Motif ID: AGCUGCC

Z-value: 0.548


Mature miRNA associated with seed AGCUGCC:

NamemiRBase Accession
hsa-miR-22 MIMAT0000077



Activity profile for motif AGCUGCC.

activity profile for motif AGCUGCC


Sorted Z-values histogram for motif AGCUGCC

Sorted Z-values for motif AGCUGCC



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCUGCC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_175161832 0.393 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr12_-_12715244 0.392 NM_030640
DUSP16
dual specificity phosphatase 16
chr2_+_17721806 0.388 NM_003385
VSNL1
visinin-like 1
chr17_+_38334241 0.387 NM_016339
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr5_-_175964223 0.321 NM_014901
RNF44
ring finger protein 44
chr5_+_36608430 0.264 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_71454200 0.254 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr6_+_90272036 0.249 NM_001242811
ANKRD6
ankyrin repeat domain 6
chr4_+_106816593 0.245 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr6_+_90276556 0.244 NM_001242814
ANKRD6
ankyrin repeat domain 6
chr6_+_90142802 0.243 NM_001242809
NM_001242813
NM_014942
ANKRD6


ankyrin repeat domain 6


chr12_-_51785192 0.242 NM_007210
GALNT6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr1_-_204329043 0.238 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr5_+_149151502 0.236 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr10_+_74033676 0.232 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr10_-_116444374 0.230 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr18_-_74844762 0.229 NM_001025100
NM_001025101
MBP

myelin basic protein

chr8_+_61591239 0.227 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr17_-_47841517 0.226 NM_030802
FAM117A
family with sequence similarity 117, member A
chr10_-_116418056 0.226 NM_002313
ABLIM1
actin binding LIM protein 1
chr5_+_149109814 0.223 NM_001172698
NM_133263
PPARGC1B

peroxisome proliferator-activated receptor gamma, coactivator 1 beta

chr9_+_116638544 0.220 NM_133374
ZNF618
zinc finger protein 618
chr1_+_158149736 0.219 NM_001766
CD1D
CD1d molecule
chr1_+_9711781 0.215 NM_005026
PIK3CD
phosphoinositide-3-kinase, catalytic, delta polypeptide
chr10_-_116286661 0.212 NM_006720
ABLIM1
actin binding LIM protein 1
chr16_+_57406398 0.209 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr6_+_53659738 0.207 NM_018214
LRRC1
leucine rich repeat containing 1
chr10_-_99094427 0.203 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr1_-_19282773 0.203 NM_001136265
IFFO2
intermediate filament family orphan 2
chr4_-_120549115 0.199 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr4_-_153273683 0.188 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr7_+_128577990 0.175 NM_001098629
NM_001098630
NM_001242452
IRF5


interferon regulatory factor 5


chr1_-_48462561 0.173 NM_001194986
LOC388630
UPF0632 protein A
chr4_-_120549827 0.172 NM_001083
PDE5A
phosphodiesterase 5A, cGMP-specific
chr6_+_15246299 0.171 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr12_+_56473808 0.165 NM_001982
NM_001005915
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chr7_+_128580725 0.162 NM_001098627
IRF5
interferon regulatory factor 5
chr19_+_47104490 0.156 NM_005184
CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr10_+_5488521 0.155 NM_005863
NET1
neuroepithelial cell transforming 1
chr8_+_103563847 0.153 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr4_-_153303663 0.151 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr12_+_53574506 0.150 NM_001004304
ZNF740
zinc finger protein 740
chr5_-_78809658 0.147 NM_004272
HOMER1
homer homolog 1 (Drosophila)
chr9_-_23826062 0.146 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_120548329 0.145 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific
chrX_+_152953751 0.143 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr3_+_111805174 0.142 NM_001171747
NM_024616
C3orf52

chromosome 3 open reading frame 52

chrX_+_152954965 0.141 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr7_+_30323922 0.139 NM_147128
ZNRF2
zinc and ring finger 2
chr1_-_17765052 0.138 NM_001136204
RCC2
regulator of chromosome condensation 2
chr1_-_17766241 0.135 NM_018715
RCC2
regulator of chromosome condensation 2
chr9_-_23821842 0.135 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_+_20370724 0.133 NM_002214
ITGB8
integrin, beta 8
chr15_+_64791618 0.132 NM_015042
ZNF609
zinc finger protein 609
chr9_-_23821477 0.131 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr3_-_50649110 0.131 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chr7_+_128578246 0.130 NM_032643
IRF5
interferon regulatory factor 5
chr14_+_24899139 0.130 NM_015299
KHNYN
KH and NYN domain containing
chr14_+_71108373 0.128 NM_015351
TTC9
tetratricopeptide repeat domain 9
chr8_-_130951996 0.127 NM_016623
FAM49B
family with sequence similarity 49, member B
chr4_-_153456152 0.126 NM_033632
FBXW7
F-box and WD repeat domain containing 7
chr17_+_29718641 0.125 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr10_+_5454516 0.122 NM_001047160
NET1
neuroepithelial cell transforming 1
chr8_-_48650703 0.122 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr17_-_16256708 0.120 NM_181716
CENPV
centromere protein V
chr6_-_143771788 0.120 NM_182503
ADAT2
adenosine deaminase, tRNA-specific 2
chr2_-_230933618 0.119 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr3_+_196295708 0.119 NM_001105573
FBXO45
F-box protein 45
chr7_+_73703704 0.119 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr10_-_105614952 0.117 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr2_+_70142152 0.117 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chr11_-_34533117 0.116 NM_001243081
NM_198381
ELF5

E74-like factor 5 (ets domain transcription factor)

chr1_-_25256767 0.115 NM_004350
RUNX3
runt-related transcription factor 3
chr9_-_117554809 0.114 NM_001204344
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr22_+_46546498 0.113 NM_001001928
NM_005036
PPARA

peroxisome proliferator-activated receptor alpha

chr6_+_36644236 0.112 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr11_-_27528298 0.112 NM_018362
LIN7C
lin-7 homolog C (C. elegans)
chr17_-_7590731 0.112 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chrX_-_80065182 0.111 NM_153252
BRWD3
bromodomain and WD repeat domain containing 3
chr4_-_78740508 0.111 NM_144571
CNOT6L
CCR4-NOT transcription complex, subunit 6-like
chr4_-_87374282 0.110 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr6_+_36646455 0.110 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr16_-_4664894 0.109 NM_145253
FAM100A
family with sequence similarity 100, member A
chr17_+_11924116 0.108 NM_003010
MAP2K4
mitogen-activated protein kinase kinase 4
chr1_+_93544786 0.107 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr3_+_8775485 0.106 NM_001234
NM_033337
CAV3

caveolin 3

chrX_-_54070606 0.106 NM_001184897
NM_015107
PHF8

PHD finger protein 8

chr5_+_176784843 0.105 NM_006480
RGS14
regulator of G-protein signaling 14
chr12_-_106533810 0.105 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr3_-_135913276 0.104 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr16_+_3014216 0.104 NM_001253725
NM_001253726
NM_024507
NM_172229
KREMEN2



kringle containing transmembrane protein 2



chr7_-_71877359 0.104 NM_031468
CALN1
calneuron 1
chr11_-_34535302 0.103 NM_001243080
NM_001422
ELF5

E74-like factor 5 (ets domain transcription factor)

chr14_+_23305792 0.103 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr15_+_91411884 0.102 NM_002569
FURIN
furin (paired basic amino acid cleaving enzyme)
chr1_-_41131323 0.101 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr2_+_166428845 0.101 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr10_+_116697914 0.101 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr11_-_75062650 0.100 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr3_-_135914654 0.099 NM_018133
MSL2
male-specific lethal 2 homolog (Drosophila)
chr1_-_114354906 0.098 NM_018364
RSBN1
round spermatid basic protein 1
chrX_-_54071568 0.095 NM_001184896
PHF8
PHD finger protein 8
chr2_+_64681270 0.095 NM_014181
LGALSL
lectin, galactoside-binding-like
chr1_-_39338976 0.094 NM_012333
MYCBP
c-myc binding protein
chr2_-_213403280 0.094 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr20_-_31071187 0.093 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr6_+_152126807 0.093 NM_001122741
ESR1
estrogen receptor 1
chr1_+_45965855 0.091 NM_015506
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr2_-_73496595 0.090 NM_001080410
FBXO41
F-box protein 41
chr2_+_166326156 0.089 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr17_-_4890920 0.089 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr1_-_38412725 0.088 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chrX_+_24483343 0.088 NM_001142386
NM_005391
PDK3

pyruvate dehydrogenase kinase, isozyme 3

chr15_-_45670955 0.085 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr9_-_117568292 0.085 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr17_-_74449272 0.085 NM_022066
UBE2O
ubiquitin-conjugating enzyme E2O
chr18_-_74729049 0.084 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr18_+_46065367 0.083 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr15_+_74833517 0.082 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr10_+_126150340 0.081 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr3_-_71803923 0.081 NM_173359
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr14_-_78083109 0.081 NM_004863
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr14_+_33408458 0.080 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr12_+_120427476 0.080 NM_207311
CCDC64
coiled-coil domain containing 64
chr16_+_30935895 0.080 NM_001099784
FBXL19
F-box and leucine-rich repeat protein 19
chr14_-_88793250 0.079 NM_021161
KCNK10
potassium channel, subfamily K, member 10
chr17_-_7578810 0.079 NM_001126115
NM_001126116
NM_001126117
TP53


tumor protein p53


chr14_+_24780654 0.079 NM_001143919
LTB4R
leukotriene B4 receptor
chr3_-_71803513 0.079 NM_001134649
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr17_-_36831156 0.078 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr16_+_50321822 0.077 NM_001114
ADCY7
adenylate cyclase 7
chr12_-_57400199 0.076 NM_014830
ZBTB39
zinc finger and BTB domain containing 39
chr16_+_24266873 0.076 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr1_-_28415071 0.076 NM_001990
EYA3
eyes absent homolog 3 (Drosophila)
chr17_-_4890664 0.075 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr7_-_11871735 0.075 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr17_-_19770988 0.073 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr4_-_41216455 0.072 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr11_-_88796815 0.072 NM_000842
GRM5
glutamate receptor, metabotropic 5
chr17_+_54911452 0.072 NM_003647
DGKE
diacylglycerol kinase, epsilon 64kDa
chr1_+_52608045 0.072 NM_004799
NM_007323
NM_007324
ZFYVE9


zinc finger, FYVE domain containing 9


chr19_-_5680910 0.072 NM_205767
C19orf70
chromosome 19 open reading frame 70
chr6_-_84418705 0.072 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr11_-_88070905 0.072 NM_001114173
NM_001814
NM_148170
CTSC


cathepsin C


chr6_+_152011630 0.071 NM_001122742
ESR1
estrogen receptor 1
chr3_-_71778268 0.071 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr17_+_73780842 0.070 NM_001080419
UNK
unkempt homolog (Drosophila)
chr5_+_139739786 0.070 NM_031467
SLC4A9
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chrX_+_123095555 0.070 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr4_-_87028805 0.070 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr9_+_34989637 0.069 NM_001135004
NM_012266
DNAJB5

DnaJ (Hsp40) homolog, subfamily B, member 5

chr20_+_35201854 0.069 NM_001199513
NM_001199514
TGIF2

TGFB-induced factor homeobox 2

chr19_-_42759279 0.068 NM_006494
ERF
Ets2 repressor factor
chr11_+_64948685 0.068 NM_001198868
CAPN1
calpain 1, (mu/I) large subunit
chr13_+_32313678 0.068 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr11_-_88781039 0.068 NM_001143831
GRM5
glutamate receptor, metabotropic 5
chr14_+_70078309 0.067 NM_014734
KIAA0247
KIAA0247
chr2_-_200820458 0.067 NM_001039693
TYW5
tRNA-yW synthesizing protein 5
chr20_+_35201948 0.067 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr7_-_71802207 0.067 NM_001017440
CALN1
calneuron 1
chr20_-_30795346 0.067 NM_002657
PLAGL2
pleiomorphic adenoma gene-like 2
chr10_-_123356158 0.066 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr1_+_147013181 0.065 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr1_-_180992044 0.065 NM_005819
STX6
syntaxin 6
chr14_+_103058988 0.065 NM_015156
RCOR1
REST corepressor 1
chr5_+_36606456 0.064 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr1_-_22263676 0.064 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr3_-_71774407 0.063 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr4_-_87281374 0.063 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr1_+_184356128 0.063 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr9_-_19786886 0.062 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr22_+_23522551 0.062 NM_004327
NM_021574
BCR

breakpoint cluster region

chr2_+_153191591 0.062 NM_052905
FMNL2
formin-like 2
chr6_-_84419108 0.061 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr20_-_48330417 0.061 NM_004776
B4GALT5
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
chr3_-_46718898 0.061 NM_182775
ALS2CL
ALS2 C-terminal like
chr10_-_123353771 0.060 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr2_-_122042767 0.060 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr8_-_101964334 0.060 NM_145690
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_+_76090971 0.059 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr14_-_88789531 0.059 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr3_-_46735133 0.059 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr17_-_27916602 0.059 NM_001085454
NM_014030
GIT1

G protein-coupled receptor kinase interacting ArfGAP 1

chr11_+_64949279 0.059 NM_005186
CAPN1
calpain 1, (mu/I) large subunit
chr4_-_40859081 0.059 NM_001166051
NM_001166052
NM_001166053
NM_001166054
APBB2



amyloid beta (A4) precursor protein-binding, family B, member 2



chr2_+_232651059 0.058 NM_022730
COPS7B
COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
chr11_-_100999793 0.058 NM_001202474
PGR
progesterone receptor
chr4_+_3076236 0.058 NM_002111
HTT
huntingtin
chr6_-_134373618 0.058 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr14_+_24782312 0.058 NM_181657
LTB4R
leukotriene B4 receptor
chr14_-_88737160 0.058 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr1_+_2985730 0.057 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr7_+_100797685 0.057 NM_001283
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr1_-_25291474 0.057 NM_001031680
RUNX3
runt-related transcription factor 3
chrX_+_123094377 0.057 NM_001042749
STAG2
stromal antigen 2
chr3_+_43328001 0.056 NM_001100594
NM_017719
SNRK

SNF related kinase

chr5_+_141016516 0.056 NM_001130029
NM_173828
RELL2

RELT-like 2

chr2_+_219187858 0.055 NM_022572
PNKD
paroxysmal nonkinesigenic dyskinesia
chr3_+_38495778 0.055 NM_001106
ACVR2B
activin A receptor, type IIB
chr1_+_110881944 0.054 NM_001201545
NM_022768
RBM15

RNA binding motif protein 15


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.86 7.29e-05 GO:0043412 macromolecule modification
1.86 1.75e-04 GO:0006464 protein modification process
1.31 1.47e-03 GO:0050794 regulation of cellular process
1.42 5.57e-03 GO:0044260 cellular macromolecule metabolic process
1.48 6.24e-03 GO:0031323 regulation of cellular metabolic process
1.28 7.98e-03 GO:0050789 regulation of biological process
1.25 2.15e-02 GO:0065007 biological regulation
1.55 3.77e-02 GO:0044267 cellular protein metabolic process
1.44 4.47e-02 GO:0080090 regulation of primary metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.25 6.67e-03 GO:0005515 protein binding
1.13 2.93e-02 GO:0005488 binding
4.72 3.87e-02 GO:0031625 ubiquitin protein ligase binding
4.14 4.95e-02 GO:0005057 receptor signaling protein activity