Motif ID: AGUGGUU

Z-value: 0.800


Mature miRNA associated with seed AGUGGUU:

NamemiRBase Accession
hsa-miR-140-5p MIMAT0000431



Activity profile for motif AGUGGUU.

activity profile for motif AGUGGUU


Sorted Z-values histogram for motif AGUGGUU

Sorted Z-values for motif AGUGGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGUGGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_48937795 0.739 NM_000138
FBN1
fibrillin 1
chr1_+_159141376 0.699 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr5_-_172756505 0.624 NM_003714
STC2
stanniocalcin 2
chr3_-_172428773 0.417 NM_001146276
NM_001146277
NM_001146278
NM_020792
NCEH1



neutral cholesterol ester hydrolase 1



chr13_+_102104941 0.386 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr5_-_64777703 0.353 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr5_+_98104998 0.325 NM_001012761
RGMB
RGM domain family, member B
chr1_-_236228476 0.310 NM_002508
NID1
nidogen 1
chr11_-_61584451 0.269 NM_013402
FADS1
fatty acid desaturase 1
chr14_-_61115906 0.263 NM_005982
SIX1
SIX homeobox 1
chr1_+_39875175 0.234 NM_015038
KIAA0754
KIAA0754
chr12_+_78225068 0.214 NM_014903
NAV3
neuron navigator 3
chr8_-_134584012 0.210 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr14_-_88460008 0.188 NM_001201402
GALC
galactosylceramidase
chr17_+_47074749 0.188 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr15_+_81071708 0.183 NM_018689
KIAA1199
KIAA1199
chr5_-_38595506 0.181 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr2_-_200322699 0.180 NM_001172509
SATB2
SATB homeobox 2
chr5_-_38556682 0.178 NM_001127671
LIFR
leukemia inhibitory factor receptor alpha
chr1_-_182361311 0.178 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr5_-_127873734 0.177 NM_001999
FBN2
fibrillin 2
chr5_-_16936371 0.170 NM_012334
MYO10
myosin X
chr8_-_95907423 0.169 NM_057749
CCNE2
cyclin E2
chr11_+_86511490 0.167 NM_007173
PRSS23
protease, serine, 23
chr2_-_200335988 0.166 NM_015265
SATB2
SATB homeobox 2
chr2_-_200329810 0.165 NM_001172517
SATB2
SATB homeobox 2
chr1_-_182360400 0.164 NM_001033056
GLUL
glutamate-ammonia ligase
chr4_-_174451356 0.161 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chrX_+_16964730 0.156 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr21_-_34100228 0.154 NM_001160302
NM_001160306
SYNJ1

synaptojanin 1

chr14_-_88459469 0.150 NM_000153
NM_001201401
GALC

galactosylceramidase

chr5_+_156693051 0.149 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr8_+_38854431 0.148 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr3_-_52713728 0.143 NM_018165
NM_181042
PBRM1

polybromo 1

chr21_-_34100316 0.141 NM_003895
NM_203446
SYNJ1

synaptojanin 1

chr5_+_156696351 0.140 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr15_-_56757239 0.136 NM_018365
MNS1
meiosis-specific nuclear structural 1
chr5_+_126112314 0.135 NM_005573
LMNB1
lamin B1
chr10_+_31608097 0.134 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr2_+_10262853 0.132 NM_001034
RRM2
ribonucleotide reductase M2
chr9_+_112887780 0.130 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr10_-_3827418 0.128 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr2_+_10262694 0.127 NM_001165931
RRM2
ribonucleotide reductase M2
chr9_+_112810877 0.126 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr5_+_149887673 0.125 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr19_+_11200037 0.125 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr5_+_126112819 0.124 NM_001198557
LMNB1
lamin B1
chr6_-_31628509 0.124 NM_021184
C6orf47
chromosome 6 open reading frame 47
chr19_+_10736167 0.123 NM_020428
SLC44A2
solute carrier family 44, member 2
chr5_-_77944341 0.121 NM_005779
LHFPL2
lipoma HMGIC fusion partner-like 2
chr8_+_81398416 0.121 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr8_+_26371461 0.120 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr10_+_31610063 0.119 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr9_+_120466453 0.116 NM_138554
TLR4
toll-like receptor 4
chr5_-_136834887 0.115 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr2_+_32582046 0.115 NM_016252
BIRC6
baculoviral IAP repeat containing 6
chr14_+_85996454 0.114 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr19_+_2476122 0.111 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr5_+_65222381 0.110 NM_001006600
NM_001253697
NM_001253698
NM_001253699
NM_001253701
NM_018695
ERBB2IP





erbb2 interacting protein





chr3_-_52719514 0.106 NM_018313
PBRM1
polybromo 1
chr12_-_49182718 0.103 NM_020983
ADCY6
adenylate cyclase 6
chr11_+_46299161 0.103 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr5_-_9546157 0.102 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr19_+_10713055 0.102 NM_001145056
SLC44A2
solute carrier family 44, member 2
chr5_-_180230889 0.101 NM_001114619
NM_001114620
MGAT1

mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

chr5_-_180230047 0.101 NM_002406
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr16_-_2264776 0.101 NM_001042371
PGP
phosphoglycolate phosphatase
chr12_-_96794207 0.100 NM_001170464
NM_002595
CDK17

cyclin-dependent kinase 17

chr11_+_61560108 0.097 NM_004111
FEN1
flap structure-specific endonuclease 1
chr11_+_30252562 0.096 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr5_-_180237114 0.095 NM_001114617
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr4_-_128887092 0.095 NM_152778
MFSD8
major facilitator superfamily domain containing 8
chr2_+_242255270 0.095 NM_001008492
NM_004404
SEPT2

septin 2

chr21_-_15755439 0.093 NM_006948
HSPA13
heat shock protein 70kDa family, member 13
chrX_+_57618268 0.093 NM_007157
ZXDB
zinc finger, X-linked, duplicated B
chr12_-_29936685 0.091 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr3_+_49506079 0.090 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr15_+_99192696 0.088 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr12_-_29937691 0.088 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr7_-_121784236 0.088 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr3_-_168865521 0.087 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr5_-_180236816 0.087 NM_001114618
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr14_-_82000198 0.087 NM_001244984
NM_005065
SEL1L

sel-1 suppressor of lin-12-like (C. elegans)

chr2_+_202316391 0.086 NM_001206864
NM_018571
STRADB

STE20-related kinase adaptor beta

chr7_-_127032717 0.086 NM_176814
ZNF800
zinc finger protein 800
chr20_+_43990576 0.086 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr12_-_80307690 0.086 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr1_-_32385258 0.084 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr13_-_95953572 0.084 NM_001105515
NM_005845
ABCC4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr9_-_107690526 0.082 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr6_-_131291480 0.082 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr7_-_25164902 0.080 NM_018947
CYCS
cytochrome c, somatic
chrX_+_70586113 0.080 NM_004606
NM_138923
TAF1

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

chr3_+_20081523 0.080 NM_003884
KAT2B
K(lysine) acetyltransferase 2B
chr17_-_60142598 0.080 NM_005121
MED13
mediator complex subunit 13
chr15_+_38544966 0.080 NM_152594
SPRED1
sprouty-related, EVH1 domain containing 1
chr11_+_12695851 0.079 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr17_-_56065596 0.078 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr3_-_195808997 0.077 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr3_+_49507470 0.077 NM_001165928
NM_001177634
NM_001177635
NM_001177636
NM_001177637
NM_001177638
NM_001177639
NM_001177640
NM_001177641
NM_001177642
NM_001177644
NM_004393
DAG1











dystroglycan 1 (dystrophin-associated glycoprotein 1)











chr18_+_9137560 0.076 NM_001204056
ANKRD12
ankyrin repeat domain 12
chr3_-_168864066 0.076 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr6_-_108395939 0.075 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr3_-_195808958 0.075 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr1_-_32403975 0.075 NM_080391
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr17_-_35766762 0.074 NM_198834
NM_198839
ACACA

acetyl-CoA carboxylase alpha

chr3_-_168864325 0.074 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr18_+_9136742 0.073 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chrX_-_77395108 0.072 NM_015975
TAF9B
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr3_+_135741576 0.071 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr15_-_23086290 0.071 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr1_-_43424834 0.071 NM_006516
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr14_-_95623665 0.070 NM_177438
DICER1
dicer 1, ribonuclease type III
chr5_+_14143287 0.070 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr17_-_35656691 0.069 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr4_-_85887543 0.069 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr21_-_16437125 0.068 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr20_-_10654429 0.068 NM_000214
JAG1
jagged 1
chr12_-_80329234 0.068 NM_001143885
NM_001244990
PPP1R12A

protein phosphatase 1, regulatory subunit 12A

chr9_+_132815984 0.067 NM_001136557
NM_001136558
NM_020960
GPR107


G protein-coupled receptor 107


chr17_-_33390676 0.066 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr10_+_102672325 0.066 NM_001136123
NM_001243770
NM_018121
FAM178A


family with sequence similarity 178, member A


chr12_-_48213567 0.066 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chrX_+_150151757 0.066 NM_005342
HMGB3
high mobility group box 3
chr1_+_100503654 0.066 NM_033055
HIAT1
hippocampus abundant transcript 1
chr17_-_35716024 0.066 NM_198836
ACACA
acetyl-CoA carboxylase alpha
chr6_+_80714321 0.065 NM_001166691
NM_003318
TTK

TTK protein kinase

chr1_-_20812727 0.065 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr10_+_1102741 0.064 NM_014023
WDR37
WD repeat domain 37
chr14_-_95608054 0.063 NM_030621
DICER1
dicer 1, ribonuclease type III
chr7_+_138144847 0.063 NM_003852
NM_015905
TRIM24

tripartite motif containing 24

chr12_-_46766563 0.063 NM_018976
SLC38A2
solute carrier family 38, member 2
chr10_-_14996008 0.063 NM_001033855
NM_001033857
NM_001033858
NM_022487
DCLRE1C



DNA cross-link repair 1C



chr14_+_56584854 0.063 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chrX_-_133930234 0.062 NM_001170756
NM_145284
FAM122B

family with sequence similarity 122B

chr1_-_33338081 0.062 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr17_-_37844266 0.062 NM_033419
PGAP3
post-GPI attachment to proteins 3
chr1_+_26348265 0.061 NM_004455
EXTL1
exostoses (multiple)-like 1
chr1_-_173962050 0.061 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr2_-_37193609 0.060 NM_003162
STRN
striatin, calmodulin binding protein
chr1_+_43766565 0.057 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr15_-_34502269 0.057 NM_024713
C15orf29
chromosome 15 open reading frame 29
chr1_+_87380317 0.057 NM_001134492
NM_012262
HS2ST1

heparan sulfate 2-O-sulfotransferase 1

chr22_-_36784055 0.057 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr7_-_112726143 0.057 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr1_-_55681024 0.056 NM_015306
USP24
ubiquitin specific peptidase 24
chr4_+_55095263 0.056 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr15_-_23086842 0.056 NM_001142275
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr8_+_26435339 0.055 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr10_-_108924287 0.055 NM_001013031
NM_001206569
NM_001206570
NM_001206571
NM_001206572
NM_052918
SORCS1





sortilin-related VPS10 domain containing receptor 1





chr9_+_112542496 0.055 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr4_+_123747815 0.055 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr19_+_54926604 0.055 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr20_-_34330179 0.054 NM_001242599
NM_001242600
NM_004902
NM_184234
RBM39



RNA binding motif protein 39



chr17_-_4167028 0.054 NM_016376
NM_020740
ANKFY1

ankyrin repeat and FYVE domain containing 1

chr11_-_47574766 0.053 NM_006560
CELF1
CUGBP, Elav-like family member 1
chr8_-_67579446 0.053 NM_025054
VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1
chr14_-_95599794 0.053 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr13_-_111567415 0.053 NM_017664
ANKRD10
ankyrin repeat domain 10
chr6_-_131384387 0.052 NM_001135554
NM_001135555
NM_001199388
NM_001431
EPB41L2



erythrocyte membrane protein band 4.1-like 2



chr4_-_153601085 0.051 NM_152680
TMEM154
transmembrane protein 154
chr19_+_48972464 0.051 NM_004228
NM_017457
CYTH2

cytohesin 2

chr1_-_29450406 0.050 NM_001003682
TMEM200B
transmembrane protein 200B
chr1_+_147013181 0.050 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr1_+_11994710 0.050 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr17_-_27621163 0.050 NM_020772
NUFIP2
nuclear fragile X mental retardation protein interacting protein 2
chr1_-_33336289 0.050 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr11_-_102323353 0.050 NM_052932
TMEM123
transmembrane protein 123
chr16_+_2479387 0.050 NM_001761
CCNF
cyclin F
chr4_+_124317884 0.050 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr2_-_198650937 0.048 NM_197970
BOLL
bol, boule-like (Drosophila)
chr9_+_101867401 0.048 NM_001130916
NM_004612
TGFBR1

transforming growth factor, beta receptor 1

chr1_-_205719340 0.048 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr4_-_80329354 0.048 NM_033214
GK2
glycerol kinase 2
chr20_-_30310597 0.048 NM_001191
NM_138578
BCL2L1

BCL2-like 1

chr10_+_98592658 0.048 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr3_+_135684463 0.047 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr7_-_100860991 0.046 NM_001084
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr11_-_47270339 0.046 NM_001131064
NM_001610
ACP2

acid phosphatase 2, lysosomal

chr17_+_33914278 0.045 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr9_+_108320382 0.045 NM_001079802
NM_001198963
NM_006731
FKTN


fukutin


chr10_-_7661613 0.045 NM_032817
ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr12_+_107168336 0.045 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr1_+_179923870 0.045 NM_014810
CEP350
centrosomal protein 350kDa
chr2_-_180129245 0.044 NM_178123
SESTD1
SEC14 and spectrin domains 1
chr1_+_198125890 0.044 NM_133494
NEK7
NIMA (never in mitosis gene a)-related kinase 7
chr9_+_131182690 0.044 NM_016174
CERCAM
cerebral endothelial cell adhesion molecule
chr20_+_32254303 0.044 NM_001024675
ACTL10
actin-like 10
chr1_-_86043932 0.044 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_+_119981383 0.043 NM_001008410
NM_018234
NM_182915
STEAP3


STEAP family member 3, metalloreductase


chr3_-_50396930 0.043 NM_007024
TMEM115
transmembrane protein 115
chr3_+_186560462 0.042 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr7_-_117513527 0.042 NM_033427
CTTNBP2
cortactin binding protein 2
chr3_-_169381417 0.041 NM_001205194
NM_004991
MECOM

MDS1 and EVI1 complex locus

chr11_-_47510518 0.041 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr11_-_47545539 0.040 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr12_-_112123770 0.040 NM_006768
BRAP
BRCA1 associated protein
chr12_-_42538432 0.039 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr1_-_52456292 0.039 NM_002867
RAB3B
RAB3B, member RAS oncogene family
chr4_+_124320664 0.039 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 2.49e-03 GO:0044260 cellular macromolecule metabolic process
1.41 3.89e-03 GO:0043170 macromolecule metabolic process
1.76 9.46e-03 GO:0006464 protein modification process
1.69 2.61e-02 GO:0043412 macromolecule modification

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.34e-03 GO:0044424 intracellular part
1.16 3.16e-03 GO:0005622 intracellular
2.13 4.85e-03 GO:0005624 membrane fraction
2.06 9.54e-03 GO:0005626 insoluble fraction
1.83 3.15e-02 GO:0000267 cell fraction

Nothing significant found in function category.