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Motif ID: EN1,2.p2

Z-value: 1.775

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_39675078	4.813	NM_002275	KRT15	keratin 15
chr1_-_242612757	4.742	NM_001195811 NM_001195812	PLD5	phospholipase D family, member 5
chr10_-_105845619	4.549	NM_000494	COL17A1	collagen, type XVII, alpha 1
chr10_-_105845556	4.515		COL17A1	collagen, type XVII, alpha 1
chr4_+_40198526	2.778	NM_004310	RHOH	ras homolog gene family, member H
chr5_+_68800003	2.735	NM_001205255	OCLN	occludin
chr12_-_53343607	2.385		KRT8	keratin 8
chr12_-_6486522	2.361	NM_001159575	SCNN1A	sodium channel, nonvoltage-gated 1 alpha
chr12_+_53342842	2.257	NM_000224	KRT18	keratin 18
chr1_+_32050510	2.192		TINAGL1	tubulointerstitial nephritis antigen-like 1
chr12_-_105322056	1.981	NM_032148	SLC41A2	solute carrier family 41, member 2
chr1_+_32043745	1.945	NM_001204415	TINAGL1	tubulointerstitial nephritis antigen-like 1
chr12_+_53342899	1.835		KRT18	keratin 18
chr15_+_43885251	1.724	NM_020990	CKMT1B CKMT1A	creatine kinase, mitochondrial 1B creatine kinase, mitochondrial 1A
chr1_+_31882411	1.691	NM_001199038	SERINC2	serine incorporator 2
chr1_+_86889768	1.672	NM_006536	CLCA2	chloride channel accessory 2
chr17_-_4643162	1.614	NM_001100812 NM_022059	CXCL16	chemokine (C-X-C motif) ligand 16
chr3_-_151034514	1.590	NM_023915	GPR87	G protein-coupled receptor 87
chr10_+_75673346	1.581		PLAU	plasminogen activator, urokinase
chr21_+_43710190	1.579		ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1
chr19_+_35739778	1.511		LSR	lipolysis stimulated lipoprotein receptor
chr10_+_118187381	1.453	NM_001011709	PNLIPRP3	pancreatic lipase-related protein 3
chr6_+_17282931	1.412	NM_153020	RBM24	RNA binding motif protein 24
chr10_-_98031154	1.343	NM_001114094 NM_013314	BLNK	B-cell linker
chr4_+_89299874	1.306	NM_001165136 NM_017912	HERC6	hect domain and RLD 6
chr2_-_161056573	1.300	NM_000888	ITGB6	integrin, beta 6
chr1_-_28520379	1.229	NM_001164721 NM_001164722	PTAFR	platelet-activating factor receptor
chr19_+_41281281	1.216	NM_006533	MIA	melanoma inhibitory activity
chr19_-_49567123	1.175	NM_006179	NTF4	neurotrophin 4
chr19_+_41281081	1.165	NM_001202553	MIA	melanoma inhibitory activity
chr5_-_176836535	1.082	NM_000505	F12	coagulation factor XII (Hageman factor)
chr2_-_142889269	1.071	NM_018557	LRP1B	low density lipoprotein receptor-related protein 1B
chr1_+_24645914	1.068	NM_001195010	GRHL3	grainyhead-like 3 (Drosophila)
chr5_+_147582338	1.036	NM_001195290 NM_205841	SPINK6	serine peptidase inhibitor, Kazal type 6
chr18_+_61254533	1.032	NM_012397	SERPINB13	serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr12_-_123201319	1.026	NM_006018	HCAR3	hydroxycarboxylic acid receptor 3
chr11_+_18287807	1.006	NM_000331 NM_001178006 NM_199161	SAA1	serum amyloid A1
chr6_-_116381765	1.004	NM_002031	FRK	fyn-related kinase
chr8_-_127570710	1.003	NM_174911	FAM84B	family with sequence similarity 84, member B
chr12_+_113344811	1.002		OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_-_53298765	0.980	NM_002273	KRT8	keratin 8
chr10_-_123353330	0.978	NM_001144913 NM_001144914	FGFR2	fibroblast growth factor receptor 2
chr11_+_124120422	0.959	NM_001002905	OR8G1	olfactory receptor, family 8, subfamily G, member 1
chr8_+_32579350	0.931	NM_001159996	NRG1	neuregulin 1
chr5_-_77844975	0.920		LHFPL2	lipoma HMGIC fusion partner-like 2
chr3_-_189840225	0.916	NM_001134418	LEPREL1	leprecan-like 1
chr4_+_71200670	0.892	NM_033122	CABS1	calcium-binding protein, spermatid-specific 1
chr19_-_51472816	0.887	NM_002774	KLK6	kallikrein-related peptidase 6
chr2_-_215896809	0.882	NM_015657	ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12
chr10_-_116418056	0.867	NM_002313	ABLIM1	actin binding LIM protein 1
chr1_+_31883020	0.853	NM_001199037	SERINC2	serine incorporator 2
chr6_+_13924676	0.851	NM_001165034	RNF182	ring finger protein 182
chr1_+_152956563	0.839	NM_001199828 NM_005987	SPRR1A	small proline-rich protein 1A
chrX_-_117119282	0.836	NM_001168299	KLHL13	kelch-like 13 (Drosophila)
chr15_-_52587851	0.805	NM_018728	MYO5C	myosin VC
chr2_+_69001932	0.796	NM_001166276 NM_014882	ARHGAP25	Rho GTPase activating protein 25
chr3_-_27498244	0.795	NM_003615	SLC4A7	solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr11_-_18270167	0.794	NM_001199744 NM_001127380 NM_030754	SAA2-SAA4 SAA2	SAA2-SAA4 readthrough serum amyloid A2
chr3_+_127641901	0.784	NM_207335	KBTBD12	kelch repeat and BTB (POZ) domain containing 12
chr7_+_26400503	0.776	NM_001199837	SNX10	sorting nexin 10
chr6_+_132859426	0.774	NM_175057	TAAR9	trace amine associated receptor 9 (gene/pseudogene)
chr6_+_106546736	0.770	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chr6_+_116782555	0.764	NM_001010919	FAM26F	family with sequence similarity 26, member F
chr6_-_136847743	0.761	NM_001198614 NM_001198618 NM_001198619	MAP7	microtubule-associated protein 7
chrX_+_41548225	0.757	NM_001097579 NM_005300	GPR34	G protein-coupled receptor 34
chr12_+_41831484	0.747	NM_013377	PDZRN4	PDZ domain containing ring finger 4
chr12_+_13043955	0.746	NM_003979	GPRC5A	G protein-coupled receptor, family C, group 5, member A
chr18_-_53071225	0.725	NM_001243232	TCF4	transcription factor 4
chr14_+_21525980	0.723	NM_138331	RNASE8	ribonuclease, RNase A family, 8
chr6_+_47624222	0.722	NM_153839	GPR111	G protein-coupled receptor 111
chr8_+_7738908	0.712	NM_018661	DEFB103B	defensin, beta 103B
chr5_+_140345746	0.708	NM_018899	PCDHAC2	protocadherin alpha subfamily C, 2
chr20_+_43803539	0.707	NM_002638	PI3	peptidase inhibitor 3, skin-derived
chr3_+_118892363	0.704	NM_006952	UPK1B	uroplakin 1B
chr17_-_27467395	0.685		MYO18A	myosin XVIIIA
chr14_+_23305792	0.675	NM_004995	MMP14	matrix metallopeptidase 14 (membrane-inserted)
chr11_-_51412447	0.669	NM_001005272	OR4A5	olfactory receptor, family 4, subfamily A, member 5
chr4_-_40516567	0.663		RBM47	RNA binding motif protein 47
chr15_+_68908878	0.640	NM_001190456	CORO2B	coronin, actin binding protein, 2B
chr9_-_125941304	0.638		STRBP	spermatid perinuclear RNA binding protein
chr6_+_14117857	0.628	NM_001040280 NM_004233	CD83	CD83 molecule
chr19_-_51512803	0.607	NM_012315	KLK9	kallikrein-related peptidase 9
chr2_+_182850550	0.604	NM_001080545	PPP1R1C	protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr9_-_104145800	0.600	NM_001127610	BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr6_-_136847609	0.593		MAP7	microtubule-associated protein 7
chr6_+_90272036	0.590	NM_001242811	ANKRD6	ankyrin repeat domain 6
chrX_+_138612894	0.586	NM_000133	F9	coagulation factor IX
chr3_+_189507448	0.583	NM_001114980 NM_001114981 NM_001114982	TP63	tumor protein p63
chr1_-_93342706	0.574	NM_001252271	FAM69A	family with sequence similarity 69, member A
chr1_+_33231260	0.553		KIAA1522	KIAA1522
chr1_+_161676761	0.550	NM_001184866 NM_001184867 NM_001184870 NM_001184871 NM_001184872 NM_001184873 NM_032738	FCRLA	Fc receptor-like A
chr12_+_56732658	0.550	NM_016584	IL23A	interleukin 23, alpha subunit p19
chr14_+_76837689	0.549	NM_004452	ESRRB	estrogen-related receptor beta
chr1_+_33231227	0.544	NM_001198972 NM_001198973	KIAA1522	KIAA1522
chr4_-_77328457	0.523	NM_001042784	CCDC158	coiled-coil domain containing 158
chr7_+_20370324	0.523		ITGB8	integrin, beta 8
chr1_-_204459445	0.520	NM_002646	PIK3C2B	phosphoinositide-3-kinase, class 2, beta polypeptide
chr12_+_10163225	0.511	NM_001129998 NM_205852	CLEC12B	C-type lectin domain family 12, member B
chr8_-_28347733	0.504	NM_172366	FBXO16 ZNF395	F-box protein 16 zinc finger protein 395
chr8_+_7738725	0.502	NM_001081551	DEFB103A DEFB103B	defensin, beta 103A defensin, beta 103B
chr19_+_56459197	0.498	NM_176811	NLRP8	NLR family, pyrin domain containing 8
chr4_-_46996423	0.495	NM_000809	GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr17_+_73720775	0.489	NM_001005619	ITGB4	integrin, beta 4
chr10_+_114154522	0.485		ACSL5	acyl-CoA synthetase long-chain family member 5
chr18_-_59854215	0.484		PIGN	phosphatidylinositol glycan anchor biosynthesis, class N
chrX_+_135614310	0.480	NM_016267	VGLL1	vestigial like 1 (Drosophila)
chr17_-_64225496	0.477	NM_000042	APOH	apolipoprotein H (beta-2-glycoprotein I)
chr8_-_66701175	0.475	NM_002603	PDE7A	phosphodiesterase 7A
chr10_-_62149487	0.469	NM_020987	ANK3	ankyrin 3, node of Ranvier (ankyrin G)
chr12_+_113344738	0.469	NM_001032409 NM_002534 NM_016816	OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr4_+_78432905	0.467	NM_006419	CXCL13	chemokine (C-X-C motif) ligand 13
chr3_+_140770742	0.458	NM_080862	SPSB4	splA/ryanodine receptor domain and SOCS box containing 4
chr11_+_1860718	0.455	NM_001145829	TNNI2	troponin I type 2 (skeletal, fast)
chr5_-_176836488	0.454		F12	coagulation factor XII (Hageman factor)
chr1_+_153940345	0.454	NM_130898	CREB3L4	cAMP responsive element binding protein 3-like 4
chr1_-_23886284	0.449	NM_002167	ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr1_+_153003677	0.446	NM_003125	SPRR1B	small proline-rich protein 1B
chr2_+_96991934	0.444	NM_178495 NM_001163524	ITPRIPL1	inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr14_-_94854910	0.439		SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr18_-_28742744	0.436	NM_004948 NM_024421	DSC1	desmocollin 1
chr7_-_41742666	0.435	NM_002192	INHBA	inhibin, beta A
chr7_-_20256942	0.435	NM_182762	MACC1	metastasis associated in colon cancer 1
chr8_-_86253863	0.434	NM_001164830	CA1	carbonic anhydrase I
chr1_-_247921707	0.432	NM_012353	OR1C1	olfactory receptor, family 1, subfamily C, member 1
chr1_+_26503973	0.431	NM_006314	CNKSR1	connector enhancer of kinase suppressor of Ras 1
chr13_+_97874540	0.430	NM_144778 NM_207304	MBNL2	muscleblind-like 2 (Drosophila)
chrX_-_117107700	0.426	NM_033495 NM_001168300	KLHL13	kelch-like 13 (Drosophila)
chr7_+_128578246	0.425	NM_032643	IRF5	interferon regulatory factor 5
chr14_-_21271002	0.415	NM_002933 NM_198234 NM_198235	RNASE1	ribonuclease, RNase A family, 1 (pancreatic)
chr12_-_48298765	0.414	NM_000376 NM_001017535 NM_001017536	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor
chr12_-_48963802	0.413	NM_002289	LALBA	lactalbumin, alpha-
chr17_-_27401216	0.413		TIAF1	TGFB1-induced anti-apoptotic factor 1
chr1_-_24469571	0.410	NM_021258	IL22RA1	interleukin 22 receptor, alpha 1
chrX_-_33229428	0.409	NM_004006	DMD	dystrophin
chr1_+_196743929	0.409	NM_001166624 NM_021023	CFHR3	complement factor H-related 3
chr4_+_77356252	0.408	NM_020859	SHROOM3	shroom family member 3
chr1_-_26680620	0.407	NM_001039775	AIM1L	absent in melanoma 1-like
chr1_+_55013806	0.406	NM_015547 NM_147161	ACOT11	acyl-CoA thioesterase 11
chr10_+_99498233	0.406	NM_001002261	ZFYVE27	zinc finger, FYVE domain containing 27
chr17_-_41322211	0.402		BRCA1	breast cancer 1, early onset
chr12_-_13103317	0.397	NM_018654	GPRC5D	G protein-coupled receptor, family C, group 5, member D
chr20_+_9458460	0.397		PLCB4	phospholipase C, beta 4
chrX_-_32430370	0.391	NM_004011 NM_004012	DMD	dystrophin
chr1_+_86934525	0.391	NM_001285	CLCA1	chloride channel accessory 1
chr1_+_145413190	0.390	NM_145277 NM_202004 NM_213652 NM_213653	HFE2	hemochromatosis type 2 (juvenile)
chr3_-_184079266	0.389	NM_001171087 NM_001171088 NM_001171089 NM_004366	CLCN2	chloride channel 2
chr12_-_71148331	0.389		PTPRR	protein tyrosine phosphatase, receptor type, R
chr11_-_124310980	0.387	NM_012378	OR8B8	olfactory receptor, family 8, subfamily B, member 8
chr3_-_38835500	0.387	NM_006514	SCN10A	sodium channel, voltage-gated, type X, alpha subunit
chr14_-_24037266	0.387	NM_003917	AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr12_-_123187842	0.385	NM_177551	HCAR2	hydroxycarboxylic acid receptor 2
chr12_-_71148383	0.379	NM_130846 NM_001207016	PTPRR	protein tyrosine phosphatase, receptor type, R
chr12_-_18243052	0.377	NM_024730	RERGL	RERG/RAS-like
chr4_+_89299980	0.377		HERC6	hect domain and RLD 6
chr1_-_216978708	0.375	NM_001243514	ESRRG	estrogen-related receptor gamma
chr17_-_26127395	0.374		NOS2	nitric oxide synthase 2, inducible
chr8_+_128427856	0.373	NM_001159542	POU5F1B	POU class 5 homeobox 1B
chr21_+_34697277	0.372		IFNAR1	interferon (alpha, beta and omega) receptor 1
chr14_-_21270537	0.371	NM_198232	RNASE1	ribonuclease, RNase A family, 1 (pancreatic)
chr2_+_102615456	0.370	NM_173343	IL1R2	interleukin 1 receptor, type II
chr7_+_50348255	0.369		IKZF1	IKAROS family zinc finger 1 (Ikaros)
chr5_+_140174443	0.369	NM_018905 NM_031495	PCDHA2	protocadherin alpha 2
chr17_-_26127474	0.367	NM_000625	NOS2	nitric oxide synthase 2, inducible
chr12_-_9760481	0.362	NM_002258	KLRB1	killer cell lectin-like receptor subfamily B, member 1
chr14_-_92333856	0.361	NM_001128596	TC2N	tandem C2 domains, nuclear
chr3_-_124930192	0.360	NM_001195483	SLC12A8	solute carrier family 12 (potassium/chloride transporters), member 8
chr17_-_4642638	0.359		CXCL16	chemokine (C-X-C motif) ligand 16
chr7_-_25268057	0.358	NM_022150	NPVF	neuropeptide VF precursor
chrX_+_65235279	0.354
chr1_+_171154387	0.353	NM_001460	FMO2	flavin containing monooxygenase 2 (non-functional)
chr8_-_17555158	0.350	NM_020749	MTUS1	microtubule associated tumor suppressor 1
chr12_+_53497273	0.344	NM_003578	SOAT2	sterol O-acyltransferase 2
chr9_-_117150217	0.343		AKNA	AT-hook transcription factor
chr17_+_73553883	0.343		LLGL2	lethal giant larvae homolog 2 (Drosophila)
chr2_+_103035148	0.342	NM_003853	IL18RAP	interleukin 18 receptor accessory protein
chr14_-_94855120	0.342	NM_000295	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr9_-_117568292	0.337	NM_005118	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15
chr6_+_30294224	0.337
chr20_-_1309809	0.336	NM_080489	SDCBP2	syndecan binding protein (syntenin) 2
chr3_-_190040192	0.334	NM_021101	CLDN1	claudin 1
chrX_+_128913897	0.334		SASH3	SAM and SH3 domain containing 3
chr6_+_129204285	0.332	NM_000426 NM_001079823	LAMA2	laminin, alpha 2
chr4_+_103422479	0.330	NM_001165412 NM_003998	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr8_-_125580745	0.329		MTSS1	metastasis suppressor 1
chrX_+_38420690	0.327	NM_004615	TSPAN7	tetraspanin 7
chrX_+_65384078	0.323	NM_001130860 NM_014799	HEPH	hephaestin
chr1_-_120935893	0.319		FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr1_+_95582827	0.318	NM_152487	TMEM56	transmembrane protein 56
chr3_+_52813936	0.317	NM_001166435 NM_001166436	ITIH1	inter-alpha-trypsin inhibitor heavy chain 1
chr12_+_21168629	0.313	NM_001009562	SLCO1B7	solute carrier organic anion transporter family, member 1B7 (non-functional)
chr9_-_117554809	0.312	NM_001204344	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15
chr1_+_160765927	0.310	NM_001033667 NM_002348	LY9	lymphocyte antigen 9
chr12_-_71148063	0.305		PTPRR	protein tyrosine phosphatase, receptor type, R
chr13_-_76055872	0.304	NM_014832	TBC1D4	TBC1 domain family, member 4
chr4_-_80247153	0.303	NM_032693	NAA11	N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr7_-_140302311	0.303	NM_015689	DENND2A	DENN/MADD domain containing 2A
chr1_+_40420837	0.302		MFSD2A	major facilitator superfamily domain containing 2A
chr5_-_141993691	0.302	NM_033137	FGF1	fibroblast growth factor 1 (acidic)
chr17_-_39538635	0.301	NM_021013	KRT34	keratin 34
chr12_+_7055736	0.300	NM_080548	PTPN6	protein tyrosine phosphatase, non-receptor type 6

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.92	8.81e-05	GO:0006955	immune response
1.74	4.37e-03	GO:0006952	defense response
1.59	4.61e-03	GO:0002376	immune system process
2.06	2.37e-02	GO:0045087	innate immune response
1.63	4.37e-02	GO:0006811	ion transport

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.27	2.62e-06	GO:0031224	intrinsic to membrane
1.27	9.11e-06	GO:0016021	integral to membrane
1.23	1.95e-05	GO:0044425	membrane part
1.30	4.86e-05	GO:0005886	plasma membrane
1.47	6.19e-05	GO:0005576	extracellular region
1.29	8.64e-05	GO:0071944	cell periphery
1.62	1.31e-04	GO:0005887	integral to plasma membrane
1.44	1.44e-04	GO:0044459	plasma membrane part
1.60	1.82e-04	GO:0031226	intrinsic to plasma membrane
1.14	1.23e-02	GO:0016020	membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
2.04	1.73e-03	GO:0015267	channel activity
2.03	1.86e-03	GO:0022803	passive transmembrane transporter activity
1.95	1.37e-02	GO:0005216	ion channel activity
3.48	1.91e-02	GO:0005254	chloride channel activity
1.92	1.98e-02	GO:0022838	substrate-specific channel activity
1.55	3.39e-02	GO:0022857	transmembrane transporter activity
2.52	4.21e-02	GO:0008509	anion transmembrane transporter activity