Motif ID: AAUCUCU

Z-value: 0.239


Mature miRNA associated with seed AAUCUCU:

NamemiRBase Accession
hsa-miR-216b MIMAT0004959



Activity profile for motif AAUCUCU.

activity profile for motif AAUCUCU


Sorted Z-values histogram for motif AAUCUCU

Sorted Z-values for motif AAUCUCU



Network of associatons between targets according to the STRING database.



First level regulatory network of AAUCUCU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_29641094 0.032 NM_006495
EVI2B
ecotropic viral integration site 2B
chr12_-_26985922 0.022 NM_002223
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
chr8_-_22550708 0.022 NM_004430
EGR3
early growth response 3
chr7_+_90032647 0.021 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr8_-_22550057 0.021 NM_001199881
EGR3
early growth response 3
chr8_-_22549901 0.020 NM_001199880
EGR3
early growth response 3
chr5_+_68788118 0.020 NM_002538
OCLN
occludin
chr5_+_68788387 0.020 NM_001205254
OCLN
occludin
chr5_+_68800003 0.020 NM_001205255
OCLN
occludin
chr1_-_109940497 0.019 NM_002959
SORT1
sortilin 1
chr5_-_148442606 0.017 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr5_-_87564615 0.017 NM_153354
TMEM161B
transmembrane protein 161B
chr4_+_155665150 0.017 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr1_-_109935869 0.017 NM_001205228
SORT1
sortilin 1
chr16_+_8768403 0.016 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr8_-_57233240 0.016 NM_138969
SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr15_+_91643429 0.015 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chr16_+_8814567 0.015 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr7_+_154862545 0.014 NM_024012
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A
chr16_+_8806825 0.014 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr17_-_47439326 0.014 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr14_+_52327021 0.014 NM_001243773
NM_001243774
NM_053064
GNG2


guanine nucleotide binding protein (G protein), gamma 2


chr16_-_49860917 0.014 NM_015069
ZNF423
zinc finger protein 423
chr4_+_81952118 0.013 NM_001201
BMP3
bone morphogenetic protein 3
chr3_-_36781351 0.013 NM_033403
DCLK3
doublecortin-like kinase 3
chr4_+_84457390 0.013 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr5_+_149109814 0.013 NM_001172698
NM_133263
PPARGC1B

peroxisome proliferator-activated receptor gamma, coactivator 1 beta

chr14_+_71108373 0.013 NM_015351
TTC9
tetratricopeptide repeat domain 9
chr2_+_26568900 0.013 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr15_-_70994608 0.012 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr1_-_200992824 0.012 NM_001252100
NM_001252102
NM_001252103
NM_017596
KIF21B



kinesin family member 21B



chr8_+_28351694 0.012 NM_017412
NM_145866
FZD3

frizzled family receptor 3

chr7_+_20370724 0.012 NM_002214
ITGB8
integrin, beta 8
chr7_+_108210188 0.012 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chrX_-_83442906 0.011 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr8_-_133493003 0.011 NM_004519
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr8_-_114449018 0.011 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr12_-_95044205 0.011 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr1_-_52831817 0.011 NM_032449
CC2D1B
coiled-coil and C2 domain containing 1B
chr8_-_139509064 0.011 NM_015912
FAM135B
family with sequence similarity 135, member B
chr11_-_132812870 0.011 NM_002545
OPCML
opioid binding protein/cell adhesion molecule-like
chr22_-_19109912 0.011 NM_001173533
NM_001173534
NM_001184781
NM_005137
DGCR2



DiGeorge syndrome critical region gene 2



chr11_+_108093558 0.011 NM_000051
ATM
ataxia telangiectasia mutated
chr1_+_228353428 0.011 NM_001010867
IBA57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chrX_-_8700170 0.011 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr8_-_114389381 0.010 NM_198124
CSMD3
CUB and Sushi multiple domains 3
chr12_+_107712151 0.010 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr16_+_12995454 0.010 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr20_+_5987897 0.010 NM_001127458
CRLS1
cardiolipin synthase 1
chr5_+_149151502 0.010 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr20_+_54933982 0.010 NM_080821
FAM210B
family with sequence similarity 210, member B
chr20_+_5986560 0.010 NM_019095
CRLS1
cardiolipin synthase 1
chr14_+_71374111 0.010 NM_014982
PCNX
pecanex homolog (Drosophila)
chrX_+_37545008 0.010 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr1_+_101361589 0.010 NM_001144884
NM_133496
SLC30A7

solute carrier family 30 (zinc transporter), member 7

chr3_+_11267666 0.010 NM_001098211
HRH1
histamine receptor H1
chr19_-_53662279 0.010 NM_001172674
NM_001172675
NM_032584
ZNF347


zinc finger protein 347


chr9_-_14693459 0.010 NM_178566
ZDHHC21
zinc finger, DHHC-type containing 21
chr6_+_160769365 0.009 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr1_+_2323200 0.009 NM_007033
RER1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
chr4_+_41937105 0.009 NM_018126
TMEM33
transmembrane protein 33
chr4_+_40058507 0.009 NM_018177
N4BP2
NEDD4 binding protein 2
chr16_-_17564737 0.009 NM_022166
XYLT1
xylosyltransferase I
chr2_+_192542860 0.009 NM_001031716
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A
chr12_+_11802726 0.009 NM_001987
ETV6
ets variant 6
chr12_+_107974633 0.009 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr14_-_80677839 0.009 NM_001007023
NM_001242502
NM_001242503
NM_013989
DIO2



deiodinase, iodothyronine, type II



chr8_+_25042254 0.009 NM_024940
DOCK5
dedicator of cytokinesis 5
chr7_-_129845216 0.009 NM_032842
TMEM209
transmembrane protein 209
chr21_-_43373938 0.009 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr3_+_11294384 0.009 NM_000861
HRH1
histamine receptor H1
chr4_-_113437327 0.009 NM_024019
NEUROG2
neurogenin 2
chr9_+_118916069 0.009 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr3_+_11196213 0.009 NM_001098212
HRH1
histamine receptor H1
chr18_-_22932109 0.009 NM_015461
ZNF521
zinc finger protein 521
chr7_-_102213013 0.009 NM_001097615
POLR2J2
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II (DNA directed) polypeptide J3
chr15_+_65822738 0.008 NM_016395
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr1_-_241799101 0.008 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr3_+_11178778 0.008 NM_001098213
HRH1
histamine receptor H1
chr19_-_23941571 0.008 NM_138286
ZNF681
zinc finger protein 681
chr7_+_89840999 0.008 NM_001244944
NM_001244945
NM_152999
NM_001040665
NM_001244946
STEAP2




STEAP family member 2, metalloreductase




chr17_-_26733185 0.008 NM_001242366
NM_080669
SLC46A1

solute carrier family 46 (folate transporter), member 1

chr2_+_173420776 0.008 NM_002610
PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr8_-_81787015 0.008 NM_001033723
ZNF704
zinc finger protein 704
chr15_-_49255640 0.008 NM_203349
SHC4
SHC (Src homology 2 domain containing) family, member 4
chrX_-_128977291 0.008 NM_001008222
ZDHHC9
zinc finger, DHHC-type containing 9
chr21_-_43346780 0.008 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr12_+_111051831 0.008 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr12_+_133757994 0.008 NM_001165883
NM_001165884
NM_001165885
NM_001165886
NM_001165887
NM_003415
NM_152943
NM_001165881
NM_001165882
ZNF268








zinc finger protein 268








chrX_-_128977719 0.008 NM_016032
ZDHHC9
zinc finger, DHHC-type containing 9
chr11_-_123065988 0.008 NM_024769
CLMP
CXADR-like membrane protein
chr2_-_202508223 0.008 NM_001044385
TMEM237
transmembrane protein 237
chr2_-_202507348 0.008 NM_152388
TMEM237
transmembrane protein 237
chr9_-_5833072 0.008 NM_024896
ERMP1
endoplasmic reticulum metallopeptidase 1
chr5_+_149340287 0.008 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr7_+_2598611 0.008 NM_001100390
NM_152558
IQCE

IQ motif containing E

chr13_+_95254021 0.008 NM_180989
GPR180
G protein-coupled receptor 180
chr17_+_18684579 0.008 NM_016078
FAM18B1
family with sequence similarity 18, member B1
chr7_+_102389325 0.008 NM_001145268
NM_001145269
FAM185A

family with sequence similarity 185, member A

chrX_-_119445306 0.007 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr15_-_35087748 0.007 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr18_-_61034350 0.007 NM_002035
KDSR
3-ketodihydrosphingosine reductase
chr4_-_2366530 0.007 NM_001172659
NM_001172660
ZFYVE28

zinc finger, FYVE domain containing 28

chr12_-_8088629 0.007 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr16_+_67679011 0.007 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr1_-_114354906 0.007 NM_018364
RSBN1
round spermatid basic protein 1
chr15_-_71055745 0.007 NM_018003
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr1_+_202172863 0.007 NM_021636
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr16_+_22019438 0.007 NM_001164579
C16orf52
chromosome 16 open reading frame 52
chr19_+_44645708 0.007 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr1_+_202183282 0.007 NM_001017404
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr3_+_156008775 0.007 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr6_-_75915566 0.007 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr12_+_56211718 0.007 NM_014182
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr1_-_216596737 0.007 NM_007123
NM_206933
USH2A

Usher syndrome 2A (autosomal recessive, mild)

chr17_-_16472463 0.006 NM_020653
ZNF287
zinc finger protein 287
chr8_+_1922030 0.006 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr17_-_62340652 0.006 NM_018469
TEX2
testis expressed 2
chr12_-_89746244 0.006 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr1_-_231473478 0.006 NM_175876
EXOC8
exocyst complex component 8
chr3_+_180319898 0.006 NM_001042601
NM_133462
TTC14

tetratricopeptide repeat domain 14

chr11_-_63536112 0.006 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr6_-_2751153 0.006 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr12_-_10022457 0.006 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr16_-_10276115 0.006 NM_001134407
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr6_+_11538486 0.006 NM_001100829
TMEM170B
transmembrane protein 170B
chr1_+_44584521 0.006 NM_173484
KLF17
Kruppel-like factor 17
chr1_+_116519118 0.006 NM_018420
SLC22A15
solute carrier family 22, member 15
chr1_+_33938231 0.006 NM_145238
ZSCAN20
zinc finger and SCAN domain containing 20
chr15_-_51914770 0.006 NM_001174116
NM_001174117
NM_015263
DMXL2


Dmx-like 2


chr1_-_220263150 0.006 NM_006085
BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr12_+_5019048 0.006 NM_000217
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr1_+_162039469 0.006 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr12_-_50616425 0.006 NM_001113547
LIMA1
LIM domain and actin binding 1
chrX_+_67718623 0.006 NM_001195214
NM_173834
YIPF6

Yip1 domain family, member 6

chr9_+_87284573 0.006 NM_001018065
NM_001018066
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr1_+_202163117 0.006 NM_001017403
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr4_-_2420252 0.006 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr2_-_151344145 0.006 NM_005168
RND3
Rho family GTPase 3
chr19_-_37407079 0.006 NM_001037232
ZNF829
zinc finger protein 829
chr7_-_91509979 0.006 NM_006980
MTERF
mitochondrial transcription termination factor
chr5_-_143550215 0.006 NM_001024947
NM_030799
YIPF5

Yip1 domain family, member 5

chr14_-_80697396 0.006 NM_000793
DIO2
deiodinase, iodothyronine, type II
chr7_+_107220421 0.006 NM_018844
BCAP29
B-cell receptor-associated protein 29
chrX_+_144902865 0.006 NM_001144006
NM_001144008
NM_001144009
NM_001144010
SLITRK2



SLIT and NTRK-like family, member 2



chr16_-_10276610 0.005 NM_000833
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr19_+_42788605 0.005 NM_015125
CIC
capicua homolog (Drosophila)
chr7_+_107221203 0.005 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chr11_-_69490093 0.005 NM_153451
ORAOV1
oral cancer overexpressed 1
chr7_-_138665853 0.005 NM_001164665
NM_020910
KIAA1549

KIAA1549

chr8_-_133459508 0.005 NM_001204824
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr7_+_155250705 0.005 NM_001427
EN2
engrailed homeobox 2
chr11_+_35160385 0.005 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr3_+_155860750 0.005 NM_003471
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr20_+_18122867 0.005 NM_020536
CSRP2BP
CSRP2 binding protein
chr20_+_11871364 0.005 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr1_-_236030219 0.005 NM_000081
LYST
lysosomal trafficking regulator
chr1_+_233463513 0.005 NM_032435
KIAA1804
mixed lineage kinase 4
chr6_-_135271206 0.005 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr9_-_111696556 0.005 NM_003640
IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr2_+_85980600 0.005 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr12_+_27933162 0.005 NM_020782
KLHDC5
kelch domain containing 5
chr5_-_133968463 0.005 NM_001033503
NM_016103
SAR1B

SAR1 homolog B (S. cerevisiae)

chrX_+_144899330 0.005 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chr11_-_102962903 0.005 NM_032299
DCUN1D5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr9_-_124132503 0.005 NM_004099
NM_198194
STOM

stomatin

chr6_-_94129059 0.005 NM_004440
EPHA7
EPH receptor A7
chr1_-_165738106 0.005 NM_019026
TMCO1
transmembrane and coiled-coil domains 1
chr1_-_151032082 0.005 NM_001038707
NM_020239
CDC42SE1

CDC42 small effector 1

chr3_+_155838336 0.005 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr2_+_46926049 0.005 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr2_+_46926323 0.005 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr2_+_128848752 0.005 NM_020120
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr1_+_162332772 0.005 NM_001126060
NOS1AP
nitric oxide synthase 1 (neuronal) adaptor protein
chr17_-_65241305 0.005 NM_014877
HELZ
helicase with zinc finger
chr2_+_135676387 0.005 NM_001241
NM_058241
CCNT2

cyclin T2

chr1_-_154155698 0.005 NM_001043351
NM_001043352
NM_001043353
NM_153649
TPM3



tropomyosin 3



chr2_+_220042901 0.005 NM_024293
FAM134A
family with sequence similarity 134, member A
chr6_+_96025343 0.005 NM_024641
MANEA
mannosidase, endo-alpha
chr19_-_55874607 0.005 NM_001145402
FAM71E2
family with sequence similarity 71, member E2
chr2_-_197791339 0.005 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr19_-_36980336 0.005 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr20_+_30697291 0.005 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr5_-_160975124 0.005 NM_000813
NM_021911
GABRB2

gamma-aminobutyric acid (GABA) A receptor, beta 2

chr15_+_44084039 0.005 NM_001018108
NM_001199875
NM_001199876
SERF2


small EDRK-rich factor 2


chr12_-_89920038 0.005 NM_001199781
NM_001199782
NM_172240
POC1B-GALNT4

POC1B
POC1B-GALNT4 readthrough

POC1 centriolar protein homolog B (Chlamydomonas)
chr6_-_88875766 0.004 NM_001160226
NM_001160258
NM_001160259
NM_016083
CNR1



cannabinoid receptor 1 (brain)



chr8_+_22457098 0.004 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr2_+_176957448 0.004 NM_000523
HOXD13
homeobox D13
chr2_-_228029274 0.004 NM_000092
COL4A4
collagen, type IV, alpha 4
chr3_-_57199402 0.004 NM_017563
IL17RD
interleukin 17 receptor D
chr1_-_220445831 0.004 NM_012414
RAB3GAP2
RAB3 GTPase activating protein subunit 2 (non-catalytic)
chr9_+_87284625 0.004 NM_001007097
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr19_-_37406918 0.004 NM_001171979
ZNF829
zinc finger protein 829
chr7_-_99756275 0.004 NM_018275
C7orf43
chromosome 7 open reading frame 43
chr18_-_29264394 0.004 NM_004775
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr7_+_134671244 0.004 NM_178563
AGBL3
ATP/GTP binding protein-like 3
chr2_-_191399449 0.004 NM_001142645
TMEM194B
transmembrane protein 194B
chr19_+_41869848 0.004 NM_001098825
TMEM91
transmembrane protein 91
chr7_-_113559048 0.004 NM_002711
PPP1R3A
protein phosphatase 1, regulatory subunit 3A

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.42 1.71e-03 GO:0005789 endoplasmic reticulum membrane
2.30 2.47e-03 GO:0044432 endoplasmic reticulum part
2.37 2.68e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.91 2.22e-02 GO:0005783 endoplasmic reticulum

Nothing significant found in function category.