcription factor 1
chr1_+_209941942 0.23 ENST00000487271.1
ENST00000477431.1
TRAF3 interacting protein 3
chrX_-_30993201 0.23 ENST00000288422.2
ENST00000378932.2
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr12_-_48963829 0.23 ENST00000301046.2
ENST00000549817.1
lactalbumin, alpha-
chr12_-_6580094 0.23 ENST00000361716.3
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr5_-_135701164 0.23 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
transient receptor potential cation channel, subfamily C, member 7
chr2_+_204801471 0.23 ENST00000316386.6
ENST00000435193.1
inducible T-cell co-stimulator
chr8_-_133637624 0.23 ENST00000522789.1
leucine rich repeat containing 6
chr2_+_233897382 0.23 ENST00000233840.3
sialidase 2 (cytosolic sialidase)
chr10_-_98031310 0.23 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr13_-_99959641 0.23 ENST00000376414.4
G protein-coupled receptor 183
chr9_+_2159850 0.23 ENST00000416751.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr21_-_36421626 0.23 ENST00000300305.3
runt-related transcription factor 1
chr1_-_48866517 0.22 ENST00000371841.1
spermatogenesis associated 6
chrX_+_21874105 0.22 ENST00000429584.2
YY2 transcription factor
chr10_-_61495760 0.22 ENST00000395347.1
solute carrier family 16, member 9
chr17_-_48785216 0.21 ENST00000285243.6
ankyrin repeat domain 40
chr8_+_30244580 0.21 ENST00000523115.1
ENST00000519647.1
RNA binding protein with multiple splicing
chr1_+_61330931 0.21 ENST00000371191.1
nuclear factor I/A
chr18_-_53070913 0.21 ENST00000568186.1
ENST00000564228.1
transcription factor 4
chr9_-_6015607 0.21 ENST00000259569.5
RAN binding protein 6
chr10_+_81892477 0.21 ENST00000372263.3
placenta-specific 9
chr18_-_24237339 0.21 ENST00000580191.1
potassium channel tetramerization domain containing 1
chr10_-_98031265 0.21 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr6_+_116691001 0.21 ENST00000537543.1
dermatan sulfate epimerase
chr1_-_155271213 0.21 ENST00000342741.4
pyruvate kinase, liver and RBC
chr7_-_74221288 0.20 ENST00000451013.2
GTF2I repeat domain containing 2
chr4_+_158141806 0.20 ENST00000393815.2
glutamate receptor, ionotropic, AMPA 2
chr5_+_43603229 0.20 ENST00000344920.4
ENST00000512996.2
nicotinamide nucleotide transhydrogenase
chr4_+_39184024 0.20 ENST00000399820.3
ENST00000509560.1
ENST00000512112.1
ENST00000288634.7
ENST00000506503.1
WD repeat domain 19
chr16_+_81272287 0.20 ENST00000425577.2
ENST00000564552.1
beta-carotene 15,15'-monooxygenase 1
chr18_-_53089723 0.20 ENST00000561992.1
ENST00000562512.2
transcription factor 4
chr9_+_5510492 0.19 ENST00000397745.2
programmed cell death 1 ligand 2
chr16_+_28763108 0.19 ENST00000357796.3
ENST00000550983.1
nuclear pore complex interacting protein family, member B9
chr3_+_57881966 0.19 ENST00000495364.1
sarcolemma associated protein
chr2_+_101437487 0.19 ENST00000427413.1
ENST00000542504.1
neuronal PAS domain protein 2
chr3_+_178866199 0.19 ENST00000263967.3
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr17_-_38938786 0.19 ENST00000301656.3
keratin 27
chr7_-_64451414 0.19 ENST00000282869.6
zinc finger protein 117
chr5_+_140557371 0.19 ENST00000239444.2
protocadherin beta 8
chr1_+_162351503 0.19 ENST00000458626.2
chromosome 1 open reading frame 226
chr7_-_122342988 0.19 ENST00000434824.1
ring finger protein 148
chr7_-_122342966 0.19 ENST00000447240.1
ring finger protein 148
chr12_-_49449107 0.19 ENST00000301067.7
lysine (K)-specific methyltransferase 2D
chr16_-_58328870 0.18 ENST00000543437.1
protease, serine, 54
chr2_-_40679148 0.18 ENST00000417271.1
solute carrier family 8 (sodium/calcium exchanger), member 1
chrX_-_19689106 0.18 ENST00000379716.1
SH3-domain kinase binding protein 1
chr1_-_8877692 0.18 ENST00000400908.2
arginine-glutamic acid dipeptide (RE) repeats
chr2_+_189839046 0.18 ENST00000304636.3
ENST00000317840.5
collagen, type III, alpha 1
chr10_+_48189612 0.18 ENST00000453919.1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
chrX_+_100663243 0.18 ENST00000316594.5
heterogeneous nuclear ribonucleoprotein H2 (H')
chr3_+_69812877 0.17 ENST00000457080.1
ENST00000328528.6
microphthalmia-associated transcription factor
chr16_-_58328923 0.17 ENST00000567164.1
ENST00000219301.4
ENST00000569727.1
protease, serine, 54
chr5_+_131993856 0.17 ENST00000304506.3
interleukin 13
chr12_+_8309630 0.17 ENST00000396570.3
zinc finger protein 705A
chr5_-_111091948 0.17 ENST00000447165.2
neuronal regeneration related protein
chr3_-_169487617 0.17 ENST00000330368.2
actin-related protein T3
chr1_-_216978709 0.17 ENST00000360012.3
estrogen-related receptor gamma
chr17_+_7792101 0.17 ENST00000358181.4
ENST00000330494.7
chromodomain helicase DNA binding protein 3
chr19_-_12777509 0.17 ENST00000221363.4
ENST00000598876.1
ENST00000456935.2
ENST00000486847.2
mannosidase, alpha, class 2B, member 1
chr16_+_75032901 0.17 ENST00000335325.4
ENST00000320619.6
zinc and ring finger 1, E3 ubiquitin protein ligase
chr5_+_173316341 0.17 ENST00000520867.1
ENST00000334035.5
cytoplasmic polyadenylation element binding protein 4
chr4_-_103998060 0.17 ENST00000339611.4
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr2_-_237416181 0.17 ENST00000409907.3
IQ motif containing with AAA domain 1
chr11_+_61522844 0.17 ENST00000265460.5
myelin regulatory factor
chr18_-_5895954 0.17 ENST00000581347.2
transmembrane protein 200C
chr1_-_157015162 0.17 ENST00000368194.3
Rho guanine nucleotide exchange factor (GEF) 11
chr4_-_89978299 0.16 ENST00000511976.1
ENST00000509094.1
ENST00000264344.5
ENST00000515600.1
family with sequence similarity 13, member A
chr9_-_36401155 0.16 ENST00000377885.2
ring finger protein 38
chr8_-_17942432 0.16 ENST00000381733.4
ENST00000314146.10
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr17_-_7387524 0.16 ENST00000311403.4
zinc finger and BTB domain containing 4
chr4_+_158141843 0.16 ENST00000509417.1
ENST00000296526.7
glutamate receptor, ionotropic, AMPA 2
chr9_-_14910420 0.16 ENST00000380880.3
FRAS1 related extracellular matrix 1
chr8_-_82024290 0.16 ENST00000220597.4
phosphoprotein associated with glycosphingolipid microdomains 1
chrX_+_133733457 0.16 ENST00000440614.1
RP11-308B5.2
chr7_+_48211048 0.16 ENST00000435803.1
ATP-binding cassette, sub-family A (ABC1), member 13
chr9_+_34989638 0.15 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr6_+_149539767 0.15 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr6_-_75912508 0.15 ENST00000416123.2
collagen, type XII, alpha 1
chr14_-_90798418 0.15 ENST00000354366.3
NRDE-2, necessary for RNA interference, domain containing
chr19_+_30863271 0.15 ENST00000355537.3
zinc finger protein 536
chr6_+_167536230 0.15 ENST00000341935.5
ENST00000349984.4
chemokine (C-C motif) receptor 6
chr8_-_15095832 0.15 ENST00000382080.1
sarcoglycan, zeta
chr17_+_39388700 0.15 ENST00000411528.2
keratin associated protein 9-3
chr8_-_16043780 0.15 ENST00000445506.2
macrophage scavenger receptor 1
chr8_+_26240414 0.15 ENST00000380629.2
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr2_-_237416071 0.15 ENST00000309507.5
ENST00000431676.2
IQ motif containing with AAA domain 1
chr19_-_43422019 0.15 ENST00000402603.4
ENST00000594375.1
pregnancy specific beta-1-glycoprotein 6
chr19_+_48773337 0.15 ENST00000595607.1
zinc finger protein 114
chr9_-_139361503 0.15 ENST00000453963.1
SEC16 homolog A (S. cerevisiae)
chr5_+_122847781 0.15 ENST00000395412.1
ENST00000395411.1
ENST00000345990.4
casein kinase 1, gamma 3
chrX_-_63005405 0.15 ENST00000374878.1
ENST00000437457.2
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr21_+_26934165 0.14 ENST00000456917.1
MIR155 host gene (non-protein coding)
chr11_+_71903169 0.14 ENST00000393676.3
folate receptor 1 (adult)
chr4_-_120243545 0.14 ENST00000274024.3
fatty acid binding protein 2, intestinal
chr4_-_153303658 0.14 ENST00000296555.5
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr12_+_26348246 0.14 ENST00000422622.2
sarcospan
chr6_+_43149903 0.14 ENST00000252050.4
ENST00000354495.3
ENST00000372647.2
cullin 9
chr3_-_121740969 0.14 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
immunoglobulin-like domain containing receptor 1
chr5_+_92919043 0.14 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chr2_+_220462560 0.14 ENST00000456909.1
ENST00000295641.10
serine/threonine kinase 11 interacting protein
chr15_+_85147127 0.13 ENST00000541040.1
ENST00000538076.1
ENST00000485222.2
zinc finger and SCAN domain containing 2
chr13_-_48669232 0.13 ENST00000258648.2
ENST00000378586.1
mediator complex subunit 4
chr10_-_47239738 0.13 ENST00000413193.2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 10

Network of associatons between targets according to the STRING database.

First level regulatory network of IKZF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0001172 transcription, RNA-templated(GO:0001172)
0.2 0.5 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 0.7 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.4 GO:0071529 cementum mineralization(GO:0071529)
0.1 0.3 GO:0070541 response to platinum ion(GO:0070541)
0.1 0.5 GO:0060648 mammary gland bud morphogenesis(GO:0060648) regulation of determination of dorsal identity(GO:2000015)
0.1 0.3 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.1 0.3 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.8 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.3 GO:1904172 NAD transport(GO:0043132) regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.1 0.2 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 0.8 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.5 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.2 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.3 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.1 0.8 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 1.5 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 0.2 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 0.3 GO:0010269 response to selenium ion(GO:0010269)
0.1 0.3 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.0 0.1 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264)
0.0 0.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.4 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.2 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.3 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.2 GO:0001555 oocyte growth(GO:0001555)
0.0 0.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.1 GO:0006566 threonine metabolic process(GO:0006566)
0.0 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.4 GO:0032310 prostaglandin secretion(GO:0032310)
0.0 0.1 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.4 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.6 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.1 GO:0090035 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.0 0.2 GO:1901374 acetate ester transport(GO:1901374)
0.0 0.1 GO:0035910 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.1 GO:0002572 pro-T cell differentiation(GO:0002572)
0.0 0.2 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 2.6 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.6 GO:0035640 exploration behavior(GO:0035640)
0.0 0.1 GO:0003409 optic cup structural organization(GO:0003409)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.6 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.0 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.0 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 1.0 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.0 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.3 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) beta-catenin destruction complex assembly(GO:1904885) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.2 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.0 GO:0072255 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.0 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.0 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.0 GO:0050902 leukocyte adhesive activation(GO:0050902)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 1.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.5 GO:0031526 brush border membrane(GO:0031526)
0.1 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.4 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.9 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.5 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0071953 elastic fiber(GO:0071953)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0002079 inner acrosomal membrane(GO:0002079) outer acrosomal membrane(GO:0002081)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 1.7 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.2 0.7 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.2 0.2 GO:0052813 phosphatidylinositol 3-kinase activity(GO:0035004) phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 1.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.8 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.4 GO:0016160 amylase activity(GO:0016160)
0.1 0.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 0.5 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.3 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.1 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.2 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.1 0.2 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.2 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.2 GO:0030305 heparanase activity(GO:0030305)
0.1 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.4 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.4 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.2 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.5 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 1.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.3 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.3 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.1 GO:0070538 oleic acid binding(GO:0070538)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 1.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.2 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.2 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.2 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 1.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.0 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.9 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 1.7 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.9 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.6 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism