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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PAX1_PAX9

Z-value: 0.59

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.9 paired box 1
PAX9
ENSG00000198807.8 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37126765_371267990.393.3e-02Click!
PAX1hg19_v2_chr20_+_21686290_216863110.212.6e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_23261589 4.64 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2
lysyl oxidase-like 2
chr4_+_75230853 4.43 ENST00000244869.2
EREG
epiregulin
chr7_+_36429424 2.40 ENST00000396068.2
ANLN
anillin, actin binding protein
chr7_+_36429409 2.35 ENST00000265748.2
ANLN
anillin, actin binding protein
chr9_+_33750667 2.31 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
PRSS3
protease, serine, 3
chr9_+_33750515 2.31 ENST00000361005.5
PRSS3
protease, serine, 3
chr9_+_33795533 1.72 ENST00000379405.3
PRSS3
protease, serine, 3
chr11_+_12308447 1.38 ENST00000256186.2
MICALCL
MICAL C-terminal like
chr19_-_40791211 1.23 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr18_-_33077556 1.20 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chr13_+_98086445 0.82 ENST00000245304.4
RAP2A
RAP2A, member of RAS oncogene family
chr7_+_142457315 0.80 ENST00000486171.1
ENST00000311737.7
PRSS1
protease, serine, 1 (trypsin 1)
chr17_-_33814851 0.80 ENST00000449046.1
ENST00000260908.7
SLFN12L
schlafen family member 12-like
chr17_+_39969183 0.73 ENST00000321562.4
FKBP10
FK506 binding protein 10, 65 kDa
chr17_+_15848231 0.58 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr9_-_124991124 0.57 ENST00000394319.4
ENST00000340587.3
LHX6
LIM homeobox 6
chr8_-_125384927 0.57 ENST00000297632.6
TMEM65
transmembrane protein 65
chr6_-_137494775 0.47 ENST00000349184.4
ENST00000296980.2
ENST00000339602.3
IL22RA2
interleukin 22 receptor, alpha 2
chr17_-_7137582 0.44 ENST00000575756.1
ENST00000575458.1
DVL2
dishevelled segment polarity protein 2
chr5_+_72251857 0.43 ENST00000507345.2
ENST00000512348.1
ENST00000287761.6
FCHO2
FCH domain only 2
chr8_-_101965559 0.42 ENST00000353245.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr6_-_137366163 0.38 ENST00000367748.1
IL20RA
interleukin 20 receptor, alpha
chr5_-_133747589 0.34 ENST00000458198.2
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr19_-_40791302 0.33 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr14_-_69261310 0.31 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr2_+_234160217 0.30 ENST00000392017.4
ENST00000347464.5
ENST00000444735.1
ENST00000373525.5
ENST00000419681.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr1_-_204165610 0.29 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr2_+_234160340 0.26 ENST00000417017.1
ENST00000392020.4
ENST00000392018.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr11_+_6947720 0.26 ENST00000414517.2
ZNF215
zinc finger protein 215
chr7_-_144533074 0.26 ENST00000360057.3
ENST00000378099.3
TPK1
thiamin pyrophosphokinase 1
chr7_-_112758665 0.25 ENST00000397764.3
LINC00998
long intergenic non-protein coding RNA 998
chr7_-_112758589 0.25 ENST00000413744.1
ENST00000439551.1
ENST00000441359.1
LINC00998
long intergenic non-protein coding RNA 998
chr17_-_39968406 0.24 ENST00000393928.1
LEPREL4
leprecan-like 4
chr19_+_14184370 0.23 ENST00000590772.1
hsa-mir-1199
hsa-mir-1199
chr3_-_57113314 0.23 ENST00000338458.4
ENST00000468727.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr2_+_119699864 0.23 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr4_+_123747834 0.23 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr10_-_99393242 0.21 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
MORN4
MORN repeat containing 4
chr11_+_6947647 0.20 ENST00000278319.5
ZNF215
zinc finger protein 215
chr14_+_64854958 0.20 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr9_-_104249400 0.19 ENST00000374848.3
TMEM246
transmembrane protein 246
chr4_-_171011084 0.17 ENST00000337664.4
AADAT
aminoadipate aminotransferase
chr17_-_39968855 0.16 ENST00000355468.3
ENST00000590496.1
LEPREL4
leprecan-like 4
chr19_-_409134 0.16 ENST00000332235.6
C2CD4C
C2 calcium-dependent domain containing 4C
chr4_-_171011323 0.15 ENST00000509167.1
ENST00000353187.2
ENST00000507375.1
ENST00000515480.1
AADAT
aminoadipate aminotransferase
chr15_+_63569785 0.14 ENST00000380343.4
ENST00000560353.1
APH1B
APH1B gamma secretase subunit
chr8_-_101965146 0.14 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_-_77997126 0.13 ENST00000537948.1
ENST00000507788.1
ENST00000237654.4
CCNI
cyclin I
chr10_-_99393208 0.13 ENST00000307450.6
MORN4
MORN repeat containing 4
chr10_-_43904608 0.13 ENST00000337970.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr12_+_57828521 0.12 ENST00000309668.2
INHBC
inhibin, beta C
chr17_+_37356555 0.12 ENST00000579374.1
RPL19
ribosomal protein L19
chr17_+_37356586 0.11 ENST00000579260.1
ENST00000582193.1
RPL19
ribosomal protein L19
chr1_+_26758790 0.11 ENST00000427245.2
ENST00000525682.2
ENST00000236342.7
ENST00000526219.1
ENST00000374185.3
ENST00000360009.2
DHDDS
dehydrodolichyl diphosphate synthase
chr7_-_19157248 0.11 ENST00000242261.5
TWIST1
twist family bHLH transcription factor 1
chr17_+_37356528 0.10 ENST00000225430.4
RPL19
ribosomal protein L19
chr11_+_63870660 0.05 ENST00000246841.3
FLRT1
fibronectin leucine rich transmembrane protein 1
chr6_+_159291090 0.05 ENST00000367073.4
ENST00000608817.1
C6orf99
chromosome 6 open reading frame 99
chr9_-_21142144 0.05 ENST00000380229.2
IFNW1
interferon, omega 1
chr1_+_26759295 0.05 ENST00000430232.1
DHDDS
dehydrodolichyl diphosphate synthase
chr6_+_34857019 0.03 ENST00000360359.3
ENST00000535627.1
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr4_-_163085141 0.03 ENST00000427802.2
ENST00000306100.5
FSTL5
follistatin-like 5
chr4_+_123747979 0.03 ENST00000608478.1
FGF2
fibroblast growth factor 2 (basic)
chr18_+_39766626 0.02 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr14_+_39703112 0.02 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr6_+_159290917 0.02 ENST00000367072.1
C6orf99
chromosome 6 open reading frame 99
chr8_+_39792474 0.02 ENST00000502986.2
IDO2
indoleamine 2,3-dioxygenase 2
chr1_+_45140360 0.01 ENST00000418644.1
ENST00000458657.2
ENST00000441519.1
ENST00000535358.1
ENST00000445071.1
C1orf228
chromosome 1 open reading frame 228

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:1904170 regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
1.5 4.4 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.4 1.6 GO:0009644 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.2 7.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 0.7 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.1 0.6 GO:0002545 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
0.1 4.6 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 0.4 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.3 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.1 0.6 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.3 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 0.8 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.3 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.1 0.3 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.1 0.1 GO:2000793 cell proliferation involved in heart valve development(GO:2000793)
0.1 0.2 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.3 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.6 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 6.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.2 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 4.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.3 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1 0.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 4.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.2 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.2 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.0 0.6 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.3 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 6.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 11.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 4.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.6 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo