Motif ID: CUACAGU

Z-value: 0.495


Mature miRNA associated with seed CUACAGU:

NamemiRBase Accession
hsa-miR-139-5p MIMAT0000250



Activity profile for motif CUACAGU.

activity profile for motif CUACAGU


Sorted Z-values histogram for motif CUACAGU

Sorted Z-values for motif CUACAGU



Network of associatons between targets according to the STRING database.



First level regulatory network of CUACAGU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_127873734 0.088 NM_001999
FBN2
fibrillin 2
chr15_+_33010174 0.087 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr1_-_72748147 0.068 NM_173808
NEGR1
neuronal growth regulator 1
chr7_-_131241321 0.066 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr5_-_136834887 0.062 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr16_+_58534045 0.062 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr1_-_245027808 0.060 NM_004501
NM_031844
HNRNPU

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

chr16_+_58497548 0.059 NM_020465
NDRG4
NDRG family member 4
chr16_+_58497993 0.057 NM_001130487
NDRG4
NDRG family member 4
chr8_+_17354562 0.055 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr7_-_92465929 0.054 NM_001145306
CDK6
cyclin-dependent kinase 6
chr1_+_162466963 0.054 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr10_+_31608097 0.052 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr16_+_58498725 0.051 NM_022910
NDRG4
NDRG family member 4
chr8_+_17396285 0.050 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr5_+_149151502 0.049 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr2_+_121554866 0.049 NM_005270
GLI2
GLI family zinc finger 2
chr7_-_92463211 0.048 NM_001259
CDK6
cyclin-dependent kinase 6
chr13_-_77460432 0.048 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr14_+_100259445 0.047 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr5_+_149109814 0.045 NM_001172698
NM_133263
PPARGC1B

peroxisome proliferator-activated receptor gamma, coactivator 1 beta

chr1_+_155829259 0.045 NM_152280
SYT11
synaptotagmin XI
chr10_+_31610063 0.045 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr5_+_148651395 0.044 NM_001146337
NM_152406
AFAP1L1

actin filament associated protein 1-like 1

chr19_+_1248548 0.043 NM_177401
MIDN
midnolin
chr1_+_162467594 0.041 NM_144624
NM_175866
UHMK1

U2AF homology motif (UHM) kinase 1

chr11_-_108368918 0.041 NM_153705
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2
chr12_+_32654976 0.040 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr9_+_91605777 0.040 NM_001001938
NM_001142413
C9orf47

chromosome 9 open reading frame 47

chr1_-_149889362 0.040 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr19_+_41725098 0.039 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr4_+_174089889 0.037 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr6_+_144471631 0.035 NM_003764
STX11
syntaxin 11
chr12_+_5153084 0.035 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr1_-_85155885 0.034 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr5_+_72143929 0.034 NM_153188
TNPO1
transportin 1
chrX_-_77041678 0.034 NM_000489
NM_138270
ATRX

alpha thalassemia/mental retardation syndrome X-linked

chr13_-_114898084 0.034 NM_007368
RASA3
RAS p21 protein activator 3
chr2_+_54785453 0.033 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_-_169680677 0.033 NM_000655
SELL
selectin L
chr2_-_200322699 0.032 NM_001172509
SATB2
SATB homeobox 2
chr11_-_128392061 0.032 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr6_-_13295817 0.032 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr20_+_39657461 0.032 NM_003286
TOP1
topoisomerase (DNA) I
chr1_+_114496498 0.032 NM_181358
HIPK1
homeodomain interacting protein kinase 1
chr10_-_931694 0.032 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr2_-_145277879 0.032 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr13_-_25497054 0.031 NM_018451
CENPJ
centromere protein J
chr4_+_55523906 0.031 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr2_-_200329810 0.031 NM_001172517
SATB2
SATB homeobox 2
chr1_-_59249687 0.031 NM_002228
JUN
jun proto-oncogene
chr5_+_179125796 0.030 NM_001024649
NM_001746
CANX

calnexin

chr10_-_14372807 0.030 NM_018027
FRMD4A
FERM domain containing 4A
chr4_+_123844210 0.030 NM_145207
SPATA5
spermatogenesis associated 5
chr1_+_179923870 0.030 NM_014810
CEP350
centrosomal protein 350kDa
chr8_+_81398416 0.030 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr16_-_25268841 0.030 NM_001012981
ZKSCAN2
zinc finger with KRAB and SCAN domains 2
chr17_-_42908178 0.030 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr7_-_139477437 0.030 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr2_-_200335988 0.030 NM_015265
SATB2
SATB homeobox 2
chr5_-_90679115 0.029 NM_020801
ARRDC3
arrestin domain containing 3
chr3_+_141043054 0.029 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr5_+_137688270 0.029 NM_016604
KDM3B
lysine (K)-specific demethylase 3B
chr11_+_119076974 0.028 NM_005188
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr1_+_114493766 0.028 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr1_-_155532322 0.028 NM_018489
ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr4_-_99579540 0.028 NM_005723
TSPAN5
tetraspanin 5
chr1_+_199996729 0.028 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr5_+_72112417 0.027 NM_002270
TNPO1
transportin 1
chr17_-_42907606 0.027 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr8_-_60031545 0.027 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr4_-_54232007 0.027 NM_152540
SCFD2
sec1 family domain containing 2
chr15_+_99192696 0.027 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr1_+_89990396 0.027 NM_001134476
LRRC8B
leucine rich repeat containing 8 family, member B
chr15_+_89631380 0.027 NM_007011
NM_152924
ABHD2

abhydrolase domain containing 2

chr12_-_88535746 0.026 NM_025114
CEP290
centrosomal protein 290kDa
chr11_+_122526339 0.026 NM_032873
UBASH3B
ubiquitin associated and SH3 domain containing B
chr5_+_134240752 0.026 NM_032151
PCBD2
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
chr11_-_33744272 0.025 NM_001127223
NM_001127225
NM_001127226
CD59


CD59 molecule, complement regulatory protein


chr9_-_27573444 0.025 NM_018325
C9orf72
chromosome 9 open reading frame 72
chr12_-_29937691 0.025 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr12_-_29936685 0.025 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr11_-_128457452 0.025 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr2_-_166650770 0.025 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr3_+_179370779 0.024 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr2_+_157291951 0.024 NM_001083112
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr11_-_33757872 0.024 NM_000611
NM_203329
NM_203330
NM_203331
CD59



CD59 molecule, complement regulatory protein



chr5_+_149340287 0.024 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr12_+_98909331 0.024 NM_001032283
NM_001032284
NM_003276
TMPO


thymopoietin


chr11_-_33744497 0.024 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr6_+_83072922 0.024 NM_006670
TPBG
trophoblast glycoprotein
chr5_+_6448735 0.023 NM_001145161
UBE2QL1
ubiquitin-conjugating enzyme E2Q family-like 1
chr3_-_98620452 0.023 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr12_-_26985922 0.023 NM_002223
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
chr3_-_52713728 0.023 NM_018165
NM_181042
PBRM1

polybromo 1

chr7_-_50800018 0.023 NM_001001549
NM_005311
GRB10

growth factor receptor-bound protein 10

chr3_+_142720371 0.023 NM_001080415
U2SURP
U2 snRNP-associated SURP domain containing
chr17_-_27621163 0.023 NM_020772
NUFIP2
nuclear fragile X mental retardation protein interacting protein 2
chr15_+_39873276 0.023 NM_003246
THBS1
thrombospondin 1
chr19_+_11094799 0.023 NM_001128845
NM_001128846
NM_001128847
NM_001128848
SMARCA4



SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4



chr19_+_10543110 0.022 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr5_-_16936371 0.022 NM_012334
MYO10
myosin X
chrX_+_77166178 0.022 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr5_+_153570270 0.022 NM_198321
GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr4_+_56212381 0.022 NM_024592
SRD5A3
steroid 5 alpha-reductase 3
chr1_+_90024271 0.022 NM_015350
LRRC8B
leucine rich repeat containing 8 family, member B
chr7_-_50772997 0.022 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr1_+_78245306 0.022 NM_198549
FAM73A
family with sequence similarity 73, member A
chr19_-_53662279 0.022 NM_001172674
NM_001172675
NM_032584
ZNF347


zinc finger protein 347


chr18_-_60986508 0.021 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chrX_+_36065052 0.021 NM_173695
CXorf59
chromosome X open reading frame 59
chr3_-_123339423 0.021 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr2_-_69870976 0.021 NM_014911
AAK1
AP2 associated kinase 1
chr15_-_91537724 0.021 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chr2_+_170683900 0.021 NM_172070
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr9_+_123850573 0.021 NM_007018
CNTRL
centriolin
chr1_-_70820363 0.021 NM_030816
ANKRD13C
ankyrin repeat domain 13C
chr5_+_173315313 0.021 NM_030627
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr17_+_34891340 0.021 NM_178517
PIGW
phosphatidylinositol glycan anchor biosynthesis, class W
chr9_-_111882209 0.021 NM_032012
C9orf5
chromosome 9 open reading frame 5
chr11_+_61891414 0.021 NM_001040694
NM_020238
INCENP

inner centromere protein antigens 135/155kDa

chr1_+_213031596 0.020 NM_014053
FLVCR1
feline leukemia virus subgroup C cellular receptor 1
chr19_+_10563581 0.020 NM_006202
PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_+_201170603 0.020 NM_015535
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr12_-_15942350 0.020 NM_004447
EPS8
epidermal growth factor receptor pathway substrate 8
chr6_+_3077031 0.020 NM_003804
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr20_+_44650260 0.020 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr2_+_178257371 0.020 NM_003659
AGPS
alkylglycerone phosphate synthase
chr4_-_139163222 0.020 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr3_+_67048726 0.020 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr16_-_75590107 0.019 NM_001077416
NM_001077418
NM_001077419
TMEM231


transmembrane protein 231


chr16_-_88851371 0.019 NM_001142864
PIEZO1
piezo-type mechanosensitive ion channel component 1
chr3_-_160283361 0.019 NM_002268
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr1_+_109102970 0.019 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr5_-_132073143 0.019 NM_007054
KIF3A
kinesin family member 3A
chr1_+_70225857 0.019 NM_020794
LRRC7
leucine rich repeat containing 7
chr1_-_55681024 0.019 NM_015306
USP24
ubiquitin specific peptidase 24
chr18_-_40857245 0.019 NM_020783
SYT4
synaptotagmin IV
chr6_+_73331570 0.019 NM_001160130
NM_001160132
NM_001160133
NM_001160134
NM_019842
KCNQ5




potassium voltage-gated channel, KQT-like subfamily, member 5




chr6_+_28249313 0.018 NM_001184743
NM_032507
PGBD1

piggyBac transposable element derived 1

chr3_+_151985828 0.018 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr17_-_39306053 0.018 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr2_+_157292826 0.018 NM_000408
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr13_+_96329392 0.018 NM_006260
DNAJC3
DnaJ (Hsp40) homolog, subfamily C, member 3
chr6_+_83073954 0.018 NM_001166392
TPBG
trophoblast glycoprotein
chr2_+_30670082 0.018 NM_182551
NM_001002257
LCLAT1

lysocardiolipin acyltransferase 1

chr13_+_33160537 0.018 NM_015032
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chrX_-_63005212 0.018 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr3_-_71632741 0.018 NM_001244808
NM_001012505
NM_001244810
NM_032682
FOXP1



forkhead box P1



chr8_+_99130067 0.018 NM_015029
POP1
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr12_+_27677044 0.017 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr12_-_77459198 0.017 NM_203394
E2F7
E2F transcription factor 7
chr21_-_36421586 0.017 NM_001754
RUNX1
runt-related transcription factor 1
chr8_+_99129488 0.017 NM_001145860
NM_001145861
POP1

processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)

chr12_+_68042493 0.017 NM_003583
NM_006482
DYRK2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

chr10_+_98592658 0.017 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr5_+_139175385 0.017 NM_032289
PSD2
pleckstrin and Sec7 domain containing 2
chr3_+_152017193 0.017 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr3_-_123603144 0.017 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr17_+_48133331 0.017 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr2_+_160568973 0.017 NM_022826
MARCH7
membrane-associated ring finger (C3HC4) 7
chr16_-_68033355 0.017 NM_022355
DPEP2
dipeptidase 2
chr1_+_38158129 0.017 NM_018101
CDCA8
cell division cycle associated 8
chr1_+_227751218 0.017 NM_178549
ZNF678
zinc finger protein 678
chr1_-_21605984 0.017 NM_001113347
ECE1
endothelin converting enzyme 1
chr2_+_242255270 0.016 NM_001008492
NM_004404
SEPT2

septin 2

chr8_-_67525426 0.016 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

uncharacterized LOC645895
chr15_+_41952572 0.016 NM_001080541
NM_001164273
MGA

MAX gene associated

chr9_-_93405066 0.016 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr2_-_11484699 0.016 NM_004850
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr5_-_59783885 0.016 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_54197786 0.016 NM_014614
PSME4
proteasome (prosome, macropain) activator subunit 4
chr6_+_39760772 0.016 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr1_+_145209067 0.016 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr7_+_55433140 0.016 NM_018697
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr16_-_56459371 0.016 NM_001144
AMFR
autocrine motility factor receptor
chr13_-_21476895 0.016 NM_022459
XPO4
exportin 4
chr15_-_43398168 0.016 NM_174916
UBR1
ubiquitin protein ligase E3 component n-recognin 1
chr2_-_202316227 0.016 NM_015049
TRAK2
trafficking protein, kinesin binding 2
chr6_-_143832770 0.016 NM_032020
FUCA2
fucosidase, alpha-L- 2, plasma
chr19_+_58095507 0.016 NM_001010879
ZIK1
zinc finger protein interacting with K protein 1 homolog (mouse)
chr5_+_135468522 0.015 NM_001001419
NM_001001420
NM_005903
SMAD5


SMAD family member 5


chr2_-_55237255 0.015 NM_007008
RTN4
reticulon 4
chr12_+_93963597 0.015 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr20_+_44657812 0.015 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr5_+_141488314 0.015 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chrX_+_41192650 0.015 NM_001193416
NM_001193417
NM_001356
DDX3X


DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked


chr12_+_105501448 0.015 NM_015275
KIAA1033
KIAA1033
chr1_-_19578045 0.015 NM_015047
KIAA0090
KIAA0090
chr17_-_56565700 0.015 NM_001080439
HSF5
heat shock transcription factor family member 5
chr15_+_38544966 0.015 NM_152594
SPRED1
sprouty-related, EVH1 domain containing 1
chr2_+_204103163 0.015 NM_177538
CYP20A1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr16_+_18995255 0.015 NM_024847
TMC7
transmembrane channel-like 7
chr1_+_15853348 0.015 NM_015291
DNAJC16
DnaJ (Hsp40) homolog, subfamily C, member 16
chr3_-_52719514 0.015 NM_018313
PBRM1
polybromo 1
chr2_+_201170795 0.015 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr5_-_114880536 0.015 NM_020177
FEM1C
fem-1 homolog c (C. elegans)
chr1_+_210001267 0.015 NM_014388
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr7_+_129932973 0.015 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr5_+_61714710 0.015 NM_001134779
IPO11
importin 11

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 3.03e-04 GO:0044260 cellular macromolecule metabolic process
1.62 7.28e-03 GO:0006464 protein modification process
1.14 1.50e-02 GO:0009987 cellular process
1.56 3.23e-02 GO:0043412 macromolecule modification
1.48 3.40e-02 GO:0044267 cellular protein metabolic process
1.30 3.85e-02 GO:0043170 macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 5.07e-04 GO:0044424 intracellular part
1.14 6.33e-04 GO:0005622 intracellular
1.18 1.28e-03 GO:0043226 organelle
1.18 1.56e-03 GO:0043229 intracellular organelle
1.18 5.08e-03 GO:0043227 membrane-bounded organelle
1.18 6.63e-03 GO:0043231 intracellular membrane-bounded organelle
1.27 7.45e-03 GO:0005634 nucleus
1.26 1.60e-02 GO:0044446 intracellular organelle part
1.47 1.96e-02 GO:0044428 nuclear part
1.25 2.02e-02 GO:0044422 organelle part
1.37 3.94e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.66 1.72e-03 GO:0016563 transcription activator activity