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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SREBF2
Z-value: 0.68
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Transcription factors associated with SREBF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SREBF2 | hg19_v2_chr22_+_42229100_42229146 | 0.63 | 1.7e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_151561085 Show fit | 4.68 |
ENST00000402676.2
|
A kinase (PRKA) anchor protein 12 |
|
| chr1_+_55505184 Show fit | 3.25 |
ENST00000302118.5
|
proprotein convertase subtilisin/kexin type 9 |
|
| chr4_+_75230853 Show fit | 3.13 |
ENST00000244869.2
|
epiregulin |
|
| chr8_+_26435359 Show fit | 3.01 |
ENST00000311151.5
|
dihydropyrimidinase-like 2 |
|
| chr19_+_11200038 Show fit | 2.41 |
ENST00000558518.1
ENST00000557933.1 ENST00000455727.2 ENST00000535915.1 ENST00000545707.1 ENST00000558013.1 |
low density lipoprotein receptor |
|
| chr6_-_53213587 Show fit | 2.27 |
ENST00000542638.1
ENST00000370913.5 ENST00000541407.1 |
ELOVL fatty acid elongase 5 |
|
| chr20_+_33464238 Show fit | 2.15 |
ENST00000360596.2
|
acyl-CoA synthetase short-chain family member 2 |
|
| chr20_+_33464407 Show fit | 1.93 |
ENST00000253382.5
|
acyl-CoA synthetase short-chain family member 2 |
|
| chr2_-_26205340 Show fit | 1.73 |
ENST00000264712.3
|
kinesin family member 3C |
|
| chr18_-_21166841 Show fit | 1.73 |
ENST00000269228.5
|
Niemann-Pick disease, type C1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.7 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 1.0 | 4.1 | GO:0019413 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542) |
| 1.1 | 3.3 | GO:2000646 | positive regulation of receptor catabolic process(GO:2000646) |
| 1.0 | 3.1 | GO:0042700 | luteinizing hormone signaling pathway(GO:0042700) |
| 0.3 | 3.1 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.3 | 2.7 | GO:0046618 | drug export(GO:0046618) |
| 0.1 | 2.6 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.0 | 2.6 | GO:0030516 | regulation of axon extension(GO:0030516) |
| 0.6 | 2.4 | GO:0090118 | receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.0 | 2.0 | GO:0030183 | B cell differentiation(GO:0030183) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.7 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.0 | 4.8 | GO:0005938 | cell cortex(GO:0005938) |
| 1.0 | 3.1 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.0 | 2.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 2.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 2.2 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 1.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.4 | 1.5 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.0 | 1.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 1.0 | GO:0000796 | condensin complex(GO:0000796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.8 | 4.1 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.7 | 4.0 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 1.1 | 3.3 | GO:0034189 | very-low-density lipoprotein particle binding(GO:0034189) |
| 0.3 | 3.1 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 1.0 | 3.0 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.5 | 2.7 | GO:0015307 | drug:proton antiporter activity(GO:0015307) |
| 0.5 | 2.4 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.0 | 2.2 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.3 | 1.7 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 2.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.6 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.3 | 4.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 3.0 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.7 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 2.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.4 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 1.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.9 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.8 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |