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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for THRB

Z-value: 0.32

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24536253_245363280.203.0e-01Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_5617976 0.92 ENST00000445329.1
TRIM6
tripartite motif containing 6
chr15_-_101084446 0.91 ENST00000538112.2
ENST00000559639.1
ENST00000558884.2
CERS3
ceramide synthase 3
chr11_+_5617858 0.89 ENST00000380097.3
TRIM6
tripartite motif containing 6
chr1_-_113498943 0.74 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr1_-_113498616 0.72 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr15_-_101084547 0.70 ENST00000394113.1
CERS3
ceramide synthase 3
chr13_-_24007815 0.69 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr17_-_73840415 0.53 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr10_+_62538089 0.43 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr3_+_50606901 0.40 ENST00000455834.1
HEMK1
HemK methyltransferase family member 1
chr8_-_124037890 0.38 ENST00000519018.1
ENST00000523036.1
DERL1
derlin 1
chr10_+_62538248 0.37 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr3_+_50606577 0.34 ENST00000434410.1
ENST00000232854.4
HEMK1
HemK methyltransferase family member 1
chr15_-_101084881 0.33 ENST00000284382.4
CERS3
ceramide synthase 3
chr15_-_35838348 0.33 ENST00000561411.1
ENST00000256538.4
ENST00000440392.2
DPH6
diphthamine biosynthesis 6
chr6_-_99842041 0.27 ENST00000254759.3
ENST00000369242.1
COQ3
coenzyme Q3 methyltransferase
chr2_-_9563469 0.27 ENST00000484735.1
ENST00000456913.2
ITGB1BP1
integrin beta 1 binding protein 1
chr18_-_47807829 0.25 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
MBD1
methyl-CpG binding domain protein 1
chr2_-_74692473 0.22 ENST00000535045.1
ENST00000409065.1
ENST00000414701.1
ENST00000448666.1
ENST00000233616.4
ENST00000452063.2
MOGS
mannosyl-oligosaccharide glucosidase
chr22_+_19938419 0.18 ENST00000412786.1
COMT
catechol-O-methyltransferase
chr17_+_7533439 0.17 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
SHBG
sex hormone-binding globulin
chr11_-_64014379 0.17 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr18_-_47808120 0.16 ENST00000587605.1
ENST00000591416.1
ENST00000382948.5
ENST00000269471.5
ENST00000269468.5
ENST00000347968.3
ENST00000436910.1
ENST00000349085.2
MBD1
methyl-CpG binding domain protein 1
chr18_-_47808050 0.15 ENST00000590208.1
MBD1
methyl-CpG binding domain protein 1
chr20_+_388679 0.14 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr17_-_73840774 0.14 ENST00000207549.4
UNC13D
unc-13 homolog D (C. elegans)
chr19_-_52643157 0.13 ENST00000597013.1
ENST00000600228.1
ENST00000596290.1
ZNF616
zinc finger protein 616
chr11_+_5617952 0.13 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr8_+_22102626 0.09 ENST00000519237.1
ENST00000397802.4
POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr14_+_75761099 0.09 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5
RP11-293M10.5
chr8_+_22102611 0.08 ENST00000306433.4
POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr21_-_37914898 0.08 ENST00000399136.1
CLDN14
claudin 14
chr11_+_57310114 0.08 ENST00000527972.1
ENST00000399154.2
SMTNL1
smoothelin-like 1
chr19_+_55085248 0.08 ENST00000391738.3
ENST00000251376.3
ENST00000391737.1
ENST00000396321.2
ENST00000418536.2
ENST00000448689.1
LILRA2
LILRB1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr11_+_46366918 0.08 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr1_-_154164534 0.07 ENST00000271850.7
ENST00000368530.2
TPM3
tropomyosin 3
chr6_+_151042224 0.07 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr11_+_73498898 0.06 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr12_-_21810765 0.05 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr12_-_21810726 0.04 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr20_+_388791 0.03 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr8_+_28174649 0.02 ENST00000301908.3
PNOC
prepronociceptin
chr1_+_3668962 0.02 ENST00000294600.2
CCDC27
coiled-coil domain containing 27
chr5_+_131746575 0.02 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr2_-_73869508 0.02 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chrX_-_1511617 0.01 ENST00000381401.5
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr2_-_9563319 0.01 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
ITGB1BP1
integrin beta 1 binding protein 1
chr5_-_156593273 0.01 ENST00000302938.4
FAM71B
family with sequence similarity 71, member B
chr7_-_100253993 0.01 ENST00000461605.1
ENST00000160382.5
ACTL6B
actin-like 6B
chr11_-_45307817 0.00 ENST00000020926.3
SYT13
synaptotagmin XIII

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.2 1.8 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.8 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.1 0.4 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.7 GO:0043320 natural killer cell degranulation(GO:0043320)
0.0 0.2 GO:0050668 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.6 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.3 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 1.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0035548 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.0 0.3 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.4 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.1 0.7 GO:0070852 cell body fiber(GO:0070852)
0.0 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.2 1.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.6 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0005497 androgen binding(GO:0005497)
0.0 0.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.1 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.8 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 0.2 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.8 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle